Incidental Mutation 'R3036:Ly6f'
| ID |
263376 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ly6f
|
| Ensembl Gene |
ENSMUSG00000022583 |
| Gene Name |
lymphocyte antigen 6 family member F |
| Synonyms |
|
| MMRRC Submission |
040552-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.060)
|
| Stock # |
R3036 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
15 |
| Chromosomal Location |
75140270-75144084 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 75140636 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 20
(C20R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000140899
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023247]
[ENSMUST00000189654]
|
| AlphaFold |
P35460 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000023247
AA Change: C20R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000023247
Gene: ENSMUSG00000022583
AA Change: C20R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
LU
|
27 |
118 |
1.94e-35 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189654
AA Change: C20R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000140899
Gene: ENSMUSG00000022583
AA Change: C20R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
26 |
N/A |
INTRINSIC |
|
LU
|
27 |
118 |
1.94e-35 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 17 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Atg10 |
A |
G |
13: 91,189,017 (GRCm39) |
S98P |
probably damaging |
Het |
| Caskin2 |
A |
G |
11: 115,697,182 (GRCm39) |
Y189H |
probably damaging |
Het |
| Ces2b |
A |
G |
8: 105,561,258 (GRCm39) |
I143V |
possibly damaging |
Het |
| Gpr108 |
A |
G |
17: 57,552,323 (GRCm39) |
V90A |
probably benign |
Het |
| Kcnk18 |
T |
A |
19: 59,223,494 (GRCm39) |
V213D |
probably benign |
Het |
| Mbl1 |
C |
A |
14: 40,880,790 (GRCm39) |
S226Y |
probably damaging |
Het |
| Mdn1 |
T |
C |
4: 32,750,013 (GRCm39) |
C4399R |
probably damaging |
Het |
| Myadm |
A |
G |
7: 3,346,059 (GRCm39) |
T274A |
probably benign |
Het |
| Nol11 |
A |
G |
11: 107,064,070 (GRCm39) |
S561P |
possibly damaging |
Het |
| Pbld2 |
T |
C |
10: 62,907,225 (GRCm39) |
S155P |
probably damaging |
Het |
| Rab36 |
G |
A |
10: 74,880,328 (GRCm39) |
V63I |
probably damaging |
Het |
| Sumf1 |
G |
A |
6: 108,130,152 (GRCm39) |
A214V |
possibly damaging |
Het |
| Teddm1a |
A |
G |
1: 153,767,656 (GRCm39) |
Y40C |
probably benign |
Het |
| Tgm2 |
C |
T |
2: 157,966,167 (GRCm39) |
G496S |
probably benign |
Het |
| Trpm5 |
G |
A |
7: 142,639,200 (GRCm39) |
T239I |
probably benign |
Het |
| Ttn |
C |
A |
2: 76,730,960 (GRCm39) |
|
probably benign |
Het |
| Uty |
G |
A |
Y: 1,099,671 (GRCm39) |
R1112* |
probably null |
Het |
|
| Other mutations in Ly6f |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0480:Ly6f
|
UTSW |
15 |
75,143,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1084:Ly6f
|
UTSW |
15 |
75,140,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3113:Ly6f
|
UTSW |
15 |
75,143,577 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4549:Ly6f
|
UTSW |
15 |
75,143,579 (GRCm39) |
missense |
probably benign |
|
|
R4824:Ly6f
|
UTSW |
15 |
75,143,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5148:Ly6f
|
UTSW |
15 |
75,143,646 (GRCm39) |
missense |
probably benign |
|
|
R5211:Ly6f
|
UTSW |
15 |
75,143,652 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5295:Ly6f
|
UTSW |
15 |
75,143,488 (GRCm39) |
missense |
probably benign |
0.39 |
|
R9106:Ly6f
|
UTSW |
15 |
75,141,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9455:Ly6f
|
UTSW |
15 |
75,141,648 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GGCAGACATGTATTCCTTGGG -3'
(R):5'- GGTTACAGACCCAGTAAAGCAC -3'
Sequencing Primer
(F):5'- CCTTGGGGAAAGCTGGG -3'
(R):5'- GCACACAACACATGAGGCTTC -3'
|
| Posted On |
2015-02-05 |
Incidental Mutation