Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01391:Gm10436'

79200

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gm10436

Ensembl Gene

ENSMUSG00000066027

Gene Name

predicted gene 10436

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.098) question?

Stock #

IGL01391

Quality Score

Status

Chromosome

Chromosomal Location

88175589-88182108 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 88178455 bp

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 34 (V34I)

Ref Sequence

ENSEMBL: ENSMUSP00000152194 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071580] [ENSMUST00000220521] [ENSMUST00000222081] [ENSMUST00000223172]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000071580
AA Change: V42I

PolyPhen 2 Score 0.759 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000071508
Gene: ENSMUSG00000066027
AA Change: V42I

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	247	445	5e-9	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000220521

Predicted Effect

probably benign
Transcript: ENSMUST00000221884

Predicted Effect

possibly damaging
Transcript: ENSMUST00000222081
AA Change: V34I

PolyPhen 2 Score 0.843 (Sensitivity: 0.83; Specificity: 0.93)

Predicted Effect

probably benign
Transcript: ENSMUST00000222391

Predicted Effect

unknown
Transcript: ENSMUST00000222556
AA Change: V33I

Predicted Effect

probably benign
Transcript: ENSMUST00000223172

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 47 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ap3m2	T	A	8: 22,799,647	I147F	probably benign	Het
Areg	T	A	5: 91,141,095	S87T	probably damaging	Het
Arid1b	T	A	17: 5,318,858		probably benign	Het
Arl6ip6	A	G	2: 53,192,144	R8G	probably benign	Het
Brms1	A	G	19: 5,046,695	E135G	possibly damaging	Het
Ccser1	A	G	6: 61,638,521		probably benign	Het
Dock3	A	T	9: 106,907,234	M258K	possibly damaging	Het
Epb41l4a	T	G	18: 33,801,625	D562A	possibly damaging	Het
Etaa1	G	A	11: 17,946,005	T704I	probably damaging	Het
Fer1l4	T	A	2: 156,036,456	H972L	probably damaging	Het
Foxn1	A	G	11: 78,361,494	M356T	probably damaging	Het
Gfral	C	A	9: 76,164,825	G388*	probably null	Het
Gm12258	A	G	11: 58,848,694	T3A	probably benign	Het
Hoxa5	T	C	6: 52,204,331	N7S	probably damaging	Het
Itgb4	T	C	11: 115,990,920	L765P	probably damaging	Het
Jchain	C	T	5: 88,521,524	C90Y	probably damaging	Het
Klhl40	A	G	9: 121,778,917	Y381C	probably damaging	Het
Lhx6	A	T	2: 36,103,465	C74S	probably benign	Het
Magel2	A	G	7: 62,380,884	S1179G	unknown	Het
Mapre3	T	C	5: 30,864,897	I236T	probably damaging	Het
Mcf2l	A	T	8: 13,014,010		probably null	Het
Med13	A	T	11: 86,328,497	H374Q	probably benign	Het
Meioc	A	G	11: 102,674,287	Y187C	probably benign	Het
Myh1	G	A	11: 67,217,863	M1368I	probably benign	Het
Olfr304	A	T	7: 86,386,000	I220N	possibly damaging	Het
Olfr921	A	G	9: 38,775,530	I92V	probably damaging	Het
Phrf1	T	C	7: 141,262,481	Y1501H	probably damaging	Het
Pigb	T	C	9: 73,022,291	T337A	probably damaging	Het
Pls1	T	C	9: 95,773,698	K334E	probably benign	Het
Rab3b	T	C	4: 108,940,802	C226R	probably damaging	Het
Ryr2	A	T	13: 11,556,685	I4889N	possibly damaging	Het
Serpinb1a	G	A	13: 32,845,415	S210L	probably benign	Het
Slc52a3	A	G	2: 152,007,602	I390V	probably benign	Het
Slc6a7	C	A	18: 61,003,310	A340S	probably damaging	Het
Tcaf3	T	C	6: 42,593,681	Y379C	probably damaging	Het
Tex261	A	G	6: 83,771,240	V180A	probably benign	Het
Tnnt1	C	T	7: 4,514,212		probably null	Het
Ttn	T	C	2: 76,968,503	T476A	possibly damaging	Het
Vcan	A	G	13: 89,704,169	S891P	probably benign	Het
Vmn2r16	T	A	5: 109,363,761	D611E	possibly damaging	Het
Vmn2r68	T	C	7: 85,237,611	T32A	probably benign	Het
Vwde	T	G	6: 13,190,527	S522R	probably benign	Het
Wdr3	G	A	3: 100,146,789		probably benign	Het
Wfs1	G	T	5: 36,971,563	Q288K	probably benign	Het
Zfp142	A	G	1: 74,579,540	V120A	probably damaging	Het
Zfp672	A	G	11: 58,317,366	F43S	probably damaging	Het
Znhit3	A	T	11: 84,911,457		probably benign	Het

Other mutations in Gm10436

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00421:Gm10436	APN	12	88177112	missense	probably benign	0.35
IGL01432:Gm10436	APN	12	88176432	missense	probably benign	0.44
IGL01519:Gm10436	APN	12	88177561	missense	probably benign	0.00
IGL01784:Gm10436	APN	12	88176315	missense	probably benign
IGL02121:Gm10436	APN	12	88178472	missense	possibly damaging	0.83
IGL02728:Gm10436	APN	12	88176022	missense	probably benign	0.17
R0336:Gm10436	UTSW	12	88178191	missense	probably benign	0.20
R0554:Gm10436	UTSW	12	88177558	missense	probably benign	0.10
R1279:Gm10436	UTSW	12	88175880	missense	probably benign	0.42
R1832:Gm10436	UTSW	12	88178448	missense	possibly damaging	0.73
R1833:Gm10436	UTSW	12	88178448	missense	possibly damaging	0.73
R1900:Gm10436	UTSW	12	88177260	missense	probably benign	0.02
R2412:Gm10436	UTSW	12	88177110	missense	probably damaging	0.98
R3040:Gm10436	UTSW	12	88178348	missense	probably benign	0.00
R3625:Gm10436	UTSW	12	88175961	missense	probably benign	0.06
R4078:Gm10436	UTSW	12	88175913	missense	probably benign	0.38
R4270:Gm10436	UTSW	12	88178283	missense	probably damaging	1.00
R4271:Gm10436	UTSW	12	88178283	missense	probably damaging	1.00
R5318:Gm10436	UTSW	12	88176228	missense	probably benign	0.01
R5552:Gm10436	UTSW	12	88178365	missense	probably benign	0.03
R5601:Gm10436	UTSW	12	88176047	missense	probably damaging	1.00
R5881:Gm10436	UTSW	12	88176341	missense	probably damaging	1.00
R5973:Gm10436	UTSW	12	88175913	missense	probably benign	0.02
R6058:Gm10436	UTSW	12	88177225	missense	possibly damaging	0.91
R6488:Gm10436	UTSW	12	88177587	missense	possibly damaging	0.87
R6656:Gm10436	UTSW	12	88175993	missense	possibly damaging	0.89
R7307:Gm10436	UTSW	12	88181749	missense	probably damaging	1.00
R7332:Gm10436	UTSW	12	88176417	missense	possibly damaging	0.72
R7544:Gm10436	UTSW	12	88176080	missense	probably benign	0.00
R7569:Gm10436	UTSW	12	88176315	missense	probably benign
R7645:Gm10436	UTSW	12	88176258	missense	probably damaging	1.00
R7752:Gm10436	UTSW	12	88175999	missense	probably damaging	1.00
R7855:Gm10436	UTSW	12	88176083	missense	probably benign	0.03
R7860:Gm10436	UTSW	12	88176352	missense	possibly damaging	0.89
R8113:Gm10436	UTSW	12	88177080	missense	probably benign	0.00
R8356:Gm10436	UTSW	12	88177216	missense	probably benign	0.01
R8456:Gm10436	UTSW	12	88177216	missense	probably benign	0.01

Posted On

2013-11-05