Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01095:Oas3'

51092

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oas3

Ensembl Gene

ENSMUSG00000032661

Gene Name

2'-5' oligoadenylate synthetase 3

Synonyms

Oasl10, 2'-5' oligoadenylate synthetase-like 10

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.064) question?

Stock #

IGL01095

Quality Score

Status

Chromosome

Chromosomal Location

120753098-120777661 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 120772889 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 209 (Y209H)

Ref Sequence

ENSEMBL: ENSMUSP00000035588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044833]

Predicted Effect

probably damaging
Transcript: ENSMUST00000044833
AA Change: Y209H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000035588
Gene: ENSMUSG00000032661
AA Change: Y209H

Domain	Start	End	E-Value	Type
Pfam:OAS1_C	159	341	6.3e-83	PFAM
Pfam:OAS1_C	610	795	3.1e-78	PFAM
Pfam:NTP_transf_2	831	920	4.5e-11	PFAM
Pfam:OAS1_C	954	1136	9e-85	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000166703

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000201006

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgra1	A	G	7: 139,845,654	T28A	possibly damaging	Het
Aldh8a1	A	G	10: 21,389,281	E269G	probably benign	Het
Alkbh7	A	G	17: 56,997,470		probably null	Het
Ap1g2	T	C	14: 55,105,114	T129A	probably benign	Het
Ap1s1	A	G	5: 137,041,809	I117T	probably damaging	Het
Brca1	G	A	11: 101,524,369	P119S	possibly damaging	Het
Chid1	A	G	7: 141,530,229	V62A	probably damaging	Het
Cpa1	A	T	6: 30,642,969	I299F	probably benign	Het
Cuzd1	A	G	7: 131,316,136	V245A	probably damaging	Het
Ddx39b	T	C	17: 35,246,961	S71P	probably benign	Het
Ddx42	A	G	11: 106,247,499	Y708C	probably damaging	Het
Dnah3	C	A	7: 119,951,597	L3166F	probably benign	Het
Erap1	A	G	13: 74,668,094	E114G	probably benign	Het
Fap	G	A	2: 62,524,201	T448I	possibly damaging	Het
Fhl2	A	T	1: 43,131,681	Y158N	probably benign	Het
Fscb	A	G	12: 64,473,381	V437A	possibly damaging	Het
Gm5346	T	A	8: 43,626,096	I364L	probably benign	Het
Il18	A	T	9: 50,579,329	D88V	probably damaging	Het
Il5ra	A	T	6: 106,742,644		probably benign	Het
Jakmip3	A	T	7: 139,020,817	Q302L	probably damaging	Het
Lrp2	A	T	2: 69,492,432	Y1857*	probably null	Het
Meis2	T	C	2: 115,864,424	T406A	probably benign	Het
Mre11a	T	A	9: 14,809,824	S346R	probably benign	Het
Myh15	A	T	16: 49,132,015	K816M	probably damaging	Het
Mysm1	C	T	4: 94,967,869		probably null	Het
Nyap1	C	A	5: 137,738,084	R47L	probably damaging	Het
Olfr1279	A	G	2: 111,306,621	R139G	probably benign	Het
Olfr1396	T	G	11: 49,112,853	Y291S	probably damaging	Het
Olfr799	A	G	10: 129,647,629	D167G	probably benign	Het
Olfr901	A	G	9: 38,430,515	I78V	probably benign	Het
Olfr974	T	C	9: 39,942,680	V140A	probably benign	Het
Pde4b	T	C	4: 102,506,044		probably null	Het
Psd3	G	A	8: 67,908,513	T99M	probably damaging	Het
R3hcc1	T	C	14: 69,700,028	E390G	probably damaging	Het
Rabgap1l	A	C	1: 160,738,969	C58W	probably benign	Het
Rasd1	A	G	11: 59,964,291	I121T	probably damaging	Het
Spta1	A	G	1: 174,213,485	N1284D	probably benign	Het
Tpr	T	C	1: 150,410,140	V525A	possibly damaging	Het

Other mutations in Oas3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00547:Oas3	APN	5	120777442	splice site	probably benign
IGL01835:Oas3	APN	5	120766128	nonsense	probably null
IGL02006:Oas3	APN	5	120769235	missense	probably benign	0.00
IGL02811:Oas3	APN	5	120764322	missense	unknown
IGL03194:Oas3	APN	5	120758953	missense	probably damaging	1.00
R0066:Oas3	UTSW	5	120758875	missense	probably damaging	1.00
R0195:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0196:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0197:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0445:Oas3	UTSW	5	120756145	missense	probably damaging	1.00
R0523:Oas3	UTSW	5	120766144	missense	unknown
R0592:Oas3	UTSW	5	120771149	missense	probably damaging	1.00
R0946:Oas3	UTSW	5	120769063	missense	unknown
R1354:Oas3	UTSW	5	120770000	missense	possibly damaging	0.94
R1642:Oas3	UTSW	5	120777574	missense	possibly damaging	0.90
R1681:Oas3	UTSW	5	120769908	missense	probably benign	0.22
R1844:Oas3	UTSW	5	120759980	missense	probably damaging	0.99
R1981:Oas3	UTSW	5	120761835	splice site	probably benign
R2443:Oas3	UTSW	5	120777488	missense	probably benign	0.35
R2902:Oas3	UTSW	5	120758917	missense	probably damaging	1.00
R3034:Oas3	UTSW	5	120771056	missense	probably damaging	1.00
R4565:Oas3	UTSW	5	120771039	missense	probably damaging	1.00
R4692:Oas3	UTSW	5	120769355	missense	probably benign	0.03
R4723:Oas3	UTSW	5	120766256	missense	unknown
R4812:Oas3	UTSW	5	120761147	unclassified	probably benign
R5288:Oas3	UTSW	5	120756990	missense	probably damaging	1.00
R5343:Oas3	UTSW	5	120756238	missense	possibly damaging	0.70
R5494:Oas3	UTSW	5	120761644	missense	unknown
R5688:Oas3	UTSW	5	120758802	missense	probably benign	0.31
R5894:Oas3	UTSW	5	120756954	missense	probably damaging	1.00
R5921:Oas3	UTSW	5	120769981	missense	probably damaging	1.00
R6037:Oas3	UTSW	5	120769319	missense	probably benign	0.41
R6037:Oas3	UTSW	5	120769319	missense	probably benign	0.41
R6066:Oas3	UTSW	5	120772924	missense	probably damaging	0.97
R6104:Oas3	UTSW	5	120761693	missense	unknown
R6134:Oas3	UTSW	5	120769048	missense	unknown
R6255:Oas3	UTSW	5	120771230	missense	probably benign	0.04
R6257:Oas3	UTSW	5	120761135	unclassified	probably benign
R6776:Oas3	UTSW	5	120758874	missense	probably damaging	1.00
R8022:Oas3	UTSW	5	120756966	missense	possibly damaging	0.91
RF006:Oas3	UTSW	5	120774100	missense	probably damaging	1.00
X0024:Oas3	UTSW	5	120761728	missense	unknown

Posted On

2013-06-21