Incidental Mutation 'IGL02517:Dpep2'
ID 296851
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Dpep2
Ensembl Gene ENSMUSG00000115067
Gene Name dipeptidase 2
Synonyms F630103D06Rik, MBD-2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.144) question?
Stock # IGL02517
Quality Score
Status
Chromosome 8
Chromosomal Location 106711577-106732658 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 106715388 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 369 (V369M)
Ref Sequence ENSEMBL: ENSMUSP00000154250 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034373] [ENSMUST00000117555] [ENSMUST00000142898] [ENSMUST00000227363]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000034373
AA Change: V280M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034373
Gene: ENSMUSG00000053687
AA Change: V280M

DomainStartEndE-ValueType
signal peptide 1 31 N/A INTRINSIC
Pfam:Peptidase_M19 80 401 3.4e-112 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000081998
AA Change: V378M
SMART Domains Protein: ENSMUSP00000080659
Gene: ENSMUSG00000115067
AA Change: V378M

DomainStartEndE-ValueType
low complexity region 97 113 N/A INTRINSIC
Pfam:Peptidase_M19 166 501 1.2e-104 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083297
Predicted Effect probably damaging
Transcript: ENSMUST00000117555
AA Change: V187M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113877
Gene: ENSMUSG00000053687
AA Change: V187M

DomainStartEndE-ValueType
Pfam:Peptidase_M19 1 308 5.7e-107 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142898
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149057
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150001
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212917
Predicted Effect probably damaging
Transcript: ENSMUST00000227363
AA Change: V369M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acnat2 T G 4: 49,380,647 (GRCm39) M244L possibly damaging Het
Acnat2 A T 4: 49,380,639 (GRCm39) C228* probably null Het
Adam24 T C 8: 41,133,218 (GRCm39) S229P probably damaging Het
Alpk3 T C 7: 80,727,643 (GRCm39) S258P probably benign Het
Atad2b A G 12: 5,068,037 (GRCm39) T1012A probably benign Het
Bltp1 A G 3: 37,013,017 (GRCm39) E1899G probably damaging Het
C4b A T 17: 34,953,382 (GRCm39) S1034T probably benign Het
Cd300ld2 T A 11: 114,901,249 (GRCm39) H277L possibly damaging Het
Chrna4 C T 2: 180,670,926 (GRCm39) V277I probably benign Het
Col3a1 A G 1: 45,364,963 (GRCm39) probably null Het
Eml2 T A 7: 18,940,055 (GRCm39) N815K probably damaging Het
Enpp3 A G 10: 24,685,746 (GRCm39) probably benign Het
Git1 T C 11: 77,390,413 (GRCm39) V86A probably benign Het
Hivep2 C T 10: 14,006,926 (GRCm39) P1175S probably benign Het
Hydin T C 8: 111,293,604 (GRCm39) I3517T probably benign Het
Ift172 T A 5: 31,410,992 (GRCm39) probably null Het
Jmy A G 13: 93,589,316 (GRCm39) I647T probably benign Het
Kifap3 T A 1: 163,653,440 (GRCm39) probably benign Het
Lama3 G A 18: 12,670,915 (GRCm39) probably null Het
Lipa A C 19: 34,471,522 (GRCm39) I351S possibly damaging Het
Ltbp2 G T 12: 84,832,091 (GRCm39) A1631D probably benign Het
Masp2 A G 4: 148,698,477 (GRCm39) I519M probably damaging Het
Mfsd6 A G 1: 52,702,436 (GRCm39) probably benign Het
Numa1 T G 7: 101,661,216 (GRCm39) D1846E probably benign Het
Oog3 A T 4: 143,885,920 (GRCm39) I226K probably damaging Het
Or11h6 A G 14: 50,880,658 (GRCm39) T301A probably benign Het
Or5an6 A T 19: 12,372,265 (GRCm39) I213F probably benign Het
Or8b3b T C 9: 38,584,209 (GRCm39) Y177C probably damaging Het
Or8g53 T G 9: 39,683,800 (GRCm39) T99P probably damaging Het
Or9s13 A T 1: 92,548,183 (GRCm39) Y185F probably benign Het
Pkdcc T C 17: 83,531,295 (GRCm39) S435P probably damaging Het
Ppm1g A G 5: 31,365,425 (GRCm39) Y70H probably damaging Het
Prcc C T 3: 87,776,984 (GRCm39) S330N probably damaging Het
Ror2 A T 13: 53,272,876 (GRCm39) L251Q probably damaging Het
Scn11a A G 9: 119,621,464 (GRCm39) L651P probably damaging Het
Skint6 A T 4: 112,805,737 (GRCm39) probably benign Het
Slc23a4 A G 6: 34,931,917 (GRCm39) F186L probably benign Het
Slc30a8 A T 15: 52,198,530 (GRCm39) D325V probably benign Het
Son C T 16: 91,452,099 (GRCm39) T282M possibly damaging Het
Tas2r118 A T 6: 23,969,891 (GRCm39) F57I probably damaging Het
Tcf7l1 A G 6: 72,606,966 (GRCm39) S447P probably benign Het
Thsd1 T A 8: 22,733,454 (GRCm39) V167E probably damaging Het
Tle3 T C 9: 61,322,063 (GRCm39) V696A probably damaging Het
Tmem67 A T 4: 12,069,463 (GRCm39) I405K possibly damaging Het
Tmem71 A C 15: 66,413,466 (GRCm39) V202G probably benign Het
Trim6 T C 7: 103,881,564 (GRCm39) probably benign Het
Trip12 A G 1: 84,721,535 (GRCm39) probably benign Het
Ubr1 A C 2: 120,694,854 (GRCm39) C1693G possibly damaging Het
Ush2a G A 1: 188,648,195 (GRCm39) R4600H probably damaging Het
Vil1 A G 1: 74,465,851 (GRCm39) I547M probably benign Het
Vmn1r219 A T 13: 23,347,266 (GRCm39) I152L probably benign Het
Vmn1r26 A G 6: 57,986,127 (GRCm39) F21L possibly damaging Het
Vmn2r45 T A 7: 8,486,185 (GRCm39) K368* probably null Het
Vmn2r68 C T 7: 84,871,153 (GRCm39) W710* probably null Het
Zfp808 T A 13: 62,321,032 (GRCm39) *754R probably null Het
Zyg11b C T 4: 108,123,515 (GRCm39) E151K probably damaging Het
Other mutations in Dpep2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00590:Dpep2 APN 8 106,715,453 (GRCm39) missense probably damaging 1.00
IGL01160:Dpep2 APN 8 106,713,076 (GRCm39) missense possibly damaging 0.95
IGL02071:Dpep2 APN 8 106,711,776 (GRCm39) missense probably benign 0.01
IGL02441:Dpep2 APN 8 106,711,723 (GRCm39) missense probably benign 0.00
IGL02836:Dpep2 APN 8 106,717,227 (GRCm39) critical splice donor site probably null
G1citation:Dpep2 UTSW 8 106,711,873 (GRCm39) missense probably benign 0.01
R0504:Dpep2 UTSW 8 106,716,620 (GRCm39) missense probably benign 0.29
R1866:Dpep2 UTSW 8 106,716,080 (GRCm39) critical splice donor site probably null
R1982:Dpep2 UTSW 8 106,716,087 (GRCm39) nonsense probably null
R2172:Dpep2 UTSW 8 106,715,630 (GRCm39) missense possibly damaging 0.88
R2399:Dpep2 UTSW 8 106,716,224 (GRCm39) missense probably damaging 1.00
R4369:Dpep2 UTSW 8 106,711,707 (GRCm39) missense probably benign 0.00
R4499:Dpep2 UTSW 8 106,712,114 (GRCm39) missense probably benign 0.32
R4500:Dpep2 UTSW 8 106,712,114 (GRCm39) missense probably benign 0.32
R4774:Dpep2 UTSW 8 106,717,388 (GRCm39) missense possibly damaging 0.48
R5114:Dpep2 UTSW 8 106,712,825 (GRCm39) missense probably damaging 1.00
R5727:Dpep2 UTSW 8 106,713,075 (GRCm39) missense probably benign 0.00
R6052:Dpep2 UTSW 8 106,717,270 (GRCm39) missense possibly damaging 0.91
R6177:Dpep2 UTSW 8 106,712,831 (GRCm39) missense probably damaging 1.00
R6658:Dpep2 UTSW 8 106,716,542 (GRCm39) missense probably benign 0.01
R6822:Dpep2 UTSW 8 106,711,873 (GRCm39) missense probably benign 0.01
R7854:Dpep2 UTSW 8 106,716,160 (GRCm39) missense
R7866:Dpep2 UTSW 8 106,716,113 (GRCm39) missense
R8169:Dpep2 UTSW 8 106,722,849 (GRCm39) missense
R9047:Dpep2 UTSW 8 106,715,944 (GRCm39) missense
R9203:Dpep2 UTSW 8 106,712,885 (GRCm39) missense probably damaging 1.00
R9222:Dpep2 UTSW 8 106,723,016 (GRCm39) missense
V7732:Dpep2 UTSW 8 106,715,892 (GRCm39) missense probably damaging 1.00
Posted On 2015-04-16