Incidental Mutation 'R9742:Dusp26'
ID 731878
Institutional Source Beutler Lab
Gene Symbol Dusp26
Ensembl Gene ENSMUSG00000039661
Gene Name dual specificity phosphatase 26
Synonyms 2310043K02Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9742 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 31579555-31587074 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 31584198 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 102 (T102S)
Ref Sequence ENSEMBL: ENSMUSP00000046794 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000036631] [ENSMUST00000161713] [ENSMUST00000170204]
AlphaFold Q9D700
Predicted Effect probably benign
Transcript: ENSMUST00000036631
AA Change: T102S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000046794
Gene: ENSMUSG00000039661
AA Change: T102S

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161713
AA Change: T102S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000124949
Gene: ENSMUSG00000039661
AA Change: T102S

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000170204
AA Change: T102S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000126397
Gene: ENSMUSG00000039661
AA Change: T102S

DomainStartEndE-ValueType
DSPc 61 204 3.1e-39 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.7%
  • 10x: 99.3%
  • 20x: 98.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tyrosine phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acan T G 7: 78,749,115 (GRCm39) S1295R probably benign Het
Acsf2 C A 11: 94,463,963 (GRCm39) V74L probably benign Het
Actrt3 T C 3: 30,652,434 (GRCm39) Y220C probably damaging Het
Adgrl2 A G 3: 148,541,986 (GRCm39) probably null Het
Ak2 T A 4: 128,901,961 (GRCm39) D211E possibly damaging Het
Atp4b G A 8: 13,440,097 (GRCm39) T83I probably damaging Het
Brat1 A G 5: 140,703,912 (GRCm39) T722A probably benign Het
Cfap65 T C 1: 74,943,840 (GRCm39) Y1557C probably benign Het
Cmya5 T C 13: 93,231,935 (GRCm39) D1051G possibly damaging Het
Cuedc2 A G 19: 46,319,727 (GRCm39) probably null Het
Dtnb A T 12: 3,736,740 (GRCm39) K293N possibly damaging Het
Epg5 T A 18: 78,024,170 (GRCm39) L1079H probably damaging Het
Epha6 T C 16: 60,026,065 (GRCm39) Y459C probably damaging Het
Fam89b A T 19: 5,779,330 (GRCm39) S76T probably benign Het
Fbxo33 A G 12: 59,251,682 (GRCm39) S278P probably damaging Het
Fndc3a C A 14: 72,777,693 (GRCm39) E1171* probably null Het
Grip1 G A 10: 119,874,569 (GRCm39) E778K possibly damaging Het
Il17ra T A 6: 120,458,466 (GRCm39) I539N probably damaging Het
Khdc1c T G 1: 21,439,945 (GRCm39) H165Q probably benign Het
Ldb1 A G 19: 46,023,858 (GRCm39) probably null Het
Lrrc27 C T 7: 138,806,229 (GRCm39) A298V probably benign Het
Lsr CTCTTCTTCTTCTTCTTC CTCTTCTTCTTCTTC 7: 30,657,492 (GRCm39) probably benign Het
Mpi A G 9: 57,452,606 (GRCm39) C309R probably damaging Het
Mrtfa G A 15: 80,901,180 (GRCm39) A472V possibly damaging Het
Mtcl3 C A 10: 29,024,394 (GRCm39) Q437K probably benign Het
Muc17 A G 5: 137,167,127 (GRCm39) Y276H Het
Myh6 T A 14: 55,194,056 (GRCm39) M778L probably benign Het
Nmnat1 T A 4: 149,553,338 (GRCm39) E258V probably damaging Het
Or10ag53 T C 2: 87,082,376 (GRCm39) F32L probably benign Het
Or5b108 T C 19: 13,168,769 (GRCm39) V246A probably damaging Het
Pik3c2b A G 1: 133,022,487 (GRCm39) E1143G probably damaging Het
Plch2 C T 4: 155,082,912 (GRCm39) D579N probably damaging Het
Slc22a19 T C 19: 7,688,281 (GRCm39) Q93R probably benign Het
Slc9c1 T A 16: 45,400,616 (GRCm39) I742N probably damaging Het
Smarcc2 A G 10: 128,297,222 (GRCm39) Y38C probably damaging Het
Strbp T C 2: 37,515,268 (GRCm39) T253A probably damaging Het
Trim40 A G 17: 37,199,902 (GRCm39) S59P possibly damaging Het
Trpm6 G T 19: 18,800,766 (GRCm39) V827L probably benign Het
Unc5d A G 8: 29,156,792 (GRCm39) probably null Het
Vmn2r118 T C 17: 55,918,009 (GRCm39) T168A probably damaging Het
Wdfy4 G A 14: 32,809,987 (GRCm39) H1745Y Het
Xrra1 A G 7: 99,563,660 (GRCm39) D549G probably benign Het
Zhx2 A G 15: 57,686,806 (GRCm39) E725G probably benign Het
Zzef1 G A 11: 72,749,179 (GRCm39) R889H probably benign Het
Other mutations in Dusp26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00964:Dusp26 APN 8 31,584,136 (GRCm39) missense probably benign 0.01
R0037:Dusp26 UTSW 8 31,586,388 (GRCm39) missense unknown
R0394:Dusp26 UTSW 8 31,581,987 (GRCm39) missense probably benign 0.16
R1792:Dusp26 UTSW 8 31,581,963 (GRCm39) missense probably benign 0.01
R4454:Dusp26 UTSW 8 31,584,172 (GRCm39) missense probably damaging 0.99
R4854:Dusp26 UTSW 8 31,584,165 (GRCm39) missense probably damaging 1.00
R5638:Dusp26 UTSW 8 31,584,169 (GRCm39) missense probably damaging 1.00
R6212:Dusp26 UTSW 8 31,584,252 (GRCm39) missense probably damaging 1.00
R6337:Dusp26 UTSW 8 31,586,325 (GRCm39) missense probably damaging 1.00
R7083:Dusp26 UTSW 8 31,581,747 (GRCm39) intron probably benign
R8754:Dusp26 UTSW 8 31,581,805 (GRCm39) intron probably benign
R8945:Dusp26 UTSW 8 31,586,367 (GRCm39) missense unknown
R8970:Dusp26 UTSW 8 31,584,232 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACCCGAGTCACTAGCCATTTTC -3'
(R):5'- GGGCTTCTAAATGCCACACC -3'

Sequencing Primer
(F):5'- TTCCACCTCGTTAGTAAGTACAGCAG -3'
(R):5'- AATGCCACACCTGATTTTTATTTTTC -3'
Posted On 2022-11-14