Incidental Mutation 'R5159:Trat1'
ID 396901
Institutional Source Beutler Lab
Gene Symbol Trat1
Ensembl Gene ENSMUSG00000030775
Gene Name T cell receptor associated transmembrane adaptor 1
Synonyms Tcrim, C030046M14Rik, Trim
MMRRC Submission 042741-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R5159 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 48551137-48592384 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 48555300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 144 (D144G)
Ref Sequence ENSEMBL: ENSMUSP00000155986 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170861] [ENSMUST00000231701]
AlphaFold Q3UU67
Predicted Effect probably benign
Transcript: ENSMUST00000170861
SMART Domains Protein: ENSMUSP00000129808
Gene: ENSMUSG00000030775

DomainStartEndE-ValueType
low complexity region 4 16 N/A INTRINSIC
Pfam:SIT 22 131 3.6e-35 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000231701
AA Change: D144G

PolyPhen 2 Score 0.982 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.1461 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency 100% (63/63)
MGI Phenotype PHENOTYPE: Mice with homozygous disruption of this gene display decreased body weight and a proportional reduction in lymph organ cell numbers; however T and B cell function are normal. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 T C 11: 48,839,352 (GRCm39) T412A probably benign Het
Aldh5a1 T A 13: 25,097,776 (GRCm39) M420L possibly damaging Het
Armc2 A G 10: 41,884,711 (GRCm39) S77P probably damaging Het
Avil A G 10: 126,856,317 (GRCm39) probably null Het
Bltp3a A G 17: 28,100,530 (GRCm39) H323R probably damaging Het
Bmp5 T A 9: 75,801,035 (GRCm39) F388L probably damaging Het
Brca2 T G 5: 150,465,573 (GRCm39) V1779G possibly damaging Het
Cblb T A 16: 51,932,483 (GRCm39) S147T probably damaging Het
Cblc T C 7: 19,519,233 (GRCm39) E409G probably benign Het
Cdc34b C T 11: 94,632,886 (GRCm39) R29W probably damaging Het
Clic6 T A 16: 92,324,954 (GRCm39) Y371N probably benign Het
Col5a2 A G 1: 45,425,991 (GRCm39) probably null Het
Coro1a A T 7: 126,302,221 (GRCm39) V42D probably damaging Het
Cpa3 C T 3: 20,281,387 (GRCm39) C173Y probably damaging Het
Crb1 A C 1: 139,170,756 (GRCm39) V817G probably damaging Het
Cyp2c39 A G 19: 39,549,378 (GRCm39) T299A possibly damaging Het
Dock5 G A 14: 68,029,738 (GRCm39) R1019C probably benign Het
Exoc8 T C 8: 125,622,952 (GRCm39) T472A probably benign Het
Fancc A G 13: 63,469,679 (GRCm39) probably null Het
Fcgbpl1 T A 7: 27,852,733 (GRCm39) M1340K probably benign Het
Inpp5d T C 1: 87,604,064 (GRCm39) L244P probably damaging Het
Ireb2 A G 9: 54,799,831 (GRCm39) N424S probably benign Het
Krt35 T C 11: 99,984,875 (GRCm39) D261G probably damaging Het
Lipc T A 9: 70,720,192 (GRCm39) I272L probably benign Het
Lpcat3 A G 6: 124,676,357 (GRCm39) probably benign Het
Lzts1 T C 8: 69,591,236 (GRCm39) D304G probably benign Het
Mdn1 A G 4: 32,774,008 (GRCm39) I5540V possibly damaging Het
Msln T C 17: 25,970,563 (GRCm39) S231G probably benign Het
Mup8 G A 4: 60,221,062 (GRCm39) T101M probably benign Het
Myh8 T C 11: 67,179,179 (GRCm39) I524T probably damaging Het
Pappa2 A G 1: 158,589,189 (GRCm39) C1679R probably damaging Het
Pcdhb1 T C 18: 37,399,416 (GRCm39) S456P possibly damaging Het
Pcdhga5 A G 18: 37,828,719 (GRCm39) N389S probably benign Het
Pitrm1 C A 13: 6,617,507 (GRCm39) S620R probably benign Het
Plod3 T A 5: 137,023,932 (GRCm39) probably benign Het
Por A T 5: 135,759,771 (GRCm39) Q194L probably benign Het
Prkag3 A T 1: 74,780,646 (GRCm39) Y396N probably damaging Het
R3hcc1 T C 14: 69,935,053 (GRCm39) probably null Het
Rcan3 C T 4: 135,152,592 (GRCm39) S43N probably damaging Het
Rhot1 A G 11: 80,111,098 (GRCm39) T31A probably damaging Het
Rnps1 T G 17: 24,637,486 (GRCm39) S43A unknown Het
Rp1 T C 1: 4,416,426 (GRCm39) D1562G possibly damaging Het
Rps19-ps13 A G 18: 40,859,428 (GRCm39) noncoding transcript Het
Serpina3c A T 12: 104,115,771 (GRCm39) S258T possibly damaging Het
Smc2 G A 4: 52,460,181 (GRCm39) R519Q possibly damaging Het
Sorbs2 A T 8: 46,248,767 (GRCm39) T593S probably benign Het
Sptbn2 A G 19: 4,787,885 (GRCm39) T955A probably benign Het
Stfa3 T C 16: 36,272,581 (GRCm39) K40E probably damaging Het
Tmem87b A G 2: 128,666,378 (GRCm39) E75G probably benign Het
Tmprss15 T C 16: 78,800,298 (GRCm39) Q595R probably benign Het
Trak1 A T 9: 121,289,478 (GRCm39) I597F probably damaging Het
Trim25 T C 11: 88,890,358 (GRCm39) V15A probably benign Het
Tulp1 A C 17: 28,578,034 (GRCm39) probably null Het
Txndc15 T A 13: 55,865,734 (GRCm39) M66K probably benign Het
Vmn1r206 T A 13: 22,804,775 (GRCm39) N144I probably damaging Het
Wwc2 T C 8: 48,353,796 (GRCm39) T113A probably benign Het
Xpo5 A C 17: 46,528,535 (GRCm39) E313D probably damaging Het
Zfp790 C T 7: 29,529,192 (GRCm39) H626Y probably benign Het
Other mutations in Trat1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1162:Trat1 UTSW 16 48,560,572 (GRCm39) missense possibly damaging 0.61
R1498:Trat1 UTSW 16 48,555,304 (GRCm39) missense probably benign 0.02
R1829:Trat1 UTSW 16 48,581,742 (GRCm39) missense probably damaging 1.00
R5018:Trat1 UTSW 16 48,555,168 (GRCm39) nonsense probably null
R5734:Trat1 UTSW 16 48,555,304 (GRCm39) missense possibly damaging 0.94
R6985:Trat1 UTSW 16 48,574,634 (GRCm39) missense probably damaging 1.00
R7501:Trat1 UTSW 16 48,574,657 (GRCm39) splice site probably null
R8057:Trat1 UTSW 16 48,562,600 (GRCm39) missense probably damaging 1.00
R8729:Trat1 UTSW 16 48,562,591 (GRCm39) missense probably damaging 1.00
R9215:Trat1 UTSW 16 48,574,637 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGTGTCACATGAGGGATTTTAACC -3'
(R):5'- GGCCATGGAAATTTCTAGACTTC -3'

Sequencing Primer
(F):5'- GGGATTTTAACCATCTTTCATAGGG -3'
(R):5'- CAGATGTGCTATGCCTCA -3'
Posted On 2016-06-21