Incidental Mutation 'R1183:Lrp4'
| ID |
101683 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp4
|
| Ensembl Gene |
ENSMUSG00000027253 |
| Gene Name |
low density lipoprotein receptor-related protein 4 |
| Synonyms |
6430526J12Rik, Megf7, mdig |
| MMRRC Submission |
039255-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.781)
|
| Stock # |
R1183 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
91287856-91344124 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
A to T
at 91307864 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000028689
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028689]
[ENSMUST00000028689]
|
| AlphaFold |
Q8VI56 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000028689
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000028689
|
| SMART Domains |
Protein: ENSMUSP00000028689
Gene: ENSMUSG00000027253
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
LDLa
|
26 |
68 |
5.77e-10 |
SMART |
|
LDLa
|
70 |
107 |
4.05e-14 |
SMART |
|
LDLa
|
109 |
145 |
1.9e-10 |
SMART |
|
LDLa
|
147 |
184 |
1.51e-13 |
SMART |
|
LDLa
|
190 |
227 |
6.83e-12 |
SMART |
|
LDLa
|
230 |
267 |
2.45e-13 |
SMART |
|
LDLa
|
269 |
306 |
6.32e-16 |
SMART |
|
LDLa
|
311 |
351 |
3.24e-13 |
SMART |
|
EGF
|
357 |
394 |
1.4e0 |
SMART |
|
EGF_CA
|
395 |
434 |
1.05e-8 |
SMART |
|
LY
|
460 |
502 |
7.01e-10 |
SMART |
|
LY
|
503 |
545 |
4.41e-16 |
SMART |
|
LY
|
546 |
589 |
1.04e-12 |
SMART |
|
LY
|
590 |
632 |
5.07e-16 |
SMART |
|
LY
|
633 |
674 |
3.12e-7 |
SMART |
|
EGF
|
701 |
737 |
9.27e-1 |
SMART |
|
LY
|
765 |
807 |
7.29e-8 |
SMART |
|
LY
|
808 |
850 |
1.92e-16 |
SMART |
|
LY
|
851 |
894 |
3.05e-10 |
SMART |
|
LY
|
895 |
937 |
6.69e-16 |
SMART |
|
LY
|
938 |
979 |
8.71e-6 |
SMART |
|
EGF
|
1005 |
1044 |
1.64e-1 |
SMART |
|
LY
|
1073 |
1115 |
2.58e-8 |
SMART |
|
LY
|
1116 |
1158 |
1.57e-12 |
SMART |
|
LY
|
1159 |
1202 |
7.4e-9 |
SMART |
|
LY
|
1203 |
1245 |
9.39e-11 |
SMART |
|
LY
|
1246 |
1285 |
6.11e-1 |
SMART |
|
EGF
|
1312 |
1349 |
1.53e-1 |
SMART |
|
LY
|
1377 |
1419 |
4.42e-7 |
SMART |
|
LY
|
1420 |
1462 |
1.04e-12 |
SMART |
|
LY
|
1463 |
1506 |
2.11e-13 |
SMART |
|
LY
|
1507 |
1549 |
4.66e-15 |
SMART |
|
LY
|
1550 |
1590 |
2.02e-1 |
SMART |
|
EGF_like
|
1616 |
1649 |
5.79e1 |
SMART |
|
low complexity region
|
1674 |
1690 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1724 |
1746 |
N/A |
INTRINSIC |
|
low complexity region
|
1857 |
1870 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000123897
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000143874
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000151907
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 95.0%
- 20x: 88.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor-related protein family. The encoded protein may be a regulator of Wnt signaling. Mutations in this gene are associated with Cenani-Lenz syndrome. [provided by RefSeq, May 2010]
PHENOTYPE: Homozygous mutations of this gene cause polysyndactyly. Additional phenotypes may include growth retardation, abnormal incisor development, kidney agenesis, and neonatal lethality associated with respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 83 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aars1 |
T |
G |
8: 111,768,206 (GRCm39) |
Y192* |
probably null |
Het |
| Abcc6 |
T |
C |
7: 45,634,677 (GRCm39) |
Y1100C |
probably damaging |
Het |
| Adamtsl2 |
T |
C |
2: 26,974,092 (GRCm39) |
W132R |
probably damaging |
Het |
| Adgra2 |
T |
A |
8: 27,604,416 (GRCm39) |
V497E |
probably damaging |
Het |
| Adtrp |
T |
G |
13: 41,981,813 (GRCm39) |
|
probably benign |
Het |
| Alg9 |
T |
A |
9: 50,700,833 (GRCm39) |
L201Q |
possibly damaging |
Het |
| Ap4e1 |
T |
A |
2: 126,856,121 (GRCm39) |
I84K |
probably damaging |
Het |
| Atrnl1 |
T |
C |
19: 57,638,725 (GRCm39) |
S288P |
probably damaging |
Het |
| Bltp1 |
T |
A |
3: 36,949,452 (GRCm39) |
L366Q |
possibly damaging |
Het |
| Cacna1a |
A |
G |
8: 85,306,846 (GRCm39) |
D1367G |
probably damaging |
Het |
| Card19 |
C |
T |
13: 49,358,727 (GRCm39) |
R82Q |
probably damaging |
Het |
| Cep128 |
T |
C |
12: 91,292,372 (GRCm39) |
I226V |
possibly damaging |
Het |
| Ces1f |
A |
C |
8: 93,994,633 (GRCm39) |
D259E |
probably benign |
Het |
| Ckap5 |
T |
A |
2: 91,416,611 (GRCm39) |
M1072K |
probably benign |
Het |
| Dcpp2 |
T |
A |
17: 24,119,468 (GRCm39) |
V94D |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,337,474 (GRCm39) |
D3209G |
possibly damaging |
Het |
| Dsg1c |
A |
G |
18: 20,416,255 (GRCm39) |
T719A |
probably damaging |
Het |
| Dsp |
G |
A |
13: 38,375,716 (GRCm39) |
W1167* |
probably null |
Het |
| Eml5 |
T |
C |
12: 98,758,305 (GRCm39) |
I1874V |
probably benign |
Het |
| Epg5 |
A |
G |
18: 78,003,926 (GRCm39) |
T645A |
probably damaging |
Het |
| F2rl2 |
T |
C |
13: 95,837,621 (GRCm39) |
L222S |
probably damaging |
Het |
| Fam114a1 |
T |
A |
5: 65,191,731 (GRCm39) |
C495S |
probably damaging |
Het |
| Fbn1 |
A |
T |
2: 125,163,537 (GRCm39) |
D2106E |
probably benign |
Het |
| Fgf14 |
T |
A |
14: 124,913,936 (GRCm39) |
N65I |
probably benign |
Het |
| Fip1l1 |
T |
C |
5: 74,755,763 (GRCm39) |
Y497H |
probably damaging |
Het |
| Fn1 |
A |
C |
1: 71,625,404 (GRCm39) |
D2376E |
probably damaging |
Het |
| Foxd2 |
T |
C |
4: 114,764,662 (GRCm39) |
T453A |
possibly damaging |
Het |
| Galnt1 |
G |
T |
18: 24,404,647 (GRCm39) |
W328L |
probably damaging |
Het |
| Gapt |
A |
G |
13: 110,490,372 (GRCm39) |
V97A |
possibly damaging |
Het |
| Gatad1 |
A |
G |
5: 3,693,707 (GRCm39) |
V154A |
possibly damaging |
Het |
| Gdf15 |
A |
G |
8: 71,084,202 (GRCm39) |
F21L |
probably benign |
Het |
| Igdcc4 |
T |
C |
9: 65,029,182 (GRCm39) |
F273S |
possibly damaging |
Het |
| Invs |
A |
T |
4: 48,421,725 (GRCm39) |
R786W |
possibly damaging |
Het |
| Itfg1 |
T |
G |
8: 86,507,152 (GRCm39) |
E236A |
probably benign |
Het |
| Jak3 |
A |
T |
8: 72,137,194 (GRCm39) |
I752F |
probably damaging |
Het |
| Kcnip3 |
C |
A |
2: 127,306,985 (GRCm39) |
G144W |
probably damaging |
Het |
| Kctd19 |
T |
C |
8: 106,109,598 (GRCm39) |
H925R |
probably benign |
Het |
| Kdr |
C |
T |
5: 76,107,511 (GRCm39) |
A1011T |
probably damaging |
Het |
| Kif13b |
C |
A |
14: 65,019,826 (GRCm39) |
H1398Q |
probably benign |
Het |
| Lrtm2 |
T |
C |
6: 119,297,846 (GRCm39) |
D65G |
probably benign |
Het |
| Lyz1 |
A |
G |
10: 117,128,715 (GRCm39) |
L10P |
probably damaging |
Het |
| Metap2 |
A |
T |
10: 93,706,046 (GRCm39) |
N245K |
probably damaging |
Het |
| Mms19 |
T |
C |
19: 41,943,270 (GRCm39) |
D297G |
possibly damaging |
Het |
| Mocs3 |
A |
G |
2: 168,073,573 (GRCm39) |
D340G |
possibly damaging |
Het |
| Mtfr1l |
A |
G |
4: 134,256,436 (GRCm39) |
L243P |
probably damaging |
Het |
| Mtss1 |
A |
G |
15: 58,842,897 (GRCm39) |
I105T |
probably damaging |
Het |
| Myo18a |
T |
C |
11: 77,748,571 (GRCm39) |
S1967P |
probably damaging |
Het |
| Ncor2 |
T |
C |
5: 125,100,585 (GRCm39) |
N2248S |
possibly damaging |
Het |
| Nfatc2 |
T |
C |
2: 168,432,008 (GRCm39) |
D35G |
possibly damaging |
Het |
| Nup210l |
T |
A |
3: 90,067,252 (GRCm39) |
M764K |
probably benign |
Het |
| Or10a3n |
A |
G |
7: 108,492,948 (GRCm39) |
L222P |
probably damaging |
Het |
| Otof |
T |
C |
5: 30,529,256 (GRCm39) |
S1753G |
probably damaging |
Het |
| Otog |
G |
A |
7: 45,939,179 (GRCm39) |
V2070I |
probably benign |
Het |
| Piezo2 |
A |
G |
18: 63,219,824 (GRCm39) |
V961A |
probably damaging |
Het |
| Pofut1 |
C |
T |
2: 153,103,158 (GRCm39) |
S169L |
probably benign |
Het |
| Ppp1r10 |
T |
A |
17: 36,240,335 (GRCm39) |
S542T |
possibly damaging |
Het |
| Prpf8 |
T |
C |
11: 75,381,156 (GRCm39) |
Y219H |
possibly damaging |
Het |
| Ptges3l |
T |
C |
11: 101,312,731 (GRCm39) |
D113G |
possibly damaging |
Het |
| Pycr3 |
G |
A |
15: 75,790,647 (GRCm39) |
L71F |
probably benign |
Het |
| Ramp3 |
A |
G |
11: 6,624,867 (GRCm39) |
K54E |
possibly damaging |
Het |
| Rbpms |
C |
A |
8: 34,294,100 (GRCm39) |
Q214H |
possibly damaging |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Robo4 |
C |
A |
9: 37,319,348 (GRCm39) |
D565E |
probably damaging |
Het |
| S100a1 |
C |
T |
3: 90,418,641 (GRCm39) |
V58I |
probably benign |
Het |
| Setx |
T |
A |
2: 29,070,104 (GRCm39) |
D2636E |
probably benign |
Het |
| Sun2 |
A |
T |
15: 79,612,669 (GRCm39) |
V417E |
probably damaging |
Het |
| Tbccd1 |
T |
C |
16: 22,660,519 (GRCm39) |
N99S |
probably benign |
Het |
| Tex15 |
A |
G |
8: 34,064,893 (GRCm39) |
D1441G |
probably benign |
Het |
| Tmc2 |
T |
A |
2: 130,089,896 (GRCm39) |
M627K |
probably damaging |
Het |
| Trim32 |
A |
G |
4: 65,532,628 (GRCm39) |
Y395C |
probably benign |
Het |
| Trpm2 |
A |
G |
10: 77,759,398 (GRCm39) |
Y1129H |
probably damaging |
Het |
| Trpm8 |
A |
T |
1: 88,275,813 (GRCm39) |
R470S |
probably damaging |
Het |
| Tsg101 |
G |
T |
7: 46,539,372 (GRCm39) |
D389E |
probably benign |
Het |
| Ubn1 |
T |
C |
16: 4,882,406 (GRCm39) |
L46P |
probably damaging |
Het |
| Ubr5 |
T |
C |
15: 37,997,419 (GRCm39) |
I1745V |
possibly damaging |
Het |
| Usp20 |
T |
C |
2: 30,901,797 (GRCm39) |
Y521H |
probably benign |
Het |
| Vmn1r159 |
A |
T |
7: 22,543,019 (GRCm39) |
H4Q |
probably null |
Het |
| Vmn2r27 |
T |
A |
6: 124,177,491 (GRCm39) |
E504D |
probably benign |
Het |
| Wdr72 |
A |
T |
9: 74,086,867 (GRCm39) |
I612F |
probably benign |
Het |
| Zbtb8a |
T |
C |
4: 129,251,520 (GRCm39) |
H317R |
possibly damaging |
Het |
| Zfp507 |
T |
C |
7: 35,494,315 (GRCm39) |
S243G |
probably damaging |
Het |
| Zfp764 |
A |
G |
7: 127,005,419 (GRCm39) |
W73R |
probably damaging |
Het |
| Zmym4 |
A |
T |
4: 126,819,632 (GRCm39) |
D90E |
probably damaging |
Het |
|
| Other mutations in Lrp4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00225:Lrp4
|
APN |
2 |
91,325,371 (GRCm39) |
missense |
probably benign |
|
|
IGL00509:Lrp4
|
APN |
2 |
91,316,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL01145:Lrp4
|
APN |
2 |
91,317,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01287:Lrp4
|
APN |
2 |
91,304,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01531:Lrp4
|
APN |
2 |
91,341,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01534:Lrp4
|
APN |
2 |
91,303,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01544:Lrp4
|
APN |
2 |
91,307,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01761:Lrp4
|
APN |
2 |
91,312,326 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01885:Lrp4
|
APN |
2 |
91,331,452 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01909:Lrp4
|
APN |
2 |
91,324,529 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02111:Lrp4
|
APN |
2 |
91,336,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02385:Lrp4
|
APN |
2 |
91,305,065 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02403:Lrp4
|
APN |
2 |
91,338,927 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02431:Lrp4
|
APN |
2 |
91,306,982 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02452:Lrp4
|
APN |
2 |
91,304,347 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Lrp4
|
APN |
2 |
91,307,055 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02828:Lrp4
|
APN |
2 |
91,305,639 (GRCm39) |
missense |
probably benign |
|
|
IGL02832:Lrp4
|
APN |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02893:Lrp4
|
APN |
2 |
91,305,161 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
artiodactyl
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
bubalus
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
riverhorse
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wallow
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
F5770:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0037:Lrp4
|
UTSW |
2 |
91,301,548 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0137:Lrp4
|
UTSW |
2 |
91,325,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0265:Lrp4
|
UTSW |
2 |
91,321,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0368:Lrp4
|
UTSW |
2 |
91,308,079 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0531:Lrp4
|
UTSW |
2 |
91,305,523 (GRCm39) |
splice site |
probably benign |
|
|
R0827:Lrp4
|
UTSW |
2 |
91,325,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Lrp4
|
UTSW |
2 |
91,317,372 (GRCm39) |
splice site |
probably benign |
|
|
R1587:Lrp4
|
UTSW |
2 |
91,306,650 (GRCm39) |
missense |
probably benign |
0.26 |
|
R1693:Lrp4
|
UTSW |
2 |
91,322,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Lrp4
|
UTSW |
2 |
91,322,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1863:Lrp4
|
UTSW |
2 |
91,328,708 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1908:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1909:Lrp4
|
UTSW |
2 |
91,328,753 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1932:Lrp4
|
UTSW |
2 |
91,327,700 (GRCm39) |
nonsense |
probably null |
|
|
R1934:Lrp4
|
UTSW |
2 |
91,310,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2358:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2433:Lrp4
|
UTSW |
2 |
91,336,360 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2698:Lrp4
|
UTSW |
2 |
91,305,557 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2919:Lrp4
|
UTSW |
2 |
91,321,075 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3105:Lrp4
|
UTSW |
2 |
91,331,394 (GRCm39) |
missense |
probably benign |
|
|
R3709:Lrp4
|
UTSW |
2 |
91,320,811 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R3711:Lrp4
|
UTSW |
2 |
91,332,299 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3735:Lrp4
|
UTSW |
2 |
91,328,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3808:Lrp4
|
UTSW |
2 |
91,307,047 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3894:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3895:Lrp4
|
UTSW |
2 |
91,304,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4397:Lrp4
|
UTSW |
2 |
91,342,015 (GRCm39) |
missense |
probably benign |
0.20 |
|
R4741:Lrp4
|
UTSW |
2 |
91,341,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4948:Lrp4
|
UTSW |
2 |
91,316,231 (GRCm39) |
missense |
probably benign |
|
|
R5050:Lrp4
|
UTSW |
2 |
91,322,767 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5096:Lrp4
|
UTSW |
2 |
91,316,137 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R5110:Lrp4
|
UTSW |
2 |
91,327,417 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5141:Lrp4
|
UTSW |
2 |
91,309,023 (GRCm39) |
splice site |
probably benign |
|
|
R5439:Lrp4
|
UTSW |
2 |
91,327,418 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5725:Lrp4
|
UTSW |
2 |
91,325,240 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5795:Lrp4
|
UTSW |
2 |
91,304,816 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5820:Lrp4
|
UTSW |
2 |
91,322,960 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5883:Lrp4
|
UTSW |
2 |
91,318,778 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5919:Lrp4
|
UTSW |
2 |
91,303,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Lrp4
|
UTSW |
2 |
91,342,029 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6080:Lrp4
|
UTSW |
2 |
91,332,345 (GRCm39) |
missense |
probably benign |
|
|
R6189:Lrp4
|
UTSW |
2 |
91,305,579 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6192:Lrp4
|
UTSW |
2 |
91,338,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6319:Lrp4
|
UTSW |
2 |
91,310,666 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6378:Lrp4
|
UTSW |
2 |
91,324,174 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6479:Lrp4
|
UTSW |
2 |
91,317,429 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6500:Lrp4
|
UTSW |
2 |
91,322,765 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6643:Lrp4
|
UTSW |
2 |
91,332,340 (GRCm39) |
missense |
probably benign |
|
|
R6657:Lrp4
|
UTSW |
2 |
91,322,398 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6696:Lrp4
|
UTSW |
2 |
91,327,690 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6714:Lrp4
|
UTSW |
2 |
91,306,710 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6734:Lrp4
|
UTSW |
2 |
91,316,242 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6770:Lrp4
|
UTSW |
2 |
91,327,648 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6774:Lrp4
|
UTSW |
2 |
91,341,849 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6957:Lrp4
|
UTSW |
2 |
91,317,387 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6978:Lrp4
|
UTSW |
2 |
91,322,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7065:Lrp4
|
UTSW |
2 |
91,341,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7142:Lrp4
|
UTSW |
2 |
91,325,339 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7219:Lrp4
|
UTSW |
2 |
91,322,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7237:Lrp4
|
UTSW |
2 |
91,303,528 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7387:Lrp4
|
UTSW |
2 |
91,306,959 (GRCm39) |
missense |
probably benign |
|
|
R7585:Lrp4
|
UTSW |
2 |
91,322,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7835:Lrp4
|
UTSW |
2 |
91,325,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7872:Lrp4
|
UTSW |
2 |
91,321,061 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7968:Lrp4
|
UTSW |
2 |
91,324,424 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R8222:Lrp4
|
UTSW |
2 |
91,305,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8338:Lrp4
|
UTSW |
2 |
91,322,713 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8342:Lrp4
|
UTSW |
2 |
91,318,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8435:Lrp4
|
UTSW |
2 |
91,307,998 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8720:Lrp4
|
UTSW |
2 |
91,324,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8774:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8774-TAIL:Lrp4
|
UTSW |
2 |
91,308,043 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8792:Lrp4
|
UTSW |
2 |
91,325,300 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R8913:Lrp4
|
UTSW |
2 |
91,331,785 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9017:Lrp4
|
UTSW |
2 |
91,324,397 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R9062:Lrp4
|
UTSW |
2 |
91,303,925 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9118:Lrp4
|
UTSW |
2 |
91,308,927 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9640:Lrp4
|
UTSW |
2 |
91,316,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9649:Lrp4
|
UTSW |
2 |
91,338,914 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9708:Lrp4
|
UTSW |
2 |
91,342,076 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9748:Lrp4
|
UTSW |
2 |
91,316,116 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Lrp4
|
UTSW |
2 |
91,316,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V7580:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7581:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7582:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
V7583:Lrp4
|
UTSW |
2 |
91,318,863 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
X0021:Lrp4
|
UTSW |
2 |
91,331,407 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGTGTGAAGCAGGGTATGAGCTAC -3'
(R):5'- TTGCACATGGCATTCCAGGCTCTC -3'
Sequencing Primer
(F):5'- GCTGCAAAGCTCTGGGTAAG -3'
(R):5'- CTGCCATTAAGGTTGGCAC -3'
|
| Posted On |
2014-01-15 |
Incidental Mutation