Incidental Mutation 'R9395:Tgtp2'
ID 710796
Institutional Source Beutler Lab
Gene Symbol Tgtp2
Ensembl Gene ENSMUSG00000078921
Gene Name T cell specific GTPase 2
Synonyms
MMRRC Submission 068965-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9395 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 48948021-48955033 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 48950083 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 163 (M163K)
Ref Sequence ENSEMBL: ENSMUSP00000045025 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046745] [ENSMUST00000056759] [ENSMUST00000102785] [ENSMUST00000179282]
AlphaFold Q3T9E4
Q62293
Predicted Effect probably benign
Transcript: ENSMUST00000046745
AA Change: M163K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000045025
Gene: ENSMUSG00000078921
AA Change: M163K

DomainStartEndE-ValueType
Pfam:IIGP 22 395 2.9e-178 PFAM
Pfam:MMR_HSR1 58 217 5.1e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000056759
SMART Domains Protein: ENSMUSP00000058544
Gene: ENSMUSG00000040328

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 4 227 5.7e-7 PFAM
Pfam:7tm_1 10 259 1.5e-33 PFAM
Pfam:7tm_4 108 252 1.7e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102785
SMART Domains Protein: ENSMUSP00000099846
Gene: ENSMUSG00000040328

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 4 227 5.7e-7 PFAM
Pfam:7tm_1 10 259 1.5e-33 PFAM
Pfam:7tm_4 108 252 1.7e-46 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000179282
SMART Domains Protein: ENSMUSP00000136647
Gene: ENSMUSG00000040328

DomainStartEndE-ValueType
Pfam:7tm_4 1 276 3.6e-51 PFAM
Pfam:7TM_GPCR_Srsx 4 227 5.7e-7 PFAM
Pfam:7tm_1 10 259 3.8e-26 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh7 A T 3: 137,927,477 (GRCm39) I8F probably damaging Het
Ak1 A G 2: 32,523,708 (GRCm39) D207G probably damaging Het
Arhgef28 TAA TA 13: 98,103,692 (GRCm39) probably null Het
Cacna2d1 T C 5: 16,140,013 (GRCm39) M1T probably null Het
Cgnl1 T C 9: 71,539,954 (GRCm39) M1097V probably benign Het
Chrm2 G A 6: 36,501,196 (GRCm39) G351D possibly damaging Het
Cntnap2 C A 6: 45,978,244 (GRCm39) R300S probably damaging Het
Cpa5 T C 6: 30,631,280 (GRCm39) L398P probably damaging Het
Csl T A 10: 99,595,020 (GRCm39) N15I probably damaging Het
Csrp3 A T 7: 48,489,231 (GRCm39) V17D probably damaging Het
Cyb5d1 T C 11: 69,284,531 (GRCm39) N207S probably benign Het
Ecel1 A T 1: 87,082,350 (GRCm39) I121N probably damaging Het
Elapor2 T C 5: 9,477,822 (GRCm39) S407P probably benign Het
Gad2 T C 2: 22,514,879 (GRCm39) L119P probably damaging Het
Gpr139 A T 7: 118,743,811 (GRCm39) M258K probably benign Het
Hhipl1 A G 12: 108,285,009 (GRCm39) Y454C probably damaging Het
Ifitm10 A T 7: 141,924,704 (GRCm39) V45D probably damaging Het
Lpl T A 8: 69,353,952 (GRCm39) I431N probably damaging Het
Myh14 A T 7: 44,274,584 (GRCm39) W1235R possibly damaging Het
Nacc2 A G 2: 25,950,128 (GRCm39) V536A probably damaging Het
Nalf2 C T X: 98,889,097 (GRCm39) R321W probably damaging Het
Neu4 T A 1: 93,950,218 (GRCm39) L59Q probably damaging Het
Obscn T A 11: 58,946,871 (GRCm39) I4088F probably damaging Het
Or8b37 T C 9: 37,959,136 (GRCm39) V206A probably damaging Het
Otof G A 5: 30,532,976 (GRCm39) R1589C probably damaging Het
Pla2g3 C T 11: 3,440,952 (GRCm39) Q306* probably null Het
Pramel12 A G 4: 143,145,605 (GRCm39) E358G probably benign Het
Prl6a1 A T 13: 27,499,400 (GRCm39) H56L possibly damaging Het
Rev3l T C 10: 39,735,219 (GRCm39) probably null Het
Rims2 T A 15: 39,155,664 (GRCm39) F115Y probably damaging Het
Spcs2 T C 7: 99,488,924 (GRCm39) T221A probably benign Het
Stmn1 C T 4: 134,200,146 (GRCm39) A73V probably damaging Het
Syne1 T A 10: 5,261,728 (GRCm39) K2250I probably damaging Het
Tcf7l2 C T 19: 55,920,200 (GRCm39) Q578* probably null Het
Ttn T C 2: 76,542,006 (GRCm39) N33660S probably benign Het
Txndc11 A G 16: 10,902,683 (GRCm39) F655L probably benign Het
Ubtf G A 11: 102,205,026 (GRCm39) T86I probably damaging Het
Vmn2r89 T A 14: 51,693,783 (GRCm39) W378R probably damaging Het
Zic1 T A 9: 91,247,070 (GRCm39) M1L probably benign Het
Other mutations in Tgtp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02450:Tgtp2 APN 11 48,950,317 (GRCm39) missense probably benign 0.35
Aha2016 UTSW 11 48,950,179 (GRCm39) missense probably damaging 1.00
R1498:Tgtp2 UTSW 11 48,950,165 (GRCm39) missense probably damaging 1.00
R1779:Tgtp2 UTSW 11 48,949,751 (GRCm39) missense probably benign
R1958:Tgtp2 UTSW 11 48,949,919 (GRCm39) missense probably damaging 1.00
R2402:Tgtp2 UTSW 11 48,949,957 (GRCm39) missense probably benign 0.00
R2962:Tgtp2 UTSW 11 48,950,363 (GRCm39) missense probably damaging 1.00
R4124:Tgtp2 UTSW 11 48,950,238 (GRCm39) missense probably damaging 0.99
R4484:Tgtp2 UTSW 11 48,950,179 (GRCm39) missense probably damaging 1.00
R4602:Tgtp2 UTSW 11 48,949,811 (GRCm39) missense probably damaging 1.00
R4772:Tgtp2 UTSW 11 48,949,811 (GRCm39) missense probably damaging 1.00
R4965:Tgtp2 UTSW 11 48,950,237 (GRCm39) missense probably damaging 1.00
R5263:Tgtp2 UTSW 11 48,950,090 (GRCm39) missense probably damaging 1.00
R5426:Tgtp2 UTSW 11 48,950,083 (GRCm39) missense probably benign
R7128:Tgtp2 UTSW 11 48,950,135 (GRCm39) missense possibly damaging 0.77
R7147:Tgtp2 UTSW 11 48,950,135 (GRCm39) missense probably damaging 1.00
R7188:Tgtp2 UTSW 11 48,950,135 (GRCm39) missense probably damaging 1.00
R8334:Tgtp2 UTSW 11 48,949,721 (GRCm39) missense probably benign 0.05
R9306:Tgtp2 UTSW 11 48,949,865 (GRCm39) missense probably benign 0.00
Z1177:Tgtp2 UTSW 11 48,950,178 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- AATACGTGACGCTTGTGGGC -3'
(R):5'- CCCAACGTGACAATATGGGAC -3'

Sequencing Primer
(F):5'- TCCAGCTTTGGGAAGTCATAC -3'
(R):5'- TGACAATATGGGACCTGCCTG -3'
Posted On 2022-04-18