Incidental Mutation 'IGL00340:Mob1b'
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ID6409
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mob1b
Ensembl Gene ENSMUSG00000006262
Gene NameMOB kinase activator 1B
SynonymsMobkl1a, 1110003E08Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.190) question?
Stock #IGL00340
Quality Score
Status
Chromosome5
Chromosomal Location88720855-88764220 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 88756155 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Serine at position 217 (T217S)
Ref Sequence ENSEMBL: ENSMUSP00000108855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000006424] [ENSMUST00000113229]
Predicted Effect probably benign
Transcript: ENSMUST00000006424
AA Change: T212S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000006424
Gene: ENSMUSG00000006262
AA Change: T212S

DomainStartEndE-ValueType
Pfam:Mob1_phocein 29 205 1.2e-83 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000113229
AA Change: T217S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000108855
Gene: ENSMUSG00000006262
AA Change: T217S

DomainStartEndE-ValueType
Mob1_phocein 31 209 2.18e-113 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for a gene trap allele exhibit no abnormal phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930430A15Rik G T 2: 111,220,762 L230I probably damaging Het
Adamts3 G A 5: 89,701,666 H632Y probably damaging Het
Adgre5 T A 8: 83,728,401 M221L probably benign Het
Apba2 A T 7: 64,736,941 I439F possibly damaging Het
Arid1b C A 17: 5,321,284 N632K probably damaging Het
Bcas3 A T 11: 85,365,591 I60L probably damaging Het
Brd9 T C 13: 73,938,547 S56P probably damaging Het
Ccdc57 T A 11: 120,860,469 D925V possibly damaging Het
Ccna1 A G 3: 55,050,655 V143A probably damaging Het
Cdhr3 T C 12: 33,052,209 T410A probably benign Het
Ddx60 G T 8: 61,958,646 D511Y probably damaging Het
Drc7 C A 8: 95,056,001 probably benign Het
Dysf A G 6: 84,141,951 E1290G probably benign Het
Fam168b T C 1: 34,836,802 M1V probably null Het
Farsa A G 8: 84,864,257 K208R probably damaging Het
Fnip2 A G 3: 79,518,061 probably benign Het
Gm17535 A T 9: 3,035,111 H170L probably benign Het
Gm4553 T C 7: 142,165,227 S155G unknown Het
Gm5852 T C 3: 93,727,194 noncoding transcript Het
Gnb2 T C 5: 137,530,706 probably benign Het
Gpr158 A G 2: 21,368,683 N143S probably damaging Het
Hcn1 C A 13: 117,602,977 Q92K unknown Het
Helb T C 10: 120,098,245 I678V possibly damaging Het
Hnrnpl C A 7: 28,813,373 A118D probably damaging Het
Klhl14 G A 18: 21,651,864 P169S probably benign Het
Kndc1 T C 7: 139,901,988 probably benign Het
Lmod2 A G 6: 24,598,052 E57G probably damaging Het
Lrch4 T C 5: 137,637,747 I300T possibly damaging Het
Lrp6 A G 6: 134,456,090 V1426A probably benign Het
Lrrc39 A G 3: 116,570,981 probably benign Het
Mamstr G A 7: 45,644,285 V262I probably benign Het
Mocs3 G A 2: 168,231,491 R286H possibly damaging Het
Mpo A T 11: 87,802,617 Q27L probably benign Het
Ncdn A T 4: 126,747,188 D506E probably benign Het
Noxa1 A G 2: 25,094,902 I8T probably benign Het
Olfr46 T A 7: 140,610,753 S196T probably damaging Het
Olfr514 C T 7: 108,825,073 V309I probably benign Het
Olfr878 A G 9: 37,919,050 Y131C probably damaging Het
Oma1 G T 4: 103,319,368 A110S probably benign Het
Pde4a A C 9: 21,211,061 K694T probably benign Het
Phc1 A G 6: 122,322,999 probably benign Het
Pias1 A G 9: 62,923,296 V187A probably damaging Het
Pifo A G 3: 106,014,508 V33A probably benign Het
Pigf C A 17: 87,020,448 L130F probably null Het
Pkd1 G T 17: 24,580,095 V2763L probably damaging Het
Ppp1r8 T C 4: 132,834,681 Y76C probably damaging Het
Ppp6r3 C A 19: 3,518,324 G158V probably damaging Het
Ptpn13 A G 5: 103,551,058 I1136V probably damaging Het
Ptprq T C 10: 107,576,929 I1770V probably damaging Het
Rhpn2 A T 7: 35,370,760 I148F probably damaging Het
Stard3 T C 11: 98,377,459 Y239H probably damaging Het
Stau1 T C 2: 166,950,809 Y412C probably benign Het
Sucnr1 A G 3: 60,086,632 I194V probably benign Het
Tanc1 A G 2: 59,790,841 T335A possibly damaging Het
Tmem126a T C 7: 90,452,755 T79A probably benign Het
Trav9-2 A T 14: 53,591,383 Y70F probably benign Het
Tspear A G 10: 77,873,236 E432G probably benign Het
Ube2o T C 11: 116,544,754 R403G probably benign Het
Unc80 C A 1: 66,606,459 S1431R possibly damaging Het
Usp24 G A 4: 106,401,139 C1578Y probably damaging Het
Vsig10 A T 5: 117,351,587 M473L probably benign Het
Xpot T A 10: 121,605,644 M559L probably benign Het
Other mutations in Mob1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01475:Mob1b APN 5 88749643 missense probably damaging 1.00
IGL02478:Mob1b APN 5 88756088 splice site probably benign
R0012:Mob1b UTSW 5 88756084 splice site probably benign
R0012:Mob1b UTSW 5 88756084 splice site probably benign
R0938:Mob1b UTSW 5 88749593 missense probably damaging 1.00
R1081:Mob1b UTSW 5 88753162 missense probably benign 0.00
R3500:Mob1b UTSW 5 88749620 missense probably benign 0.00
R3890:Mob1b UTSW 5 88753202 missense probably damaging 0.97
R3891:Mob1b UTSW 5 88753202 missense probably damaging 0.97
R3892:Mob1b UTSW 5 88753202 missense probably damaging 0.97
R7243:Mob1b UTSW 5 88743445 missense probably damaging 0.96
R7302:Mob1b UTSW 5 88753177 missense probably benign
R7782:Mob1b UTSW 5 88749683 splice site probably null
R8101:Mob1b UTSW 5 88753234 missense probably benign 0.10
Posted On2012-04-20