Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02558:Gdf10'

298387

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gdf10

Ensembl Gene

ENSMUSG00000021943

Gene Name

growth differentiation factor 10

Synonyms

Bmp3b

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02558

Quality Score

Status

Chromosome

Chromosomal Location

33645544-33658471 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 33645937 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Glycine at position 29 (C29G)

Ref Sequence

ENSEMBL: ENSMUSP00000128621 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168727]

AlphaFold

P97737

Predicted Effect

probably benign
Transcript: ENSMUST00000168727
AA Change: C29G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000128621
Gene: ENSMUSG00000021943
AA Change: C29G

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	56	67	N/A	INTRINSIC
TGFB	374	476	1e-50	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein has been shown to promote neural repair after stroke and may act as a tumor suppressor. [provided by RefSeq, Jul 2016]
PHENOTYPE: Mice homozygous for disruption of this gene display a normal phenotype. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	A	C	5: 3,632,194 (GRCm39)	*25C	probably null	Het
Abca13	T	C	11: 9,349,387 (GRCm39)	Y3654H	probably damaging	Het
Ankle1	T	C	8: 71,861,636 (GRCm39)	F438S	probably damaging	Het
Atp10a	A	T	7: 58,469,390 (GRCm39)	R1080S	probably damaging	Het
Ccdc51	A	T	9: 108,921,252 (GRCm39)	N380Y	probably damaging	Het
Ccr8	A	T	9: 119,923,724 (GRCm39)	I280F	probably benign	Het
Cdc45	C	T	16: 18,617,479 (GRCm39)	M200I	probably benign	Het
Cep162	T	C	9: 87,107,786 (GRCm39)	T535A	probably benign	Het
Cep162	G	T	9: 87,107,779 (GRCm39)	T537N	probably benign	Het
Cfap52	T	C	11: 67,844,964 (GRCm39)	D35G	probably benign	Het
Cmip	G	A	8: 118,175,827 (GRCm39)	S530N	probably damaging	Het
Col9a3	A	T	2: 180,248,599 (GRCm39)		probably null	Het
Csf3r	T	C	4: 125,931,928 (GRCm39)		probably benign	Het
Csk	C	T	9: 57,537,546 (GRCm39)	E123K	probably benign	Het
Csrnp3	G	A	2: 65,852,573 (GRCm39)	E322K	probably damaging	Het
Ddx11	A	T	17: 66,455,667 (GRCm39)	I663F	probably damaging	Het
Dnah1	T	A	14: 30,996,336 (GRCm39)	M2667L	possibly damaging	Het
Foxred1	T	C	9: 35,121,429 (GRCm39)	K40E	probably damaging	Het
Gata2	C	T	6: 88,176,762 (GRCm39)	P74S	probably benign	Het
Hectd4	A	G	5: 121,482,848 (GRCm39)	E3133G	probably benign	Het
Ints8	G	A	4: 11,218,771 (GRCm39)	R784W	probably damaging	Het
Lrriq1	T	C	10: 102,982,144 (GRCm39)	E1392G	probably damaging	Het
Muc19	T	C	15: 91,781,816 (GRCm39)		noncoding transcript	Het
Myom2	A	T	8: 15,164,237 (GRCm39)	D1044V	probably benign	Het
Nphp4	G	T	4: 152,639,988 (GRCm39)	R958L	probably damaging	Het
Nup205	C	T	6: 35,166,859 (GRCm39)	P293S	probably damaging	Het
Or10ag60	T	C	2: 87,437,903 (GRCm39)	I57T	probably benign	Het
Or1e17	A	T	11: 73,831,651 (GRCm39)	H193L	probably benign	Het
Plxdc2	A	G	2: 16,674,409 (GRCm39)		probably benign	Het
Pwp2	T	C	10: 78,014,899 (GRCm39)	S362G	probably damaging	Het
Siglec1	G	T	2: 130,916,915 (GRCm39)	S1113R	possibly damaging	Het
Sirpa	A	G	2: 129,471,989 (GRCm39)	E472G	probably damaging	Het
Slc39a4	G	T	15: 76,498,403 (GRCm39)	L345M	probably damaging	Het
Snx27	C	T	3: 94,410,188 (GRCm39)	R496Q	probably damaging	Het
Stard9	A	G	2: 120,527,388 (GRCm39)	H1215R	possibly damaging	Het
Stau1	A	G	2: 166,792,768 (GRCm39)	Y371H	probably benign	Het
Sult2a1	A	C	7: 13,566,520 (GRCm39)	W152G	probably benign	Het
Syt16	A	T	12: 74,281,832 (GRCm39)	K319*	probably null	Het
Tcf7	T	A	11: 52,144,797 (GRCm39)		probably benign	Het
Tfdp1	A	G	8: 13,419,546 (GRCm39)	N92D	possibly damaging	Het
Zfp13	C	T	17: 23,795,072 (GRCm39)	A493T	probably benign	Het

Other mutations in Gdf10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03203:Gdf10	APN	14	33,656,430 (GRCm39)	missense	possibly damaging	0.94
R0178:Gdf10	UTSW	14	33,646,058 (GRCm39)	missense	probably damaging	1.00
R0890:Gdf10	UTSW	14	33,654,113 (GRCm39)	missense	possibly damaging	0.57
R1218:Gdf10	UTSW	14	33,654,710 (GRCm39)	missense	probably benign	0.01
R1219:Gdf10	UTSW	14	33,654,710 (GRCm39)	missense	probably benign	0.01
R1221:Gdf10	UTSW	14	33,654,710 (GRCm39)	missense	probably benign	0.01
R1670:Gdf10	UTSW	14	33,654,000 (GRCm39)	missense	possibly damaging	0.92
R1956:Gdf10	UTSW	14	33,654,710 (GRCm39)	missense	probably benign	0.01
R1957:Gdf10	UTSW	14	33,654,710 (GRCm39)	missense	probably benign	0.01
R1958:Gdf10	UTSW	14	33,654,710 (GRCm39)	missense	probably benign	0.01
R2154:Gdf10	UTSW	14	33,656,346 (GRCm39)	missense	probably damaging	0.99
R2260:Gdf10	UTSW	14	33,654,234 (GRCm39)	missense	probably damaging	1.00
R2971:Gdf10	UTSW	14	33,646,148 (GRCm39)	missense	probably damaging	1.00
R3896:Gdf10	UTSW	14	33,656,438 (GRCm39)	missense	probably damaging	1.00
R4027:Gdf10	UTSW	14	33,654,572 (GRCm39)	missense	probably damaging	1.00
R4393:Gdf10	UTSW	14	33,654,695 (GRCm39)	missense	probably damaging	1.00
R4782:Gdf10	UTSW	14	33,653,870 (GRCm39)	missense	probably benign	0.00
R5436:Gdf10	UTSW	14	33,654,213 (GRCm39)	missense	probably damaging	0.97
R5829:Gdf10	UTSW	14	33,654,674 (GRCm39)	missense	probably damaging	0.99
R6387:Gdf10	UTSW	14	33,645,961 (GRCm39)	missense	probably benign	0.05
R8346:Gdf10	UTSW	14	33,653,802 (GRCm39)	missense	probably benign	0.00
R8742:Gdf10	UTSW	14	33,654,426 (GRCm39)	missense	probably benign	0.00
R9086:Gdf10	UTSW	14	33,654,221 (GRCm39)	missense	probably damaging	1.00
R9517:Gdf10	UTSW	14	33,654,522 (GRCm39)	missense	probably benign	0.31
Z1088:Gdf10	UTSW	14	33,654,347 (GRCm39)	missense	probably damaging	1.00
Z1176:Gdf10	UTSW	14	33,654,489 (GRCm39)	missense	possibly damaging	0.79

Posted On

2015-04-16