Incidental Mutation 'IGL00502:Foxk2'
ID4451
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Foxk2
Ensembl Gene ENSMUSG00000039275
Gene Nameforkhead box K2
Synonyms5730434B08Rik, Ilf1, 1110054H05Rik
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00502
Quality Score
Status
Chromosome11
Chromosomal Location121259990-121309896 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to G at 121297099 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000101719 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106113]
Predicted Effect probably benign
Transcript: ENSMUST00000106113
SMART Domains Protein: ENSMUSP00000101719
Gene: ENSMUSG00000039275

DomainStartEndE-ValueType
low complexity region 2 32 N/A INTRINSIC
FHA 47 119 9.96e-10 SMART
FH 247 338 2.2e-52 SMART
low complexity region 440 465 N/A INTRINSIC
low complexity region 486 498 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151492
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153579
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 A T 15: 94,403,397 I82N probably damaging Het
Ampd2 A T 3: 108,077,396 L422H probably damaging Het
Angptl2 T A 2: 33,228,394 V60E probably damaging Het
Ano3 G A 2: 110,771,050 probably benign Het
Arhgap40 A G 2: 158,531,158 D112G probably benign Het
Bcorl1 T G X: 48,406,042 V1730G probably damaging Het
Btrc A T 19: 45,527,265 E553V probably damaging Het
Cacna1b A T 2: 24,651,200 Y1323* probably null Het
Ccdc146 A G 5: 21,301,422 C674R possibly damaging Het
Ccdc170 A G 10: 4,546,836 D458G probably damaging Het
Cfap57 T A 4: 118,581,001 M898L probably benign Het
Crybg1 C T 10: 43,958,313 V1961I probably damaging Het
Dsp T C 13: 38,197,846 S2257P probably damaging Het
Dytn A G 1: 63,678,840 V12A probably benign Het
Gfi1b G A 2: 28,614,785 Q70* probably null Het
Gm20388 T C 8: 124,328,098 M204T probably damaging Het
Gsdmc T C 15: 63,804,421 T58A probably benign Het
Hikeshi G A 7: 89,923,610 T26I probably benign Het
Mpdz T C 4: 81,369,723 D433G probably damaging Het
Ndufb5 T A 3: 32,744,899 V55D probably damaging Het
Nostrin T C 2: 69,183,992 S431P probably benign Het
Papd5 C T 8: 88,252,258 Q63* probably null Het
Pdcd1lg2 A T 19: 29,446,062 T169S possibly damaging Het
Plekha7 A T 7: 116,135,184 M1006K probably damaging Het
Rgs6 A T 12: 83,051,323 I94F probably benign Het
Rims2 A T 15: 39,506,984 D938V probably damaging Het
Slc4a8 A G 15: 100,807,438 T842A possibly damaging Het
Spata21 C A 4: 141,111,364 probably null Het
Stk32a C T 18: 43,310,445 T229I possibly damaging Het
Trim33 C T 3: 103,330,182 P185S probably benign Het
Tspoap1 A G 11: 87,777,821 probably null Het
Vcan A G 13: 89,692,319 V742A probably benign Het
Vrtn A T 12: 84,649,063 I196F probably benign Het
Wasf1 A T 10: 40,920,297 I8F probably damaging Het
Ythdc2 A G 18: 44,847,812 I491M probably damaging Het
Zfp292 T C 4: 34,809,775 T1095A possibly damaging Het
Other mutations in Foxk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Foxk2 APN 11 121299734 missense probably damaging 1.00
IGL02619:Foxk2 APN 11 121299576 splice site probably benign
IGL03067:Foxk2 APN 11 121285568 missense possibly damaging 0.87
R1843:Foxk2 UTSW 11 121285537 missense probably benign 0.01
R2153:Foxk2 UTSW 11 121260387 missense probably benign 0.08
R2847:Foxk2 UTSW 11 121260491 small insertion probably benign
R3770:Foxk2 UTSW 11 121260491 small insertion probably benign
R4024:Foxk2 UTSW 11 121285613 missense possibly damaging 0.67
R6958:Foxk2 UTSW 11 121299737 missense probably benign 0.16
R6968:Foxk2 UTSW 11 121260482 missense possibly damaging 0.87
R7558:Foxk2 UTSW 11 121288058 missense probably benign 0.00
R7736:Foxk2 UTSW 11 121299647 missense possibly damaging 0.92
R7902:Foxk2 UTSW 11 121299727 missense probably benign
R7985:Foxk2 UTSW 11 121299727 missense probably benign
Posted On2012-04-20