Incidental Mutation 'IGL01095:Olfr974'
ID51908
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr974
Ensembl Gene ENSMUSG00000051493
Gene Nameolfactory receptor 974
SynonymsGA_x6K02T2PVTD-33640290-33641222, MOR171-1
Accession Numbers

Genbank: NM_147107

Is this an essential gene? Probably non essential (E-score: 0.057) question?
Stock #IGL01095
Quality Score
Status
Chromosome9
Chromosomal Location39937501-39945170 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 39942680 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 140 (V140A)
Ref Sequence ENSEMBL: ENSMUSP00000149630 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062833] [ENSMUST00000213246]
Predicted Effect probably benign
Transcript: ENSMUST00000062833
AA Change: V140A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000062985
Gene: ENSMUSG00000051493
AA Change: V140A

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 3.6e-52 PFAM
Pfam:7tm_1 41 290 1.3e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213246
AA Change: V140A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgra1 A G 7: 139,845,654 T28A possibly damaging Het
Aldh8a1 A G 10: 21,389,281 E269G probably benign Het
Alkbh7 A G 17: 56,997,470 probably null Het
Ap1g2 T C 14: 55,105,114 T129A probably benign Het
Ap1s1 A G 5: 137,041,809 I117T probably damaging Het
Brca1 G A 11: 101,524,369 P119S possibly damaging Het
Chid1 A G 7: 141,530,229 V62A probably damaging Het
Cpa1 A T 6: 30,642,969 I299F probably benign Het
Cuzd1 A G 7: 131,316,136 V245A probably damaging Het
Ddx39b T C 17: 35,246,961 S71P probably benign Het
Ddx42 A G 11: 106,247,499 Y708C probably damaging Het
Dnah3 C A 7: 119,951,597 L3166F probably benign Het
Erap1 A G 13: 74,668,094 E114G probably benign Het
Fap G A 2: 62,524,201 T448I possibly damaging Het
Fhl2 A T 1: 43,131,681 Y158N probably benign Het
Fscb A G 12: 64,473,381 V437A possibly damaging Het
Gm5346 T A 8: 43,626,096 I364L probably benign Het
Il18 A T 9: 50,579,329 D88V probably damaging Het
Il5ra A T 6: 106,742,644 probably benign Het
Jakmip3 A T 7: 139,020,817 Q302L probably damaging Het
Lrp2 A T 2: 69,492,432 Y1857* probably null Het
Meis2 T C 2: 115,864,424 T406A probably benign Het
Mre11a T A 9: 14,809,824 S346R probably benign Het
Myh15 A T 16: 49,132,015 K816M probably damaging Het
Mysm1 C T 4: 94,967,869 probably null Het
Nyap1 C A 5: 137,738,084 R47L probably damaging Het
Oas3 A G 5: 120,772,889 Y209H probably damaging Het
Olfr1279 A G 2: 111,306,621 R139G probably benign Het
Olfr1396 T G 11: 49,112,853 Y291S probably damaging Het
Olfr799 A G 10: 129,647,629 D167G probably benign Het
Olfr901 A G 9: 38,430,515 I78V probably benign Het
Pde4b T C 4: 102,506,044 probably null Het
Psd3 G A 8: 67,908,513 T99M probably damaging Het
R3hcc1 T C 14: 69,700,028 E390G probably damaging Het
Rabgap1l A C 1: 160,738,969 C58W probably benign Het
Rasd1 A G 11: 59,964,291 I121T probably damaging Het
Spta1 A G 1: 174,213,485 N1284D probably benign Het
Tpr T C 1: 150,410,140 V525A possibly damaging Het
Other mutations in Olfr974
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01638:Olfr974 APN 9 39942520 missense probably benign 0.03
IGL02826:Olfr974 APN 9 39942958 missense probably damaging 1.00
IGL03136:Olfr974 APN 9 39943036 missense probably damaging 1.00
H2330:Olfr974 UTSW 9 39942920 missense probably damaging 1.00
R0005:Olfr974 UTSW 9 39942956 missense probably benign
R0106:Olfr974 UTSW 9 39942823 frame shift probably null
R1769:Olfr974 UTSW 9 39942955 missense probably benign 0.43
R1870:Olfr974 UTSW 9 39942821 missense probably damaging 0.99
R4416:Olfr974 UTSW 9 39942428 missense probably damaging 1.00
R4860:Olfr974 UTSW 9 39942504 missense probably benign 0.04
R4860:Olfr974 UTSW 9 39942504 missense probably benign 0.04
R5105:Olfr974 UTSW 9 39942398 missense probably benign 0.19
R5273:Olfr974 UTSW 9 39942557 missense probably benign
R6520:Olfr974 UTSW 9 39942362 missense possibly damaging 0.90
R7203:Olfr974 UTSW 9 39942509 missense probably benign 0.01
R7923:Olfr974 UTSW 9 39942967 nonsense probably null
R8037:Olfr974 UTSW 9 39942881 missense probably damaging 0.98
R8038:Olfr974 UTSW 9 39942881 missense probably damaging 0.98
R8712:Olfr974 UTSW 9 39942595 missense probably damaging 0.99
Posted On2013-06-21