Incidental Mutation 'IGL01516:Olfr1413'
ID90376
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1413
Ensembl Gene ENSMUSG00000058904
Gene Nameolfactory receptor 1413
SynonymsGA_x6K02T2R7CC-81180849-81179878, MOR208-1
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01516
Quality Score
Status
Chromosome1
Chromosomal Location92571322-92574397 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 92573443 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 91 (I91F)
Ref Sequence ENSEMBL: ENSMUSP00000150792 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074859] [ENSMUST00000214239]
Predicted Effect probably benign
Transcript: ENSMUST00000074859
AA Change: I91F

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000074402
Gene: ENSMUSG00000058904
AA Change: I91F

DomainStartEndE-ValueType
low complexity region 16 27 N/A INTRINSIC
Pfam:7tm_4 38 314 2.3e-50 PFAM
Pfam:7tm_1 48 297 2.7e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000181755
Predicted Effect noncoding transcript
Transcript: ENSMUST00000185802
Predicted Effect probably benign
Transcript: ENSMUST00000214239
AA Change: I91F

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik A G 13: 59,690,734 S95P probably benign Het
Abca6 T A 11: 110,218,217 H709L possibly damaging Het
BC051142 A G 17: 34,449,260 D168G possibly damaging Het
Bpifb1 A G 2: 154,218,252 Y455C probably benign Het
Clk1 G A 1: 58,414,404 T341I probably damaging Het
Corin A T 5: 72,454,487 Y77* probably null Het
Cps1 C T 1: 67,230,284 R1481C probably damaging Het
Cspg5 A G 9: 110,246,693 K166E probably benign Het
Dcxr A G 11: 120,725,758 probably null Het
Epha5 C A 5: 84,386,276 L65F probably damaging Het
Erbb4 T A 1: 68,328,245 K438* probably null Het
Gldc A T 19: 30,099,032 C1005S probably damaging Het
Hs3st5 C T 10: 36,833,051 T194I probably damaging Het
Hspa12a T A 19: 58,827,676 D45V probably benign Het
Il1rn C T 2: 24,349,539 T130I probably damaging Het
Klk1b22 G T 7: 44,116,308 C196F probably damaging Het
Lamp1 C T 8: 13,173,863 H332Y probably damaging Het
Limd2 T C 11: 106,159,044 T40A probably benign Het
Lztr1 G A 16: 17,522,391 probably null Het
Mbd4 T C 6: 115,849,530 T167A probably damaging Het
Mitf T A 6: 98,010,390 probably null Het
Mlph A G 1: 90,939,390 D378G probably damaging Het
Mrgprb5 A T 7: 48,168,384 L201Q probably damaging Het
Myo5b A T 18: 74,627,195 I261F probably damaging Het
Olfr918 C T 9: 38,672,863 V207I probably benign Het
Paics T A 5: 76,956,731 L68I probably damaging Het
Pramef20 A G 4: 144,377,767 V56A probably damaging Het
Prkca C T 11: 107,961,602 V102M probably null Het
Ptpn21 G A 12: 98,715,189 T62I probably damaging Het
Ptpre A T 7: 135,664,999 E212V probably damaging Het
Rufy2 A C 10: 63,011,433 K539Q possibly damaging Het
Serpinb9d T A 13: 33,202,671 probably null Het
Smarcd1 T C 15: 99,712,213 F442L probably benign Het
Tas2r115 A G 6: 132,737,613 V125A probably damaging Het
Tmem154 C T 3: 84,684,590 H120Y probably benign Het
Tnrc6b A G 15: 80,902,622 K1321E possibly damaging Het
Trmt13 A G 3: 116,589,810 probably benign Het
Vmn1r19 T C 6: 57,404,872 F137L probably benign Het
Vmn1r202 T A 13: 22,501,462 T262S possibly damaging Het
Vmn2r57 A G 7: 41,399,946 V793A probably damaging Het
Wapl A G 14: 34,692,081 N300S probably damaging Het
Xpot T A 10: 121,590,222 probably null Het
Zfp784 G A 7: 5,036,037 probably benign Het
Zfyve26 G T 12: 79,287,851 P131Q probably benign Het
Other mutations in Olfr1413
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01829:Olfr1413 APN 1 92573329 missense probably benign 0.37
IGL02160:Olfr1413 APN 1 92573357 missense probably damaging 1.00
IGL02535:Olfr1413 APN 1 92573221 missense probably benign 0.10
IGL03304:Olfr1413 APN 1 92573303 missense probably benign 0.01
R0001:Olfr1413 UTSW 1 92573461 missense possibly damaging 0.62
R0033:Olfr1413 UTSW 1 92573260 missense probably benign 0.05
R2027:Olfr1413 UTSW 1 92573767 missense probably damaging 0.99
R2152:Olfr1413 UTSW 1 92573908 missense probably damaging 1.00
R2174:Olfr1413 UTSW 1 92573657 missense probably benign 0.00
R3407:Olfr1413 UTSW 1 92573953 missense probably damaging 0.99
R3408:Olfr1413 UTSW 1 92573953 missense probably damaging 0.99
R3951:Olfr1413 UTSW 1 92573789 missense possibly damaging 0.53
R4687:Olfr1413 UTSW 1 92573330 missense possibly damaging 0.63
R4793:Olfr1413 UTSW 1 92573485 missense possibly damaging 0.89
R5069:Olfr1413 UTSW 1 92573413 missense probably damaging 1.00
R5070:Olfr1413 UTSW 1 92573413 missense probably damaging 1.00
R5160:Olfr1413 UTSW 1 92573822 missense probably benign 0.02
R5411:Olfr1413 UTSW 1 92573824 missense probably benign 0.00
R7487:Olfr1413 UTSW 1 92573795 missense possibly damaging 0.49
R7677:Olfr1413 UTSW 1 92573261 missense not run
R7832:Olfr1413 UTSW 1 92573497 missense probably benign 0.03
R7860:Olfr1413 UTSW 1 92574088 missense probably benign 0.11
Posted On2013-12-09