Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02756:Trim27'

306473

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trim27

Ensembl Gene

ENSMUSG00000021326

Gene Name

tripartite motif-containing 27

Synonyms

Rfp

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.369) question?

Stock #

IGL02756

Quality Score

Status

Chromosome

Chromosomal Location

21363615-21378894 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to C at 21374256 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000152179 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021761] [ENSMUST00000221464] [ENSMUST00000222544] [ENSMUST00000223065]

AlphaFold

Q62158

Predicted Effect

probably benign
Transcript: ENSMUST00000021761

SMART Domains

Protein: ENSMUSP00000021761
Gene: ENSMUSG00000021326

Domain	Start	End	E-Value	Type
RING	16	56	2.53e-6	SMART
BBOX	91	132	4.71e-15	SMART
low complexity region	146	170	N/A	INTRINSIC
low complexity region	199	210	N/A	INTRINSIC
PRY	315	367	7.09e-28	SMART
SPRY	368	493	1e-42	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000124794

Predicted Effect

probably benign
Transcript: ENSMUST00000139287

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000220690

Predicted Effect

probably benign
Transcript: ENSMUST00000221464

Predicted Effect

probably benign
Transcript: ENSMUST00000222544

Predicted Effect

probably benign
Transcript: ENSMUST00000223065

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit exhibit increased potassium/calcium channel activity and TCR-stimulated calcium influx in Th1 and Th2 CD4 T cells. Mice homozygous for another gene trap allele exhibit decreased incidence of chemically-induced tumors. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700113H08Rik	A	T	10: 87,000,970 (GRCm39)	D54V	probably damaging	Het
Adamts18	C	A	8: 114,440,976 (GRCm39)		probably benign	Het
Angptl3	T	A	4: 98,919,399 (GRCm39)	L53Q	probably damaging	Het
Apc	A	G	18: 34,447,588 (GRCm39)	T1461A	probably damaging	Het
Arl11	T	A	14: 61,548,535 (GRCm39)	V115D	probably damaging	Het
Cabp4	C	A	19: 4,188,560 (GRCm39)	V173L	possibly damaging	Het
Casq1	T	A	1: 172,042,672 (GRCm39)	D230V	probably damaging	Het
Cdc42bpa	A	G	1: 179,936,824 (GRCm39)	I821V	possibly damaging	Het
Cfap65	T	C	1: 74,944,239 (GRCm39)	Y1494C	probably benign	Het
Chd1	T	A	17: 15,951,069 (GRCm39)	S215T	probably damaging	Het
Csf2rb2	T	C	15: 78,169,049 (GRCm39)	E593G	possibly damaging	Het
Cstf1	A	G	2: 172,217,795 (GRCm39)	D136G	probably damaging	Het
Ddx19b	T	C	8: 111,737,910 (GRCm39)		probably benign	Het
Dido1	A	T	2: 180,303,716 (GRCm39)	L1396Q	probably benign	Het
Ermn	A	G	2: 57,937,824 (GRCm39)	I263T	probably damaging	Het
F12	T	A	13: 55,568,880 (GRCm39)	Q294L	possibly damaging	Het
Far2	A	T	6: 148,058,889 (GRCm39)	I192F	probably damaging	Het
Fshb	T	A	2: 106,889,218 (GRCm39)	I29F	probably damaging	Het
Gcgr	T	A	11: 120,427,811 (GRCm39)	Y251N	probably benign	Het
Gpr158	A	G	2: 21,831,890 (GRCm39)	I997V	possibly damaging	Het
Gprc5d	A	G	6: 135,093,613 (GRCm39)	V98A	probably damaging	Het
H2-T23	T	C	17: 36,342,580 (GRCm39)	E186G	probably damaging	Het
Khdrbs3	C	T	15: 68,896,685 (GRCm39)	T115I	probably benign	Het
Kifap3	C	T	1: 163,689,597 (GRCm39)	T527M	probably damaging	Het
Mfsd2a	C	T	4: 122,842,332 (GRCm39)	A512T	probably benign	Het
Mmp9	A	G	2: 164,791,235 (GRCm39)	D135G	probably benign	Het
Mylk	T	C	16: 34,784,016 (GRCm39)	V1394A	probably benign	Het
Nek9	A	C	12: 85,358,110 (GRCm39)		probably null	Het
Or51q1c	T	C	7: 103,652,866 (GRCm39)	I128T	probably damaging	Het
Or8k16	T	C	2: 85,520,402 (GRCm39)	S210P	probably damaging	Het
P2rx2	T	A	5: 110,490,276 (GRCm39)		probably benign	Het
P4htm	A	G	9: 108,456,977 (GRCm39)	L410P	probably damaging	Het
Pik3c2a	A	T	7: 115,963,748 (GRCm39)	W921R	probably benign	Het
Pnisr	T	C	4: 21,862,175 (GRCm39)	F288L	probably benign	Het
Ppp4r3a	C	T	12: 101,024,582 (GRCm39)		probably null	Het
Prss34	T	C	17: 25,518,251 (GRCm39)	S144P	probably damaging	Het
Qrsl1	T	C	10: 43,758,110 (GRCm39)	T328A	probably benign	Het
Rab33b	A	T	3: 51,391,945 (GRCm39)	T65S	probably damaging	Het
Rdh8	A	G	9: 20,736,637 (GRCm39)	S235G	possibly damaging	Het
Rrp12	T	C	19: 41,884,500 (GRCm39)	K6R	probably benign	Het
Sec24a	T	C	11: 51,587,560 (GRCm39)	D1025G	probably benign	Het
Sgo2a	T	G	1: 58,055,509 (GRCm39)	N564K	probably damaging	Het
Slc43a3	A	T	2: 84,774,612 (GRCm39)	M130L	probably benign	Het
Soat1	T	C	1: 156,274,145 (GRCm39)	I89V	probably benign	Het
St3gal5	A	G	6: 72,126,157 (GRCm39)	D307G	probably null	Het
Stxbp3-ps	C	T	19: 9,535,193 (GRCm39)		noncoding transcript	Het
Tacr2	A	G	10: 62,097,469 (GRCm39)		probably benign	Het
Tg	C	T	15: 66,606,435 (GRCm39)	T193I	probably benign	Het
Tnik	A	G	3: 28,596,179 (GRCm39)	T191A	probably damaging	Het
Usf2	A	T	7: 30,646,417 (GRCm39)	C134*	probably null	Het
Usp14	A	G	18: 10,001,769 (GRCm39)		probably null	Het
Usp47	T	C	7: 111,692,270 (GRCm39)	S911P	possibly damaging	Het
Vmn1r73	T	A	7: 11,490,574 (GRCm39)	S131T	possibly damaging	Het
Vmn2r80	T	C	10: 79,030,145 (GRCm39)	I657T	probably damaging	Het
Zfp935	A	T	13: 62,602,701 (GRCm39)	C166*	probably null	Het

Other mutations in Trim27

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01865:Trim27	APN	13	21,376,662 (GRCm39)	missense	probably damaging	0.98
IGL03199:Trim27	APN	13	21,375,421 (GRCm39)	splice site	probably null
R0016:Trim27	UTSW	13	21,375,399 (GRCm39)	missense	probably benign	0.14
R0016:Trim27	UTSW	13	21,375,399 (GRCm39)	missense	probably benign	0.14
R1709:Trim27	UTSW	13	21,372,235 (GRCm39)	critical splice donor site	probably null
R2188:Trim27	UTSW	13	21,367,987 (GRCm39)	missense	probably damaging	1.00
R4472:Trim27	UTSW	13	21,374,056 (GRCm39)	missense	probably benign	0.00
R4657:Trim27	UTSW	13	21,367,930 (GRCm39)	missense	probably damaging	1.00
R4677:Trim27	UTSW	13	21,365,086 (GRCm39)	critical splice donor site	probably null
R5019:Trim27	UTSW	13	21,374,134 (GRCm39)	missense	probably damaging	1.00
R5584:Trim27	UTSW	13	21,376,719 (GRCm39)	missense	probably damaging	1.00
R6226:Trim27	UTSW	13	21,365,086 (GRCm39)	critical splice donor site	probably benign
R6774:Trim27	UTSW	13	21,376,624 (GRCm39)	missense	probably damaging	1.00
R7378:Trim27	UTSW	13	21,376,631 (GRCm39)	missense	possibly damaging	0.92
R7573:Trim27	UTSW	13	21,364,770 (GRCm39)	missense	probably damaging	0.96
R7662:Trim27	UTSW	13	21,376,328 (GRCm39)	missense	probably benign	0.05
R8272:Trim27	UTSW	13	21,364,780 (GRCm39)	missense	probably benign	0.14
R8723:Trim27	UTSW	13	21,374,807 (GRCm39)	intron	probably benign
R8914:Trim27	UTSW	13	21,364,993 (GRCm39)	missense	possibly damaging	0.77
R9380:Trim27	UTSW	13	21,364,680 (GRCm39)	missense	probably benign	0.00
R9717:Trim27	UTSW	13	21,374,296 (GRCm39)	critical splice donor site	probably null
X0062:Trim27	UTSW	13	21,368,044 (GRCm39)	missense	probably benign	0.44

Posted On

2015-04-16