Incidental Mutation 'R9207:Ifnz'
ID 698571
Institutional Source Beutler Lab
Gene Symbol Ifnz
Ensembl Gene ENSMUSG00000096854
Gene Name interferon zeta
Synonyms Lmtn, 6030405N23Rik, BGIF
MMRRC Submission 068981-MU
Accession Numbers
Essential gene? Not available question?
Stock # R9207 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 88700368-88701829 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 88701525 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 168 (V168A)
Ref Sequence ENSEMBL: ENSMUSP00000100775 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105144] [ENSMUST00000179372] [ENSMUST00000179425]
AlphaFold Q8BQT1
Predicted Effect probably benign
Transcript: ENSMUST00000105144
AA Change: V168A

PolyPhen 2 Score 0.264 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000100775
Gene: ENSMUSG00000096854
AA Change: V168A

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IFabd 58 170 1.18e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179372
SMART Domains Protein: ENSMUSP00000140435
Gene: ENSMUSG00000099545

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IFabd 58 170 4.8e-13 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000179425
SMART Domains Protein: ENSMUSP00000135918
Gene: ENSMUSG00000096591

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IFabd 58 170 2.91e-12 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (43/43)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat T G 8: 60,979,657 (GRCm39) I173S probably damaging Het
Actrt2 T A 4: 154,751,920 (GRCm39) H72L probably benign Het
Adgrf1 A G 17: 43,621,164 (GRCm39) D467G probably benign Het
Axdnd1 A G 1: 156,215,616 (GRCm39) L226P Het
Begain T C 12: 108,999,250 (GRCm39) D507G probably damaging Het
Bsdc1 A G 4: 129,362,830 (GRCm39) N134S probably benign Het
Ccdc39 C A 3: 33,886,706 (GRCm39) E301* probably null Het
Cdh23 A G 10: 60,243,210 (GRCm39) V1055A probably damaging Het
Efcab8 A G 2: 153,656,339 (GRCm39) D591G unknown Het
Fibcd1 G A 2: 31,706,455 (GRCm39) R459C probably damaging Het
Frem3 T G 8: 81,340,071 (GRCm39) V788G possibly damaging Het
Ftcd A T 10: 76,422,973 (GRCm39) I423L probably benign Het
Gad1 G A 2: 70,409,546 (GRCm39) probably null Het
Gm8229 T C 14: 44,606,238 (GRCm39) L156P Het
Grm7 T C 6: 111,335,874 (GRCm39) Y762H probably damaging Het
Hectd4 T A 5: 121,433,496 (GRCm39) V937D possibly damaging Het
Irx4 C G 13: 73,416,649 (GRCm39) C348W probably damaging Het
Itgb4 G T 11: 115,897,923 (GRCm39) G1603V probably damaging Het
Krt32 A G 11: 99,977,580 (GRCm39) V162A possibly damaging Het
Mpped2 A G 2: 106,697,319 (GRCm39) T265A probably benign Het
Npas3 T C 12: 54,114,818 (GRCm39) L580P possibly damaging Het
Or4f47 G A 2: 111,972,397 (GRCm39) V36M probably benign Het
Or5b109 A T 19: 13,212,400 (GRCm39) Q262L possibly damaging Het
Or8b54 G A 9: 38,686,960 (GRCm39) M136I possibly damaging Het
Plec A G 15: 76,058,117 (GRCm39) L3940P probably damaging Het
Pum2 T C 12: 8,763,904 (GRCm39) Y283H probably damaging Het
Rad54l T C 4: 115,967,215 (GRCm39) H281R probably damaging Het
Rftn2 T A 1: 55,224,149 (GRCm39) Q397L probably damaging Het
Rnf166 C T 8: 123,195,068 (GRCm39) A151T probably benign Het
Setdb1 A T 3: 95,246,113 (GRCm39) I604N possibly damaging Het
Smr2 A G 5: 88,256,726 (GRCm39) T135A unknown Het
Snai2 C A 16: 14,524,946 (GRCm39) H151N possibly damaging Het
Spag6l A T 16: 16,598,492 (GRCm39) I333N probably benign Het
Spta1 A G 1: 174,039,139 (GRCm39) T1161A probably benign Het
Sult2a1 G T 7: 13,566,627 (GRCm39) A116E probably benign Het
Tas2r120 T A 6: 132,634,626 (GRCm39) L236* probably null Het
Tchhl1 T A 3: 93,377,819 (GRCm39) N174K possibly damaging Het
Tex15 T C 8: 34,065,784 (GRCm39) L1738P probably damaging Het
Timp4 T C 6: 115,224,270 (GRCm39) Y133C probably damaging Het
Tmem25 A G 9: 44,710,476 (GRCm39) probably null Het
Tubd1 A T 11: 86,456,537 (GRCm39) T399S probably benign Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Zfp110 A T 7: 12,582,485 (GRCm39) I378L probably benign Het
Other mutations in Ifnz
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01374:Ifnz APN 4 88,701,578 (GRCm39) unclassified probably benign
IGL01870:Ifnz APN 4 88,701,548 (GRCm39) missense possibly damaging 0.78
IGL02705:Ifnz APN 4 88,701,574 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TTTGACACAGAGGCCAGCAG -3'
(R):5'- CGAAGTTCTTTGTCGATGCACG -3'

Sequencing Primer
(F):5'- AGCTGCCTGGCACGAGAG -3'
(R):5'- GTCGATGCACGCCCATTTCG -3'
Posted On 2022-02-07