Incidental Mutation 'IGL03028:Clk1'
ID 408300
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Clk1
Ensembl Gene ENSMUSG00000026034
Gene Name CDC-like kinase 1
Synonyms Clk1, STY
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03028
Quality Score
Status
Chromosome 1
Chromosomal Location 58451147-58463247 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 58460261 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Stop codon at position 123 (S123*)
Ref Sequence ENSEMBL: ENSMUSP00000137815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034868] [ENSMUST00000151338] [ENSMUST00000148330]
AlphaFold P22518
Predicted Effect probably null
Transcript: ENSMUST00000034868
AA Change: S123*
SMART Domains Protein: ENSMUSP00000034868
Gene: ENSMUSG00000026034
AA Change: S123*

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 82 93 N/A INTRINSIC
low complexity region 99 139 N/A INTRINSIC
S_TKc 160 476 3.55e-79 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123580
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129577
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131051
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135380
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147258
Predicted Effect probably null
Transcript: ENSMUST00000151338
AA Change: S123*
SMART Domains Protein: ENSMUSP00000137815
Gene: ENSMUSG00000026034
AA Change: S123*

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 82 93 N/A INTRINSIC
low complexity region 99 129 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000148330
AA Change: S123*
SMART Domains Protein: ENSMUSP00000137649
Gene: ENSMUSG00000026034
AA Change: S123*

DomainStartEndE-ValueType
low complexity region 23 37 N/A INTRINSIC
low complexity region 82 93 N/A INTRINSIC
low complexity region 99 129 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156931
Predicted Effect noncoding transcript
Transcript: ENSMUST00000186552
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acat1 A C 9: 53,506,062 (GRCm39) V86G probably benign Het
Adgra3 A T 5: 50,174,194 (GRCm39) W115R probably benign Het
Ahr G A 12: 35,554,709 (GRCm39) A470V probably benign Het
Aoah A T 13: 21,000,752 (GRCm39) Q62L possibly damaging Het
Arhgef12 A T 9: 42,937,524 (GRCm39) D100E possibly damaging Het
Asic1 A G 15: 99,570,038 (GRCm39) N120D probably benign Het
Atp2b2 A G 6: 113,736,103 (GRCm39) L988P probably damaging Het
Atxn2 T A 5: 121,948,972 (GRCm39) H789Q probably damaging Het
Col10a1 C T 10: 34,271,012 (GRCm39) A328V probably benign Het
Col26a1 G T 5: 136,771,972 (GRCm39) D415E possibly damaging Het
Ctla2a A G 13: 61,083,273 (GRCm39) probably benign Het
Cwf19l2 A G 9: 3,430,622 (GRCm39) E318G probably benign Het
Dnajc16 C T 4: 141,495,043 (GRCm39) W523* probably null Het
Ehhadh T C 16: 21,581,144 (GRCm39) E616G probably damaging Het
F5 A T 1: 164,020,569 (GRCm39) K1015* probably null Het
Fam78a A G 2: 31,972,894 (GRCm39) W9R possibly damaging Het
Frs2 A T 10: 116,909,838 (GRCm39) M508K possibly damaging Het
Gm3164 A T 14: 4,440,111 (GRCm38) M200L probably benign Het
Gm44511 T C 6: 128,757,358 (GRCm39) S179G probably damaging Het
Gpr25 G A 1: 136,188,550 (GRCm39) S21L probably benign Het
Hsdl2 A G 4: 59,594,471 (GRCm39) D34G probably damaging Het
Kcnt1 A G 2: 25,799,215 (GRCm39) probably null Het
Kl A G 5: 150,915,015 (GRCm39) Y914C probably damaging Het
Map3k3 T G 11: 106,001,577 (GRCm39) V45G probably damaging Het
Mppe1 A C 18: 67,360,755 (GRCm39) C261W probably damaging Het
Nin T C 12: 70,082,044 (GRCm39) T1640A probably benign Het
Or51a8 T A 7: 102,550,036 (GRCm39) I154N possibly damaging Het
Or51ac3 A G 7: 103,213,796 (GRCm39) probably null Het
Or5c1 C T 2: 37,221,968 (GRCm39) L70F probably damaging Het
Or5p59 T A 7: 107,703,380 (GRCm39) M288K probably damaging Het
Or7g26 A T 9: 19,230,664 (GRCm39) Y284F probably damaging Het
Oxr1 A G 15: 41,680,559 (GRCm39) N166D probably damaging Het
Pank4 T A 4: 155,054,442 (GRCm39) probably benign Het
Pgd A G 4: 149,246,084 (GRCm39) probably null Het
Pitrm1 C T 13: 6,624,429 (GRCm39) H831Y probably benign Het
Pkd1l2 G A 8: 117,792,484 (GRCm39) T436I probably benign Het
Rad51 A C 2: 118,946,795 (GRCm39) M1L possibly damaging Het
Recql5 G T 11: 115,785,257 (GRCm39) S746R possibly damaging Het
Rhbdl3 C T 11: 80,214,287 (GRCm39) Q133* probably null Het
Rpp40 A T 13: 36,088,494 (GRCm39) L59Q probably damaging Het
Rtca C A 3: 116,286,741 (GRCm39) probably benign Het
Rtkn C T 6: 83,124,853 (GRCm39) Q108* probably null Het
Shoc1 A C 4: 59,094,274 (GRCm39) I150S possibly damaging Het
Sirt6 C T 10: 81,463,375 (GRCm39) probably benign Het
Slc9a4 G A 1: 40,649,537 (GRCm39) V517M probably benign Het
Smarca2 G T 19: 26,655,712 (GRCm39) probably benign Het
Snx33 A T 9: 56,833,735 (GRCm39) D111E probably benign Het
Tgfb1 T C 7: 25,403,621 (GRCm39) I311T probably damaging Het
Tgfb2 C T 1: 186,362,806 (GRCm39) probably null Het
Tmem232 T C 17: 65,563,384 (GRCm39) T670A probably benign Het
Tnfsf4 T C 1: 161,223,213 (GRCm39) F21L possibly damaging Het
Ubr5 T C 15: 38,047,837 (GRCm39) T47A probably benign Het
Unc79 T C 12: 103,139,785 (GRCm39) V2515A possibly damaging Het
Utp6 T C 11: 79,844,450 (GRCm39) K192E probably damaging Het
Vmn2r102 T C 17: 19,914,328 (GRCm39) F631S possibly damaging Het
Zfp516 A C 18: 82,974,038 (GRCm39) I79L possibly damaging Het
Other mutations in Clk1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01152:Clk1 APN 1 58,452,611 (GRCm39) missense possibly damaging 0.93
IGL01516:Clk1 APN 1 58,453,563 (GRCm39) missense probably damaging 1.00
IGL01684:Clk1 APN 1 58,456,424 (GRCm39) critical splice donor site probably null
IGL02621:Clk1 APN 1 58,453,614 (GRCm39) missense probably damaging 1.00
IGL02812:Clk1 APN 1 58,453,635 (GRCm39) missense probably damaging 0.98
IGL03117:Clk1 APN 1 58,456,166 (GRCm39) splice site probably null
PIT4243001:Clk1 UTSW 1 58,458,836 (GRCm39) missense probably damaging 1.00
R0149:Clk1 UTSW 1 58,453,760 (GRCm39) missense probably damaging 1.00
R0309:Clk1 UTSW 1 58,452,192 (GRCm39) splice site probably benign
R0730:Clk1 UTSW 1 58,453,558 (GRCm39) missense probably benign 0.38
R1570:Clk1 UTSW 1 58,453,584 (GRCm39) missense probably benign 0.28
R1729:Clk1 UTSW 1 58,460,420 (GRCm39) missense probably damaging 1.00
R1905:Clk1 UTSW 1 58,461,101 (GRCm39) splice site probably benign
R2382:Clk1 UTSW 1 58,460,448 (GRCm39) missense probably benign 0.01
R2850:Clk1 UTSW 1 58,451,438 (GRCm39) missense probably damaging 1.00
R4658:Clk1 UTSW 1 58,452,146 (GRCm39) missense probably benign 0.01
R4846:Clk1 UTSW 1 58,460,261 (GRCm39) missense probably benign 0.33
R5011:Clk1 UTSW 1 58,453,642 (GRCm39) missense probably benign
R5196:Clk1 UTSW 1 58,453,772 (GRCm39) missense probably benign 0.00
R5699:Clk1 UTSW 1 58,459,354 (GRCm39) missense probably damaging 1.00
R5838:Clk1 UTSW 1 58,451,819 (GRCm39) missense probably damaging 1.00
R5839:Clk1 UTSW 1 58,461,074 (GRCm39) missense probably benign 0.09
R6697:Clk1 UTSW 1 58,453,781 (GRCm39) missense probably benign 0.21
R7293:Clk1 UTSW 1 58,453,772 (GRCm39) missense probably benign 0.00
R7332:Clk1 UTSW 1 58,451,853 (GRCm39) missense probably benign 0.16
R7663:Clk1 UTSW 1 58,460,319 (GRCm39) missense probably damaging 1.00
R8550:Clk1 UTSW 1 58,451,835 (GRCm39) missense probably damaging 0.99
R9090:Clk1 UTSW 1 58,459,312 (GRCm39) missense possibly damaging 0.81
R9268:Clk1 UTSW 1 58,458,882 (GRCm39) missense unknown
R9271:Clk1 UTSW 1 58,459,312 (GRCm39) missense possibly damaging 0.81
Z1176:Clk1 UTSW 1 58,456,531 (GRCm39) missense probably benign 0.00
Posted On 2016-08-02