Mutagenetix > Incidental Mutation

Incidental Mutation 'R8459:Vmn1r50'

655178

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r50

Ensembl Gene

ENSMUSG00000094553

Gene Name

vomeronasal 1 receptor 50

Synonyms

V1rb1, VN2

MMRRC Submission

067836-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.096) question?

Stock #

R8459 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

90084257-90085189 bp(+) (GRCm39)

Type of Mutation

start gained

DNA Base Change (assembly)

A to G at 90084235 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000154560 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000081706] [ENSMUST00000089417] [ENSMUST00000226577]

AlphaFold

Q9EP51

Predicted Effect

probably benign
Transcript: ENSMUST00000081706

SMART Domains

Protein: ENSMUSP00000080407
Gene: ENSMUSG00000094553

Domain	Start	End	E-Value	Type
transmembrane domain	15	37	N/A	INTRINSIC
Pfam:V1R	38	302	1e-137	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000089417

SMART Domains

Protein: ENSMUSP00000100705
Gene: ENSMUSG00000094553

Domain	Start	End	E-Value	Type
Pfam:V1R	39	303	9.8e-139	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000226577

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aim2	CTTGTTGT	CTTGT	1: 173,289,536 (GRCm39)		probably benign	Het
Ank1	T	C	8: 23,605,528 (GRCm39)	V1132A	probably damaging	Het
Bpifb9a	T	G	2: 154,102,153 (GRCm39)	S83R	probably damaging	Het
Cacnb3	C	T	15: 98,537,393 (GRCm39)	R24C	probably damaging	Het
Car8	C	T	4: 8,189,302 (GRCm39)	V171I	probably benign	Het
Cd200l1	T	A	16: 45,238,271 (GRCm39)	H294L	probably benign	Het
Cdk17	G	C	10: 93,068,289 (GRCm39)	V349L	probably damaging	Het
Celsr3	A	G	9: 108,706,829 (GRCm39)	E1104G	probably damaging	Het
Chml	T	C	1: 175,515,597 (GRCm39)	D108G	probably benign	Het
Cluap1	T	C	16: 3,755,453 (GRCm39)	M356T	probably damaging	Het
Cmtm1	A	G	8: 105,036,143 (GRCm39)	V162A	possibly damaging	Het
Cryge	T	C	1: 65,087,841 (GRCm39)	D156G	possibly damaging	Het
Disc1	A	C	8: 125,891,894 (GRCm39)	D649A	possibly damaging	Het
Dnah8	T	C	17: 30,944,221 (GRCm39)		probably null	Het
Dpp7	C	A	2: 25,242,550 (GRCm39)	V468F	probably damaging	Het
Ecpas	A	G	4: 58,821,379 (GRCm39)	V1207A	probably damaging	Het
Ep400	A	G	5: 110,856,757 (GRCm39)	F1163S	unknown	Het
Fbrs	C	T	7: 127,082,329 (GRCm39)	R327W	probably damaging	Het
Fsip2	T	A	2: 82,810,022 (GRCm39)	Y2114N	possibly damaging	Het
Gnas	A	T	2: 174,126,732 (GRCm39)	H89L	probably benign	Het
Gstt1	G	A	10: 75,629,943 (GRCm39)	R107W	probably damaging	Het
Hal	A	G	10: 93,352,177 (GRCm39)	D656G	probably benign	Het
Htra3	G	A	5: 35,828,569 (GRCm39)		probably benign	Het
Ighv1-64	G	A	12: 115,471,256 (GRCm39)	A87V	probably benign	Het
Itga3	A	G	11: 94,959,633 (GRCm39)	V80A	probably benign	Het
Lrrc58	A	G	16: 37,698,872 (GRCm39)	N280D	probably benign	Het
Macf1	T	C	4: 123,374,107 (GRCm39)	E1501G	possibly damaging	Het
Madd	A	G	2: 90,992,871 (GRCm39)	I1016T	probably benign	Het
Mbnl1	T	G	3: 60,529,628 (GRCm39)	S260R	probably damaging	Het
Or5h17	A	T	16: 58,820,348 (GRCm39)	Q100L	probably damaging	Het
Phip	G	T	9: 82,758,106 (GRCm39)	A1529D	probably benign	Het
Pramel58	A	G	5: 94,830,742 (GRCm39)	D80G	probably damaging	Het
Prorsd1	T	C	11: 29,463,286 (GRCm39)	T159A	probably damaging	Het
Sh3tc1	C	A	5: 35,878,933 (GRCm39)	R67L	probably benign	Het
Skint5	A	T	4: 113,703,481 (GRCm39)	L518*	probably null	Het
Slc26a11	T	A	11: 119,259,643 (GRCm39)	I280N	possibly damaging	Het
Spata16	A	G	3: 26,721,676 (GRCm39)	T66A	probably benign	Het
Syne1	G	A	10: 5,374,277 (GRCm39)	R177*	probably null	Het
Vmn1r16	A	C	6: 57,300,347 (GRCm39)	C92G	probably benign	Het

Other mutations in Vmn1r50

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02177:Vmn1r50	APN	6	90,085,139 (GRCm39)	missense	probably benign
IGL02383:Vmn1r50	APN	6	90,084,461 (GRCm39)	missense	possibly damaging	0.66
IGL03304:Vmn1r50	APN	6	90,084,625 (GRCm39)	missense	probably damaging	0.97
IGL03412:Vmn1r50	APN	6	90,085,007 (GRCm39)	missense	probably damaging	1.00
R0032:Vmn1r50	UTSW	6	90,084,782 (GRCm39)	missense	probably damaging	0.98
R0504:Vmn1r50	UTSW	6	90,084,863 (GRCm39)	missense	probably damaging	1.00
R2191:Vmn1r50	UTSW	6	90,085,121 (GRCm39)	missense	probably benign	0.09
R3548:Vmn1r50	UTSW	6	90,084,476 (GRCm39)	missense	probably damaging	1.00
R4668:Vmn1r50	UTSW	6	90,084,513 (GRCm39)	missense	probably benign	0.44
R4763:Vmn1r50	UTSW	6	90,085,062 (GRCm39)	missense	probably benign	0.00
R5238:Vmn1r50	UTSW	6	90,084,465 (GRCm39)	missense	possibly damaging	0.60
R7002:Vmn1r50	UTSW	6	90,084,819 (GRCm39)	missense	probably benign
R7172:Vmn1r50	UTSW	6	90,084,386 (GRCm39)	missense	possibly damaging	0.89
R8478:Vmn1r50	UTSW	6	90,085,071 (GRCm39)	missense	probably benign	0.07
R8985:Vmn1r50	UTSW	6	90,085,017 (GRCm39)	missense	probably benign	0.26
R9096:Vmn1r50	UTSW	6	90,085,022 (GRCm39)	missense	probably benign	0.01
R9097:Vmn1r50	UTSW	6	90,085,022 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn1r50	UTSW	6	90,084,951 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTTCAGACAGTGGGAATGGC -3'
(R):5'- ATGTCCACAGCTATGAGTCCC -3'

Sequencing Primer
(F):5'- TCAGACAGTGGGAATGGCTTTCAG -3'
(R):5'- TGAGTCCCATAGTTATAAGCAGC -3'

Posted On

2020-10-20