Incidental Mutation 'IGL01118:Mup11'
ID50929
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mup11
Ensembl Gene ENSMUSG00000073834
Gene Namemajor urinary protein 11
SynonymsGm12549
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL01118
Quality Score
Status
Chromosome4
Chromosomal Location60658466-60662411 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 60659780 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 153 (F153I)
Ref Sequence ENSEMBL: ENSMUSP00000095654 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084544] [ENSMUST00000098046]
Predicted Effect probably damaging
Transcript: ENSMUST00000084544
AA Change: F66I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000081592
Gene: ENSMUSG00000073834
AA Change: F66I

DomainStartEndE-ValueType
Pfam:Lipocalin 1 87 2.9e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000098046
AA Change: F153I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000095654
Gene: ENSMUSG00000073834
AA Change: F153I

DomainStartEndE-ValueType
low complexity region 4 14 N/A INTRINSIC
Pfam:Lipocalin 35 174 3.4e-34 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148206
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154733
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C T 3: 124,401,409 R539Q probably benign Het
Abcb1a G A 5: 8,674,687 R40H probably damaging Het
Acan T A 7: 79,098,653 S1057R possibly damaging Het
Ahnak A T 19: 9,012,578 D3742V probably damaging Het
Amdhd1 A T 10: 93,531,568 D241E probably benign Het
Cntn5 T C 9: 9,831,560 Y605C possibly damaging Het
Dgcr14 A T 16: 17,902,932 I350N probably damaging Het
Dnmt3l T C 10: 78,057,286 F299S probably damaging Het
G6pd2 A T 5: 61,810,063 M394L probably benign Het
Gm21319 T A 12: 87,773,442 N116Y probably damaging Het
Gm9839 A T 1: 32,519,843 M386K probably benign Het
Gtf2h3 T C 5: 124,595,668 V268A probably damaging Het
Hgs T C 11: 120,475,214 V195A probably damaging Het
Igkv3-2 A T 6: 70,698,994 S96C probably damaging Het
Mgl2 A G 11: 70,134,189 E12G probably benign Het
Nf1 T A 11: 79,546,986 C2057S probably damaging Het
Nkrf A G X: 36,888,757 F624S probably damaging Het
Noto T C 6: 85,424,210 S74P probably benign Het
Olfr1090 A G 2: 86,753,970 I256T probably benign Het
Pax8 T C 2: 24,442,932 probably benign Het
Psg28 A T 7: 18,428,092 V162D probably damaging Het
Rai1 T C 11: 60,187,438 F776S probably damaging Het
Taar8a A T 10: 24,076,861 H121L probably damaging Het
Tas2r113 A G 6: 132,893,315 N102S probably benign Het
Trpm1 A G 7: 64,235,824 T863A probably benign Het
Ttf2 A G 3: 100,967,097 probably benign Het
Wdr62 T C 7: 30,242,781 H611R probably damaging Het
Wdr90 A T 17: 25,854,687 L762Q probably damaging Het
Yeats2 T G 16: 20,186,304 S364A probably damaging Het
Zdhhc15 G T X: 104,598,106 Q82K probably benign Het
Other mutations in Mup11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00955:Mup11 APN 4 60659550 missense probably benign 0.16
IGL01914:Mup11 APN 4 60659822 splice site probably benign
IGL02991:Mup11 UTSW 4 60662276 small deletion probably benign
R5980:Mup11 UTSW 4 60660888 missense possibly damaging 0.67
R6164:Mup11 UTSW 4 60662240 missense possibly damaging 0.49
R6589:Mup11 UTSW 4 60659541 missense possibly damaging 0.68
R7208:Mup11 UTSW 4 60659726 missense possibly damaging 0.80
R8072:Mup11 UTSW 4 60659778 missense probably damaging 1.00
Z1176:Mup11 UTSW 4 60660215 missense probably benign 0.02
Posted On2013-06-21