Incidental Mutation 'R8994:Or10p1'
ID 684604
Institutional Source Beutler Lab
Gene Symbol Or10p1
Ensembl Gene ENSMUSG00000052012
Gene Name olfactory receptor family 10 subfamily P member 1
Synonyms MOR269-1, Olfr796, GA_x6K02T2PULF-11287099-11286167
MMRRC Submission 068825-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.157) question?
Stock # R8994 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129443416-129444348 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129444005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Histidine at position 115 (L115H)
Ref Sequence ENSEMBL: ENSMUSP00000150534 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037071] [ENSMUST00000214584]
AlphaFold Q8VGJ1
Predicted Effect probably damaging
Transcript: ENSMUST00000037071
AA Change: L115H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000040207
Gene: ENSMUSG00000052012
AA Change: L115H

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 7.5e-50 PFAM
Pfam:7tm_1 41 291 2e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214584
AA Change: L115H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.1%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 T A 14: 118,771,556 (GRCm39) probably null Het
Adgrv1 GTT GT 13: 81,553,457 (GRCm39) probably null Het
Ank2 A T 3: 126,723,471 (GRCm39) M952K probably benign Het
Ccser2 A T 14: 36,662,076 (GRCm39) N369K probably benign Het
Cd300e A T 11: 114,946,348 (GRCm39) Y38N probably damaging Het
Crat G T 2: 30,297,887 (GRCm39) F212L probably damaging Het
Dnah8 T A 17: 31,009,807 (GRCm39) S3733T probably benign Het
Fam135a C T 1: 24,067,621 (GRCm39) D1083N probably damaging Het
Fam174a C A 1: 95,241,689 (GRCm39) P50T possibly damaging Het
Fars2 T A 13: 36,388,849 (GRCm39) Y113N probably damaging Het
Fpr3 T C 17: 18,191,341 (GRCm39) I204T possibly damaging Het
Frmd3 T C 4: 74,088,985 (GRCm39) V394A probably benign Het
Garin5a G T 7: 44,146,342 (GRCm39) R16L probably benign Het
Gpbp1 C A 13: 111,603,384 (GRCm39) probably null Het
Hectd4 T A 5: 121,441,629 (GRCm39) F1197Y probably benign Het
Herc3 A G 6: 58,851,328 (GRCm39) T526A probably benign Het
Hnrnpul2 T C 19: 8,802,350 (GRCm39) C406R probably damaging Het
Hsd17b3 T C 13: 64,210,695 (GRCm39) Q220R probably damaging Het
Igf2r T A 17: 12,935,537 (GRCm39) Y651F possibly damaging Het
Kcng1 C T 2: 168,110,768 (GRCm39) R132Q probably benign Het
Kif1a G A 1: 92,983,457 (GRCm39) S680F possibly damaging Het
Kif1b T C 4: 149,279,939 (GRCm39) D27G Het
Klk12 A T 7: 43,421,485 (GRCm39) T180S probably damaging Het
Klk1b27 A G 7: 43,705,136 (GRCm39) H101R probably damaging Het
Lrp6 C A 6: 134,518,656 (GRCm39) E136D probably benign Het
Mcm9 T C 10: 53,424,620 (GRCm39) I657V probably benign Het
Med13l A C 5: 118,866,226 (GRCm39) K427Q possibly damaging Het
Nol10 A T 12: 17,402,717 (GRCm39) D63V probably damaging Het
Nudcd2 A G 11: 40,624,862 (GRCm39) T24A probably damaging Het
Nup155 T C 15: 8,172,645 (GRCm39) probably null Het
Or10al7 T C 17: 38,366,220 (GRCm39) Y79C possibly damaging Het
Or51af1 A T 7: 103,141,800 (GRCm39) M95K probably benign Het
Or5p81 G A 7: 108,267,169 (GRCm39) C182Y probably damaging Het
Or8c19-ps1 A T 9: 38,220,581 (GRCm39) *163Y probably null Het
Piezo1 T C 8: 123,209,829 (GRCm39) D2314G unknown Het
Pkhd1l1 T C 15: 44,410,499 (GRCm39) F2669L probably damaging Het
Plpp4 A G 7: 128,981,157 (GRCm39) R178G probably damaging Het
Ppp1r13l G T 7: 19,102,695 (GRCm39) A37S possibly damaging Het
Prl6a1 A G 13: 27,499,417 (GRCm39) T62A probably benign Het
Ranbp2 C A 10: 58,315,891 (GRCm39) Q2204K possibly damaging Het
Rbm48 T A 5: 3,640,795 (GRCm39) M195L probably benign Het
Rigi C A 4: 40,205,941 (GRCm39) E884* probably null Het
Shank3 T A 15: 89,417,416 (GRCm39) F4L probably benign Het
Slain2 T A 5: 73,114,984 (GRCm39) V405D probably damaging Het
Slitrk5 A C 14: 111,918,227 (GRCm39) D617A probably benign Het
Sp140 T A 1: 85,549,603 (GRCm39) probably null Het
Stk32a A G 18: 43,443,542 (GRCm39) T240A probably benign Het
Timm21 T C 18: 84,969,489 (GRCm39) probably benign Het
Tmem131 T C 1: 36,854,538 (GRCm39) S904G probably benign Het
Tmem86b A G 7: 4,632,706 (GRCm39) C53R unknown Het
Wdr33 T C 18: 31,960,459 (GRCm39) L41P probably benign Het
Zfp112 A C 7: 23,825,490 (GRCm39) H490P probably benign Het
Zfp455 T C 13: 67,355,478 (GRCm39) Y184H probably damaging Het
Other mutations in Or10p1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02674:Or10p1 APN 10 129,443,939 (GRCm39) missense possibly damaging 0.95
R0092:Or10p1 UTSW 10 129,444,090 (GRCm39) missense probably damaging 0.99
R1074:Or10p1 UTSW 10 129,444,335 (GRCm39) missense probably damaging 1.00
R4747:Or10p1 UTSW 10 129,444,053 (GRCm39) missense possibly damaging 0.95
R4762:Or10p1 UTSW 10 129,444,043 (GRCm39) missense probably damaging 0.98
R5237:Or10p1 UTSW 10 129,443,732 (GRCm39) missense probably benign 0.00
R7082:Or10p1 UTSW 10 129,443,417 (GRCm39) makesense probably null
R7082:Or10p1 UTSW 10 129,443,416 (GRCm39) makesense probably null
R7111:Or10p1 UTSW 10 129,443,829 (GRCm39) missense possibly damaging 0.80
R7313:Or10p1 UTSW 10 129,443,949 (GRCm39) missense probably benign 0.01
R7565:Or10p1 UTSW 10 129,444,029 (GRCm39) missense possibly damaging 0.81
R9622:Or10p1 UTSW 10 129,444,084 (GRCm39) missense probably benign 0.00
Z1176:Or10p1 UTSW 10 129,443,972 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTGGCAGGATGTCACAGAG -3'
(R):5'- TTACCCAAACCAGCCCTGTG -3'

Sequencing Primer
(F):5'- CAGGATGTCACAGAGGAAGTGTG -3'
(R):5'- GTGCTGCACTCCCCCATG -3'
Posted On 2021-10-11