Incidental Mutation 'IGL02315:Parp6'
ID288019
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Parp6
Ensembl Gene ENSMUSG00000025237
Gene Namepoly (ADP-ribose) polymerase family, member 6
Synonyms
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.598) question?
Stock #IGL02315
Quality Score
Status
Chromosome9
Chromosomal Location59617284-59650285 bp(+) (GRCm38)
Type of Mutationintron
DNA Base Change (assembly) A to G at 59641738 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000148866 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026267] [ENSMUST00000050483] [ENSMUST00000167091] [ENSMUST00000216351]
Predicted Effect probably benign
Transcript: ENSMUST00000026267
SMART Domains Protein: ENSMUSP00000026267
Gene: ENSMUSG00000025237

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
low complexity region 175 189 N/A INTRINSIC
low complexity region 323 335 N/A INTRINSIC
Pfam:PARP 450 580 5.6e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000050483
SMART Domains Protein: ENSMUSP00000063065
Gene: ENSMUSG00000025237

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
low complexity region 175 189 N/A INTRINSIC
low complexity region 303 315 N/A INTRINSIC
SCOP:d1a26_2 409 475 4e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000167091
SMART Domains Protein: ENSMUSP00000129456
Gene: ENSMUSG00000025237

DomainStartEndE-ValueType
low complexity region 9 21 N/A INTRINSIC
low complexity region 175 189 N/A INTRINSIC
low complexity region 323 335 N/A INTRINSIC
SCOP:d1a26_2 429 473 4e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000214956
Predicted Effect probably benign
Transcript: ENSMUST00000216351
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216482
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930402F06Rik T A 2: 35,376,173 I162F probably damaging Het
Akap8 T C 17: 32,305,501 D607G probably benign Het
Ap2b1 G A 11: 83,336,799 V327I probably damaging Het
Bmpr1b A G 3: 141,857,529 V218A probably damaging Het
Cfap157 T A 2: 32,778,165 D421V probably benign Het
Ctsm A G 13: 61,539,648 V100A probably benign Het
Cwf19l2 C T 9: 3,410,030 T53I probably damaging Het
Dst T C 1: 34,198,665 C3663R probably damaging Het
Fbxo10 T A 4: 45,062,469 H19L probably benign Het
Ghitm A T 14: 37,131,564 N106K probably benign Het
Hivep2 T C 10: 14,131,239 F1194L probably benign Het
Hpse2 A G 19: 42,966,947 probably benign Het
Ighv1-67 C T 12: 115,604,067 G56D probably benign Het
Ikzf4 A G 10: 128,634,145 F502S probably damaging Het
Lrrc24 A T 15: 76,718,306 F126L probably damaging Het
Mapt G A 11: 104,328,078 R355Q probably damaging Het
Mug1 T A 6: 121,840,167 V65E probably benign Het
Myh6 T C 14: 54,953,834 E850G probably damaging Het
Myh9 C A 15: 77,769,973 V1211L probably benign Het
Naip2 T A 13: 100,161,236 D764V probably damaging Het
Olfr926 G A 9: 38,878,057 V294I probably damaging Het
Ppp4r4 C T 12: 103,600,361 probably benign Het
Pramef6 T C 4: 143,897,928 probably benign Het
Pxylp1 A G 9: 96,839,143 L56P probably damaging Het
Rita1 C T 5: 120,609,793 A147T probably damaging Het
Skida1 T C 2: 18,046,005 probably benign Het
Slc35d2 A G 13: 64,107,035 S210P possibly damaging Het
Slit2 C T 5: 47,987,871 T71M probably damaging Het
Spem2 A T 11: 69,817,365 L258Q probably damaging Het
Stxbp2 C T 8: 3,635,607 probably benign Het
Vit G A 17: 78,622,658 V351I possibly damaging Het
Zwilch A G 9: 64,150,267 S285P probably damaging Het
Zzef1 A T 11: 72,875,257 R1537* probably null Het
Other mutations in Parp6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00961:Parp6 APN 9 59632959 missense probably damaging 1.00
IGL01366:Parp6 APN 9 59636713 missense possibly damaging 0.75
IGL01385:Parp6 APN 9 59630612 splice site probably benign
IGL02000:Parp6 APN 9 59648892 missense probably benign 0.00
IGL02001:Parp6 APN 9 59649961 missense possibly damaging 0.90
IGL02719:Parp6 APN 9 59630738 missense probably benign 0.26
IGL02928:Parp6 APN 9 59641063 missense possibly damaging 0.70
IGL03169:Parp6 APN 9 59650017 nonsense probably null
IGL03398:Parp6 APN 9 59641053 missense probably damaging 0.97
R0165:Parp6 UTSW 9 59632925 missense probably damaging 1.00
R0602:Parp6 UTSW 9 59649365 splice site probably benign
R0781:Parp6 UTSW 9 59649564 missense probably damaging 0.99
R1110:Parp6 UTSW 9 59649564 missense probably damaging 0.99
R1730:Parp6 UTSW 9 59633538 nonsense probably null
R1783:Parp6 UTSW 9 59633538 nonsense probably null
R2264:Parp6 UTSW 9 59624005 missense probably damaging 1.00
R4323:Parp6 UTSW 9 59630686 missense possibly damaging 0.84
R4654:Parp6 UTSW 9 59641100 splice site probably null
R4672:Parp6 UTSW 9 59640110 missense probably damaging 1.00
R4673:Parp6 UTSW 9 59640110 missense probably damaging 1.00
R4708:Parp6 UTSW 9 59641769 missense probably damaging 0.98
R4709:Parp6 UTSW 9 59641769 missense probably damaging 0.98
R4763:Parp6 UTSW 9 59631365 missense probably damaging 1.00
R4782:Parp6 UTSW 9 59634984 splice site probably null
R4825:Parp6 UTSW 9 59624362 splice site probably null
R5563:Parp6 UTSW 9 59628673 splice site probably null
R5700:Parp6 UTSW 9 59624727 missense probably damaging 1.00
R6235:Parp6 UTSW 9 59630815 missense probably benign 0.34
R6269:Parp6 UTSW 9 59650012 missense probably benign
R6383:Parp6 UTSW 9 59623939 missense probably damaging 0.99
X0061:Parp6 UTSW 9 59630765 missense probably benign 0.25
Posted On2015-04-16