Incidental Mutation 'R0798:Ptp4a1'
ID 76473
Institutional Source Beutler Lab
Gene Symbol Ptp4a1
Ensembl Gene ENSMUSG00000026064
Gene Name protein tyrosine phosphatase 4a1
Synonyms Prl-1
MMRRC Submission 038978-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0798 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 30979384-30988846 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) A to T at 30984005 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000143884 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027232] [ENSMUST00000076587] [ENSMUST00000202889]
AlphaFold Q63739
Predicted Effect probably benign
Transcript: ENSMUST00000027232
SMART Domains Protein: ENSMUSP00000027232
Gene: ENSMUSG00000026064

DomainStartEndE-ValueType
Pfam:DSPc 26 153 2.8e-10 PFAM
Pfam:Y_phosphatase 51 151 1.2e-7 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000076587
SMART Domains Protein: ENSMUSP00000110861
Gene: ENSMUSG00000026064

DomainStartEndE-ValueType
Pfam:DSPc 25 155 5.8e-12 PFAM
Pfam:Y_phosphatase 52 152 3.8e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124445
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130934
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153681
Predicted Effect probably benign
Transcript: ENSMUST00000202889
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.4%
  • 20x: 95.2%
Validation Efficiency 100% (30/30)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]
PHENOTYPE: Single homozygous KO leads to an increase in preweaning lethality. Homozygous KO in combination with homozygous KO of Ptp4a2 (Ptp4a2Gt(AQ0673)Wtsi) is embryonic lethal. Heterozygous-homozygous and homozygous-heterozygous KO combinations lead to reduced male fertility, with the het-hom combination exacerbating the phenotype of single homozygous Ptp4a2 KO. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T C 9: 124,057,789 (GRCm39) probably benign Het
4930579C12Rik T A 9: 89,034,880 (GRCm39) noncoding transcript Het
Baz2a T A 10: 127,962,192 (GRCm39) probably benign Het
Bcar3 T C 3: 122,318,948 (GRCm39) V695A probably benign Het
C130074G19Rik G A 1: 184,614,873 (GRCm39) probably benign Het
Cmas T C 6: 142,710,382 (GRCm39) V167A probably damaging Het
Crppa G A 12: 36,571,998 (GRCm39) R302H probably benign Het
Cyp3a25 T C 5: 145,928,343 (GRCm39) E234G probably damaging Het
Gopc C T 10: 52,234,907 (GRCm39) G79S probably damaging Het
Herc2 T A 7: 55,785,431 (GRCm39) probably null Het
Iqca1 C A 1: 90,070,453 (GRCm39) G133V probably null Het
Kcnq5 A G 1: 22,031,399 (GRCm39) probably null Het
Lpp G T 16: 24,790,622 (GRCm39) G29* probably null Het
Ly6g6e T C 17: 35,297,017 (GRCm39) F86S probably benign Het
Myo5c T C 9: 75,165,266 (GRCm39) F358S probably damaging Het
Nlgn1 A G 3: 25,488,410 (GRCm39) Y613H probably benign Het
Or4k38 T C 2: 111,165,689 (GRCm39) I245V probably benign Het
Or7e178 A T 9: 20,225,495 (GRCm39) Y232* probably null Het
Plekhn1 T A 4: 156,312,720 (GRCm39) D46V probably damaging Het
Rab23 A T 1: 33,773,908 (GRCm39) I123F probably damaging Het
Samd4b G A 7: 28,101,048 (GRCm39) probably benign Het
Shisa4 G A 1: 135,300,886 (GRCm39) probably benign Het
Slc39a11 C T 11: 113,414,330 (GRCm39) A90T probably benign Het
Tas1r2 T C 4: 139,397,024 (GRCm39) Y788H probably damaging Het
Tasor T A 14: 27,198,593 (GRCm39) F1308L probably damaging Het
Tial1 C T 7: 128,045,602 (GRCm39) M327I probably benign Het
Ubr2 C T 17: 47,280,102 (GRCm39) probably benign Het
Utp4 T C 8: 107,648,858 (GRCm39) S630P probably benign Het
Vmn1r212 T C 13: 23,067,868 (GRCm39) N155S probably damaging Het
Zmym6 C T 4: 126,997,316 (GRCm39) P312S probably benign Het
Other mutations in Ptp4a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0972:Ptp4a1 UTSW 1 30,984,080 (GRCm39) missense possibly damaging 0.94
R2696:Ptp4a1 UTSW 1 30,985,213 (GRCm39) missense probably benign 0.01
R2901:Ptp4a1 UTSW 1 30,982,385 (GRCm39) missense possibly damaging 0.94
R4796:Ptp4a1 UTSW 1 30,983,019 (GRCm39) missense probably damaging 0.97
R5407:Ptp4a1 UTSW 1 30,984,044 (GRCm39) missense probably benign 0.34
R9257:Ptp4a1 UTSW 1 30,985,346 (GRCm39) unclassified probably benign
Z1176:Ptp4a1 UTSW 1 30,983,650 (GRCm39) missense probably benign 0.09
Predicted Primers PCR Primer
(F):5'- TGCGACACAATGGACAGCAATACAG -3'
(R):5'- GGCACAGCAAGAATACGGTTCCAG -3'

Sequencing Primer
(F):5'- TTAGCCAGTCATCGACAATCTG -3'
(R):5'- AGAATACGGTTCCAGAAACCTC -3'
Posted On 2013-10-16