Incidental Mutation 'IGL02684:Mettl15'
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ID303471
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mettl15
Ensembl Gene ENSMUSG00000057234
Gene Namemethyltransferase like 15
Synonyms0610027B03Rik, Mett5d1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.217) question?
Stock #IGL02684
Quality Score
Status
Chromosome2
Chromosomal Location109092297-109280748 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 109131580 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Glycine at position 228 (E228G)
Ref Sequence ENSEMBL: ENSMUSP00000116829 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081631] [ENSMUST00000147770]
Predicted Effect possibly damaging
Transcript: ENSMUST00000081631
AA Change: E228G

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000080337
Gene: ENSMUSG00000057234
AA Change: E228G

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 406 1.5e-90 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147376
Predicted Effect probably damaging
Transcript: ENSMUST00000147770
AA Change: E228G

PolyPhen 2 Score 0.974 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000116829
Gene: ENSMUSG00000057234
AA Change: E228G

DomainStartEndE-ValueType
Pfam:Methyltransf_5 69 230 1.6e-47 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930596D02Rik A T 14: 35,810,063 L185* probably null Het
Actrt3 A T 3: 30,599,691 D53E probably benign Het
Ankrd34b T C 13: 92,438,508 S83P probably damaging Het
Asap1 A G 15: 64,094,169 V1029A probably benign Het
Blk T C 14: 63,379,694 E288G probably benign Het
Cep192 T G 18: 67,834,563 V706G probably damaging Het
Chd2 T C 7: 73,475,349 K908E probably damaging Het
Dnm1l A T 16: 16,321,657 I391N possibly damaging Het
Fam84a T C 12: 14,150,645 D27G probably damaging Het
Fmn1 A G 2: 113,525,277 R688G unknown Het
Gdap2 A G 3: 100,171,020 D100G probably benign Het
Gm43638 T C 5: 87,462,910 I522V possibly damaging Het
Gm438 A G 4: 144,778,185 probably benign Het
Gsap A T 5: 21,242,803 probably null Het
Hoxd12 A G 2: 74,675,561 S159G probably benign Het
Ints7 A G 1: 191,613,637 probably null Het
Iqsec3 G A 6: 121,412,941 Q524* probably null Het
Klra10 T A 6: 130,281,882 H14L possibly damaging Het
Olfr466 G A 13: 65,152,396 M57I probably damaging Het
Olfr624 T C 7: 103,670,384 M216V probably benign Het
Pabpc1l A G 2: 164,031,277 N156D probably benign Het
Pkhd1l1 G T 15: 44,516,209 probably null Het
Pm20d1 T A 1: 131,804,959 N345K probably benign Het
Rasgrp1 A G 2: 117,282,576 V785A probably benign Het
Sos2 A G 12: 69,596,666 L980S probably damaging Het
Stam2 A T 2: 52,719,935 H56Q probably damaging Het
Trpm6 T A 19: 18,802,207 probably benign Het
Trpm7 A T 2: 126,846,159 D249E probably damaging Het
Vmn1r203 A T 13: 22,524,369 T107S possibly damaging Het
Vmn2r55 A G 7: 12,670,960 L172P probably damaging Het
Vrtn A G 12: 84,650,149 R558G probably benign Het
Zfp977 A T 7: 42,583,015 D7E probably damaging Het
Other mutations in Mettl15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00155:Mettl15 APN 2 109093176 nonsense probably null
IGL00657:Mettl15 APN 2 109093207 missense probably damaging 1.00
IGL03367:Mettl15 APN 2 109131571 missense probably benign 0.10
R1433:Mettl15 UTSW 2 109092921 missense probably benign 0.00
R1538:Mettl15 UTSW 2 109131665 critical splice acceptor site probably null
R3890:Mettl15 UTSW 2 109191579 missense probably benign 0.03
R5464:Mettl15 UTSW 2 109191622 missense probably benign 0.00
R6609:Mettl15 UTSW 2 109137342 missense probably null 1.00
R7619:Mettl15 UTSW 2 109092875 nonsense probably null
R7737:Mettl15 UTSW 2 109137378 missense probably damaging 0.99
Posted On2015-04-16