Incidental Mutation 'IGL01074:Fcrl6'
| ID |
50201 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Fcrl6
|
| Ensembl Gene |
ENSMUSG00000070504 |
| Gene Name |
Fc receptor-like 6 |
| Synonyms |
FcRH6, moFcRH6, mIFGP6, ENSMUSG00000070504 |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01074
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
1 |
| Chromosomal Location |
172424209-172430118 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 172426680 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Methionine
at position 89
(V89M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091861
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094303]
|
| AlphaFold |
A1YIY0 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000094303
AA Change: V89M
PolyPhen 2
Score 0.890 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000091861
Gene: ENSMUSG00000070504
AA Change: V89M
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
16 |
N/A |
INTRINSIC |
|
Pfam:Ig_3
|
19 |
91 |
1.2e-4 |
PFAM |
|
Pfam:Ig_2
|
20 |
106 |
8e-9 |
PFAM |
|
Pfam:Ig_3
|
113 |
187 |
1.9e-9 |
PFAM |
|
transmembrane domain
|
215 |
237 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193431
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193566
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca7 |
A |
G |
10: 79,849,726 (GRCm39) |
D1934G |
possibly damaging |
Het |
| Adcy2 |
A |
T |
13: 68,944,773 (GRCm39) |
I203N |
possibly damaging |
Het |
| Asxl3 |
T |
C |
18: 22,655,902 (GRCm39) |
V1304A |
probably damaging |
Het |
| Bltp3a |
A |
G |
17: 28,098,265 (GRCm39) |
I136V |
possibly damaging |
Het |
| Cmah |
A |
G |
13: 24,648,238 (GRCm39) |
D491G |
possibly damaging |
Het |
| Cobll1 |
A |
G |
2: 64,938,192 (GRCm39) |
S364P |
probably damaging |
Het |
| Cspg4 |
T |
C |
9: 56,806,149 (GRCm39) |
L2320P |
probably damaging |
Het |
| Defa5 |
T |
A |
8: 21,787,592 (GRCm39) |
F46L |
possibly damaging |
Het |
| Erich6b |
T |
A |
14: 75,896,208 (GRCm39) |
N31K |
probably benign |
Het |
| Gm5458 |
G |
T |
14: 19,649,760 (GRCm39) |
L155I |
probably damaging |
Het |
| Hlx |
T |
C |
1: 184,460,010 (GRCm39) |
D376G |
probably damaging |
Het |
| Hmcn1 |
A |
G |
1: 150,502,784 (GRCm39) |
S3948P |
possibly damaging |
Het |
| Igf2bp2 |
G |
A |
16: 21,882,454 (GRCm39) |
R416W |
probably damaging |
Het |
| Lama4 |
T |
C |
10: 38,974,484 (GRCm39) |
|
probably null |
Het |
| Lingo4 |
T |
C |
3: 94,310,595 (GRCm39) |
V511A |
probably benign |
Het |
| Mllt3 |
C |
A |
4: 87,710,118 (GRCm39) |
V29L |
probably benign |
Het |
| Mmp16 |
T |
C |
4: 18,110,584 (GRCm39) |
|
probably benign |
Het |
| Moxd1 |
A |
G |
10: 24,155,282 (GRCm39) |
R228G |
probably benign |
Het |
| Myrfl |
T |
C |
10: 116,615,490 (GRCm39) |
N802S |
possibly damaging |
Het |
| Nmu |
C |
A |
5: 76,491,774 (GRCm39) |
V121F |
probably damaging |
Het |
| Npepps |
T |
C |
11: 97,108,637 (GRCm39) |
T760A |
probably damaging |
Het |
| Ogfod1 |
G |
T |
8: 94,789,634 (GRCm39) |
W445L |
probably damaging |
Het |
| Oplah |
G |
A |
15: 76,189,948 (GRCm39) |
P222S |
probably damaging |
Het |
| Or4c116 |
T |
C |
2: 88,942,023 (GRCm39) |
T278A |
probably benign |
Het |
| Slc4a4 |
T |
A |
5: 89,327,633 (GRCm39) |
L699H |
probably damaging |
Het |
| Sod3 |
C |
T |
5: 52,525,540 (GRCm39) |
Q80* |
probably null |
Het |
| Syne2 |
C |
T |
12: 76,078,361 (GRCm39) |
Q4732* |
probably null |
Het |
| Syne2 |
T |
C |
12: 76,033,785 (GRCm39) |
I3678T |
probably benign |
Het |
| Tedc1 |
C |
T |
12: 113,126,808 (GRCm39) |
R357* |
probably null |
Het |
| Tmem220 |
T |
C |
11: 66,922,999 (GRCm39) |
|
probably benign |
Het |
| Ush1c |
A |
G |
7: 45,874,674 (GRCm39) |
|
probably benign |
Het |
| Wbp2nl |
T |
C |
15: 82,198,491 (GRCm39) |
S343P |
possibly damaging |
Het |
|
| Other mutations in Fcrl6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Fcrl6
|
APN |
1 |
172,426,674 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL02146:Fcrl6
|
APN |
1 |
172,426,264 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02277:Fcrl6
|
APN |
1 |
172,426,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03162:Fcrl6
|
APN |
1 |
172,425,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03303:Fcrl6
|
APN |
1 |
172,425,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
K3955:Fcrl6
|
UTSW |
1 |
172,425,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0051:Fcrl6
|
UTSW |
1 |
172,426,320 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0051:Fcrl6
|
UTSW |
1 |
172,426,320 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1336:Fcrl6
|
UTSW |
1 |
172,426,791 (GRCm39) |
nonsense |
probably null |
|
|
R2125:Fcrl6
|
UTSW |
1 |
172,426,815 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2126:Fcrl6
|
UTSW |
1 |
172,426,815 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5376:Fcrl6
|
UTSW |
1 |
172,426,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5395:Fcrl6
|
UTSW |
1 |
172,426,287 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6314:Fcrl6
|
UTSW |
1 |
172,426,186 (GRCm39) |
splice site |
probably null |
|
|
R7525:Fcrl6
|
UTSW |
1 |
172,425,239 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7690:Fcrl6
|
UTSW |
1 |
172,426,223 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8033:Fcrl6
|
UTSW |
1 |
172,426,748 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8894:Fcrl6
|
UTSW |
1 |
172,426,856 (GRCm39) |
missense |
probably benign |
0.05 |
|
U24488:Fcrl6
|
UTSW |
1 |
172,426,437 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Posted On |
2013-06-21 |
Incidental Mutation