Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02825:Spin1'

361191

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Spin1

Ensembl Gene

ENSMUSG00000021395

Gene Name

spindlin 1

Synonyms

Spin

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL02825

Quality Score

Status

Chromosome

Chromosomal Location

51254916-51306582 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

C to A at 51277332 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000093473 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095797]

AlphaFold

Q61142

Predicted Effect

probably benign
Transcript: ENSMUST00000095797

SMART Domains

Protein: ENSMUSP00000093473
Gene: ENSMUSG00000021395

Domain	Start	End	E-Value	Type
Pfam:Spin-Ssty	54	103	7.3e-30	PFAM
Pfam:Spin-Ssty	133	182	1.2e-26	PFAM
Pfam:Spin-Ssty	214	259	1.2e-24	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abo	A	G	2: 26,733,710 (GRCm39)	V163A	possibly damaging	Het
Ap1b1	G	T	11: 4,983,738 (GRCm39)	A664S	possibly damaging	Het
B3gnt4	T	C	5: 123,649,114 (GRCm39)	F160L	possibly damaging	Het
Brd3	T	C	2: 27,339,275 (GRCm39)	E685G	probably damaging	Het
Cacna2d2	C	T	9: 107,401,659 (GRCm39)	R746C	probably damaging	Het
Ces1d	C	A	8: 93,896,346 (GRCm39)		probably null	Het
Chl1	T	A	6: 103,645,764 (GRCm39)	V268E	possibly damaging	Het
Cpb1	T	A	3: 20,303,889 (GRCm39)	I392F	probably damaging	Het
Dnai1	T	C	4: 41,625,101 (GRCm39)		probably benign	Het
Dync2h1	T	C	9: 6,955,901 (GRCm39)		probably benign	Het
Edc4	T	C	8: 106,617,243 (GRCm39)	S1021P	probably damaging	Het
Exoc7	A	C	11: 116,188,411 (GRCm39)	L296R	probably damaging	Het
Fgd5	A	G	6: 92,015,068 (GRCm39)		probably null	Het
Gm28042	T	A	2: 119,862,125 (GRCm39)	M232K	probably damaging	Het
Ints1	A	T	5: 139,750,494 (GRCm39)	S888T	probably benign	Het
Kirrel1	A	T	3: 86,996,595 (GRCm39)		probably benign	Het
Lrp1	C	T	10: 127,378,474 (GRCm39)	R4037Q	probably damaging	Het
Lrrc37	G	A	11: 103,507,894 (GRCm39)		probably benign	Het
Lrrn3	A	T	12: 41,502,592 (GRCm39)	V575D	probably damaging	Het
Mapk11	A	G	15: 89,030,585 (GRCm39)	Y103H	probably damaging	Het
Mrpl19	G	T	6: 81,942,796 (GRCm39)	T38K	probably benign	Het
Nefl	A	T	14: 68,321,795 (GRCm39)	K128N	possibly damaging	Het
Olfm1	A	G	2: 28,119,090 (GRCm39)	N242D	probably damaging	Het
Oprd1	T	A	4: 131,844,670 (GRCm39)	T113S	probably damaging	Het
Or10d1	A	T	9: 39,483,877 (GRCm39)	I226N	probably damaging	Het
Or52s19	T	C	7: 103,007,568 (GRCm39)	I278V	probably benign	Het
Pds5b	C	T	5: 150,652,435 (GRCm39)	T234I	possibly damaging	Het
Prpf3	A	T	3: 95,760,792 (GRCm39)	C37S	probably damaging	Het
Rpgrip1l	G	A	8: 92,031,433 (GRCm39)	T148M	possibly damaging	Het
Rph3a	T	C	5: 121,083,509 (GRCm39)	K587R	possibly damaging	Het
Scn3b	T	C	9: 40,188,441 (GRCm39)	C5R	probably damaging	Het
Sirpa	C	T	2: 129,457,372 (GRCm39)	P149S	probably damaging	Het
Slco1a1	A	T	6: 141,864,343 (GRCm39)	C486S	probably damaging	Het
Stom	C	A	2: 35,211,644 (GRCm39)	V126F	probably damaging	Het
Tom1	A	G	8: 75,783,883 (GRCm39)	D64G	probably damaging	Het
Trbv4	T	A	6: 41,036,613 (GRCm39)	L46Q	probably damaging	Het
Trhr	A	T	15: 44,092,921 (GRCm39)	D386V	possibly damaging	Het
Vmn2r101	T	A	17: 19,810,132 (GRCm39)	I306N	probably benign	Het
Vmn2r51	C	T	7: 9,832,046 (GRCm39)		probably benign	Het
Vmn2r63	A	G	7: 42,576,274 (GRCm39)		probably null	Het
Zfp277	T	C	12: 40,367,175 (GRCm39)	K494E	probably benign	Het
Zranb3	A	T	1: 127,887,489 (GRCm39)	S979R	probably benign	Het

Other mutations in Spin1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Spin1	APN	13	51,298,577 (GRCm39)	splice site	probably null
IGL03366:Spin1	APN	13	51,281,973 (GRCm39)	missense	probably benign	0.03
R0050:Spin1	UTSW	13	51,304,454 (GRCm39)	utr 3 prime	probably benign
R0139:Spin1	UTSW	13	51,303,048 (GRCm39)	missense	probably benign	0.01
R0745:Spin1	UTSW	13	51,293,551 (GRCm39)	missense	probably damaging	0.96
R1394:Spin1	UTSW	13	51,298,517 (GRCm39)	missense	probably damaging	1.00
R1674:Spin1	UTSW	13	51,303,135 (GRCm39)	missense	probably damaging	1.00
R1980:Spin1	UTSW	13	51,298,506 (GRCm39)	missense	probably damaging	1.00
R2070:Spin1	UTSW	13	51,298,573 (GRCm39)	critical splice donor site	probably null
R5326:Spin1	UTSW	13	51,293,563 (GRCm39)	missense	probably damaging	1.00
R5741:Spin1	UTSW	13	51,303,171 (GRCm39)	missense	possibly damaging	0.81
R6030:Spin1	UTSW	13	51,293,552 (GRCm39)	nonsense	probably null
R6030:Spin1	UTSW	13	51,293,552 (GRCm39)	nonsense	probably null
R6182:Spin1	UTSW	13	51,298,374 (GRCm39)	missense	probably benign
R7423:Spin1	UTSW	13	51,277,326 (GRCm39)	critical splice donor site	probably null
R7555:Spin1	UTSW	13	51,303,085 (GRCm39)	missense	probably benign	0.02
R8912:Spin1	UTSW	13	51,298,433 (GRCm39)	missense	probably damaging	1.00
R9014:Spin1	UTSW	13	51,282,010 (GRCm39)	critical splice donor site	probably null
R9735:Spin1	UTSW	13	51,293,521 (GRCm39)	missense	probably damaging	1.00

Posted On

2015-12-18