Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02686:Zdhhc4'

303562

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zdhhc4

Ensembl Gene

ENSMUSG00000001844

Gene Name

zinc finger, DHHC domain containing 4

Synonyms

1810021D01Rik, 2900029I10Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

IGL02686

Quality Score

Status

Chromosome

Chromosomal Location

143302244-143315007 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 143306146 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 194 (F194S)

Ref Sequence

ENSEMBL: ENSMUSP00000124813 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000001900] [ENSMUST00000159813] [ENSMUST00000159941] [ENSMUST00000161915] [ENSMUST00000162066] [ENSMUST00000162358] [ENSMUST00000162941]

AlphaFold

Q9D6H5

Predicted Effect

probably damaging
Transcript: ENSMUST00000001900
AA Change: F194S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000001900
Gene: ENSMUSG00000001844
AA Change: F194S

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
low complexity region	97	110	N/A	INTRINSIC
Pfam:zf-DHHC	112	294	5e-38	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159718

Predicted Effect

probably benign
Transcript: ENSMUST00000159813

SMART Domains

Protein: ENSMUSP00000137935
Gene: ENSMUSG00000001844

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
low complexity region	97	110	N/A	INTRINSIC
Pfam:zf-DHHC	112	175	3.6e-10	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000159941

SMART Domains

Protein: ENSMUSP00000124026
Gene: ENSMUSG00000001844

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
low complexity region	97	110	N/A	INTRINSIC
Pfam:zf-DHHC	112	178	2.2e-16	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161333

Predicted Effect

probably damaging
Transcript: ENSMUST00000161915
AA Change: F194S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000124813
Gene: ENSMUSG00000001844
AA Change: F194S

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
transmembrane domain	100	122	N/A	INTRINSIC
Pfam:zf-DHHC	144	294	9.7e-37	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000162066

SMART Domains

Protein: ENSMUSP00000125130
Gene: ENSMUSG00000001844

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000200220

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000162287

Predicted Effect

probably benign
Transcript: ENSMUST00000162358

SMART Domains

Protein: ENSMUSP00000124416
Gene: ENSMUSG00000001844

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
transmembrane domain	100	122	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000162941

SMART Domains

Protein: ENSMUSP00000124997
Gene: ENSMUSG00000001844

Domain	Start	End	E-Value	Type
transmembrane domain	5	24	N/A	INTRINSIC
transmembrane domain	68	90	N/A	INTRINSIC
low complexity region	97	110	N/A	INTRINSIC
Pfam:zf-DHHC	112	176	4.2e-14	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam4	C	T	12: 81,468,448 (GRCm39)	G58S	possibly damaging	Het
Adcyap1r1	G	A	6: 55,458,110 (GRCm39)	A304T	probably benign	Het
Adipoq	A	G	16: 22,975,865 (GRCm39)	T110A	possibly damaging	Het
Ago2	T	C	15: 72,985,591 (GRCm39)	Y668C	possibly damaging	Het
Ampd2	A	T	3: 107,983,811 (GRCm39)	D575E	possibly damaging	Het
Anxa5	C	T	3: 36,503,504 (GRCm39)	E317K	probably benign	Het
Atf2	A	T	2: 73,675,844 (GRCm39)	M169K	possibly damaging	Het
Bicc1	C	A	10: 70,779,190 (GRCm39)		probably benign	Het
Bicra	A	G	7: 15,721,840 (GRCm39)	M559T	probably benign	Het
Bltp3a	T	C	17: 28,113,563 (GRCm39)	I1245T	probably benign	Het
Bltp3b	A	T	10: 89,641,055 (GRCm39)	Q742L	probably benign	Het
Cacna1e	G	A	1: 154,369,155 (GRCm39)	A294V	probably damaging	Het
Cacna1h	G	A	17: 25,604,723 (GRCm39)	P1197S	possibly damaging	Het
Cmya5	G	A	13: 93,227,505 (GRCm39)	Q2528*	probably null	Het
Csgalnact1	C	A	8: 68,854,144 (GRCm39)	G219V	probably damaging	Het
Cts8	T	C	13: 61,398,784 (GRCm39)	T241A	probably benign	Het
Cubn	T	C	2: 13,330,037 (GRCm39)	I2615V	possibly damaging	Het
Cxcl12	A	G	6: 117,150,546 (GRCm39)		probably benign	Het
Fig4	T	C	10: 41,140,000 (GRCm39)	D307G	probably damaging	Het
Flt1	T	C	5: 147,525,412 (GRCm39)	I909V	probably damaging	Het
Foxk1	T	A	5: 142,439,340 (GRCm39)	S427T	probably damaging	Het
Gosr1	G	A	11: 76,641,688 (GRCm39)	T130M	probably benign	Het
Grik1	G	T	16: 87,806,649 (GRCm39)		probably null	Het
Hipk1	C	T	3: 103,685,333 (GRCm39)	S94N	possibly damaging	Het
Ints7	T	C	1: 191,318,704 (GRCm39)	L147P	probably damaging	Het
Nsd3	A	G	8: 26,156,086 (GRCm39)	D551G	probably damaging	Het
Or11g25	G	A	14: 50,723,426 (GRCm39)	M170I	probably benign	Het
Or5p81	A	T	7: 108,267,093 (GRCm39)	I157F	probably benign	Het
Prrc2c	T	C	1: 162,535,516 (GRCm39)		probably benign	Het
Ren1	A	T	1: 133,286,207 (GRCm39)	N250I	possibly damaging	Het
Ripply2	A	C	9: 86,898,009 (GRCm39)		probably benign	Het
Ryr1	G	T	7: 28,768,975 (GRCm39)		probably benign	Het
Smad3	T	A	9: 63,575,064 (GRCm39)	K51M	probably damaging	Het
Snapc1	C	A	12: 74,011,370 (GRCm39)		probably benign	Het
Srfbp1	T	G	18: 52,608,726 (GRCm39)	V42G	probably damaging	Het
Srrm1	G	A	4: 135,052,415 (GRCm39)	P658L	unknown	Het
Tab1	T	C	15: 80,033,031 (GRCm39)	V105A	probably benign	Het
Tat	T	C	8: 110,723,481 (GRCm39)	V323A	probably damaging	Het
Tdo2	T	C	3: 81,875,462 (GRCm39)	N164S	probably benign	Het
Tefm	T	A	11: 80,027,722 (GRCm39)	L345F	probably damaging	Het
Tmem145	C	A	7: 25,014,150 (GRCm39)	N407K	probably damaging	Het
Vmn2r116	A	G	17: 23,607,767 (GRCm39)	N445S	probably damaging	Het
Vmn2r20	A	G	6: 123,362,585 (GRCm39)	M733T	probably benign	Het
Vmn2r93	G	A	17: 18,533,526 (GRCm39)	V477M	possibly damaging	Het
Zfp738	A	T	13: 67,821,771 (GRCm39)	S25T	probably damaging	Het

Other mutations in Zdhhc4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R2022:Zdhhc4	UTSW	5	143,307,538 (GRCm39)	missense	probably damaging	1.00
R2138:Zdhhc4	UTSW	5	143,310,017 (GRCm39)	nonsense	probably null
R2228:Zdhhc4	UTSW	5	143,306,162 (GRCm39)	missense	probably damaging	0.98
R4298:Zdhhc4	UTSW	5	143,309,997 (GRCm39)	missense	probably damaging	0.96
R4305:Zdhhc4	UTSW	5	143,310,099 (GRCm39)	intron	probably benign
R4722:Zdhhc4	UTSW	5	143,307,536 (GRCm39)	missense	probably damaging	1.00
R4773:Zdhhc4	UTSW	5	143,311,931 (GRCm39)	missense	possibly damaging	0.50
R5000:Zdhhc4	UTSW	5	143,310,688 (GRCm39)	missense	probably damaging	0.98
R5063:Zdhhc4	UTSW	5	143,302,377 (GRCm39)	missense	probably damaging	1.00
R5341:Zdhhc4	UTSW	5	143,311,915 (GRCm39)	missense	probably benign	0.01
R5945:Zdhhc4	UTSW	5	143,310,641 (GRCm39)	missense	probably damaging	1.00
R5956:Zdhhc4	UTSW	5	143,310,604 (GRCm39)	intron	probably benign
R7284:Zdhhc4	UTSW	5	143,307,646 (GRCm39)	missense	probably benign	0.01
R7843:Zdhhc4	UTSW	5	143,306,031 (GRCm39)	missense	probably damaging	1.00
R7955:Zdhhc4	UTSW	5	143,307,619 (GRCm39)	missense	probably damaging	1.00
R8261:Zdhhc4	UTSW	5	143,307,588 (GRCm39)	missense	probably benign	0.17

Posted On

2015-04-16