Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01391:Tex261'

79211

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tex261

Ensembl Gene

ENSMUSG00000014748

Gene Name

testis expressed gene 261

Synonyms

3110001O07Rik, TEG-261

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.206) question?

Stock #

IGL01391

Quality Score

Status

Chromosome

Chromosomal Location

83745867-83752795 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 83748222 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 180 (V180A)

Ref Sequence

ENSEMBL: ENSMUSP00000014892 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000014891] [ENSMUST00000014892] [ENSMUST00000206496]

AlphaFold

Q62302

Predicted Effect

probably benign
Transcript: ENSMUST00000014891

SMART Domains

Protein: ENSMUSP00000014891
Gene: ENSMUSG00000014747

Domain	Start	End	E-Value	Type
low complexity region	12	27	N/A	INTRINSIC
ANK	110	140	1.15e0	SMART
ANK	144	177	1.63e0	SMART
ANK	181	210	1.78e-6	SMART
Blast:ANK	215	243	6e-12	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000014892
AA Change: V180A

PolyPhen 2 Score 0.043 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000014892
Gene: ENSMUSG00000014748
AA Change: V180A

Domain	Start	End	E-Value	Type
Pfam:Erv26	1	186	6.2e-58	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125614

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000137773

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000138192

Predicted Effect

probably benign
Transcript: ENSMUST00000206496

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap3m2	T	A	8: 23,289,663 (GRCm39)	I147F	probably benign	Het
Areg	T	A	5: 91,288,954 (GRCm39)	S87T	probably damaging	Het
Arid1b	T	A	17: 5,369,133 (GRCm39)		probably benign	Het
Arl6ip6	A	G	2: 53,082,156 (GRCm39)	R8G	probably benign	Het
Brms1	A	G	19: 5,096,723 (GRCm39)	E135G	possibly damaging	Het
Ccser1	A	G	6: 61,615,505 (GRCm39)		probably benign	Het
Dock3	A	T	9: 106,784,433 (GRCm39)	M258K	possibly damaging	Het
Epb41l4a	T	G	18: 33,934,678 (GRCm39)	D562A	possibly damaging	Het
Etaa1	G	A	11: 17,896,005 (GRCm39)	T704I	probably damaging	Het
Fer1l4	T	A	2: 155,878,376 (GRCm39)	H972L	probably damaging	Het
Foxn1	A	G	11: 78,252,320 (GRCm39)	M356T	probably damaging	Het
Gfral	C	A	9: 76,072,107 (GRCm39)	G388*	probably null	Het
Gm12258	A	G	11: 58,739,520 (GRCm39)	T3A	probably benign	Het
Hoxa5	T	C	6: 52,181,311 (GRCm39)	N7S	probably damaging	Het
Itgb4	T	C	11: 115,881,746 (GRCm39)	L765P	probably damaging	Het
Jchain	C	T	5: 88,669,383 (GRCm39)	C90Y	probably damaging	Het
Klhl40	A	G	9: 121,607,983 (GRCm39)	Y381C	probably damaging	Het
Lhx6	A	T	2: 35,993,477 (GRCm39)	C74S	probably benign	Het
Magel2	A	G	7: 62,030,632 (GRCm39)	S1179G	unknown	Het
Mapre3	T	C	5: 31,022,241 (GRCm39)	I236T	probably damaging	Het
Mcf2l	A	T	8: 13,064,010 (GRCm39)		probably null	Het
Med13	A	T	11: 86,219,323 (GRCm39)	H374Q	probably benign	Het
Meioc	A	G	11: 102,565,113 (GRCm39)	Y187C	probably benign	Het
Myh1	G	A	11: 67,108,689 (GRCm39)	M1368I	probably benign	Het
Or14a258	A	T	7: 86,035,208 (GRCm39)	I220N	possibly damaging	Het
Or8b54	A	G	9: 38,686,826 (GRCm39)	I92V	probably damaging	Het
Phrf1	T	C	7: 140,842,394 (GRCm39)	Y1501H	probably damaging	Het
Pigb	T	C	9: 72,929,573 (GRCm39)	T337A	probably damaging	Het
Pls1	T	C	9: 95,655,751 (GRCm39)	K334E	probably benign	Het
Pramel51	C	T	12: 88,145,225 (GRCm39)	V34I	possibly damaging	Het
Rab3b	T	C	4: 108,797,999 (GRCm39)	C226R	probably damaging	Het
Ryr2	A	T	13: 11,571,571 (GRCm39)	I4889N	possibly damaging	Het
Serpinb1a	G	A	13: 33,029,398 (GRCm39)	S210L	probably benign	Het
Slc52a3	A	G	2: 151,849,522 (GRCm39)	I390V	probably benign	Het
Slc6a7	C	A	18: 61,136,382 (GRCm39)	A340S	probably damaging	Het
Tcaf3	T	C	6: 42,570,615 (GRCm39)	Y379C	probably damaging	Het
Tnnt1	C	T	7: 4,517,211 (GRCm39)		probably null	Het
Ttn	T	C	2: 76,798,847 (GRCm39)	T476A	possibly damaging	Het
Vcan	A	G	13: 89,852,288 (GRCm39)	S891P	probably benign	Het
Vmn2r16	T	A	5: 109,511,627 (GRCm39)	D611E	possibly damaging	Het
Vmn2r68	T	C	7: 84,886,819 (GRCm39)	T32A	probably benign	Het
Vwde	T	G	6: 13,190,526 (GRCm39)	S522R	probably benign	Het
Wdr3	G	A	3: 100,054,105 (GRCm39)		probably benign	Het
Wfs1	G	T	5: 37,128,907 (GRCm39)	Q288K	probably benign	Het
Zfp142	A	G	1: 74,618,699 (GRCm39)	V120A	probably damaging	Het
Zfp672	A	G	11: 58,208,192 (GRCm39)	F43S	probably damaging	Het
Znhit3	A	T	11: 84,802,283 (GRCm39)		probably benign	Het

Other mutations in Tex261

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00960:Tex261	APN	6	83,752,650 (GRCm39)	missense	possibly damaging	0.84
IGL03352:Tex261	APN	6	83,748,249 (GRCm39)	missense	possibly damaging	0.56
R1634:Tex261	UTSW	6	83,752,004 (GRCm39)	missense	possibly damaging	0.95
R2001:Tex261	UTSW	6	83,750,713 (GRCm39)	missense	probably damaging	1.00
R2049:Tex261	UTSW	6	83,749,241 (GRCm39)	missense	probably damaging	1.00
R2221:Tex261	UTSW	6	83,748,497 (GRCm39)	missense	probably benign	0.17
R8169:Tex261	UTSW	6	83,751,999 (GRCm39)	critical splice donor site	probably null
R8853:Tex261	UTSW	6	83,750,727 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-11-05