Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01677:Vmn2r11'

103659

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r11

Ensembl Gene

ENSMUSG00000091450

Gene Name

vomeronasal 2, receptor 11

Synonyms

EG384219

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL01677

Quality Score

Status

Chromosome

Chromosomal Location

109194739-109207318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 109201823 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Alanine at position 227 (D227A)

Ref Sequence

ENSEMBL: ENSMUSP00000133218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000164875]

AlphaFold

E9Q4X4

Predicted Effect

possibly damaging
Transcript: ENSMUST00000164875
AA Change: D227A

PolyPhen 2 Score 0.502 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: D227A

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	167	475	1.6e-29	PFAM
Pfam:NCD3G	520	574	9.1e-19	PFAM
Pfam:7tm_3	607	842	4.6e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arap3	T	A	18: 38,129,700 (GRCm39)	M154L	probably benign	Het
Asph	T	C	4: 9,607,853 (GRCm39)	D131G	probably damaging	Het
Cdc45	G	A	16: 18,605,750 (GRCm39)	T429I	probably benign	Het
Cnga3	C	T	1: 37,283,999 (GRCm39)	R101*	probably null	Het
Cp	T	C	3: 20,020,598 (GRCm39)	I197T	probably damaging	Het
Cyp4b1	T	C	4: 115,493,479 (GRCm39)	D77G	probably damaging	Het
Dnah5	G	T	15: 28,367,928 (GRCm39)	W2771L	probably damaging	Het
Fas	G	A	19: 34,296,218 (GRCm39)	V177I	probably benign	Het
Gde1	A	G	7: 118,293,710 (GRCm39)		probably benign	Het
Hyou1	T	C	9: 44,293,309 (GRCm39)	S223P	probably benign	Het
Klre1	G	T	6: 129,559,006 (GRCm39)	G75C	probably damaging	Het
Lama1	T	C	17: 68,086,143 (GRCm39)	C1461R	probably benign	Het
Map3k7	T	C	4: 32,017,158 (GRCm39)		probably benign	Het
Mrpl18	A	T	17: 13,130,575 (GRCm39)	I178N	probably damaging	Het
Nckap1	T	C	2: 80,360,641 (GRCm39)	T503A	probably benign	Het
Or2n1	T	C	17: 38,486,766 (GRCm39)	S264P	probably damaging	Het
Or52n5	T	C	7: 104,587,852 (GRCm39)	S40P	probably benign	Het
Or52u1	T	C	7: 104,237,352 (GRCm39)	S114P	probably damaging	Het
Or7g28	T	C	9: 19,272,441 (GRCm39)	D70G	probably damaging	Het
Orc1	C	T	4: 108,461,782 (GRCm39)	T593I	probably damaging	Het
Phtf1	T	A	3: 103,906,099 (GRCm39)	S594T	probably damaging	Het
Ppp1r13b	A	T	12: 111,810,099 (GRCm39)	D78E	probably benign	Het
Proz	T	C	8: 13,115,238 (GRCm39)		probably benign	Het
Rtcb	C	A	10: 85,779,793 (GRCm39)	Q292H	probably damaging	Het
Septin11	A	T	5: 93,296,392 (GRCm39)	T95S	probably damaging	Het
Slc12a1	A	G	2: 125,020,069 (GRCm39)		probably benign	Het
Slc45a3	T	A	1: 131,906,708 (GRCm39)	I394N	probably damaging	Het
Slc8a1	T	C	17: 81,956,036 (GRCm39)	H334R	probably damaging	Het
Sort1	T	C	3: 108,252,201 (GRCm39)	I466T	probably benign	Het
Susd2	A	T	10: 75,475,265 (GRCm39)	V515E	possibly damaging	Het
Ttll3	A	G	6: 113,389,945 (GRCm39)	R778G	probably benign	Het
Ubfd1	T	A	7: 121,670,922 (GRCm39)		probably benign	Het
Utrn	G	A	10: 12,619,901 (GRCm39)	T248M	probably damaging	Het

Other mutations in Vmn2r11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00925:Vmn2r11	APN	5	109,194,885 (GRCm39)	missense	probably benign	0.00
IGL02048:Vmn2r11	APN	5	109,202,658 (GRCm39)	missense	probably benign	0.00
IGL02559:Vmn2r11	APN	5	109,200,046 (GRCm39)	missense	probably damaging	0.98
IGL02879:Vmn2r11	APN	5	109,201,704 (GRCm39)	missense	possibly damaging	0.95
IGL03084:Vmn2r11	APN	5	109,207,209 (GRCm39)	missense	probably benign	0.00
IGL03163:Vmn2r11	APN	5	109,201,692 (GRCm39)	missense	probably benign	0.41
IGL03289:Vmn2r11	APN	5	109,196,788 (GRCm39)	splice site	probably benign
IGL03294:Vmn2r11	APN	5	109,201,935 (GRCm39)	missense	probably benign	0.22
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0233:Vmn2r11	UTSW	5	109,201,968 (GRCm39)	missense	probably benign	0.16
R0421:Vmn2r11	UTSW	5	109,207,294 (GRCm39)	missense	probably benign	0.00
R0549:Vmn2r11	UTSW	5	109,199,963 (GRCm39)	missense	possibly damaging	0.80
R0628:Vmn2r11	UTSW	5	109,195,597 (GRCm39)	missense	possibly damaging	0.88
R1523:Vmn2r11	UTSW	5	109,201,707 (GRCm39)	missense	probably benign	0.25
R1660:Vmn2r11	UTSW	5	109,201,724 (GRCm39)	missense	possibly damaging	0.79
R1827:Vmn2r11	UTSW	5	109,199,938 (GRCm39)	missense	probably benign	0.01
R1913:Vmn2r11	UTSW	5	109,202,654 (GRCm39)	missense	probably benign
R2260:Vmn2r11	UTSW	5	109,201,657 (GRCm39)	nonsense	probably null
R2400:Vmn2r11	UTSW	5	109,199,928 (GRCm39)	missense	probably benign	0.03
R3933:Vmn2r11	UTSW	5	109,201,260 (GRCm39)	missense	probably damaging	0.97
R4091:Vmn2r11	UTSW	5	109,202,616 (GRCm39)	critical splice donor site	probably null
R4624:Vmn2r11	UTSW	5	109,200,101 (GRCm39)	missense	probably damaging	0.99
R4762:Vmn2r11	UTSW	5	109,195,436 (GRCm39)	missense	probably damaging	1.00
R5256:Vmn2r11	UTSW	5	109,202,658 (GRCm39)	missense	probably benign	0.26
R5370:Vmn2r11	UTSW	5	109,195,421 (GRCm39)	missense	probably damaging	1.00
R5419:Vmn2r11	UTSW	5	109,207,224 (GRCm39)	missense	possibly damaging	0.55
R5516:Vmn2r11	UTSW	5	109,195,032 (GRCm39)	missense	probably damaging	0.98
R5643:Vmn2r11	UTSW	5	109,194,869 (GRCm39)	missense	probably damaging	1.00
R5671:Vmn2r11	UTSW	5	109,202,772 (GRCm39)	missense	probably benign	0.03
R5679:Vmn2r11	UTSW	5	109,202,708 (GRCm39)	missense	probably benign	0.00
R5739:Vmn2r11	UTSW	5	109,207,114 (GRCm39)	critical splice donor site	probably null
R5746:Vmn2r11	UTSW	5	109,201,560 (GRCm39)	missense	probably benign	0.41
R5995:Vmn2r11	UTSW	5	109,194,921 (GRCm39)	missense	probably damaging	1.00
R6147:Vmn2r11	UTSW	5	109,202,700 (GRCm39)	missense	probably benign	0.04
R6220:Vmn2r11	UTSW	5	109,201,434 (GRCm39)	missense	probably benign	0.09
R6374:Vmn2r11	UTSW	5	109,201,679 (GRCm39)	missense	possibly damaging	0.65
R6491:Vmn2r11	UTSW	5	109,196,800 (GRCm39)	missense	possibly damaging	0.95
R6804:Vmn2r11	UTSW	5	109,201,350 (GRCm39)	missense	probably damaging	1.00
R6814:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R6872:Vmn2r11	UTSW	5	109,194,976 (GRCm39)	missense	possibly damaging	0.81
R7014:Vmn2r11	UTSW	5	109,201,289 (GRCm39)	missense	probably damaging	1.00
R7041:Vmn2r11	UTSW	5	109,202,816 (GRCm39)	missense	probably damaging	1.00
R7043:Vmn2r11	UTSW	5	109,200,098 (GRCm39)	missense	probably benign	0.00
R7050:Vmn2r11	UTSW	5	109,202,657 (GRCm39)	missense	probably benign	0.05
R7184:Vmn2r11	UTSW	5	109,201,281 (GRCm39)	missense	probably damaging	1.00
R7388:Vmn2r11	UTSW	5	109,202,742 (GRCm39)	missense	probably benign	0.05
R7477:Vmn2r11	UTSW	5	109,207,214 (GRCm39)	missense	possibly damaging	0.67
R7524:Vmn2r11	UTSW	5	109,201,848 (GRCm39)	missense	probably benign	0.01
R7682:Vmn2r11	UTSW	5	109,195,481 (GRCm39)	missense	probably benign	0.02
R7715:Vmn2r11	UTSW	5	109,195,307 (GRCm39)	missense	probably damaging	0.99
R7869:Vmn2r11	UTSW	5	109,199,986 (GRCm39)	missense	probably damaging	1.00
R8094:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8277:Vmn2r11	UTSW	5	109,202,833 (GRCm39)	missense	probably benign	0.00
R8506:Vmn2r11	UTSW	5	109,207,270 (GRCm39)	missense	probably benign	0.00
R8676:Vmn2r11	UTSW	5	109,201,626 (GRCm39)	missense	probably damaging	1.00
R8701:Vmn2r11	UTSW	5	109,195,556 (GRCm39)	missense	probably damaging	1.00
R8749:Vmn2r11	UTSW	5	109,195,319 (GRCm39)	missense	probably damaging	0.97
R9046:Vmn2r11	UTSW	5	109,202,850 (GRCm39)	missense	probably benign	0.00
R9138:Vmn2r11	UTSW	5	109,201,904 (GRCm39)	missense	probably damaging	1.00
R9267:Vmn2r11	UTSW	5	109,199,929 (GRCm39)	missense	possibly damaging	0.93
R9306:Vmn2r11	UTSW	5	109,196,831 (GRCm39)	missense	probably damaging	1.00
R9384:Vmn2r11	UTSW	5	109,201,266 (GRCm39)	missense	probably damaging	1.00
R9443:Vmn2r11	UTSW	5	109,195,159 (GRCm39)	nonsense	probably null
R9520:Vmn2r11	UTSW	5	109,201,455 (GRCm39)	missense	probably benign	0.35
R9596:Vmn2r11	UTSW	5	109,201,563 (GRCm39)	missense	possibly damaging	0.67
R9677:Vmn2r11	UTSW	5	109,201,332 (GRCm39)	missense

Posted On

2014-01-21