Incidental Mutation 'R9298:Or5b95'
ID 704762
Institutional Source Beutler Lab
Gene Symbol Or5b95
Ensembl Gene ENSMUSG00000045030
Gene Name olfactory receptor family 5 subfamily B member 95
Synonyms MOR202-8, Olfr1443, GA_x6K02T2RE5P-3006492-3007430
MMRRC Submission 068963-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.052) question?
Stock # R9298 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 12655530-12661215 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 12658190 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Stop codon at position 239 (C239*)
Ref Sequence ENSEMBL: ENSMUSP00000059886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049724] [ENSMUST00000207341] [ENSMUST00000208494] [ENSMUST00000208657] [ENSMUST00000213486] [ENSMUST00000215134]
AlphaFold Q8VFW8
Predicted Effect probably null
Transcript: ENSMUST00000049724
AA Change: C239*
SMART Domains Protein: ENSMUSP00000059886
Gene: ENSMUSG00000045030
AA Change: C239*

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 2.4e-50 PFAM
Pfam:7TM_GPCR_Srsx 33 303 1.5e-6 PFAM
Pfam:7tm_1 39 288 8.6e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207341
Predicted Effect probably benign
Transcript: ENSMUST00000208494
Predicted Effect probably benign
Transcript: ENSMUST00000208657
Predicted Effect probably null
Transcript: ENSMUST00000213486
AA Change: C239*
Predicted Effect probably null
Transcript: ENSMUST00000215134
AA Change: C239*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030K09Rik C A 8: 73,198,923 (GRCm39) A110D probably benign Het
4930407I10Rik A G 15: 81,947,615 (GRCm39) E504G probably benign Het
Apbb2 T C 5: 66,609,018 (GRCm39) K210E probably benign Het
Arhgef37 G T 18: 61,651,072 (GRCm39) A151D probably damaging Het
Btaf1 A G 19: 36,964,114 (GRCm39) Y895C probably benign Het
Catsperb A G 12: 101,560,600 (GRCm39) I864V possibly damaging Het
Cdhr17 T A 5: 16,996,855 (GRCm39) C10* probably null Het
Cmklr1 G C 5: 113,752,043 (GRCm39) H319Q probably benign Het
Col18a1 G A 10: 76,893,204 (GRCm39) T1057M probably damaging Het
Col1a2 T A 6: 4,515,260 (GRCm39) probably null Het
Col6a4 A G 9: 105,945,534 (GRCm39) I860T probably damaging Het
Csmd3 A C 15: 47,617,187 (GRCm39) H1000Q Het
Cyp4a29 T A 4: 115,108,395 (GRCm39) M373K probably damaging Het
Dnhd1 A G 7: 105,333,173 (GRCm39) E215G probably damaging Het
Dop1b A G 16: 93,597,087 (GRCm39) E1972G probably damaging Het
Dusp19 T C 2: 80,447,729 (GRCm39) M1T probably null Het
Eif4b A G 15: 101,990,449 (GRCm39) T18A possibly damaging Het
Exosc6 G A 8: 111,783,513 (GRCm39) A171T probably damaging Het
Fau G A 19: 6,108,297 (GRCm39) R6H probably benign Het
Flrt3 T C 2: 140,501,879 (GRCm39) D583G probably damaging Het
Fpgt A T 3: 154,792,695 (GRCm39) L444* probably null Het
Gm10226 A G 17: 21,910,768 (GRCm39) E1G probably null Het
Gm14443 A T 2: 175,011,869 (GRCm39) C192* probably null Het
Gm4353 T A 7: 115,682,843 (GRCm39) N246I probably benign Het
Igfn1 A G 1: 135,926,327 (GRCm39) L41P probably benign Het
Iigp1 T G 18: 60,523,063 (GRCm39) D60E probably benign Het
Kcnt2 T A 1: 140,353,035 (GRCm39) V248D probably damaging Het
Kctd14 A G 7: 97,107,243 (GRCm39) K166R probably benign Het
Kdm4d G A 9: 14,375,336 (GRCm39) T174M probably damaging Het
Kdm5b T C 1: 134,528,493 (GRCm39) probably null Het
Maz CGCGGCCTCGGCGGCTGGTGCGG CGCGG 7: 126,625,075 (GRCm39) probably benign Het
Mrtfb A G 16: 13,202,082 (GRCm39) Q115R probably benign Het
Nox4 G A 7: 87,025,448 (GRCm39) R525Q probably benign Het
Or10a5 A T 7: 106,635,640 (GRCm39) I93F probably damaging Het
Or2h1b A T 17: 37,462,572 (GRCm39) V97D probably damaging Het
Pigc C T 1: 161,798,032 (GRCm39) R5C probably benign Het
Plekhm2 C A 4: 141,356,829 (GRCm39) M771I probably benign Het
Runx1 T A 16: 92,441,147 (GRCm39) T221S possibly damaging Het
S100pbp A G 4: 129,044,847 (GRCm39) Y363H probably damaging Het
Sema5a A G 15: 32,619,040 (GRCm39) T523A probably benign Het
Slc38a8 A G 8: 120,212,851 (GRCm39) F270S possibly damaging Het
Slc4a1ap T C 5: 31,693,538 (GRCm39) S491P probably damaging Het
Slc66a2 T C 18: 80,300,300 (GRCm39) L57P probably damaging Het
Slc7a6 T C 8: 106,922,534 (GRCm39) V440A probably damaging Het
Sobp A T 10: 42,898,902 (GRCm39) C228S probably damaging Het
Svop G A 5: 114,168,231 (GRCm39) T456M probably benign Het
Synrg A G 11: 83,900,278 (GRCm39) D750G probably damaging Het
Syt14 C A 1: 192,612,944 (GRCm39) E336* probably null Het
Tcp11l1 C T 2: 104,528,897 (GRCm39) V134I possibly damaging Het
Tex51 T C 18: 32,594,029 (GRCm39) R110G possibly damaging Het
Tle3 T A 9: 61,319,562 (GRCm39) H443Q possibly damaging Het
Unc13a C T 8: 72,108,335 (GRCm39) R506Q possibly damaging Het
Vmn1r121 A C 7: 20,832,344 (GRCm39) V32G probably damaging Het
Wiz A G 17: 32,580,714 (GRCm39) F246L probably benign Het
Zfp672 A T 11: 58,220,590 (GRCm39) M3K unknown Het
Zfp709 A T 8: 72,644,648 (GRCm39) E692D possibly damaging Het
Zglp1 A T 9: 20,977,482 (GRCm39) L111Q probably benign Het
Other mutations in Or5b95
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01322:Or5b95 APN 19 12,658,113 (GRCm39) missense probably benign 0.02
IGL01392:Or5b95 APN 19 12,658,167 (GRCm39) missense probably benign 0.42
IGL01470:Or5b95 APN 19 12,658,035 (GRCm39) missense possibly damaging 0.91
IGL03106:Or5b95 APN 19 12,658,287 (GRCm39) missense possibly damaging 0.61
R2036:Or5b95 UTSW 19 12,658,165 (GRCm39) missense probably damaging 1.00
R3942:Or5b95 UTSW 19 12,657,768 (GRCm39) missense probably benign 0.03
R5459:Or5b95 UTSW 19 12,657,799 (GRCm39) missense probably damaging 1.00
R5643:Or5b95 UTSW 19 12,658,336 (GRCm39) missense probably damaging 1.00
R5644:Or5b95 UTSW 19 12,658,336 (GRCm39) missense probably damaging 1.00
R6879:Or5b95 UTSW 19 12,658,135 (GRCm39) missense probably benign 0.18
R6991:Or5b95 UTSW 19 12,658,112 (GRCm39) missense probably benign 0.14
R7084:Or5b95 UTSW 19 12,658,198 (GRCm39) missense probably damaging 0.98
R7352:Or5b95 UTSW 19 12,658,115 (GRCm39) missense possibly damaging 0.78
R7749:Or5b95 UTSW 19 12,657,576 (GRCm39) missense probably benign 0.10
R8133:Or5b95 UTSW 19 12,657,844 (GRCm39) missense probably damaging 1.00
R8163:Or5b95 UTSW 19 12,657,552 (GRCm39) missense probably benign 0.01
R8941:Or5b95 UTSW 19 12,657,471 (GRCm39) start gained probably benign
R9109:Or5b95 UTSW 19 12,658,190 (GRCm39) nonsense probably null
R9176:Or5b95 UTSW 19 12,657,600 (GRCm39) missense probably benign 0.14
R9414:Or5b95 UTSW 19 12,657,712 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGTCCAATGTGGTCCATCAC -3'
(R):5'- TCCACAACTTTCTTGAATGCAC -3'

Sequencing Primer
(F):5'- ATGTTCCAGCCGTCATGG -3'
(R):5'- ACAACTTTCTTGAATGCACTTTTCAC -3'
Posted On 2022-03-25