Incidental Mutation 'R8994:Or10al7'
ID 684623
Institutional Source Beutler Lab
Gene Symbol Or10al7
Ensembl Gene ENSMUSG00000081724
Gene Name olfactory receptor family 10 subfamily AL member 7
Synonyms MOR263-9, GA_x6K02T2PSCP-2503741-2502776, Olfr129
MMRRC Submission 068825-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R8994 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38365490-38370675 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 38366220 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 79 (Y79C)
Ref Sequence ENSEMBL: ENSMUSP00000149327 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122318] [ENSMUST00000216476]
AlphaFold Q8VEY1
Predicted Effect possibly damaging
Transcript: ENSMUST00000122318
AA Change: Y88C

PolyPhen 2 Score 0.636 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000113564
Gene: ENSMUSG00000081724
AA Change: Y88C

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 4.6e-56 PFAM
Pfam:7TM_GPCR_Srsx 50 319 1.1e-5 PFAM
Pfam:7tm_1 56 305 3.2e-21 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000216476
AA Change: Y79C

PolyPhen 2 Score 0.636 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.1%
Validation Efficiency 98% (52/53)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 T A 14: 118,771,556 (GRCm39) probably null Het
Adgrv1 GTT GT 13: 81,553,457 (GRCm39) probably null Het
Ank2 A T 3: 126,723,471 (GRCm39) M952K probably benign Het
Ccser2 A T 14: 36,662,076 (GRCm39) N369K probably benign Het
Cd300e A T 11: 114,946,348 (GRCm39) Y38N probably damaging Het
Crat G T 2: 30,297,887 (GRCm39) F212L probably damaging Het
Dnah8 T A 17: 31,009,807 (GRCm39) S3733T probably benign Het
Fam135a C T 1: 24,067,621 (GRCm39) D1083N probably damaging Het
Fam174a C A 1: 95,241,689 (GRCm39) P50T possibly damaging Het
Fars2 T A 13: 36,388,849 (GRCm39) Y113N probably damaging Het
Fpr3 T C 17: 18,191,341 (GRCm39) I204T possibly damaging Het
Frmd3 T C 4: 74,088,985 (GRCm39) V394A probably benign Het
Garin5a G T 7: 44,146,342 (GRCm39) R16L probably benign Het
Gpbp1 C A 13: 111,603,384 (GRCm39) probably null Het
Hectd4 T A 5: 121,441,629 (GRCm39) F1197Y probably benign Het
Herc3 A G 6: 58,851,328 (GRCm39) T526A probably benign Het
Hnrnpul2 T C 19: 8,802,350 (GRCm39) C406R probably damaging Het
Hsd17b3 T C 13: 64,210,695 (GRCm39) Q220R probably damaging Het
Igf2r T A 17: 12,935,537 (GRCm39) Y651F possibly damaging Het
Kcng1 C T 2: 168,110,768 (GRCm39) R132Q probably benign Het
Kif1a G A 1: 92,983,457 (GRCm39) S680F possibly damaging Het
Kif1b T C 4: 149,279,939 (GRCm39) D27G Het
Klk12 A T 7: 43,421,485 (GRCm39) T180S probably damaging Het
Klk1b27 A G 7: 43,705,136 (GRCm39) H101R probably damaging Het
Lrp6 C A 6: 134,518,656 (GRCm39) E136D probably benign Het
Mcm9 T C 10: 53,424,620 (GRCm39) I657V probably benign Het
Med13l A C 5: 118,866,226 (GRCm39) K427Q possibly damaging Het
Nol10 A T 12: 17,402,717 (GRCm39) D63V probably damaging Het
Nudcd2 A G 11: 40,624,862 (GRCm39) T24A probably damaging Het
Nup155 T C 15: 8,172,645 (GRCm39) probably null Het
Or10p1 A T 10: 129,444,005 (GRCm39) L115H probably damaging Het
Or51af1 A T 7: 103,141,800 (GRCm39) M95K probably benign Het
Or5p81 G A 7: 108,267,169 (GRCm39) C182Y probably damaging Het
Or8c19-ps1 A T 9: 38,220,581 (GRCm39) *163Y probably null Het
Piezo1 T C 8: 123,209,829 (GRCm39) D2314G unknown Het
Pkhd1l1 T C 15: 44,410,499 (GRCm39) F2669L probably damaging Het
Plpp4 A G 7: 128,981,157 (GRCm39) R178G probably damaging Het
Ppp1r13l G T 7: 19,102,695 (GRCm39) A37S possibly damaging Het
Prl6a1 A G 13: 27,499,417 (GRCm39) T62A probably benign Het
Ranbp2 C A 10: 58,315,891 (GRCm39) Q2204K possibly damaging Het
Rbm48 T A 5: 3,640,795 (GRCm39) M195L probably benign Het
Rigi C A 4: 40,205,941 (GRCm39) E884* probably null Het
Shank3 T A 15: 89,417,416 (GRCm39) F4L probably benign Het
Slain2 T A 5: 73,114,984 (GRCm39) V405D probably damaging Het
Slitrk5 A C 14: 111,918,227 (GRCm39) D617A probably benign Het
Sp140 T A 1: 85,549,603 (GRCm39) probably null Het
Stk32a A G 18: 43,443,542 (GRCm39) T240A probably benign Het
Timm21 T C 18: 84,969,489 (GRCm39) probably benign Het
Tmem131 T C 1: 36,854,538 (GRCm39) S904G probably benign Het
Tmem86b A G 7: 4,632,706 (GRCm39) C53R unknown Het
Wdr33 T C 18: 31,960,459 (GRCm39) L41P probably benign Het
Zfp112 A C 7: 23,825,490 (GRCm39) H490P probably benign Het
Zfp455 T C 13: 67,355,478 (GRCm39) Y184H probably damaging Het
Other mutations in Or10al7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02140:Or10al7 APN 17 38,366,481 (GRCm39) start codon destroyed probably null 0.15
IGL02163:Or10al7 APN 17 38,365,641 (GRCm39) missense probably benign 0.06
IGL02374:Or10al7 APN 17 38,366,412 (GRCm39) missense probably damaging 1.00
R0840:Or10al7 UTSW 17 38,366,463 (GRCm39) missense probably benign 0.00
R1774:Or10al7 UTSW 17 38,366,328 (GRCm39) missense probably benign 0.00
R3720:Or10al7 UTSW 17 38,366,259 (GRCm39) missense probably damaging 1.00
R3794:Or10al7 UTSW 17 38,365,786 (GRCm39) missense probably damaging 1.00
R3840:Or10al7 UTSW 17 38,366,239 (GRCm39) missense probably damaging 1.00
R4002:Or10al7 UTSW 17 38,365,879 (GRCm39) missense probably damaging 1.00
R4273:Or10al7 UTSW 17 38,366,163 (GRCm39) missense probably damaging 1.00
R4872:Or10al7 UTSW 17 38,366,467 (GRCm39) missense probably benign
R5606:Or10al7 UTSW 17 38,365,693 (GRCm39) missense probably damaging 0.98
R6309:Or10al7 UTSW 17 38,366,043 (GRCm39) missense probably damaging 1.00
R7269:Or10al7 UTSW 17 38,366,442 (GRCm39) missense probably damaging 1.00
R7450:Or10al7 UTSW 17 38,366,000 (GRCm39) missense probably benign 0.00
R7829:Or10al7 UTSW 17 38,366,220 (GRCm39) missense possibly damaging 0.64
R8103:Or10al7 UTSW 17 38,365,903 (GRCm39) missense probably damaging 1.00
R9388:Or10al7 UTSW 17 38,366,148 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTTCCCCATGAAACTATTGCC -3'
(R):5'- TGCCAAGTTCTCTGAGGTCC -3'

Sequencing Primer
(F):5'- CCATGAAACTATTGCCAAATGGG -3'
(R):5'- AGGTCCCTGGAGAATGCTTC -3'
Posted On 2021-10-11