Incidental Mutation 'IGL01633:Fn3krp'
ID 93629
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fn3krp
Ensembl Gene ENSMUSG00000039253
Gene Name fructosamine 3 kinase related protein
Accession Numbers
Essential gene? Probably non essential (E-score: 0.096) question?
Stock # IGL01633
Quality Score
Chromosome 11
Chromosomal Location 121312227-121322114 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 121320533 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 293 (G293*)
Ref Sequence ENSEMBL: ENSMUSP00000038061 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038096]
AlphaFold Q8K274
Predicted Effect probably null
Transcript: ENSMUST00000038096
AA Change: G293*
SMART Domains Protein: ENSMUSP00000038061
Gene: ENSMUSG00000039253
AA Change: G293*

Pfam:Fructosamin_kin 1 309 6e-81 PFAM
Pfam:APH 22 267 1.5e-12 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] A high concentration of glucose can result in non-enzymatic oxidation of proteins by reaction of glucose and lysine residues (glycation). Proteins modified in this way are less active or functional. This gene encodes an enzyme which catalyzes the phosphorylation of psicosamines and ribulosamines compared to the neighboring gene which encodes a highly similar enzyme, fructosamine-3-kinase, which has different substrate specificity. The activity of both enzymes may result in deglycation of proteins to restore their function. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca2 T A 2: 25,334,406 (GRCm39) S1868T possibly damaging Het
Abca3 G A 17: 24,616,327 (GRCm39) W923* probably null Het
Abca8b A G 11: 109,827,580 (GRCm39) M1476T probably damaging Het
Abi3bp T C 16: 56,498,163 (GRCm39) F729S probably damaging Het
Acacb T C 5: 114,356,919 (GRCm39) probably benign Het
Aldh3a2 A G 11: 61,139,731 (GRCm39) L467P probably benign Het
Appl1 T C 14: 26,684,795 (GRCm39) T85A probably damaging Het
Aspm T A 1: 139,408,574 (GRCm39) I2487N possibly damaging Het
Bcl2a1c G A 9: 114,159,290 (GRCm39) V23I probably benign Het
C2cd2 T A 16: 97,676,323 (GRCm39) probably benign Het
Carmil3 A T 14: 55,731,684 (GRCm39) H170L possibly damaging Het
Ccdc141 C T 2: 76,919,593 (GRCm39) V305I probably benign Het
Ccdc174 G A 6: 91,857,343 (GRCm39) probably null Het
Cep126 T G 9: 8,103,320 (GRCm39) Q230P possibly damaging Het
Chrm1 T C 19: 8,655,859 (GRCm39) I188T probably benign Het
Depdc5 T C 5: 33,081,544 (GRCm39) S569P probably damaging Het
Drc1 G A 5: 30,503,007 (GRCm39) E177K probably damaging Het
Duox1 A G 2: 122,164,279 (GRCm39) E913G probably benign Het
Fbxw9 T C 8: 85,791,055 (GRCm39) S241P probably damaging Het
Fez2 C A 17: 78,712,147 (GRCm39) probably benign Het
Fga G T 3: 82,937,606 (GRCm39) R161L possibly damaging Het
Gfra1 C T 19: 58,255,479 (GRCm39) E318K probably benign Het
Gli3 C T 13: 15,823,219 (GRCm39) P314S probably damaging Het
Gm5114 A T 7: 39,057,490 (GRCm39) S710T probably benign Het
Gpr141 T C 13: 19,936,769 (GRCm39) D2G probably benign Het
Inppl1 G A 7: 101,483,041 (GRCm39) Q63* probably null Het
Lrrc73 T A 17: 46,566,657 (GRCm39) V169E possibly damaging Het
Lsm11 C T 11: 45,824,615 (GRCm39) R304Q probably benign Het
Macf1 T C 4: 123,395,964 (GRCm39) D788G probably damaging Het
Nbas T A 12: 13,533,898 (GRCm39) D1844E probably damaging Het
Nt5c A G 11: 115,382,161 (GRCm39) F73L probably damaging Het
Osmr A T 15: 6,854,085 (GRCm39) I541N probably damaging Het
Phrf1 A G 7: 140,840,413 (GRCm39) I1203V probably benign Het
Pram1 C A 17: 33,861,109 (GRCm39) P510Q possibly damaging Het
Prepl A G 17: 85,379,444 (GRCm39) Y415H probably benign Het
Prss27 A T 17: 24,264,650 (GRCm39) H271L probably damaging Het
Ptpn18 A G 1: 34,510,989 (GRCm39) S287G probably benign Het
Ptprq T C 10: 107,535,584 (GRCm39) probably benign Het
Sars2 A G 7: 28,446,974 (GRCm39) K218E probably benign Het
Senp6 G T 9: 79,999,676 (GRCm39) S31I probably damaging Het
Shld2 G T 14: 33,971,136 (GRCm39) T31K probably damaging Het
Skint6 C A 4: 113,095,246 (GRCm39) V138F probably damaging Het
Slc4a8 C A 15: 100,685,128 (GRCm39) H168N probably damaging Het
Tbx15 T G 3: 99,220,358 (GRCm39) I150S probably damaging Het
Tbxas1 A G 6: 38,959,125 (GRCm39) N103D probably benign Het
Tmc5 A G 7: 118,222,809 (GRCm39) N170D probably damaging Het
Tmem108 A T 9: 103,361,950 (GRCm39) N545K probably benign Het
Trub1 A G 19: 57,441,616 (GRCm39) K80E possibly damaging Het
Tulp3 A T 6: 128,302,923 (GRCm39) Y299N probably damaging Het
Other mutations in Fn3krp
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01295:Fn3krp APN 11 121,312,380 (GRCm39) missense probably damaging 1.00
IGL02123:Fn3krp APN 11 121,320,270 (GRCm39) missense probably benign 0.00
IGL03189:Fn3krp APN 11 121,320,456 (GRCm39) missense probably damaging 1.00
R0278:Fn3krp UTSW 11 121,312,406 (GRCm39) missense probably damaging 1.00
R1927:Fn3krp UTSW 11 121,315,803 (GRCm39) missense probably damaging 0.99
R3744:Fn3krp UTSW 11 121,317,531 (GRCm39) critical splice donor site probably null
R4471:Fn3krp UTSW 11 121,317,499 (GRCm39) missense probably benign 0.01
R4850:Fn3krp UTSW 11 121,315,879 (GRCm39) missense possibly damaging 0.56
R5027:Fn3krp UTSW 11 121,320,274 (GRCm39) missense probably benign 0.01
R5162:Fn3krp UTSW 11 121,320,410 (GRCm39) missense probably damaging 1.00
R5444:Fn3krp UTSW 11 121,312,430 (GRCm39) critical splice donor site probably null
R6230:Fn3krp UTSW 11 121,316,418 (GRCm39) missense probably damaging 1.00
R7183:Fn3krp UTSW 11 121,312,431 (GRCm39) critical splice donor site probably null
R8802:Fn3krp UTSW 11 121,315,813 (GRCm39) missense probably damaging 0.99
R9765:Fn3krp UTSW 11 121,312,304 (GRCm39) missense probably benign 0.44
Posted On 2013-12-09