Incidental Mutation 'R1348:Or1e1'
ID 156575
Institutional Source Beutler Lab
Gene Symbol Or1e1
Ensembl Gene ENSMUSG00000062128
Gene Name olfactory receptor family 1 subfamily E member 1
Synonyms MTPCR06, MOR135-11, Olfr20, Olfr21, MTPCR55, GA_x6K02T2P1NL-3514066-3515010
MMRRC Submission 039413-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R1348 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73241685-73245525 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 73244682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Isoleucine at position 34 (M34I)
Ref Sequence ENSEMBL: ENSMUSP00000114110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108465] [ENSMUST00000117445] [ENSMUST00000120137]
AlphaFold Q7TRX9
Predicted Effect probably benign
Transcript: ENSMUST00000108465
AA Change: M34I

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000104105
Gene: ENSMUSG00000062128
AA Change: M34I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.9e-60 PFAM
Pfam:7TM_GPCR_Srsx 35 305 7.8e-8 PFAM
Pfam:7tm_1 41 290 1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117445
Predicted Effect probably benign
Transcript: ENSMUST00000120137
AA Change: M34I

PolyPhen 2 Score 0.019 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000114110
Gene: ENSMUSG00000062128
AA Change: M34I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.3e-61 PFAM
Pfam:7TM_GPCR_Srsx 35 305 1.5e-6 PFAM
Pfam:7tm_1 41 290 2.2e-26 PFAM
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 97.6%
  • 10x: 94.2%
  • 20x: 87.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A G 17: 24,593,212 (GRCm39) probably null Het
Art1 G A 7: 101,756,579 (GRCm39) A33T possibly damaging Het
Aspa G A 11: 73,215,309 (GRCm39) T2I probably damaging Het
Cntn1 C T 15: 92,212,544 (GRCm39) T902I probably damaging Het
Dpep1 G A 8: 123,925,899 (GRCm39) C118Y probably benign Het
Garin1a A G 6: 29,283,284 (GRCm39) H36R probably benign Het
Gucy2g C T 19: 55,211,338 (GRCm39) V631I possibly damaging Het
Igf1r C G 7: 67,868,216 (GRCm39) N1220K probably damaging Het
Insr A T 8: 3,242,635 (GRCm39) I28N probably damaging Het
Katnal2 T C 18: 77,066,238 (GRCm39) probably null Het
Klrb1a T C 6: 128,586,797 (GRCm39) D156G possibly damaging Het
Kpna6 G A 4: 129,555,152 (GRCm39) R26* probably null Het
Muc2 CGTG CGTGTG 7: 141,699,185 (GRCm38) probably null Het
Naa15 C G 3: 51,373,091 (GRCm39) C661W probably damaging Het
Or10g7 T C 9: 39,905,124 (GRCm39) I6T probably benign Het
Or8g20 A G 9: 39,396,532 (GRCm39) S3P probably benign Het
Paxbp1 A G 16: 90,831,904 (GRCm39) V328A probably damaging Het
Pkd1l1 T C 11: 8,784,806 (GRCm39) T1993A probably benign Het
Pold1 C T 7: 44,184,106 (GRCm39) V865I probably benign Het
Racgap1 A G 15: 99,524,246 (GRCm39) I387T possibly damaging Het
Rbm15 G T 3: 107,239,946 (GRCm39) R151S possibly damaging Het
Rbms2 C T 10: 128,012,214 (GRCm39) probably null Het
Recql4 A G 15: 76,593,411 (GRCm39) I140T probably benign Het
Shld2 T A 14: 33,990,880 (GRCm39) I9F probably damaging Het
Sorl1 A T 9: 41,911,708 (GRCm39) probably null Het
Speg G A 1: 75,399,516 (GRCm39) G2321D probably damaging Het
Trp53tg5 A G 2: 164,315,521 (GRCm39) probably null Het
Tyw3 A C 3: 154,299,451 (GRCm39) M86R possibly damaging Het
Vmn1r11 G A 6: 57,114,963 (GRCm39) C209Y probably benign Het
Zfp472 T A 17: 33,196,794 (GRCm39) F290I probably benign Het
Other mutations in Or1e1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Or1e1 APN 11 73,244,869 (GRCm39) missense probably damaging 1.00
IGL02163:Or1e1 APN 11 73,245,320 (GRCm39) missense probably damaging 1.00
R0598:Or1e1 UTSW 11 73,244,729 (GRCm39) missense probably benign
R2006:Or1e1 UTSW 11 73,245,518 (GRCm39) missense probably benign
R2085:Or1e1 UTSW 11 73,245,247 (GRCm39) missense possibly damaging 0.95
R2263:Or1e1 UTSW 11 73,245,131 (GRCm39) missense possibly damaging 0.89
R3421:Or1e1 UTSW 11 73,245,460 (GRCm39) missense probably damaging 1.00
R3422:Or1e1 UTSW 11 73,245,460 (GRCm39) missense probably damaging 1.00
R4229:Or1e1 UTSW 11 73,245,058 (GRCm39) missense probably damaging 1.00
R4749:Or1e1 UTSW 11 73,245,322 (GRCm39) missense probably damaging 1.00
R5410:Or1e1 UTSW 11 73,244,632 (GRCm39) missense probably benign 0.11
R6035:Or1e1 UTSW 11 73,244,582 (GRCm39) start codon destroyed probably null 1.00
R6035:Or1e1 UTSW 11 73,244,582 (GRCm39) start codon destroyed probably null 1.00
R6499:Or1e1 UTSW 11 73,245,011 (GRCm39) missense probably damaging 1.00
R7840:Or1e1 UTSW 11 73,244,585 (GRCm39) missense probably benign
R7959:Or1e1 UTSW 11 73,244,744 (GRCm39) missense probably damaging 1.00
R8186:Or1e1 UTSW 11 73,245,247 (GRCm39) missense possibly damaging 0.95
R9072:Or1e1 UTSW 11 73,244,797 (GRCm39) missense probably damaging 1.00
R9135:Or1e1 UTSW 11 73,245,316 (GRCm39) missense probably damaging 0.99
R9225:Or1e1 UTSW 11 73,244,595 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAGGGTGCAGTCAATCACTGAAC -3'
(R):5'- TGGGGCTCATGATGCTCATGTAATG -3'

Sequencing Primer
(F):5'- GGTGCAGTCAATCACTGAACATATAG -3'
(R):5'- TGTCAGGCATCCTGCATAG -3'
Posted On 2014-02-11