Incidental Mutation 'IGL01934:Or1o2'
ID 180540
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1o2
Ensembl Gene ENSMUSG00000058802
Gene Name olfactory receptor family 1 subfamily O member 2
Synonyms MOR156-2, GA_x6K02T2PSCP-1672287-1671355, Olfr97
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL01934
Quality Score
Status
Chromosome 17
Chromosomal Location 37542327-37543259 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37542439 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Aspartic acid at position 274 (V274D)
Ref Sequence ENSEMBL: ENSMUSP00000151044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073667] [ENSMUST00000207414] [ENSMUST00000213328] [ENSMUST00000213475] [ENSMUST00000214482] [ENSMUST00000214622] [ENSMUST00000214848] [ENSMUST00000216225]
AlphaFold Q8VFE1
Predicted Effect probably damaging
Transcript: ENSMUST00000073667
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000094937
Gene: ENSMUSG00000058802
AA Change: V274D

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 24 305 4.5e-9 PFAM
Pfam:7tm_4 29 306 1.4e-54 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.1e-5 PFAM
Pfam:7tm_1 39 288 8.6e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207414
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000213328
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000213475
Predicted Effect probably benign
Transcript: ENSMUST00000214482
Predicted Effect probably damaging
Transcript: ENSMUST00000214622
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000214848
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000216225
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik T C 14: 54,823,112 (GRCm39) K362E probably damaging Het
4932438H23Rik T A 16: 90,852,753 (GRCm39) T128S probably damaging Het
Aars1 T A 8: 111,774,650 (GRCm39) I593N probably damaging Het
Abca6 A T 11: 110,079,481 (GRCm39) N1224K probably benign Het
Abcc5 A T 16: 20,241,191 (GRCm39) probably benign Het
Adam7 A G 14: 68,770,048 (GRCm39) L35P probably damaging Het
Ahnak T A 19: 8,980,021 (GRCm39) L435Q probably damaging Het
Ankef1 A G 2: 136,394,451 (GRCm39) E620G possibly damaging Het
Aoc1l3 A T 6: 48,965,695 (GRCm39) I568F probably damaging Het
Ap3d1 A T 10: 80,545,092 (GRCm39) L1082* probably null Het
Atp6v0a4 T A 6: 38,028,481 (GRCm39) I712F possibly damaging Het
Bco1 T A 8: 117,822,784 (GRCm39) F5L possibly damaging Het
Cacna2d4 A T 6: 119,285,729 (GRCm39) S794C probably damaging Het
Camk2d T C 3: 126,628,304 (GRCm39) probably null Het
Capn15 T C 17: 26,181,998 (GRCm39) T604A probably damaging Het
Cd180 A T 13: 102,839,366 (GRCm39) D83V probably damaging Het
Ces1a C A 8: 93,759,278 (GRCm39) R286L probably damaging Het
Col6a6 A G 9: 105,575,858 (GRCm39) probably null Het
Crnkl1 A G 2: 145,773,202 (GRCm39) V148A probably benign Het
Epas1 A T 17: 87,131,157 (GRCm39) K312N probably damaging Het
Fbxw2 T C 2: 34,712,618 (GRCm39) S148G probably damaging Het
Fig4 T C 10: 41,104,108 (GRCm39) T791A probably benign Het
Galnt9 A T 5: 110,750,502 (GRCm39) I340F possibly damaging Het
Gfap G A 11: 102,785,286 (GRCm39) A230V probably damaging Het
Gm10718 A T 9: 3,025,118 (GRCm39) Y194F probably benign Het
Gm454 T C 5: 138,205,424 (GRCm39) noncoding transcript Het
Il24 A T 1: 130,811,614 (GRCm39) L115Q probably damaging Het
Ipp C A 4: 116,367,852 (GRCm39) N28K probably damaging Het
Kalrn A T 16: 34,018,882 (GRCm39) probably null Het
Klf10 C T 15: 38,297,528 (GRCm39) V171M probably benign Het
Man1b1 T C 2: 25,235,523 (GRCm39) S350P probably benign Het
Mfsd4a T C 1: 131,974,049 (GRCm39) Y343C probably damaging Het
Mrpl58 C A 11: 115,301,555 (GRCm39) probably benign Het
Myo7b A G 18: 32,134,394 (GRCm39) probably null Het
Nbas T C 12: 13,339,880 (GRCm39) probably benign Het
Nisch A G 14: 30,898,696 (GRCm39) probably benign Het
Or52z14 T C 7: 103,253,182 (GRCm39) F107S probably damaging Het
Or5p69 A G 7: 107,967,368 (GRCm39) I224V probably damaging Het
Parva T A 7: 112,187,760 (GRCm39) C352* probably null Het
Ptf1a T A 2: 19,451,431 (GRCm39) C254S possibly damaging Het
R3hdm1 G T 1: 128,164,272 (GRCm39) R1062L probably benign Het
Rnf44 A G 13: 54,829,763 (GRCm39) V407A probably damaging Het
Shank3 T C 15: 89,434,049 (GRCm39) L1598P probably damaging Het
Slit2 T C 5: 48,395,747 (GRCm39) S717P possibly damaging Het
Tdpoz4 A G 3: 93,704,779 (GRCm39) K359E probably damaging Het
Tmtc4 A T 14: 123,165,047 (GRCm39) L604* probably null Het
Tnfrsf21 A T 17: 43,376,078 (GRCm39) N488I probably benign Het
Tnfsf8 A G 4: 63,752,747 (GRCm39) probably benign Het
Tnpo3 A T 6: 29,575,019 (GRCm39) L382M probably benign Het
Tut1 T C 19: 8,931,355 (GRCm39) C18R probably damaging Het
Ugt8a A G 3: 125,708,424 (GRCm39) S229P probably benign Het
Usp22 T C 11: 61,046,114 (GRCm39) E476G probably damaging Het
Vill G T 9: 118,895,877 (GRCm39) A146S probably damaging Het
Vmn1r178 T C 7: 23,593,362 (GRCm39) Y137H probably damaging Het
Wdfy1 A T 1: 79,717,833 (GRCm39) W51R probably damaging Het
Zc3hav1 A T 6: 38,296,768 (GRCm39) probably null Het
Zfp236 A T 18: 82,651,245 (GRCm39) V889E probably damaging Het
Zscan20 T C 4: 128,486,277 (GRCm39) D141G possibly damaging Het
Other mutations in Or1o2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02424:Or1o2 APN 17 37,543,263 (GRCm39) start gained probably benign
IGL03129:Or1o2 APN 17 37,543,087 (GRCm39) missense probably damaging 1.00
R0619:Or1o2 UTSW 17 37,543,046 (GRCm39) missense possibly damaging 0.92
R0811:Or1o2 UTSW 17 37,543,223 (GRCm39) missense probably benign 0.00
R0812:Or1o2 UTSW 17 37,543,223 (GRCm39) missense probably benign 0.00
R1122:Or1o2 UTSW 17 37,542,934 (GRCm39) missense probably damaging 1.00
R1927:Or1o2 UTSW 17 37,542,434 (GRCm39) missense probably damaging 1.00
R1997:Or1o2 UTSW 17 37,542,523 (GRCm39) missense probably damaging 1.00
R3771:Or1o2 UTSW 17 37,542,356 (GRCm39) missense possibly damaging 0.53
R3775:Or1o2 UTSW 17 37,543,121 (GRCm39) missense probably damaging 0.98
R4182:Or1o2 UTSW 17 37,542,739 (GRCm39) missense possibly damaging 0.93
R4183:Or1o2 UTSW 17 37,542,739 (GRCm39) missense possibly damaging 0.93
R4184:Or1o2 UTSW 17 37,542,739 (GRCm39) missense possibly damaging 0.93
R4198:Or1o2 UTSW 17 37,543,025 (GRCm39) missense probably benign 0.01
R7453:Or1o2 UTSW 17 37,542,871 (GRCm39) missense probably damaging 1.00
R7615:Or1o2 UTSW 17 37,542,341 (GRCm39) missense probably benign 0.25
R7829:Or1o2 UTSW 17 37,543,201 (GRCm39) missense probably benign 0.01
R8223:Or1o2 UTSW 17 37,542,727 (GRCm39) missense possibly damaging 0.89
R8526:Or1o2 UTSW 17 37,542,470 (GRCm39) missense probably damaging 0.97
R9098:Or1o2 UTSW 17 37,542,961 (GRCm39) missense probably benign 0.12
Z1177:Or1o2 UTSW 17 37,543,187 (GRCm39) missense probably benign 0.00
Posted On 2014-05-07