Incidental Mutation 'R9192:Or51i2'
ID 697747
Institutional Source Beutler Lab
Gene Symbol Or51i2
Ensembl Gene ENSMUSG00000073932
Gene Name olfactory receptor family 51 subfamily I member 2
Synonyms Olfr641, MOR13-3, GA_x6K02T2PBJ9-6773690-6774628
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.111) question?
Stock # R9192 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 103689005-103689943 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 103689875 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 291 (I291F)
Ref Sequence ENSEMBL: ENSMUSP00000149866 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098183] [ENSMUST00000138055] [ENSMUST00000213214]
AlphaFold Q8VGX6
Predicted Effect possibly damaging
Transcript: ENSMUST00000098183
AA Change: I291F

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000095785
Gene: ENSMUSG00000073932
AA Change: I291F

DomainStartEndE-ValueType
Pfam:7tm_4 31 310 2.5e-118 PFAM
Pfam:7TM_GPCR_Srsx 35 307 7e-7 PFAM
Pfam:7tm_1 41 292 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000138055
SMART Domains Protein: ENSMUSP00000139240
Gene: ENSMUSG00000109824

DomainStartEndE-ValueType
transmembrane domain 29 51 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000213214
AA Change: I291F

PolyPhen 2 Score 0.940 (Sensitivity: 0.80; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 T A 7: 75,354,249 (GRCm39) M71K probably benign Het
Angptl4 C T 17: 34,000,285 (GRCm39) A28T probably benign Het
Baz1b T G 5: 135,239,648 (GRCm39) N249K possibly damaging Het
BC035947 A T 1: 78,475,877 (GRCm39) Y218* probably null Het
Ctbp1 T C 5: 33,408,333 (GRCm39) I211V probably benign Het
Dars1 T C 1: 128,299,889 (GRCm39) E365G probably benign Het
E2f7 G T 10: 110,599,851 (GRCm39) R202L probably damaging Het
Fscb A C 12: 64,520,890 (GRCm39) I192S possibly damaging Het
Fsip2 A G 2: 82,817,844 (GRCm39) I4526V probably benign Het
Gucy2e A T 11: 69,127,303 (GRCm39) F57I probably damaging Het
Hcar2 A T 5: 124,003,354 (GRCm39) C50S possibly damaging Het
Herc1 G A 9: 66,321,413 (GRCm39) V1267I probably benign Het
Kansl1 A T 11: 104,227,142 (GRCm39) D845E probably damaging Het
Kdm2b T A 5: 123,070,679 (GRCm39) T473S probably benign Het
Klhdc10 T A 6: 30,449,499 (GRCm39) I327N probably damaging Het
Kmt5b T C 19: 3,854,442 (GRCm39) L235P probably damaging Het
Lama2 C T 10: 27,204,181 (GRCm39) E486K possibly damaging Het
Lhx6 A T 2: 35,981,145 (GRCm39) W266R probably benign Het
Mettl15 A T 2: 109,104,810 (GRCm39) L65* probably null Het
Mocos A G 18: 24,812,594 (GRCm39) Q496R probably benign Het
Neb T C 2: 52,203,847 (GRCm39) S285G probably damaging Het
Nos3 A G 5: 24,582,611 (GRCm39) N613S probably benign Het
Nphs2 G A 1: 156,138,386 (GRCm39) R10Q probably benign Het
Or2ag16 A G 7: 106,352,430 (GRCm39) L55P probably damaging Het
Or4x13 C A 2: 90,231,716 (GRCm39) T237N probably damaging Het
Osbpl10 T C 9: 114,996,294 (GRCm39) C119R probably damaging Het
Otop1 T C 5: 38,445,274 (GRCm39) V144A probably benign Het
Ovca2 A G 11: 75,068,862 (GRCm39) V179A possibly damaging Het
Pcdha11 A G 18: 37,140,527 (GRCm39) T719A probably benign Het
Pcdhga1 A G 18: 37,973,084 (GRCm39) N900D probably damaging Het
Pcdhga8 A T 18: 37,859,163 (GRCm39) Q73L probably damaging Het
Pclo A G 5: 14,590,204 (GRCm39) K835E unknown Het
Psmd2 T A 16: 20,473,412 (GRCm39) Y158N probably damaging Het
Pygl A G 12: 70,243,822 (GRCm39) V631A probably damaging Het
Rhoq A T 17: 87,304,405 (GRCm39) I179F Het
Rnf26rt T C 6: 76,473,566 (GRCm39) D350G probably benign Het
Rps6kb1 T C 11: 86,404,381 (GRCm39) I257M probably damaging Het
Sall3 G A 18: 81,017,124 (GRCm39) A268V probably benign Het
Serinc4 G A 2: 121,287,250 (GRCm39) probably benign Het
Slc27a2 T A 2: 126,429,807 (GRCm39) M605K probably damaging Het
Slc5a7 T C 17: 54,594,389 (GRCm39) I197M probably benign Het
Slc6a7 A G 18: 61,133,649 (GRCm39) Y516H probably damaging Het
Spag16 A G 1: 69,963,007 (GRCm39) T385A unknown Het
Stat6 G A 10: 127,493,479 (GRCm39) R600H probably damaging Het
Stk32b A G 5: 37,786,344 (GRCm39) V40A probably damaging Het
Sv2c T A 13: 96,224,755 (GRCm39) I185L probably benign Het
Syne2 T A 12: 76,156,703 (GRCm39) L2115H probably damaging Het
Tas2r121 T C 6: 132,677,492 (GRCm39) E160G probably benign Het
Tle1 G T 4: 72,036,753 (GRCm39) T727K probably benign Het
Tmem79 A T 3: 88,240,764 (GRCm39) D61E probably benign Het
Tnrc18 C A 5: 142,773,602 (GRCm39) R409L Het
Tnrc6a C A 7: 122,789,176 (GRCm39) P1665Q probably damaging Het
Tns2 C A 15: 102,021,416 (GRCm39) P1027Q probably damaging Het
Trav7-5 C G 14: 53,768,615 (GRCm39) A61G probably benign Het
Ttn A G 2: 76,745,255 (GRCm39) S5265P possibly damaging Het
Tuba1c T A 15: 98,935,737 (GRCm39) Y399* probably null Het
Vav2 A T 2: 27,172,394 (GRCm39) I504N probably damaging Het
Vmn2r5 G T 3: 64,398,938 (GRCm39) C680* probably null Het
Zfp644 G C 5: 106,785,829 (GRCm39) S239R probably benign Het
Zfp954 C T 7: 7,118,933 (GRCm39) G204S probably damaging Het
Zswim8 C T 14: 20,769,588 (GRCm39) T1265I probably damaging Het
Other mutations in Or51i2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Or51i2 APN 7 103,689,051 (GRCm39) missense probably damaging 1.00
IGL01515:Or51i2 APN 7 103,689,183 (GRCm39) missense probably benign 0.03
IGL01940:Or51i2 APN 7 103,689,129 (GRCm39) missense probably damaging 1.00
IGL02209:Or51i2 APN 7 103,689,663 (GRCm39) missense probably damaging 1.00
IGL02486:Or51i2 APN 7 103,689,617 (GRCm39) missense probably damaging 1.00
R2075:Or51i2 UTSW 7 103,689,180 (GRCm39) missense probably damaging 0.97
R4110:Or51i2 UTSW 7 103,689,609 (GRCm39) missense probably damaging 1.00
R7786:Or51i2 UTSW 7 103,689,930 (GRCm39) missense unknown
R8133:Or51i2 UTSW 7 103,689,122 (GRCm39) missense probably benign 0.03
R9195:Or51i2 UTSW 7 103,689,345 (GRCm39) missense probably damaging 0.99
R9328:Or51i2 UTSW 7 103,689,268 (GRCm39) missense
R9375:Or51i2 UTSW 7 103,689,273 (GRCm39) missense possibly damaging 0.64
R9396:Or51i2 UTSW 7 103,689,720 (GRCm39) missense probably benign 0.11
R9525:Or51i2 UTSW 7 103,689,820 (GRCm39) missense possibly damaging 0.86
R9622:Or51i2 UTSW 7 103,689,522 (GRCm39) missense probably damaging 1.00
Z1177:Or51i2 UTSW 7 103,688,934 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- TTGCTTCTCATGAGGAACGCC -3'
(R):5'- TGGTCTCATAGCTTGCCATC -3'

Sequencing Primer
(F):5'- GCCTTAAAGCTCTCAACACATGTG -3'
(R):5'- GGTCTCATAGCTTGCCATCTAATTAC -3'
Posted On 2022-02-07