Incidental Mutation 'IGL00583:Sult2a3'
ID332705
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a3
Ensembl Gene ENSMUSG00000074375
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3
SynonymsGm6955
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00583
Quality Score
Status
Chromosome7
Chromosomal Location14067446-14123044 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 14122980 bp
ZygosityHeterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 5 (Y5F)
Ref Sequence ENSEMBL: ENSMUSP00000096407 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098809]
Predicted Effect probably benign
Transcript: ENSMUST00000098809
AA Change: Y5F

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000096407
Gene: ENSMUSG00000074375
AA Change: Y5F

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 278 1.5e-83 PFAM
Pfam:Sulfotransfer_3 35 205 3.4e-11 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts6 C T 13: 104,297,218 Q52* probably null Het
Ambp G T 4: 63,154,018 A13D possibly damaging Het
Angptl3 A G 4: 99,034,840 T283A probably damaging Het
Atp13a5 A T 16: 29,275,453 probably benign Het
Borcs8 A G 8: 70,145,107 H93R probably benign Het
Bzw1 T C 1: 58,401,335 probably benign Het
Cd200 A C 16: 45,397,109 I73R probably damaging Het
Coq8a T C 1: 180,168,389 D528G probably benign Het
Edem1 T A 6: 108,855,559 probably benign Het
Enpp5 C T 17: 44,085,197 probably benign Het
Eprs G T 1: 185,407,148 C910F probably benign Het
Erich6 T C 3: 58,637,043 E41G unknown Het
Gls2 A G 10: 128,204,882 M340V probably benign Het
Gna12 A T 5: 140,761,018 V224E probably damaging Het
Golph3l T C 3: 95,589,103 L46P possibly damaging Het
Limch1 T C 5: 66,953,679 I83T probably damaging Het
Mas1 T C 17: 12,841,965 I190M possibly damaging Het
Mefv T A 16: 3,716,072 K112* probably null Het
Oas1e T A 5: 120,794,272 E102V probably damaging Het
Pde6a T C 18: 61,257,268 C521R probably damaging Het
Pigw A G 11: 84,877,888 V205A possibly damaging Het
Ptpn21 G A 12: 98,733,601 S18F probably damaging Het
Shprh C T 10: 11,188,020 T1279I probably benign Het
Slc11a2 T C 15: 100,397,737 E501G probably benign Het
Tll1 A G 8: 64,205,292 L31P probably benign Het
Tubgcp3 G A 8: 12,621,906 Q779* probably null Het
U2surp T A 9: 95,461,524 probably benign Het
Other mutations in Sult2a3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02353:Sult2a3 APN 7 14121650 nonsense probably null
IGL02360:Sult2a3 APN 7 14121650 nonsense probably null
IGL02806:Sult2a3 APN 7 14122932 missense probably damaging 1.00
IGL03252:Sult2a3 APN 7 14067634 missense probably damaging 1.00
R0029:Sult2a3 UTSW 7 14073074 missense probably benign 0.11
R1480:Sult2a3 UTSW 7 14122911 missense possibly damaging 0.51
R1491:Sult2a3 UTSW 7 14122942 missense probably benign 0.01
R4078:Sult2a3 UTSW 7 14121737 missense possibly damaging 0.94
R4668:Sult2a3 UTSW 7 14122861 missense probably damaging 1.00
R4928:Sult2a3 UTSW 7 14111557 missense probably benign 0.06
R6311:Sult2a3 UTSW 7 14111557 missense probably benign 0.00
R6749:Sult2a3 UTSW 7 14082704 missense probably benign 0.00
R7030:Sult2a3 UTSW 7 14067568 missense probably damaging 1.00
R7232:Sult2a3 UTSW 7 14082760 missense possibly damaging 0.89
R7394:Sult2a3 UTSW 7 14111524 missense probably benign 0.05
R7617:Sult2a3 UTSW 7 14073056 missense probably benign 0.00
R8029:Sult2a3 UTSW 7 14121628 missense probably damaging 1.00
R8097:Sult2a3 UTSW 7 14082710 missense possibly damaging 0.93
Posted On2015-08-05