Incidental Mutation 'IGL02682:Zglp1'
ID 303403
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zglp1
Ensembl Gene ENSMUSG00000079681
Gene Name zinc finger, GATA-like protein 1
Synonyms Glp1
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.471) question?
Stock # IGL02682
Quality Score
Status
Chromosome 9
Chromosomal Location 20973689-20978389 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 20977534 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 94 (S94P)
Ref Sequence ENSEMBL: ENSMUSP00000111157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000010348] [ENSMUST00000115494] [ENSMUST00000213826] [ENSMUST00000217359]
AlphaFold Q1WG82
Predicted Effect probably benign
Transcript: ENSMUST00000010348
SMART Domains Protein: ENSMUSP00000010348
Gene: ENSMUSG00000079677

DomainStartEndE-ValueType
Pfam:Fer2 64 147 5.3e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000115494
AA Change: S94P

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000111157
Gene: ENSMUSG00000079681
AA Change: S94P

DomainStartEndE-ValueType
Pfam:GATA 197 231 7.8e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213826
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215338
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215631
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216484
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216967
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217150
Predicted Effect probably benign
Transcript: ENSMUST00000217282
Predicted Effect probably benign
Transcript: ENSMUST00000217359
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mutations result in female and male infertility due to failure of germ cell development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acvr1 A G 2: 58,367,823 (GRCm39) S113P probably benign Het
Arhgdib A T 6: 136,901,166 (GRCm39) W188R probably damaging Het
Bcr T A 10: 75,001,878 (GRCm39) N927K possibly damaging Het
Cd209c A G 8: 3,990,324 (GRCm39) Y165H probably damaging Het
Cnnm2 A G 19: 46,750,515 (GRCm39) K102E probably benign Het
Col12a1 T C 9: 79,606,623 (GRCm39) E600G probably damaging Het
Ddx4 A T 13: 112,758,720 (GRCm39) H280Q probably benign Het
Eya4 T C 10: 22,992,498 (GRCm39) Y462C probably damaging Het
Fibcd1 T A 2: 31,728,576 (GRCm39) I94F probably damaging Het
Gm4846 C A 1: 166,322,195 (GRCm39) G124V probably damaging Het
Gm5624 A G 14: 44,797,469 (GRCm39) I108T possibly damaging Het
Gpr179 A T 11: 97,242,691 (GRCm39) M51K probably benign Het
Hck A G 2: 152,976,054 (GRCm39) I198V probably damaging Het
Kcnd2 T A 6: 21,216,924 (GRCm39) C209* probably null Het
Klhl1 T A 14: 96,438,778 (GRCm39) I507F possibly damaging Het
Knl1 A T 2: 118,908,450 (GRCm39) K1693N possibly damaging Het
Mcam T C 9: 44,051,714 (GRCm39) V490A possibly damaging Het
Mrgprx1 A T 7: 47,671,740 (GRCm39) D2E probably damaging Het
Mtg1 T C 7: 139,724,642 (GRCm39) probably benign Het
Myof C A 19: 37,909,929 (GRCm39) R1512L probably benign Het
Nrp2 C T 1: 62,810,996 (GRCm39) T679I probably benign Het
Nwd2 C A 5: 63,962,020 (GRCm39) L535I probably benign Het
Nwd2 T A 5: 63,962,021 (GRCm39) L535H probably damaging Het
Or4f14b T A 2: 111,775,285 (GRCm39) N172I probably damaging Het
Or52j3 A T 7: 102,836,221 (GRCm39) I138F probably damaging Het
Or5b94 T C 19: 12,652,033 (GRCm39) S155P probably damaging Het
Phkb A G 8: 86,602,275 (GRCm39) *41W probably null Het
Prl5a1 T A 13: 28,329,403 (GRCm39) N27K probably benign Het
Rims1 T C 1: 22,358,708 (GRCm39) T1292A probably damaging Het
Rnf38 G A 4: 44,133,745 (GRCm39) A376V probably damaging Het
Slc34a2 T C 5: 53,216,580 (GRCm39) V117A possibly damaging Het
Slfn8 A T 11: 82,894,517 (GRCm39) F707L probably damaging Het
Snx16 G A 3: 10,503,235 (GRCm39) P4L probably damaging Het
Snx6 T C 12: 54,801,130 (GRCm39) D289G probably damaging Het
St8sia3 G T 18: 64,402,750 (GRCm39) V130F probably damaging Het
U2surp A G 9: 95,363,704 (GRCm39) probably null Het
Ubqln3 A G 7: 103,791,272 (GRCm39) F273L probably benign Het
Vmn2r101 A T 17: 19,832,507 (GRCm39) R834S possibly damaging Het
Vmn2r18 G T 5: 151,508,102 (GRCm39) H341N probably damaging Het
Vrk3 A G 7: 44,403,244 (GRCm39) I2V probably benign Het
Other mutations in Zglp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01718:Zglp1 APN 9 20,974,675 (GRCm39) missense probably benign 0.31
IGL02039:Zglp1 APN 9 20,978,335 (GRCm39) missense possibly damaging 0.95
IGL03040:Zglp1 APN 9 20,974,622 (GRCm39) missense probably damaging 1.00
PIT4515001:Zglp1 UTSW 9 20,977,485 (GRCm39) missense probably benign 0.01
R0366:Zglp1 UTSW 9 20,974,675 (GRCm39) missense probably benign 0.31
R4174:Zglp1 UTSW 9 20,977,366 (GRCm39) missense possibly damaging 0.94
R4888:Zglp1 UTSW 9 20,973,957 (GRCm39) missense probably benign 0.00
R5121:Zglp1 UTSW 9 20,973,957 (GRCm39) missense probably benign 0.00
R7103:Zglp1 UTSW 9 20,977,368 (GRCm39) missense probably benign 0.30
R7481:Zglp1 UTSW 9 20,973,903 (GRCm39) missense probably benign
R7581:Zglp1 UTSW 9 20,974,004 (GRCm39) missense probably damaging 1.00
R9109:Zglp1 UTSW 9 20,977,482 (GRCm39) missense probably benign 0.08
R9298:Zglp1 UTSW 9 20,977,482 (GRCm39) missense probably benign 0.08
Z1088:Zglp1 UTSW 9 20,978,296 (GRCm39) missense possibly damaging 0.88
Posted On 2015-04-16