Incidental Mutation 'R1442:Vmn2r108'
| ID |
161573 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r108
|
| Ensembl Gene |
ENSMUSG00000091805 |
| Gene Name |
vomeronasal 2, receptor 108 |
| Synonyms |
EG627805 |
| MMRRC Submission |
039497-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R1442 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 20692623 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Stop codon
at position 78
(K78*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
| AlphaFold |
E9PYS0 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000167314
AA Change: K78*
|
| SMART Domains |
Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: K78*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 97.9%
- 10x: 95.0%
- 20x: 88.4%
|
| Validation Efficiency |
100% (71/71) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 5031439G07Rik |
A |
T |
15: 84,839,833 (GRCm39) |
|
probably benign |
Het |
| Adamts7 |
T |
A |
9: 90,070,823 (GRCm39) |
I648N |
probably damaging |
Het |
| Akap13 |
T |
A |
7: 75,385,526 (GRCm39) |
F2252I |
probably damaging |
Het |
| Akr1c6 |
A |
T |
13: 4,507,159 (GRCm39) |
H314L |
probably damaging |
Het |
| Anxa3 |
T |
A |
5: 96,976,549 (GRCm39) |
|
probably null |
Het |
| Apob |
T |
G |
12: 8,036,165 (GRCm39) |
F298V |
probably benign |
Het |
| Atp8a2 |
A |
C |
14: 60,097,772 (GRCm39) |
|
probably benign |
Het |
| Atp8b5 |
A |
T |
4: 43,334,313 (GRCm39) |
T360S |
probably damaging |
Het |
| BC051665 |
A |
T |
13: 60,932,555 (GRCm39) |
N43K |
probably benign |
Het |
| Bicral |
T |
A |
17: 47,112,650 (GRCm39) |
H850L |
probably benign |
Het |
| C1qtnf1 |
A |
G |
11: 118,339,011 (GRCm39) |
D227G |
probably damaging |
Het |
| C8a |
T |
A |
4: 104,685,275 (GRCm39) |
T323S |
possibly damaging |
Het |
| Cep89 |
T |
C |
7: 35,117,636 (GRCm39) |
|
probably benign |
Het |
| Cercam |
G |
T |
2: 29,770,652 (GRCm39) |
V408L |
probably benign |
Het |
| CN725425 |
G |
A |
15: 91,123,158 (GRCm39) |
V76M |
possibly damaging |
Het |
| Cops7b |
T |
A |
1: 86,532,835 (GRCm39) |
M231K |
probably benign |
Het |
| Cpa2 |
T |
A |
6: 30,544,865 (GRCm39) |
|
probably null |
Het |
| Dab2ip |
A |
T |
2: 35,600,268 (GRCm39) |
I287F |
probably damaging |
Het |
| Defb10 |
A |
T |
8: 22,348,944 (GRCm39) |
M1L |
probably benign |
Het |
| Dscam |
C |
A |
16: 96,409,274 (GRCm39) |
R1883L |
possibly damaging |
Het |
| Dsg4 |
T |
A |
18: 20,595,717 (GRCm39) |
I640N |
possibly damaging |
Het |
| Duox2 |
G |
C |
2: 122,112,232 (GRCm39) |
P1318R |
probably benign |
Het |
| Dzip3 |
T |
C |
16: 48,765,985 (GRCm39) |
D466G |
probably benign |
Het |
| E230025N22Rik |
T |
A |
18: 36,824,462 (GRCm39) |
|
probably null |
Het |
| E2f3 |
A |
G |
13: 30,102,652 (GRCm39) |
L80P |
probably damaging |
Het |
| Eif2b2 |
T |
C |
12: 85,266,360 (GRCm39) |
S9P |
probably benign |
Het |
| Etaa1 |
A |
T |
11: 17,897,201 (GRCm39) |
D305E |
probably benign |
Het |
| Fads6 |
C |
A |
11: 115,188,235 (GRCm39) |
R23L |
probably benign |
Het |
| Flrt2 |
T |
C |
12: 95,746,979 (GRCm39) |
V439A |
probably damaging |
Het |
| Galm |
A |
C |
17: 80,452,614 (GRCm39) |
Q184P |
probably damaging |
Het |
| Gtse1 |
C |
T |
15: 85,744,303 (GRCm39) |
|
probably benign |
Het |
| Irf7 |
T |
C |
7: 140,843,935 (GRCm39) |
T246A |
probably damaging |
Het |
| Kif28 |
A |
G |
1: 179,532,697 (GRCm39) |
V639A |
possibly damaging |
Het |
| Klhdc8a |
G |
A |
1: 132,230,385 (GRCm39) |
A167T |
possibly damaging |
Het |
| Lrfn3 |
T |
C |
7: 30,059,469 (GRCm39) |
H252R |
probably benign |
Het |
| Lzts1 |
G |
T |
8: 69,591,638 (GRCm39) |
A170E |
probably damaging |
Het |
| Mphosph9 |
T |
A |
5: 124,403,461 (GRCm39) |
I856F |
possibly damaging |
Het |
| Mroh2a |
C |
T |
1: 88,160,075 (GRCm39) |
|
probably benign |
Het |
| Mroh2a |
C |
A |
1: 88,170,142 (GRCm39) |
A685D |
possibly damaging |
Het |
| Myh3 |
A |
G |
11: 66,978,103 (GRCm39) |
N392D |
possibly damaging |
Het |
| Naalad2 |
T |
C |
9: 18,262,328 (GRCm39) |
|
probably benign |
Het |
| Npc1 |
T |
A |
18: 12,328,106 (GRCm39) |
M1068L |
probably benign |
Het |
| Nup58 |
T |
A |
14: 60,469,992 (GRCm39) |
|
probably benign |
Het |
| Or10c1 |
T |
C |
17: 37,522,595 (GRCm39) |
T50A |
probably benign |
Het |
| Or4k40 |
A |
T |
2: 111,250,438 (GRCm39) |
I286N |
probably damaging |
Het |
| Or8b1 |
A |
T |
9: 38,399,939 (GRCm39) |
I205F |
probably benign |
Het |
| Or8s16 |
T |
C |
15: 98,211,068 (GRCm39) |
Y121C |
probably damaging |
Het |
| Parp2 |
T |
G |
14: 51,056,732 (GRCm39) |
|
probably null |
Het |
| Ppp4r4 |
T |
C |
12: 103,564,504 (GRCm39) |
V9A |
probably damaging |
Het |
| Ptprc |
T |
A |
1: 138,000,050 (GRCm39) |
D856V |
probably damaging |
Het |
| Ptpru |
T |
A |
4: 131,535,580 (GRCm39) |
T466S |
probably benign |
Het |
| Rhob |
A |
G |
12: 8,549,325 (GRCm39) |
V103A |
possibly damaging |
Het |
| Sec23ip |
A |
C |
7: 128,378,510 (GRCm39) |
S775R |
probably benign |
Het |
| Slit2 |
T |
G |
5: 48,395,725 (GRCm39) |
D709E |
probably damaging |
Het |
| Smok2b |
C |
G |
17: 13,454,390 (GRCm39) |
I183M |
probably damaging |
Het |
| Smtnl1 |
T |
A |
2: 84,648,780 (GRCm39) |
D158V |
probably damaging |
Het |
| Syne2 |
T |
C |
12: 75,993,489 (GRCm39) |
I2087T |
probably damaging |
Het |
| Tada1 |
G |
A |
1: 166,214,319 (GRCm39) |
R106H |
possibly damaging |
Het |
| Tecta |
T |
A |
9: 42,243,778 (GRCm39) |
I2025F |
probably damaging |
Het |
| Themis |
T |
C |
10: 28,658,131 (GRCm39) |
V386A |
probably damaging |
Het |
| Ubr5 |
G |
A |
15: 38,015,168 (GRCm39) |
|
probably benign |
Het |
| Vcl |
T |
A |
14: 21,033,446 (GRCm39) |
I134N |
probably damaging |
Het |
| Vegfa |
G |
A |
17: 46,336,418 (GRCm39) |
T56I |
possibly damaging |
Het |
| Vmn2r82 |
A |
T |
10: 79,215,201 (GRCm39) |
T395S |
probably benign |
Het |
| Wbp2nl |
T |
C |
15: 82,198,407 (GRCm39) |
S315P |
probably benign |
Het |
| Zfp566 |
T |
C |
7: 29,777,344 (GRCm39) |
Y279C |
probably damaging |
Het |
| Zmym2 |
T |
C |
14: 57,180,784 (GRCm39) |
Y899H |
probably damaging |
Het |
|
| Other mutations in Vmn2r108 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9226:Vmn2r108
|
UTSW |
17 |
20,691,330 (GRCm39) |
missense |
probably benign |
|
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
|
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTCTGCCCTTGACCAGTGAGC -3'
(R):5'- TGTGACTGGACATCTGTACCCAGTG -3'
Sequencing Primer
(F):5'- TTGACCAGTGAGCCAAAAACAG -3'
(R):5'- GAGCAATTTCAGACTGCCATACTG -3'
|
| Posted On |
2014-03-14 |
Incidental Mutation