Incidental Mutation 'IGL01861:Fam133b'
ID178331
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fam133b
Ensembl Gene ENSMUSG00000058503
Gene Namefamily with sequence similarity 133, member B
Synonyms
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.508) question?
Stock #IGL01861
Quality Score
Status
Chromosome5
Chromosomal Location3543833-3570238 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 3564242 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000115527] [ENSMUST00000197082] [ENSMUST00000199666]
Predicted Effect noncoding transcript
Transcript: ENSMUST00000083110
Predicted Effect unknown
Transcript: ENSMUST00000115527
AA Change: D173G
SMART Domains Protein: ENSMUSP00000111189
Gene: ENSMUSG00000058503
AA Change: D173G

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 85 141 N/A INTRINSIC
low complexity region 145 166 N/A INTRINSIC
low complexity region 218 244 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196059
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196499
Predicted Effect unknown
Transcript: ENSMUST00000197082
AA Change: D156G
SMART Domains Protein: ENSMUSP00000142744
Gene: ENSMUSG00000058503
AA Change: D156G

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 85 158 N/A INTRINSIC
low complexity region 201 227 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198598
Predicted Effect probably benign
Transcript: ENSMUST00000199666
SMART Domains Protein: ENSMUSP00000143004
Gene: ENSMUSG00000058503

DomainStartEndE-ValueType
coiled coil region 40 82 N/A INTRINSIC
low complexity region 86 109 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200354
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arrdc5 T C 17: 56,300,144 T34A possibly damaging Het
Atm C A 9: 53,494,612 R1252L probably null Het
Cd34 T C 1: 194,958,580 probably benign Het
Cmya5 A G 13: 93,089,748 V2944A probably damaging Het
Cntnap3 C T 13: 64,799,108 G169D probably damaging Het
Dnah7a T A 1: 53,640,349 T326S probably benign Het
Dnah7a C T 1: 53,584,449 probably benign Het
Fhod1 A G 8: 105,331,176 S906P probably damaging Het
Gli3 A G 13: 15,725,325 Y1099C probably damaging Het
Gpr63 C T 4: 25,008,545 T423M probably damaging Het
Hpx A T 7: 105,592,186 Y339* probably null Het
Lingo2 A T 4: 35,709,526 D151E probably benign Het
Mill2 A T 7: 18,856,640 Q215L probably damaging Het
Naf1 T C 8: 66,864,533 probably benign Het
Ndufv1 A G 19: 4,008,803 V235A probably benign Het
Olfr890 T C 9: 38,143,750 I205T probably damaging Het
Pafah1b1 A T 11: 74,690,577 N22K possibly damaging Het
Prune1 G T 3: 95,265,557 R66S probably damaging Het
Ptcd1 A T 5: 145,158,777 I291N possibly damaging Het
Ptprk A G 10: 28,383,445 I294V possibly damaging Het
Rfx6 G A 10: 51,721,579 V471M probably damaging Het
Rnase6 C A 14: 51,130,291 Q47K probably benign Het
Skint5 T C 4: 113,559,824 probably benign Het
Srcap T A 7: 127,525,285 probably benign Het
Stap1 A G 5: 86,096,524 I217V possibly damaging Het
Taf1d T C 9: 15,308,739 probably null Het
Tecta T C 9: 42,373,362 H809R probably benign Het
Tex15 A G 8: 33,570,689 N49S probably damaging Het
Tubb4b-ps1 A G 5: 7,179,374 probably benign Het
Uhrf2 A G 19: 30,086,404 Y589C probably damaging Het
Zfp616 A T 11: 74,082,916 T4S possibly damaging Het
Zfp687 A T 3: 95,011,860 F200L probably damaging Het
Other mutations in Fam133b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03026:Fam133b APN 5 3559646 utr 3 prime probably benign
IGL03218:Fam133b APN 5 3554684 nonsense probably null
R0433:Fam133b UTSW 5 3558560 splice site probably benign
R1299:Fam133b UTSW 5 3554626 splice site probably benign
R3176:Fam133b UTSW 5 3558522 missense probably damaging 1.00
R3276:Fam133b UTSW 5 3558522 missense probably damaging 1.00
R3705:Fam133b UTSW 5 3561034 splice site probably benign
R4722:Fam133b UTSW 5 3543949 critical splice donor site probably null
R4799:Fam133b UTSW 5 3557815 missense probably damaging 0.99
R6151:Fam133b UTSW 5 3559133 missense probably null
R6709:Fam133b UTSW 5 3569059 utr 3 prime probably benign
R6835:Fam133b UTSW 5 3554732 missense possibly damaging 0.94
Posted On2014-05-07