Incidental Mutation 'IGL03326:Igtp'
ID |
416642 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Igtp
|
Ensembl Gene |
ENSMUSG00000078853 |
Gene Name |
interferon gamma induced GTPase |
Synonyms |
Irgm3 |
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
IGL03326
|
Quality Score |
|
Status
|
|
Chromosome |
11 |
Chromosomal Location |
58090382-58098417 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 58097054 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 75
(D75G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000047356
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000035266]
[ENSMUST00000058704]
[ENSMUST00000094169]
[ENSMUST00000168280]
|
AlphaFold |
Q9DCE9 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000035266
AA Change: D75G
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
SMART Domains |
Protein: ENSMUSP00000047356 Gene: ENSMUSG00000078853 AA Change: D75G
Domain | Start | End | E-Value | Type |
Pfam:IIGP
|
50 |
412 |
4.6e-161 |
PFAM |
Pfam:MMR_HSR1
|
86 |
200 |
1.1e-6 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000058704
|
SMART Domains |
Protein: ENSMUSP00000056001 Gene: ENSMUSG00000069874
Domain | Start | End | E-Value | Type |
Pfam:IIGP
|
30 |
387 |
8.1e-165 |
PFAM |
Pfam:MMR_HSR1
|
66 |
179 |
9.3e-7 |
PFAM |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000094169
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000168280
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Mice homozygous for disruptions in this gene display an essentially normal phenotype. They do have a severely compromised response to Toxoplasma gondii infections however [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Adam22 |
A |
G |
5: 8,177,421 (GRCm39) |
S563P |
probably damaging |
Het |
Adamtsl1 |
A |
T |
4: 86,170,985 (GRCm39) |
|
probably benign |
Het |
Ampd2 |
T |
A |
3: 107,986,603 (GRCm39) |
Y227F |
probably benign |
Het |
Cyp2c67 |
A |
T |
19: 39,631,713 (GRCm39) |
|
probably null |
Het |
Gk5 |
G |
A |
9: 96,019,892 (GRCm39) |
|
probably null |
Het |
Gm20422 |
T |
C |
8: 70,219,348 (GRCm39) |
T59A |
possibly damaging |
Het |
Gria1 |
A |
T |
11: 57,208,599 (GRCm39) |
K831N |
probably damaging |
Het |
Hspa5 |
C |
A |
2: 34,666,129 (GRCm39) |
|
probably benign |
Het |
Jmjd8 |
T |
C |
17: 26,048,139 (GRCm39) |
|
probably null |
Het |
Kcnh2 |
A |
T |
5: 24,531,411 (GRCm39) |
F158Y |
probably damaging |
Het |
Kmt2a |
A |
T |
9: 44,730,044 (GRCm39) |
C456* |
probably null |
Het |
Krtap5-2 |
A |
T |
7: 141,729,100 (GRCm39) |
C193* |
probably null |
Het |
Mrpl2 |
T |
C |
17: 46,960,853 (GRCm39) |
V249A |
possibly damaging |
Het |
Obscn |
A |
T |
11: 58,923,728 (GRCm39) |
I6433N |
probably damaging |
Het |
Or52a20 |
T |
A |
7: 103,366,069 (GRCm39) |
F89L |
probably benign |
Het |
Or5p63 |
T |
C |
7: 107,810,837 (GRCm39) |
I300V |
probably benign |
Het |
Or5w14 |
A |
C |
2: 87,542,039 (GRCm39) |
D70E |
probably damaging |
Het |
Plb1 |
C |
T |
5: 32,488,671 (GRCm39) |
T985I |
probably benign |
Het |
Polr3b |
T |
C |
10: 84,503,259 (GRCm39) |
I392T |
probably benign |
Het |
Ppp1r1c |
A |
T |
2: 79,638,727 (GRCm39) |
N107I |
probably benign |
Het |
Ppp1r3a |
C |
T |
6: 14,719,765 (GRCm39) |
R383Q |
probably damaging |
Het |
Ptpre |
T |
C |
7: 135,274,546 (GRCm39) |
I499T |
probably damaging |
Het |
Rapgef2 |
A |
G |
3: 78,999,140 (GRCm39) |
I544T |
probably damaging |
Het |
Rbm20 |
A |
T |
19: 53,802,431 (GRCm39) |
Q313L |
possibly damaging |
Het |
Rnf38 |
A |
T |
4: 44,149,182 (GRCm39) |
I55N |
probably benign |
Het |
Rtel1 |
T |
C |
2: 180,997,354 (GRCm39) |
|
probably benign |
Het |
Scube1 |
T |
C |
15: 83,491,617 (GRCm39) |
Y959C |
probably damaging |
Het |
Selenow |
A |
G |
7: 15,654,051 (GRCm39) |
|
probably benign |
Het |
Tbx5 |
T |
C |
5: 120,009,363 (GRCm39) |
Y291H |
probably damaging |
Het |
Tln2 |
A |
T |
9: 67,241,539 (GRCm39) |
M1022K |
possibly damaging |
Het |
Tmtc4 |
G |
A |
14: 123,182,952 (GRCm39) |
R249W |
probably damaging |
Het |
Trim34a |
A |
G |
7: 103,910,587 (GRCm39) |
Q463R |
probably benign |
Het |
Vps35 |
C |
A |
8: 86,001,526 (GRCm39) |
E431* |
probably null |
Het |
Wdpcp |
T |
C |
11: 21,835,048 (GRCm39) |
C684R |
probably benign |
Het |
Xirp2 |
G |
A |
2: 67,312,590 (GRCm39) |
V20I |
probably benign |
Het |
|
Other mutations in Igtp |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01138:Igtp
|
APN |
11 |
58,096,970 (GRCm39) |
missense |
possibly damaging |
0.66 |
R0281:Igtp
|
UTSW |
11 |
58,096,880 (GRCm39) |
missense |
probably damaging |
0.97 |
R2762:Igtp
|
UTSW |
11 |
58,096,891 (GRCm39) |
missense |
possibly damaging |
0.91 |
R3426:Igtp
|
UTSW |
11 |
58,097,419 (GRCm39) |
missense |
probably damaging |
0.99 |
R3427:Igtp
|
UTSW |
11 |
58,097,419 (GRCm39) |
missense |
probably damaging |
0.99 |
R3428:Igtp
|
UTSW |
11 |
58,097,419 (GRCm39) |
missense |
probably damaging |
0.99 |
R4484:Igtp
|
UTSW |
11 |
58,097,824 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4588:Igtp
|
UTSW |
11 |
58,097,508 (GRCm39) |
missense |
probably damaging |
1.00 |
R5299:Igtp
|
UTSW |
11 |
58,097,959 (GRCm39) |
missense |
possibly damaging |
0.79 |
R5652:Igtp
|
UTSW |
11 |
58,097,455 (GRCm39) |
missense |
probably benign |
0.07 |
R5662:Igtp
|
UTSW |
11 |
58,097,105 (GRCm39) |
missense |
probably damaging |
1.00 |
R5893:Igtp
|
UTSW |
11 |
58,097,474 (GRCm39) |
missense |
probably damaging |
1.00 |
R7657:Igtp
|
UTSW |
11 |
58,097,654 (GRCm39) |
missense |
probably benign |
0.02 |
R7738:Igtp
|
UTSW |
11 |
58,097,906 (GRCm39) |
missense |
probably benign |
0.00 |
R7989:Igtp
|
UTSW |
11 |
58,097,205 (GRCm39) |
missense |
probably damaging |
0.99 |
R8920:Igtp
|
UTSW |
11 |
58,096,999 (GRCm39) |
missense |
probably damaging |
0.98 |
R8986:Igtp
|
UTSW |
11 |
58,096,947 (GRCm39) |
critical splice donor site |
probably null |
|
R9103:Igtp
|
UTSW |
11 |
58,097,726 (GRCm39) |
missense |
|
|
R9180:Igtp
|
UTSW |
11 |
58,098,091 (GRCm39) |
nonsense |
probably null |
|
R9375:Igtp
|
UTSW |
11 |
58,097,026 (GRCm39) |
missense |
probably damaging |
1.00 |
R9502:Igtp
|
UTSW |
11 |
58,097,800 (GRCm39) |
missense |
possibly damaging |
0.91 |
Z1186:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1186:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1186:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1187:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1187:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1187:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1188:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1188:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1188:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1189:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1189:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1189:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1190:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1190:Igtp
|
UTSW |
11 |
58,097,416 (GRCm39) |
missense |
possibly damaging |
0.84 |
Z1190:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1190:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1191:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1191:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1191:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
Z1192:Igtp
|
UTSW |
11 |
58,097,944 (GRCm39) |
missense |
probably benign |
0.00 |
Z1192:Igtp
|
UTSW |
11 |
58,097,791 (GRCm39) |
missense |
possibly damaging |
0.55 |
Z1192:Igtp
|
UTSW |
11 |
58,097,169 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Posted On |
2016-08-02 |