Mutagenetix > Incidental Mutation

Incidental Mutation 'R8776:Dennd11'

686565

Institutional Source

Beutler Lab

Gene Symbol

Dennd11

Ensembl Gene

ENSMUSG00000037172

Gene Name

DENN domain containing 11

Synonyms

E330009J07Rik

MMRRC Submission

068629-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.086) question?

Stock #

R8776 (G1)

Quality Score

116.008

Status

Validated

Chromosome

Chromosomal Location

40378309-40413069 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

T to C at 40395775 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143916 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039008] [ENSMUST00000101492] [ENSMUST00000201712]

AlphaFold

Q3UHG7

Predicted Effect

probably benign
Transcript: ENSMUST00000039008

SMART Domains

Protein: ENSMUSP00000045103
Gene: ENSMUSG00000037172

Domain	Start	End	E-Value	Type
low complexity region	30	60	N/A	INTRINSIC
Pfam:DUF2347	80	347	3.4e-79	PFAM
Pfam:SPA	234	345	5.2e-15	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000101492

SMART Domains

Protein: ENSMUSP00000099031
Gene: ENSMUSG00000037172

Domain	Start	End	E-Value	Type
low complexity region	30	60	N/A	INTRINSIC
Pfam:DUF2347	80	347	3.2e-78	PFAM
Pfam:SPA	234	345	6.3e-16	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000201712

SMART Domains

Protein: ENSMUSP00000143916
Gene: ENSMUSG00000037172

Domain	Start	End	E-Value	Type
Pfam:DUF2347	15	133	1.4e-29	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930568D16Rik	A	G	2: 35,245,002 (GRCm39)	Y117H	probably benign	Het
a	A	G	2: 154,892,612 (GRCm39)	D97G	probably damaging	Het
Cdca7l	T	C	12: 117,836,098 (GRCm39)	S190P	probably damaging	Het
Chst9	T	A	18: 15,586,086 (GRCm39)	Y159F	possibly damaging	Het
Col26a1	G	A	5: 136,911,708 (GRCm39)	R52C	probably damaging	Het
Dchs2	A	T	3: 83,263,701 (GRCm39)	D3323V	possibly damaging	Het
Dqx1	T	A	6: 83,035,619 (GRCm39)	I44N	probably damaging	Het
Edc4	A	G	8: 106,613,992 (GRCm39)	D415G	probably damaging	Het
Enpp3	T	A	10: 24,650,733 (GRCm39)	D801V	probably damaging	Het
Fam13b	G	A	18: 34,584,446 (GRCm39)	R573C	probably damaging	Het
Fgfr2	A	T	7: 129,798,002 (GRCm39)	I415N	possibly damaging	Het
Gm32742	T	A	9: 51,067,230 (GRCm39)	M366L	probably benign	Het
Gm49336	A	T	14: 60,457,515 (GRCm39)	S563T	possibly damaging	Het
Gm5475	T	C	15: 100,324,892 (GRCm39)	F107L	unknown	Het
Lamp3	T	C	16: 19,474,252 (GRCm39)	D374G	probably damaging	Het
Lin9	T	C	1: 180,496,450 (GRCm39)		probably null	Het
Mef2d	T	C	3: 88,074,956 (GRCm39)	S381P	probably benign	Het
Mfsd9	A	G	1: 40,812,915 (GRCm39)	*467Q	probably null	Het
Mpo	A	G	11: 87,693,538 (GRCm39)	I639V	possibly damaging	Het
Mrgprh	T	C	17: 13,096,375 (GRCm39)	I205T	probably benign	Het
Ncapd2	T	C	6: 125,154,476 (GRCm39)	D580G	probably benign	Het
Nkain4	T	A	2: 180,585,920 (GRCm39)	I48F	probably damaging	Het
Notch4	C	A	17: 34,806,579 (GRCm39)	R1839S	probably damaging	Het
Nr6a1	A	G	2: 38,650,244 (GRCm39)	Y129H	probably damaging	Het
Nras	T	C	3: 102,966,176 (GRCm39)		probably benign	Het
Or7g19	T	A	9: 18,856,286 (GRCm39)	I114N	possibly damaging	Het
Robo1	G	T	16: 72,821,141 (GRCm39)	E1294*	probably null	Het
Septin8	A	G	11: 53,428,343 (GRCm39)	K331R	probably benign	Het
Shmt2	A	G	10: 127,356,785 (GRCm39)		probably null	Het
Skint6	A	C	4: 112,661,885 (GRCm39)	L1233R	possibly damaging	Het
Slc41a3	A	T	6: 90,621,165 (GRCm39)	T402S	probably benign	Het
Slc9a2	A	G	1: 40,781,889 (GRCm39)	T373A	probably damaging	Het
Spata31d1b	T	C	13: 59,863,283 (GRCm39)	C144R	probably benign	Het
Syne1	A	G	10: 5,181,783 (GRCm39)	V4184A	possibly damaging	Het
Tenm4	G	A	7: 96,544,239 (GRCm39)	R2122H	probably damaging	Het
Tlnrd1	A	T	7: 83,532,316 (GRCm39)	D38E	probably benign	Het
Tnnc2	C	T	2: 164,620,135 (GRCm39)	A6T	probably benign	Het
Usp9y	A	G	Y: 1,356,320 (GRCm39)	V1127A	probably benign	Het
Ylpm1	T	C	12: 85,077,195 (GRCm39)	Y1307H	probably damaging	Het
Zfp266	T	C	9: 20,411,509 (GRCm39)	S223G	probably benign	Het

Other mutations in Dennd11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02813:Dennd11	APN	6	40,395,473 (GRCm39)	missense	probably benign	0.00
IGL03143:Dennd11	APN	6	40,399,828 (GRCm39)	splice site	probably benign
R1812:Dennd11	UTSW	6	40,386,365 (GRCm39)	missense	probably benign	0.02
R1928:Dennd11	UTSW	6	40,388,648 (GRCm39)	missense	probably benign	0.14
R2443:Dennd11	UTSW	6	40,383,710 (GRCm39)	missense	probably damaging	0.99
R3012:Dennd11	UTSW	6	40,412,926 (GRCm39)	missense	probably benign
R6913:Dennd11	UTSW	6	40,383,851 (GRCm39)	missense	possibly damaging	0.91
R7318:Dennd11	UTSW	6	40,386,098 (GRCm39)	missense	possibly damaging	0.72
R7456:Dennd11	UTSW	6	40,383,774 (GRCm39)	missense	probably benign	0.33
R8087:Dennd11	UTSW	6	40,395,526 (GRCm39)	missense	possibly damaging	0.94
R8231:Dennd11	UTSW	6	40,395,546 (GRCm39)	missense	probably benign	0.35
R8858:Dennd11	UTSW	6	40,399,669 (GRCm39)	missense	probably benign	0.02
Y4340:Dennd11	UTSW	6	40,412,992 (GRCm39)	missense	probably benign

Predicted Primers

Posted On

2021-11-03