Incidental Mutation 'R0098:Fam237b'
ID 64099
Institutional Source Beutler Lab
Gene Symbol Fam237b
Ensembl Gene ENSMUSG00000073234
Gene Name family with sequence similarity 237, member B
Synonyms Gm8773, Gm29287
MMRRC Submission 038384-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.194) question?
Stock # R0098 (G1)
Quality Score 96
Status Validated
Chromosome 5
Chromosomal Location 5624004-5626205 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 5625355 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Glutamine at position 17 (L17Q)
Ref Sequence ENSEMBL: ENSMUSP00000147824 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054865] [ENSMUST00000101627] [ENSMUST00000196165]
AlphaFold Q3UQ24
Predicted Effect probably benign
Transcript: ENSMUST00000054865
SMART Domains Protein: ENSMUSP00000053206
Gene: ENSMUSG00000040473

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
low complexity region 847 860 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000101627
AA Change: L17Q

PolyPhen 2 Score 0.684 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000099149
Gene: ENSMUSG00000073234
AA Change: L17Q

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000101627
AA Change: L17Q

PolyPhen 2 Score 0.684 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect probably benign
Transcript: ENSMUST00000196165
SMART Domains Protein: ENSMUSP00000143393
Gene: ENSMUSG00000040473

DomainStartEndE-ValueType
low complexity region 2 16 N/A INTRINSIC
low complexity region 676 689 N/A INTRINSIC
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.8%
  • 20x: 96.2%
Validation Efficiency 100% (54/54)
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 T C 3: 36,127,689 (GRCm39) I97T probably damaging Het
Acp3 C T 9: 104,197,144 (GRCm39) probably null Het
Adam32 T A 8: 25,404,405 (GRCm39) Y200F possibly damaging Het
Alpk2 A G 18: 65,482,982 (GRCm39) L342S probably damaging Het
Arfgef3 A G 10: 18,465,390 (GRCm39) V2151A probably damaging Het
Atm T C 9: 53,429,869 (GRCm39) D389G probably benign Het
Atp10b A T 11: 43,080,431 (GRCm39) S236C probably benign Het
B3gat1 C T 9: 26,668,237 (GRCm39) R276C probably damaging Het
Cndp1 T A 18: 84,646,949 (GRCm39) E246D probably damaging Het
Crebbp A G 16: 3,909,792 (GRCm39) L1078P probably damaging Het
Cyp20a1 G T 1: 60,426,413 (GRCm39) E452* probably null Het
Emb T C 13: 117,404,034 (GRCm39) V262A probably damaging Het
Ephb1 C T 9: 101,918,339 (GRCm39) R390H probably damaging Het
Faf1 T C 4: 109,792,696 (GRCm39) L556S probably damaging Het
Fbf1 A T 11: 116,038,945 (GRCm39) probably null Het
Gid8 T A 2: 180,356,528 (GRCm39) I55N possibly damaging Het
Hexa T C 9: 59,465,383 (GRCm39) Y213H probably damaging Het
Kalrn A T 16: 33,795,989 (GRCm39) I1262K possibly damaging Het
Lrp1 C T 10: 127,388,607 (GRCm39) V3281I probably benign Het
Lrp2 T C 2: 69,305,756 (GRCm39) D2935G probably damaging Het
Lypd6 T A 2: 50,080,792 (GRCm39) V160E probably benign Het
Muc19 C T 15: 91,777,101 (GRCm39) noncoding transcript Het
Mybpc1 T C 10: 88,365,426 (GRCm39) D899G probably benign Het
Myo18a A G 11: 77,736,591 (GRCm39) E1564G probably damaging Het
Nrxn3 A G 12: 89,226,971 (GRCm39) D202G probably damaging Het
Palld C A 8: 61,978,120 (GRCm39) G890V probably damaging Het
Pcx C A 19: 4,651,775 (GRCm39) probably benign Het
Plcg1 T C 2: 160,573,920 (GRCm39) W62R probably damaging Het
Ppa2 C T 3: 133,076,234 (GRCm39) probably benign Het
Ppp1r18 A G 17: 36,178,888 (GRCm39) I254M probably benign Het
Prune2 A G 19: 17,101,267 (GRCm39) E2257G possibly damaging Het
Rd3 A G 1: 191,717,261 (GRCm39) M244V probably benign Het
Rfx5 T A 3: 94,865,679 (GRCm39) V326E probably damaging Het
Rgs3 G C 4: 62,544,143 (GRCm39) R305P probably damaging Het
Rpp40 A G 13: 36,082,970 (GRCm39) Y173H probably benign Het
Ryr3 T C 2: 112,731,376 (GRCm39) N645D probably damaging Het
Sema3e T C 5: 14,302,446 (GRCm39) V657A possibly damaging Het
Serpina3n T A 12: 104,379,777 (GRCm39) V390E probably damaging Het
Shank1 A G 7: 43,962,709 (GRCm39) Y141C unknown Het
Stat2 T A 10: 128,119,131 (GRCm39) H428Q probably damaging Het
Stat5a A T 11: 100,766,452 (GRCm39) Q378L probably damaging Het
Tfrc G T 16: 32,442,244 (GRCm39) V490F probably damaging Het
Tnnt1 T C 7: 4,512,044 (GRCm39) N155S probably damaging Het
Topaz1 T C 9: 122,619,188 (GRCm39) Y1262H possibly damaging Het
Ubxn8 T C 8: 34,125,393 (GRCm39) probably benign Het
Unk A G 11: 115,940,995 (GRCm39) Y252C probably damaging Het
Vmn2r66 A C 7: 84,654,965 (GRCm39) M448R probably damaging Het
Zfp386 T A 12: 116,022,834 (GRCm39) L184* probably null Het
Zfp985 T C 4: 147,661,566 (GRCm39) S4P probably damaging Het
Other mutations in Fam237b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01572:Fam237b APN 5 5,625,475 (GRCm39) missense probably damaging 0.97
IGL03040:Fam237b APN 5 5,625,566 (GRCm39) nonsense probably null
B5639:Fam237b UTSW 5 5,624,060 (GRCm39) utr 5 prime probably benign
R0972:Fam237b UTSW 5 5,625,512 (GRCm39) missense probably benign 0.09
R1789:Fam237b UTSW 5 5,625,652 (GRCm39) missense possibly damaging 0.82
R4952:Fam237b UTSW 5 5,625,387 (GRCm39) missense probably benign 0.02
R5229:Fam237b UTSW 5 5,625,565 (GRCm39) missense possibly damaging 0.94
R8881:Fam237b UTSW 5 5,625,379 (GRCm39) missense possibly damaging 0.93
R9649:Fam237b UTSW 5 5,625,549 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GATTCCAGTGAATCCCAGAGACAGC -3'
(R):5'- CCCATGAGACCTTGAAAGCAAGCAG -3'

Sequencing Primer
(F):5'- TCCATTTAAAGGATAGTCCGAGAGC -3'
(R):5'- ATACTGTAATGCCCAGGACG -3'
Posted On 2013-08-06