Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01118:Mup11'

50929

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Mup11

Ensembl Gene

ENSMUSG00000073834

Gene Name

major urinary protein 11

Synonyms

Gm12549

Accession Numbers

Essential gene?

Not available question?

Stock #

IGL01118

Quality Score

Status

Chromosome

Chromosomal Location

60614465-60618410 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 60615779 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 153 (F153I)

Ref Sequence

ENSEMBL: ENSMUSP00000095654 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084544] [ENSMUST00000098046]

AlphaFold

A2BIM8
P04938

Predicted Effect

probably damaging
Transcript: ENSMUST00000084544
AA Change: F66I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000081592
Gene: ENSMUSG00000073834
AA Change: F66I

Domain	Start	End	E-Value	Type
Pfam:Lipocalin	1	87	2.9e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000098046
AA Change: F153I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000095654
Gene: ENSMUSG00000073834
AA Change: F153I

Domain	Start	End	E-Value	Type
low complexity region	4	14	N/A	INTRINSIC
Pfam:Lipocalin	35	174	3.4e-34	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148206

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000154733

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	C	T	3: 124,195,058 (GRCm39)	R539Q	probably benign	Het
Abcb1a	G	A	5: 8,724,687 (GRCm39)	R40H	probably damaging	Het
Acan	T	A	7: 78,748,401 (GRCm39)	S1057R	possibly damaging	Het
Ahnak	A	T	19: 8,989,942 (GRCm39)	D3742V	probably damaging	Het
Amdhd1	A	T	10: 93,367,430 (GRCm39)	D241E	probably benign	Het
Cntn5	T	C	9: 9,831,565 (GRCm39)	Y605C	possibly damaging	Het
Dnmt3l	T	C	10: 77,893,120 (GRCm39)	F299S	probably damaging	Het
Eif1ad19	T	A	12: 87,740,212 (GRCm39)	N116Y	probably damaging	Het
Ess2	A	T	16: 17,720,796 (GRCm39)	I350N	probably damaging	Het
G6pd2	A	T	5: 61,967,406 (GRCm39)	M394L	probably benign	Het
Gm9839	A	T	1: 32,558,924 (GRCm39)	M386K	probably benign	Het
Gtf2h3	T	C	5: 124,733,731 (GRCm39)	V268A	probably damaging	Het
Hgs	T	C	11: 120,366,040 (GRCm39)	V195A	probably damaging	Het
Igkv3-2	A	T	6: 70,675,978 (GRCm39)	S96C	probably damaging	Het
Mgl2	A	G	11: 70,025,015 (GRCm39)	E12G	probably benign	Het
Nf1	T	A	11: 79,437,812 (GRCm39)	C2057S	probably damaging	Het
Nkrf	A	G	X: 36,152,410 (GRCm39)	F624S	probably damaging	Het
Noto	T	C	6: 85,401,192 (GRCm39)	S74P	probably benign	Het
Or8k40	A	G	2: 86,584,314 (GRCm39)	I256T	probably benign	Het
Pax8	T	C	2: 24,332,944 (GRCm39)		probably benign	Het
Psg28	A	T	7: 18,162,017 (GRCm39)	V162D	probably damaging	Het
Rai1	T	C	11: 60,078,264 (GRCm39)	F776S	probably damaging	Het
Taar8a	A	T	10: 23,952,759 (GRCm39)	H121L	probably damaging	Het
Tas2r113	A	G	6: 132,870,278 (GRCm39)	N102S	probably benign	Het
Trpm1	A	G	7: 63,885,572 (GRCm39)	T863A	probably benign	Het
Ttf2	A	G	3: 100,874,413 (GRCm39)		probably benign	Het
Wdr62	T	C	7: 29,942,206 (GRCm39)	H611R	probably damaging	Het
Wdr90	A	T	17: 26,073,661 (GRCm39)	L762Q	probably damaging	Het
Yeats2	T	G	16: 20,005,054 (GRCm39)	S364A	probably damaging	Het
Zdhhc15	G	T	X: 103,641,712 (GRCm39)	Q82K	probably benign	Het

Other mutations in Mup11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00955:Mup11	APN	4	60,615,549 (GRCm39)	missense	probably benign	0.16
IGL01914:Mup11	APN	4	60,615,821 (GRCm39)	splice site	probably benign
IGL02991:Mup11	UTSW	4	60,618,275 (GRCm39)	small deletion	probably benign
R5980:Mup11	UTSW	4	60,616,887 (GRCm39)	missense	possibly damaging	0.67
R6164:Mup11	UTSW	4	60,618,239 (GRCm39)	missense	possibly damaging	0.49
R6589:Mup11	UTSW	4	60,615,540 (GRCm39)	missense	possibly damaging	0.68
R7208:Mup11	UTSW	4	60,615,725 (GRCm39)	missense	possibly damaging	0.80
R8072:Mup11	UTSW	4	60,615,777 (GRCm39)	missense	probably damaging	1.00
Z1176:Mup11	UTSW	4	60,616,214 (GRCm39)	missense	probably benign	0.02

Posted On

2013-06-21