Incidental Mutation 'IGL02404:Zfp668'
ID |
292015 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Zfp668
|
Ensembl Gene |
ENSMUSG00000049728 |
Gene Name |
zinc finger protein 668 |
Synonyms |
E130018B19Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.147)
|
Stock # |
IGL02404
|
Quality Score |
|
Status
|
|
Chromosome |
7 |
Chromosomal Location |
127462219-127476000 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 127465532 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Glutamic Acid
at position 551
(K551E)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000101870
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054415]
[ENSMUST00000106261]
[ENSMUST00000106262]
[ENSMUST00000106263]
[ENSMUST00000144721]
|
AlphaFold |
Q8K2R5 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000054415
AA Change: K551E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000056105 Gene: ENSMUSG00000049728 AA Change: K551E
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000106261
AA Change: K551E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000101868 Gene: ENSMUSG00000049728 AA Change: K551E
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000106262
AA Change: K551E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000101869 Gene: ENSMUSG00000049728 AA Change: K551E
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000106263
AA Change: K551E
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000101870 Gene: ENSMUSG00000049728 AA Change: K551E
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
ZnF_C2H2
|
112 |
134 |
3.63e-3 |
SMART |
ZnF_C2H2
|
140 |
162 |
2.36e-2 |
SMART |
ZnF_C2H2
|
168 |
190 |
1.98e-4 |
SMART |
ZnF_C2H2
|
196 |
218 |
2.91e-2 |
SMART |
ZnF_C2H2
|
224 |
246 |
1.26e-2 |
SMART |
ZnF_C2H2
|
252 |
274 |
5.21e-4 |
SMART |
ZnF_C2H2
|
280 |
302 |
2.57e-3 |
SMART |
ZnF_C2H2
|
308 |
330 |
5.59e-4 |
SMART |
ZnF_C2H2
|
336 |
358 |
1.79e-2 |
SMART |
ZnF_C2H2
|
364 |
386 |
7.9e-4 |
SMART |
ZnF_C2H2
|
392 |
414 |
5.5e-3 |
SMART |
low complexity region
|
428 |
470 |
N/A |
INTRINSIC |
ZnF_C2H2
|
516 |
538 |
3.63e-3 |
SMART |
ZnF_C2H2
|
544 |
566 |
1.3e-4 |
SMART |
ZnF_C2H2
|
572 |
594 |
5.59e-4 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000144721
|
SMART Domains |
Protein: ENSMUSP00000116730 Gene: ENSMUSG00000049728
Domain | Start | End | E-Value | Type |
ZnF_C2H2
|
22 |
44 |
7.67e-2 |
SMART |
ZnF_C2H2
|
84 |
106 |
9.44e-2 |
SMART |
|
Coding Region Coverage |
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adcy6 |
T |
C |
15: 98,494,819 (GRCm39) |
I745V |
probably benign |
Het |
Alppl2 |
A |
G |
1: 87,016,585 (GRCm39) |
V163A |
possibly damaging |
Het |
Atad2b |
T |
A |
12: 4,991,972 (GRCm39) |
S190R |
probably benign |
Het |
Cep68 |
A |
G |
11: 20,190,004 (GRCm39) |
V336A |
possibly damaging |
Het |
Clcn4 |
A |
C |
7: 7,290,857 (GRCm39) |
N587K |
probably benign |
Het |
Clic1 |
A |
G |
17: 35,271,852 (GRCm39) |
E82G |
probably damaging |
Het |
Cnbd1 |
T |
C |
4: 18,895,047 (GRCm39) |
S232G |
possibly damaging |
Het |
Cplane1 |
T |
C |
15: 8,216,768 (GRCm39) |
I662T |
possibly damaging |
Het |
Csgalnact1 |
C |
A |
8: 68,854,144 (GRCm39) |
G219V |
probably damaging |
Het |
Daw1 |
A |
G |
1: 83,174,952 (GRCm39) |
T151A |
probably benign |
Het |
Dysf |
A |
G |
6: 84,093,043 (GRCm39) |
E1052G |
probably damaging |
Het |
Gpr12 |
G |
A |
5: 146,520,733 (GRCm39) |
A63V |
probably damaging |
Het |
Inmt |
C |
T |
6: 55,148,095 (GRCm39) |
R178Q |
possibly damaging |
Het |
Metap1 |
A |
T |
3: 138,195,069 (GRCm39) |
C22S |
probably damaging |
Het |
Mst1r |
A |
T |
9: 107,790,266 (GRCm39) |
|
probably benign |
Het |
Or2ag17 |
A |
C |
7: 106,389,566 (GRCm39) |
I214S |
probably damaging |
Het |
Phkb |
T |
C |
8: 86,604,744 (GRCm39) |
S58P |
possibly damaging |
Het |
Pigs |
T |
A |
11: 78,230,857 (GRCm39) |
I368N |
probably benign |
Het |
Plekhm1 |
C |
T |
11: 103,285,824 (GRCm39) |
D204N |
probably benign |
Het |
Pot1a |
A |
T |
6: 25,764,431 (GRCm39) |
|
probably benign |
Het |
Rps4l |
A |
G |
6: 148,256,277 (GRCm39) |
|
probably benign |
Het |
Scn8a |
T |
A |
15: 100,937,611 (GRCm39) |
M1660K |
probably damaging |
Het |
Sec31b |
A |
C |
19: 44,523,227 (GRCm39) |
V23G |
probably damaging |
Het |
Sorcs3 |
T |
C |
19: 48,692,809 (GRCm39) |
|
probably benign |
Het |
Thap12 |
A |
G |
7: 98,359,340 (GRCm39) |
Y73C |
probably damaging |
Het |
Thsd7b |
G |
A |
1: 129,540,888 (GRCm39) |
C254Y |
probably damaging |
Het |
Tmem214 |
G |
A |
5: 31,030,090 (GRCm39) |
A296T |
probably benign |
Het |
Ttn |
T |
A |
2: 76,770,322 (GRCm39) |
N2623I |
possibly damaging |
Het |
Ulk1 |
A |
T |
5: 110,944,100 (GRCm39) |
|
probably null |
Het |
Vps13d |
T |
C |
4: 144,875,305 (GRCm39) |
Y1734C |
probably damaging |
Het |
Vsig10l |
A |
G |
7: 43,113,171 (GRCm39) |
D143G |
possibly damaging |
Het |
Wac |
A |
G |
18: 7,917,570 (GRCm39) |
T347A |
probably damaging |
Het |
Wdr62 |
G |
T |
7: 29,967,298 (GRCm39) |
R319S |
probably damaging |
Het |
|
Other mutations in Zfp668 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00944:Zfp668
|
APN |
7 |
127,467,079 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01063:Zfp668
|
APN |
7 |
127,465,454 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01909:Zfp668
|
APN |
7 |
127,465,994 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02543:Zfp668
|
APN |
7 |
127,467,494 (GRCm39) |
nonsense |
probably null |
|
IGL02946:Zfp668
|
APN |
7 |
127,465,690 (GRCm39) |
missense |
possibly damaging |
0.70 |
R0078:Zfp668
|
UTSW |
7 |
127,467,210 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1521:Zfp668
|
UTSW |
7 |
127,466,252 (GRCm39) |
missense |
probably benign |
0.09 |
R1775:Zfp668
|
UTSW |
7 |
127,465,778 (GRCm39) |
missense |
possibly damaging |
0.75 |
R1873:Zfp668
|
UTSW |
7 |
127,465,654 (GRCm39) |
splice site |
probably null |
|
R1875:Zfp668
|
UTSW |
7 |
127,465,654 (GRCm39) |
splice site |
probably null |
|
R2066:Zfp668
|
UTSW |
7 |
127,466,203 (GRCm39) |
missense |
probably damaging |
0.98 |
R2068:Zfp668
|
UTSW |
7 |
127,465,837 (GRCm39) |
missense |
probably benign |
0.06 |
R2278:Zfp668
|
UTSW |
7 |
127,465,998 (GRCm39) |
missense |
probably benign |
0.05 |
R5516:Zfp668
|
UTSW |
7 |
127,466,318 (GRCm39) |
missense |
probably damaging |
1.00 |
R5569:Zfp668
|
UTSW |
7 |
127,466,995 (GRCm39) |
nonsense |
probably null |
|
R5875:Zfp668
|
UTSW |
7 |
127,465,474 (GRCm39) |
missense |
possibly damaging |
0.61 |
R6663:Zfp668
|
UTSW |
7 |
127,466,941 (GRCm39) |
missense |
probably damaging |
1.00 |
R8543:Zfp668
|
UTSW |
7 |
127,466,392 (GRCm39) |
missense |
probably damaging |
1.00 |
R8822:Zfp668
|
UTSW |
7 |
127,466,315 (GRCm39) |
missense |
probably damaging |
1.00 |
R8905:Zfp668
|
UTSW |
7 |
127,465,598 (GRCm39) |
missense |
probably benign |
0.04 |
R9191:Zfp668
|
UTSW |
7 |
127,465,658 (GRCm39) |
missense |
probably benign |
|
R9217:Zfp668
|
UTSW |
7 |
127,465,804 (GRCm39) |
nonsense |
probably null |
|
R9655:Zfp668
|
UTSW |
7 |
127,466,113 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
Posted On |
2015-04-16 |