Incidental Mutation 'IGL00955:Mup11'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mup11
Ensembl Gene ENSMUSG00000073834
Gene Namemajor urinary protein 11
Accession Numbers
Is this an essential gene? Not available question?
Stock #IGL00955
Quality Score
Chromosomal Location60658466-60662411 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) C to T at 60659550 bp
Amino Acid Change Arginine to Histidine at position 175 (R175H)
Ref Sequence ENSEMBL: ENSMUSP00000095654 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084544] [ENSMUST00000098046]
Predicted Effect probably benign
Transcript: ENSMUST00000084544
AA Change: R88H

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000081592
Gene: ENSMUSG00000073834
AA Change: R88H

Pfam:Lipocalin 1 87 2.9e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000098046
AA Change: R175H

PolyPhen 2 Score 0.162 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000095654
Gene: ENSMUSG00000073834
AA Change: R175H

low complexity region 4 14 N/A INTRINSIC
Pfam:Lipocalin 35 174 3.4e-34 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148206
Predicted Effect noncoding transcript
Transcript: ENSMUST00000154733
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl11 A T 14: 61,311,242 Q167L probably benign Het
Ces3a T A 8: 105,050,570 V175E probably damaging Het
Cherp C T 8: 72,470,194 E140K probably damaging Het
Clpx A T 9: 65,324,270 T546S probably damaging Het
Csgalnact2 A G 6: 118,129,264 L31P probably damaging Het
Cxcr1 A T 1: 74,192,220 F214L probably benign Het
Cyp2c67 T A 19: 39,643,385 T123S possibly damaging Het
Dbt G A 3: 116,546,114 G384S probably benign Het
Dzank1 G A 2: 144,490,174 T414I probably benign Het
Erich3 A G 3: 154,748,519 I641V probably benign Het
Gtf2e1 A T 16: 37,535,920 D83E possibly damaging Het
Hars2 T C 18: 36,789,357 probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kcnh2 T C 5: 24,324,966 D372G probably damaging Het
Kcnk2 A T 1: 189,243,014 I264N probably damaging Het
Kctd4 A G 14: 75,963,228 D213G probably damaging Het
Lhx9 T C 1: 138,828,680 T323A possibly damaging Het
Lilra6 C A 7: 3,911,404 probably benign Het
Meig1 T C 2: 3,409,274 D63G probably damaging Het
Mov10l1 A G 15: 88,994,989 Y184C probably damaging Het
Mrpl24 T A 3: 87,922,219 L91* probably null Het
Nbea T C 3: 56,005,472 K965E possibly damaging Het
Olfr598 C A 7: 103,329,321 H278Q probably damaging Het
Papss1 G A 3: 131,599,949 E252K probably benign Het
Robo2 A T 16: 74,015,972 L278Q probably damaging Het
Sned1 A T 1: 93,274,403 I638F probably damaging Het
Spin1 T C 13: 51,144,541 probably null Het
Taar9 T C 10: 24,109,531 T2A probably benign Het
Tbc1d8b T C X: 139,725,880 probably null Het
Other mutations in Mup11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01118:Mup11 APN 4 60659780 missense probably damaging 1.00
IGL01914:Mup11 APN 4 60659822 splice site probably benign
IGL02991:Mup11 UTSW 4 60662276 small deletion probably benign
R5980:Mup11 UTSW 4 60660888 missense possibly damaging 0.67
R6164:Mup11 UTSW 4 60662240 missense possibly damaging 0.49
R6589:Mup11 UTSW 4 60659541 missense possibly damaging 0.68
R7208:Mup11 UTSW 4 60659726 missense possibly damaging 0.80
R8072:Mup11 UTSW 4 60659778 missense probably damaging 1.00
Z1176:Mup11 UTSW 4 60660215 missense probably benign 0.02
Posted On2013-04-17