Incidental Mutation 'IGL02558:Sult2a1'
ID 298371
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a1
Ensembl Gene ENSMUSG00000078798
Gene Name sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
Synonyms Std, Sth1, mSTa1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL02558
Quality Score
Status
Chromosome 7
Chromosomal Location 13796246-13837409 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to C at 13832595 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Glycine at position 152 (W152G)
Ref Sequence ENSEMBL: ENSMUSP00000104162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108522]
AlphaFold P52843
Predicted Effect probably benign
Transcript: ENSMUST00000108522
AA Change: W152G

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000104162
Gene: ENSMUSG00000078798
AA Change: W152G

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 4.6e-83 PFAM
Pfam:Sulfotransfer_3 35 205 5.8e-11 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700109H08Rik A C 5: 3,582,194 *25C probably null Het
Abca13 T C 11: 9,399,387 Y3654H probably damaging Het
Ankle1 T C 8: 71,408,992 F438S probably damaging Het
Atp10a A T 7: 58,819,642 R1080S probably damaging Het
Ccdc51 A T 9: 109,092,184 N380Y probably damaging Het
Ccr8 A T 9: 120,094,658 I280F probably benign Het
Cdc45 C T 16: 18,798,729 M200I probably benign Het
Cep162 G T 9: 87,225,726 T537N probably benign Het
Cep162 T C 9: 87,225,733 T535A probably benign Het
Cfap52 T C 11: 67,954,138 D35G probably benign Het
Cmip G A 8: 117,449,088 S530N probably damaging Het
Col9a3 A T 2: 180,606,806 probably null Het
Csf3r T C 4: 126,038,135 probably benign Het
Csk C T 9: 57,630,263 E123K probably benign Het
Csrnp3 G A 2: 66,022,229 E322K probably damaging Het
Ddx11 A T 17: 66,148,672 I663F probably damaging Het
Dnah1 T A 14: 31,274,379 M2667L possibly damaging Het
Foxred1 T C 9: 35,210,133 K40E probably damaging Het
Gata2 C T 6: 88,199,780 P74S probably benign Het
Gdf10 T G 14: 33,923,980 C29G probably benign Het
Hectd4 A G 5: 121,344,785 E3133G probably benign Het
Ints8 G A 4: 11,218,771 R784W probably damaging Het
Lrriq1 T C 10: 103,146,283 E1392G probably damaging Het
Muc19 T C 15: 91,897,622 noncoding transcript Het
Myom2 A T 8: 15,114,237 D1044V probably benign Het
Nphp4 G T 4: 152,555,531 R958L probably damaging Het
Nup205 C T 6: 35,189,924 P293S probably damaging Het
Olfr1130 T C 2: 87,607,559 I57T probably benign Het
Olfr23 A T 11: 73,940,825 H193L probably benign Het
Plxdc2 A G 2: 16,669,598 probably benign Het
Pwp2 T C 10: 78,179,065 S362G probably damaging Het
Siglec1 G T 2: 131,074,995 S1113R possibly damaging Het
Sirpa A G 2: 129,630,069 E472G probably damaging Het
Slc39a4 G T 15: 76,614,203 L345M probably damaging Het
Snx27 C T 3: 94,502,881 R496Q probably damaging Het
Stard9 A G 2: 120,696,907 H1215R possibly damaging Het
Stau1 A G 2: 166,950,848 Y371H probably benign Het
Syt16 A T 12: 74,235,058 K319* probably null Het
Tcf7 T A 11: 52,253,970 probably benign Het
Tfdp1 A G 8: 13,369,546 N92D possibly damaging Het
Zfp13 C T 17: 23,576,098 A493T probably benign Het
Other mutations in Sult2a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Sult2a1 APN 7 13832640 missense probably benign 0.02
IGL00990:Sult2a1 APN 7 13804036 missense probably benign
IGL01322:Sult2a1 APN 7 13832679 nonsense probably null
IGL03033:Sult2a1 APN 7 13832710 splice site probably benign
IGL03199:Sult2a1 APN 7 13832660 missense probably damaging 1.00
R1633:Sult2a1 UTSW 7 13801426 missense probably benign 0.01
R1903:Sult2a1 UTSW 7 13835975 missense possibly damaging 0.94
R2295:Sult2a1 UTSW 7 13835959 critical splice donor site probably null
R4207:Sult2a1 UTSW 7 13801547 missense probably benign 0.00
R5444:Sult2a1 UTSW 7 13836019 missense possibly damaging 0.80
R6233:Sult2a1 UTSW 7 13832675 missense probably damaging 1.00
R6317:Sult2a1 UTSW 7 13836020 missense probably benign 0.00
R6853:Sult2a1 UTSW 7 13801487 missense possibly damaging 0.50
R7098:Sult2a1 UTSW 7 13816053 splice site probably null
R8948:Sult2a1 UTSW 7 13796417 missense probably damaging 0.99
R8950:Sult2a1 UTSW 7 13796417 missense probably damaging 0.99
R9207:Sult2a1 UTSW 7 13832702 missense probably benign 0.40
Z1088:Sult2a1 UTSW 7 13801414 missense probably benign
Z1088:Sult2a1 UTSW 7 13801435 missense probably benign 0.00
Z1088:Sult2a1 UTSW 7 13804036 missense probably benign
Z1176:Sult2a1 UTSW 7 13801414 missense probably benign
Z1176:Sult2a1 UTSW 7 13801435 missense probably benign 0.00
Z1176:Sult2a1 UTSW 7 13804036 missense probably benign
Z1176:Sult2a1 UTSW 7 13835967 missense probably damaging 1.00
Z1177:Sult2a1 UTSW 7 13796363 frame shift probably null
Z1177:Sult2a1 UTSW 7 13801414 missense probably benign
Z1177:Sult2a1 UTSW 7 13801435 missense probably benign 0.00
Z1177:Sult2a1 UTSW 7 13804036 missense probably benign
Posted On 2015-04-16