Incidental Mutation 'IGL01934:Olfr97'
ID180540
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr97
Ensembl Gene ENSMUSG00000058802
Gene Nameolfactory receptor 97
SynonymsMOR156-2, GA_x6K02T2PSCP-1672287-1671355
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.063) question?
Stock #IGL01934
Quality Score
Status
Chromosome17
Chromosomal Location37230963-37237330 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 37231548 bp
ZygosityHeterozygous
Amino Acid Change Valine to Aspartic acid at position 274 (V274D)
Ref Sequence ENSEMBL: ENSMUSP00000151044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073667] [ENSMUST00000207414] [ENSMUST00000213328] [ENSMUST00000213475] [ENSMUST00000214482] [ENSMUST00000214622] [ENSMUST00000214848] [ENSMUST00000216225]
Predicted Effect probably damaging
Transcript: ENSMUST00000073667
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000094937
Gene: ENSMUSG00000058802
AA Change: V274D

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srv 24 305 4.5e-9 PFAM
Pfam:7tm_4 29 306 1.4e-54 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.1e-5 PFAM
Pfam:7tm_1 39 288 8.6e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000207414
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000213328
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably benign
Transcript: ENSMUST00000213475
Predicted Effect probably benign
Transcript: ENSMUST00000214482
Predicted Effect probably damaging
Transcript: ENSMUST00000214622
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000214848
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000216225
AA Change: V274D

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931414P19Rik T C 14: 54,585,655 K362E probably damaging Het
4932438H23Rik T A 16: 91,055,865 T128S probably damaging Het
Aars T A 8: 111,048,018 I593N probably damaging Het
Abca6 A T 11: 110,188,655 N1224K probably benign Het
Abcc5 A T 16: 20,422,441 probably benign Het
Adam7 A G 14: 68,532,599 L35P probably damaging Het
Ahnak T A 19: 9,002,657 L435Q probably damaging Het
Ankef1 A G 2: 136,552,531 E620G possibly damaging Het
Ap3d1 A T 10: 80,709,258 L1082* probably null Het
Atp6v0a4 T A 6: 38,051,546 I712F possibly damaging Het
Bco1 T A 8: 117,096,045 F5L possibly damaging Het
Cacna2d4 A T 6: 119,308,768 S794C probably damaging Het
Camk2d T C 3: 126,834,655 probably null Het
Capn15 T C 17: 25,963,024 T604A probably damaging Het
Cd180 A T 13: 102,702,858 D83V probably damaging Het
Ces1a C A 8: 93,032,650 R286L probably damaging Het
Col6a6 A G 9: 105,698,659 probably null Het
Crnkl1 A G 2: 145,931,282 V148A probably benign Het
Epas1 A T 17: 86,823,729 K312N probably damaging Het
Fbxw2 T C 2: 34,822,606 S148G probably damaging Het
Fig4 T C 10: 41,228,112 T791A probably benign Het
Galnt9 A T 5: 110,602,636 I340F possibly damaging Het
Gfap G A 11: 102,894,460 A230V probably damaging Het
Gm10718 A T 9: 3,025,118 Y194F probably benign Het
Gm454 T C 5: 138,207,162 noncoding transcript Het
Il24 A T 1: 130,883,877 L115Q probably damaging Het
Ipp C A 4: 116,510,655 N28K probably damaging Het
Kalrn A T 16: 34,198,512 probably null Het
Klf10 C T 15: 38,297,284 V171M probably benign Het
Man1b1 T C 2: 25,345,511 S350P probably benign Het
Mfsd4a T C 1: 132,046,311 Y343C probably damaging Het
Mrpl58 C A 11: 115,410,729 probably benign Het
Myo7b A G 18: 32,001,341 probably null Het
Nbas T C 12: 13,289,879 probably benign Het
Nisch A G 14: 31,176,739 probably benign Het
Olfr494 A G 7: 108,368,161 I224V probably damaging Het
Olfr619 T C 7: 103,603,975 F107S probably damaging Het
Parva T A 7: 112,588,553 C352* probably null Het
Ptf1a T A 2: 19,446,620 C254S possibly damaging Het
R3hdm1 G T 1: 128,236,535 R1062L probably benign Het
Rnf44 A G 13: 54,681,950 V407A probably damaging Het
Shank3 T C 15: 89,549,846 L1598P probably damaging Het
Slit2 T C 5: 48,238,405 S717P possibly damaging Het
Svs1 A T 6: 48,988,761 I568F probably damaging Het
Tdpoz4 A G 3: 93,797,472 K359E probably damaging Het
Tmtc4 A T 14: 122,927,635 L604* probably null Het
Tnfrsf21 A T 17: 43,065,187 N488I probably benign Het
Tnfsf8 A G 4: 63,834,510 probably benign Het
Tnpo3 A T 6: 29,575,020 L382M probably benign Het
Tut1 T C 19: 8,953,991 C18R probably damaging Het
Ugt8a A G 3: 125,914,775 S229P probably benign Het
Usp22 T C 11: 61,155,288 E476G probably damaging Het
Vill G T 9: 119,066,809 A146S probably damaging Het
Vmn1r178 T C 7: 23,893,937 Y137H probably damaging Het
Wdfy1 A T 1: 79,740,116 W51R probably damaging Het
Zc3hav1 A T 6: 38,319,833 probably null Het
Zfp236 A T 18: 82,633,120 V889E probably damaging Het
Zscan20 T C 4: 128,592,484 D141G possibly damaging Het
Other mutations in Olfr97
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02424:Olfr97 APN 17 37232372 start gained probably benign
IGL03129:Olfr97 APN 17 37232196 missense probably damaging 1.00
R0619:Olfr97 UTSW 17 37232155 missense possibly damaging 0.92
R0811:Olfr97 UTSW 17 37232332 missense probably benign 0.00
R0812:Olfr97 UTSW 17 37232332 missense probably benign 0.00
R1122:Olfr97 UTSW 17 37232043 missense probably damaging 1.00
R1927:Olfr97 UTSW 17 37231543 missense probably damaging 1.00
R1997:Olfr97 UTSW 17 37231632 missense probably damaging 1.00
R3771:Olfr97 UTSW 17 37231465 missense possibly damaging 0.53
R3775:Olfr97 UTSW 17 37232230 missense probably damaging 0.98
R4182:Olfr97 UTSW 17 37231848 missense possibly damaging 0.93
R4183:Olfr97 UTSW 17 37231848 missense possibly damaging 0.93
R4184:Olfr97 UTSW 17 37231848 missense possibly damaging 0.93
R4198:Olfr97 UTSW 17 37232134 missense probably benign 0.01
R7453:Olfr97 UTSW 17 37231980 missense probably damaging 1.00
R7615:Olfr97 UTSW 17 37231450 missense probably benign 0.25
R7829:Olfr97 UTSW 17 37232310 missense probably benign 0.01
R8223:Olfr97 UTSW 17 37231836 missense possibly damaging 0.89
R8526:Olfr97 UTSW 17 37231579 missense probably damaging 0.97
Z1177:Olfr97 UTSW 17 37232296 missense probably benign 0.00
Posted On2014-05-07