Mutagenetix > Incidental Mutation

Incidental Mutation 'R1835:Fat4'

205140

Institutional Source

Beutler Lab

Gene Symbol

Fat4

Ensembl Gene

ENSMUSG00000046743

Gene Name

FAT atypical cadherin 4

Synonyms

6030410K14Rik

MMRRC Submission

039862-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R1835 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

38941089-39066134 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 39037720 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 3791 (I3791V)

Ref Sequence

ENSEMBL: ENSMUSP00000061836 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061260]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000061260
AA Change: I3791V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000061836
Gene: ENSMUSG00000046743
AA Change: I3791V

Domain	Start	End	E-Value	Type
low complexity region	2	21	N/A	INTRINSIC
CA	60	133	4.09e-7	SMART
CA	157	248	4.51e-18	SMART
CA	272	351	7.66e-30	SMART
CA	380	473	2.55e-17	SMART
CA	497	580	8.27e-26	SMART
CA	605	687	6.46e-28	SMART
CA	711	791	1e-24	SMART
CA	815	891	3.78e-20	SMART
CA	915	994	8.6e-24	SMART
CA	1018	1098	7.09e-25	SMART
CA	1122	1208	6.78e-22	SMART
CA	1232	1313	2.63e-28	SMART
CA	1337	1418	7.25e-31	SMART
CA	1442	1527	4.58e-19	SMART
CA	1550	1629	4.52e-9	SMART
CA	1651	1738	1.3e-9	SMART
CA	1762	1839	2.01e-24	SMART
CA	1863	1942	3.11e-21	SMART
CA	1966	2049	5.85e-26	SMART
CA	2072	2152	1.88e-29	SMART
CA	2176	2257	3.06e-29	SMART
CA	2282	2362	2.61e-23	SMART
CA	2386	2466	2.99e-32	SMART
CA	2490	2568	9.92e-6	SMART
CA	2588	2669	6.58e-20	SMART
CA	2692	2773	7.25e-31	SMART
CA	2796	2872	1.69e-22	SMART
CA	2896	2983	3.16e-22	SMART
CA	3007	3089	1.01e-15	SMART
CA	3113	3194	1.25e-25	SMART
CA	3218	3298	7e-15	SMART
CA	3322	3405	3.96e-14	SMART
CA	3428	3510	3.41e-27	SMART
CA	3532	3614	5.64e-19	SMART
EGF	3807	3862	1.78e-2	SMART
EGF_CA	3864	3900	2.36e-16	SMART
EGF_CA	3902	3938	7.99e-14	SMART
EGF	3943	3976	1.24e-1	SMART
LamG	3996	4144	4.08e-19	SMART
EGF	4167	4200	5.88e-3	SMART
LamG	4244	4375	1.76e-23	SMART
EGF	4430	4464	1.41e-5	SMART
low complexity region	4514	4526	N/A	INTRINSIC
low complexity region	4533	4550	N/A	INTRINSIC
low complexity region	4840	4849	N/A	INTRINSIC

Coding Region Coverage

1x: 97.4%
3x: 96.8%
10x: 94.9%
20x: 91.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protocadherin family. This gene may play a role in regulating planar cell polarity (PCP). Studies in mice suggest that loss of PCP signaling may cause cystic kidney disease, and mutations in this gene have been associated with Van Maldergem Syndrome 2. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Mar 2014]
PHENOTYPE: Homozygous inactivation of this gene leads to neonatal lethality, reduced birth body size, curly tails, kyphosis, small lungs, renal cysts, and defects in sternum and vertebrae morphology, neural tube width, cochlear elongation, stereocilia orientation, kidney development, and intestinal elongation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 97 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acss2	T	A	2: 155,400,550 (GRCm39)	Y530N	probably damaging	Het
Adam4	T	C	12: 81,466,333 (GRCm39)	I763V	probably benign	Het
Aipl1	T	G	11: 71,921,325 (GRCm39)	K190T	possibly damaging	Het
Alms1	T	A	6: 85,655,485 (GRCm39)	S3344T	possibly damaging	Het
Alpi	A	G	1: 87,027,136 (GRCm39)	V381A	possibly damaging	Het
Ankfn1	A	T	11: 89,338,444 (GRCm39)	S365R	probably benign	Het
Aox1	G	A	1: 58,348,150 (GRCm39)	A623T	probably benign	Het
Apc	T	A	18: 34,450,130 (GRCm39)	L2308Q	probably damaging	Het
Atp9b	C	T	18: 80,822,098 (GRCm39)	V501I	probably benign	Het
Baz2b	T	C	2: 59,732,163 (GRCm39)	E1994G	probably benign	Het
Bltp2	G	T	11: 78,178,576 (GRCm39)	V1993F	probably damaging	Het
Cacna1a	T	C	8: 85,307,986 (GRCm39)		probably null	Het
Cacna1h	C	A	17: 25,611,050 (GRCm39)	V583L	probably benign	Het
Cd55	T	C	1: 130,375,346 (GRCm39)		probably benign	Het
Cep192	T	A	18: 67,937,494 (GRCm39)	S75T	possibly damaging	Het
Cfap54	T	A	10: 92,798,237 (GRCm39)	D1674V	probably benign	Het
Churc1	T	C	12: 76,820,071 (GRCm39)	F27L	possibly damaging	Het
Coro1c	A	G	5: 113,986,604 (GRCm39)	I280T	probably benign	Het
Creb1	C	T	1: 64,590,109 (GRCm39)	Q32*	probably null	Het
Cyp2b9	A	G	7: 25,900,208 (GRCm39)	T339A	probably benign	Het
Dctn3	T	C	4: 41,720,813 (GRCm39)	R51G	probably damaging	Het
Ddb1	T	C	19: 10,603,957 (GRCm39)	V888A	probably damaging	Het
Disp1	A	G	1: 182,870,564 (GRCm39)	Y619H	probably damaging	Het
Dnajc9	T	C	14: 20,438,402 (GRCm39)	D96G	possibly damaging	Het
Eepd1	A	G	9: 25,394,164 (GRCm39)	T143A	possibly damaging	Het
Eps8	T	A	6: 137,499,277 (GRCm39)	K204*	probably null	Het
Ercc5	T	A	1: 44,220,035 (GRCm39)	S1102R	probably benign	Het
Ergic2	T	A	6: 148,091,079 (GRCm39)	Y211F	possibly damaging	Het
Fam135b	G	T	15: 71,362,560 (GRCm39)	L274M	probably damaging	Het
Fat3	G	A	9: 15,909,384 (GRCm39)	T2206I	probably damaging	Het
Gemin4	A	G	11: 76,104,122 (GRCm39)	M213T	possibly damaging	Het
Gnai3	T	C	3: 108,025,723 (GRCm39)	M119V	probably benign	Het
Heatr5b	A	T	17: 79,080,992 (GRCm39)	L1420Q	probably damaging	Het
Herc2	G	T	7: 55,856,513 (GRCm39)	G3918*	probably null	Het
Ints9	A	G	14: 65,269,705 (GRCm39)	Y465C	probably damaging	Het
Ist1	A	G	8: 110,405,515 (GRCm39)	V175A	probably damaging	Het
Kcnj12	T	C	11: 60,960,383 (GRCm39)	L227P	possibly damaging	Het
Kcnq5	T	C	1: 21,536,611 (GRCm39)	S416G	probably benign	Het
Kdm3a	T	A	6: 71,590,940 (GRCm39)	T295S	probably benign	Het
Kif1c	T	A	11: 70,599,797 (GRCm39)	M479K	probably damaging	Het
Kif20b	T	C	19: 34,933,438 (GRCm39)	L83P	probably damaging	Het
Kndc1	A	G	7: 139,507,624 (GRCm39)	E1194G	probably damaging	Het
Llgl1	A	G	11: 60,595,556 (GRCm39)	M81V	probably benign	Het
Map4k5	C	A	12: 69,871,436 (GRCm39)	M495I	probably damaging	Het
Mest	C	T	6: 30,742,790 (GRCm39)	R146C	probably benign	Het
Mettl24	T	A	10: 40,613,812 (GRCm39)		probably null	Het
Mical1	T	C	10: 41,359,531 (GRCm39)	S586P	probably benign	Het
Mrgpra3	G	T	7: 47,239,694 (GRCm39)	Y77*	probably null	Het
Mss51	A	T	14: 20,533,246 (GRCm39)	C408*	probably null	Het
Myh6	T	C	14: 55,194,858 (GRCm39)	T666A	probably benign	Het
Myo10	T	C	15: 25,805,673 (GRCm39)	C1685R	possibly damaging	Het
Naip5	A	T	13: 100,359,726 (GRCm39)	Y503*	probably null	Het
Neil1	A	C	9: 57,053,888 (GRCm39)	F144C	probably damaging	Het
Nipbl	T	A	15: 8,373,001 (GRCm39)	I1082F	possibly damaging	Het
Nkiras1	T	C	14: 18,276,732 (GRCm38)	V7A	probably damaging	Het
Nt5el	C	A	13: 105,218,702 (GRCm39)	A12E	unknown	Het
Ntng2	G	A	2: 29,087,069 (GRCm39)	Q384*	probably null	Het
Ocrl	T	A	X: 47,050,993 (GRCm39)	I74N	probably damaging	Het
Or10j27	A	G	1: 172,958,382 (GRCm39)	V134A	probably benign	Het
Or13a22	A	G	7: 140,072,622 (GRCm39)	S24G	probably benign	Het
Or14j8	C	T	17: 38,263,276 (GRCm39)	G213E	possibly damaging	Het
Or1e22	A	C	11: 73,377,200 (GRCm39)	V150G	probably benign	Het
Or2j3	A	T	17: 38,616,203 (GRCm39)	S50T	probably benign	Het
Or2y1	A	T	11: 49,385,497 (GRCm39)	I46F	probably damaging	Het
Patj	A	G	4: 98,379,827 (GRCm39)	D151G	probably benign	Het
Plpbp	T	C	8: 27,539,259 (GRCm39)	V126A	probably damaging	Het
Pold2	A	G	11: 5,823,454 (GRCm39)	L325P	possibly damaging	Het
Ppp1r12c	A	C	7: 4,486,650 (GRCm39)	S480A	probably damaging	Het
Pum1	T	C	4: 130,428,359 (GRCm39)	S124P	possibly damaging	Het
Pwp2	C	G	10: 78,014,925 (GRCm39)	G353A	probably damaging	Het
Reln	C	A	5: 22,184,000 (GRCm39)	Q1666H	probably damaging	Het
Rnf19a	T	C	15: 36,266,071 (GRCm39)	I9V	probably benign	Het
Ryr2	T	C	13: 11,784,764 (GRCm39)	H1063R	probably benign	Het
Samd14	C	G	11: 94,914,426 (GRCm39)	D361E	probably damaging	Het
Samd15	A	T	12: 87,248,617 (GRCm39)	N365I	probably damaging	Het
Sec16b	A	G	1: 157,358,882 (GRCm39)	H105R	probably benign	Het
Sez6	T	C	11: 77,844,329 (GRCm39)	S51P	probably benign	Het
Sh3bp1	T	A	15: 78,789,350 (GRCm39)	L236Q	probably damaging	Het
Sspo	C	T	6: 48,434,274 (GRCm39)	T991I	probably damaging	Het
Suco	A	T	1: 161,687,069 (GRCm39)	L97*	probably null	Het
Tab1	C	A	15: 80,032,497 (GRCm39)	R35S	probably benign	Het
Tet3	C	A	6: 83,381,145 (GRCm39)	S341I	possibly damaging	Het
Tlr1	A	T	5: 65,083,043 (GRCm39)	D511E	probably benign	Het
Tmem132b	A	C	5: 125,862,963 (GRCm39)	D656A	probably damaging	Het
Tmtc4	T	A	14: 123,179,400 (GRCm39)		probably null	Het
Trmo	T	C	4: 46,380,158 (GRCm39)	T404A	probably damaging	Het
Trpm1	A	G	7: 63,880,016 (GRCm39)	K790E	probably damaging	Het
Ulk4	C	A	9: 120,997,250 (GRCm39)	R774M	probably null	Het
Ush2a	C	T	1: 188,184,015 (GRCm39)	L1440F	probably benign	Het
Usp16	A	G	16: 87,277,795 (GRCm39)	K682E	probably damaging	Het
Virma	T	C	4: 11,540,511 (GRCm39)	S1471P	probably benign	Het
Vmn1r177	A	T	7: 23,565,111 (GRCm39)	I255N	probably damaging	Het
Vmn2r61	A	T	7: 41,916,076 (GRCm39)	R230*	probably null	Het
Vps13c	T	A	9: 67,900,295 (GRCm39)	F3671L	probably benign	Het
Washc5	T	C	15: 59,231,189 (GRCm39)	N358S	possibly damaging	Het
Wdr72	A	G	9: 74,058,899 (GRCm39)	K331E	probably damaging	Het
Zfp986	A	T	4: 145,625,805 (GRCm39)	K155I	probably benign	Het

Other mutations in Fat4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00235:Fat4	APN	3	39,036,398 (GRCm39)	missense	probably damaging	1.00
IGL00509:Fat4	APN	3	38,943,188 (GRCm39)	missense	probably damaging	1.00
IGL00698:Fat4	APN	3	39,035,294 (GRCm39)	missense	probably benign	0.17
IGL00934:Fat4	APN	3	38,944,822 (GRCm39)	missense	probably damaging	1.00
IGL01063:Fat4	APN	3	38,944,728 (GRCm39)	missense	possibly damaging	0.80
IGL01123:Fat4	APN	3	39,011,418 (GRCm39)	missense	probably benign	0.00
IGL01313:Fat4	APN	3	39,061,350 (GRCm39)	missense	possibly damaging	0.53
IGL01328:Fat4	APN	3	39,034,807 (GRCm39)	missense	probably damaging	1.00
IGL01328:Fat4	APN	3	38,944,140 (GRCm39)	missense	probably damaging	1.00
IGL01374:Fat4	APN	3	38,941,647 (GRCm39)	missense	probably damaging	1.00
IGL01412:Fat4	APN	3	38,945,330 (GRCm39)	missense	probably benign	0.09
IGL01472:Fat4	APN	3	38,942,219 (GRCm39)	missense	probably damaging	1.00
IGL01514:Fat4	APN	3	39,003,683 (GRCm39)	missense	possibly damaging	0.89
IGL01548:Fat4	APN	3	39,063,406 (GRCm39)	missense	probably damaging	1.00
IGL01548:Fat4	APN	3	38,941,907 (GRCm39)	missense	probably damaging	0.99
IGL01576:Fat4	APN	3	38,943,096 (GRCm39)	missense	probably damaging	1.00
IGL01591:Fat4	APN	3	39,064,524 (GRCm39)	nonsense	probably null
IGL01626:Fat4	APN	3	39,005,181 (GRCm39)	missense	probably damaging	1.00
IGL01746:Fat4	APN	3	39,045,880 (GRCm39)	nonsense	probably null
IGL01800:Fat4	APN	3	39,035,878 (GRCm39)	missense	probably damaging	0.99
IGL01815:Fat4	APN	3	38,942,922 (GRCm39)	missense	probably damaging	1.00
IGL01863:Fat4	APN	3	39,024,768 (GRCm39)	splice site	probably benign
IGL01917:Fat4	APN	3	38,943,879 (GRCm39)	missense	possibly damaging	0.89
IGL01936:Fat4	APN	3	39,033,923 (GRCm39)	missense	probably benign	0.10
IGL02060:Fat4	APN	3	39,064,420 (GRCm39)	missense	probably damaging	1.00
IGL02103:Fat4	APN	3	38,943,348 (GRCm39)	missense	probably damaging	0.97
IGL02119:Fat4	APN	3	39,037,088 (GRCm39)	missense	probably benign	0.10
IGL02124:Fat4	APN	3	38,942,553 (GRCm39)	missense	probably damaging	1.00
IGL02164:Fat4	APN	3	39,050,354 (GRCm39)	critical splice donor site	probably null
IGL02182:Fat4	APN	3	38,944,695 (GRCm39)	missense	probably damaging	1.00
IGL02207:Fat4	APN	3	39,005,412 (GRCm39)	missense	probably benign	0.16
IGL02210:Fat4	APN	3	38,946,002 (GRCm39)	missense	probably benign	0.01
IGL02257:Fat4	APN	3	39,055,288 (GRCm39)	missense	probably benign	0.09
IGL02271:Fat4	APN	3	39,034,068 (GRCm39)	missense	probably benign	0.18
IGL02305:Fat4	APN	3	39,064,137 (GRCm39)	missense	probably damaging	1.00
IGL02314:Fat4	APN	3	38,941,779 (GRCm39)	missense	probably damaging	1.00
IGL02455:Fat4	APN	3	39,005,280 (GRCm39)	missense	possibly damaging	0.48
IGL02468:Fat4	APN	3	39,037,195 (GRCm39)	missense	probably benign
IGL02478:Fat4	APN	3	38,942,364 (GRCm39)	missense	probably damaging	1.00
IGL02480:Fat4	APN	3	39,064,579 (GRCm39)	missense	probably damaging	1.00
IGL02487:Fat4	APN	3	38,941,394 (GRCm39)	missense	probably damaging	1.00
IGL02632:Fat4	APN	3	39,056,913 (GRCm39)	missense	probably benign	0.04
IGL02665:Fat4	APN	3	39,056,985 (GRCm39)	missense	probably benign	0.08
IGL02674:Fat4	APN	3	39,037,486 (GRCm39)	missense	probably benign	0.35
IGL02692:Fat4	APN	3	39,005,235 (GRCm39)	missense	probably damaging	1.00
IGL02710:Fat4	APN	3	38,944,744 (GRCm39)	missense	probably damaging	1.00
IGL02803:Fat4	APN	3	38,943,444 (GRCm39)	missense	probably damaging	1.00
IGL02834:Fat4	APN	3	39,010,893 (GRCm39)	missense	probably damaging	1.00
IGL02891:Fat4	APN	3	39,005,422 (GRCm39)	missense	probably damaging	1.00
IGL02982:Fat4	APN	3	38,944,992 (GRCm39)	missense	probably damaging	1.00
IGL02993:Fat4	APN	3	39,011,304 (GRCm39)	missense	probably damaging	1.00
IGL02996:Fat4	APN	3	39,012,674 (GRCm39)	missense	probably damaging	1.00
IGL03029:Fat4	APN	3	39,036,740 (GRCm39)	missense	possibly damaging	0.46
IGL03124:Fat4	APN	3	39,035,701 (GRCm39)	missense	possibly damaging	0.61
IGL03144:Fat4	APN	3	39,011,008 (GRCm39)	missense	possibly damaging	0.68
IGL03149:Fat4	APN	3	39,045,834 (GRCm39)	missense	probably damaging	1.00
IGL03169:Fat4	APN	3	39,011,547 (GRCm39)	missense	probably benign	0.02
IGL03190:Fat4	APN	3	39,035,390 (GRCm39)	missense	probably damaging	1.00
IGL03272:Fat4	APN	3	39,063,852 (GRCm39)	missense	probably benign
IGL03371:Fat4	APN	3	39,037,336 (GRCm39)	missense	possibly damaging	0.65
IGL03372:Fat4	APN	3	38,943,283 (GRCm39)	missense	possibly damaging	0.88
IGL03388:Fat4	APN	3	39,011,376 (GRCm39)	missense	probably damaging	1.00
IGL03394:Fat4	APN	3	38,946,168 (GRCm39)	missense	probably damaging	0.99
IGL03394:Fat4	APN	3	39,063,513 (GRCm39)	missense	probably damaging	1.00
IGL03405:Fat4	APN	3	39,012,599 (GRCm39)	missense	probably benign	0.02
IGL03410:Fat4	APN	3	38,945,325 (GRCm39)	missense	probably damaging	1.00
Asahi	UTSW	3	39,035,968 (GRCm39)	missense	probably damaging	1.00
Expulsion	UTSW	3	38,943,798 (GRCm39)	missense	probably benign	0.00
heineken	UTSW	3	39,034,529 (GRCm39)	missense	probably damaging	1.00
schlitz	UTSW	3	39,034,808 (GRCm39)	missense	probably damaging	1.00
PIT4696001:Fat4	UTSW	3	39,036,506 (GRCm39)	missense	probably damaging	0.98
PIT4696001:Fat4	UTSW	3	38,943,153 (GRCm39)	missense	probably benign	0.04
R0015:Fat4	UTSW	3	39,036,652 (GRCm39)	missense	probably damaging	1.00
R0015:Fat4	UTSW	3	39,036,652 (GRCm39)	missense	probably damaging	1.00
R0078:Fat4	UTSW	3	38,943,080 (GRCm39)	missense	probably benign	0.35
R0100:Fat4	UTSW	3	39,034,397 (GRCm39)	missense	probably damaging	1.00
R0100:Fat4	UTSW	3	39,034,397 (GRCm39)	missense	probably damaging	1.00
R0201:Fat4	UTSW	3	38,945,745 (GRCm39)	missense	probably damaging	0.99
R0280:Fat4	UTSW	3	38,944,965 (GRCm39)	missense	probably benign
R0357:Fat4	UTSW	3	38,945,376 (GRCm39)	missense	probably damaging	1.00
R0409:Fat4	UTSW	3	39,031,562 (GRCm39)	missense	probably damaging	1.00
R0498:Fat4	UTSW	3	39,034,786 (GRCm39)	missense	probably benign	0.00
R0502:Fat4	UTSW	3	39,057,073 (GRCm39)	missense	probably damaging	0.98
R0506:Fat4	UTSW	3	38,942,463 (GRCm39)	missense	probably benign	0.00
R0532:Fat4	UTSW	3	39,035,870 (GRCm39)	missense	probably benign	0.02
R0616:Fat4	UTSW	3	38,997,019 (GRCm39)	missense	probably damaging	1.00
R0630:Fat4	UTSW	3	39,054,321 (GRCm39)	missense	probably damaging	1.00
R0678:Fat4	UTSW	3	38,943,843 (GRCm39)	missense	probably damaging	1.00
R0685:Fat4	UTSW	3	39,055,327 (GRCm39)	missense	probably benign
R0729:Fat4	UTSW	3	39,054,444 (GRCm39)	splice site	probably benign
R0748:Fat4	UTSW	3	38,941,977 (GRCm39)	missense	possibly damaging	0.67
R0811:Fat4	UTSW	3	39,011,623 (GRCm39)	missense	probably damaging	1.00
R0812:Fat4	UTSW	3	39,011,623 (GRCm39)	missense	probably damaging	1.00
R0830:Fat4	UTSW	3	39,053,258 (GRCm39)	missense	probably benign	0.26
R0841:Fat4	UTSW	3	39,050,147 (GRCm39)	missense	probably damaging	0.99
R0884:Fat4	UTSW	3	39,037,007 (GRCm39)	missense	possibly damaging	0.89
R1056:Fat4	UTSW	3	38,945,541 (GRCm39)	missense	probably damaging	1.00
R1066:Fat4	UTSW	3	39,011,376 (GRCm39)	missense	probably damaging	1.00
R1078:Fat4	UTSW	3	39,037,235 (GRCm39)	missense	probably benign	0.10
R1084:Fat4	UTSW	3	39,033,974 (GRCm39)	missense	possibly damaging	0.88
R1118:Fat4	UTSW	3	39,037,091 (GRCm39)	missense	possibly damaging	0.88
R1213:Fat4	UTSW	3	38,944,520 (GRCm39)	missense	probably benign	0.01
R1418:Fat4	UTSW	3	38,944,962 (GRCm39)	missense	probably damaging	1.00
R1475:Fat4	UTSW	3	38,942,472 (GRCm39)	missense	probably damaging	1.00
R1487:Fat4	UTSW	3	39,050,066 (GRCm39)	missense	possibly damaging	0.77
R1511:Fat4	UTSW	3	39,037,225 (GRCm39)	missense	probably damaging	0.97
R1534:Fat4	UTSW	3	38,944,238 (GRCm39)	missense	probably damaging	1.00
R1558:Fat4	UTSW	3	38,943,135 (GRCm39)	missense	probably damaging	1.00
R1586:Fat4	UTSW	3	38,943,009 (GRCm39)	missense	probably damaging	1.00
R1592:Fat4	UTSW	3	39,061,326 (GRCm39)	missense	probably damaging	0.99
R1655:Fat4	UTSW	3	39,011,467 (GRCm39)	missense	probably damaging	0.97
R1662:Fat4	UTSW	3	39,034,928 (GRCm39)	missense	probably damaging	1.00
R1710:Fat4	UTSW	3	39,005,304 (GRCm39)	missense	probably damaging	1.00
R1731:Fat4	UTSW	3	38,945,459 (GRCm39)	missense	probably damaging	1.00
R1761:Fat4	UTSW	3	38,941,638 (GRCm39)	missense	possibly damaging	0.61
R1770:Fat4	UTSW	3	39,064,417 (GRCm39)	missense	probably damaging	1.00
R1828:Fat4	UTSW	3	39,037,607 (GRCm39)	missense	probably damaging	1.00
R1846:Fat4	UTSW	3	39,036,532 (GRCm39)	missense	probably benign	0.00
R1861:Fat4	UTSW	3	39,064,633 (GRCm39)	missense	probably benign	0.09
R1871:Fat4	UTSW	3	39,035,221 (GRCm39)	missense	possibly damaging	0.63
R1981:Fat4	UTSW	3	39,045,813 (GRCm39)	missense	probably damaging	1.00
R1988:Fat4	UTSW	3	39,050,239 (GRCm39)	missense	probably damaging	1.00
R1988:Fat4	UTSW	3	38,941,264 (GRCm39)	missense	probably benign
R2056:Fat4	UTSW	3	38,945,319 (GRCm39)	missense	possibly damaging	0.88
R2058:Fat4	UTSW	3	38,945,319 (GRCm39)	missense	possibly damaging	0.88
R2059:Fat4	UTSW	3	38,945,319 (GRCm39)	missense	possibly damaging	0.88
R2070:Fat4	UTSW	3	39,064,804 (GRCm39)	missense	probably benign	0.00
R2078:Fat4	UTSW	3	38,943,822 (GRCm39)	missense	probably damaging	1.00
R2114:Fat4	UTSW	3	39,035,633 (GRCm39)	missense	probably benign	0.01
R2135:Fat4	UTSW	3	39,034,882 (GRCm39)	missense	probably damaging	0.98
R2152:Fat4	UTSW	3	39,037,544 (GRCm39)	missense	probably damaging	1.00
R2153:Fat4	UTSW	3	39,037,544 (GRCm39)	missense	probably damaging	1.00
R2154:Fat4	UTSW	3	38,941,688 (GRCm39)	missense	probably damaging	1.00
R2196:Fat4	UTSW	3	39,035,566 (GRCm39)	missense	probably benign	0.23
R2211:Fat4	UTSW	3	38,945,676 (GRCm39)	missense	possibly damaging	0.77
R2219:Fat4	UTSW	3	39,064,364 (GRCm39)	missense	probably damaging	1.00
R2247:Fat4	UTSW	3	38,946,198 (GRCm39)	missense	probably damaging	1.00
R2263:Fat4	UTSW	3	38,943,138 (GRCm39)	missense	possibly damaging	0.93
R2264:Fat4	UTSW	3	38,944,571 (GRCm39)	missense	probably benign	0.25
R2274:Fat4	UTSW	3	39,050,048 (GRCm39)	missense	possibly damaging	0.47
R2337:Fat4	UTSW	3	39,034,160 (GRCm39)	missense	probably damaging	1.00
R2343:Fat4	UTSW	3	39,011,254 (GRCm39)	missense	probably damaging	0.97
R2365:Fat4	UTSW	3	39,034,568 (GRCm39)	missense	probably benign
R2412:Fat4	UTSW	3	39,011,221 (GRCm39)	missense	probably benign	0.05
R2883:Fat4	UTSW	3	39,034,953 (GRCm39)	missense	probably damaging	1.00
R2942:Fat4	UTSW	3	39,036,485 (GRCm39)	missense	probably damaging	1.00
R2989:Fat4	UTSW	3	39,061,302 (GRCm39)	missense	probably benign
R3103:Fat4	UTSW	3	38,946,089 (GRCm39)	missense	probably benign	0.03
R3158:Fat4	UTSW	3	38,944,940 (GRCm39)	missense	possibly damaging	0.87
R3800:Fat4	UTSW	3	39,035,423 (GRCm39)	missense	possibly damaging	0.48
R3808:Fat4	UTSW	3	39,036,587 (GRCm39)	missense	possibly damaging	0.52
R3848:Fat4	UTSW	3	39,061,410 (GRCm39)	missense	probably benign	0.10
R3850:Fat4	UTSW	3	39,061,410 (GRCm39)	missense	probably benign	0.10
R3957:Fat4	UTSW	3	39,036,495 (GRCm39)	missense	probably benign
R4065:Fat4	UTSW	3	39,063,346 (GRCm39)	missense	probably benign	0.13
R4078:Fat4	UTSW	3	39,034,169 (GRCm39)	missense	probably damaging	1.00
R4096:Fat4	UTSW	3	38,942,024 (GRCm39)	missense	possibly damaging	0.46
R4161:Fat4	UTSW	3	38,996,958 (GRCm39)	missense	possibly damaging	0.95
R4273:Fat4	UTSW	3	38,945,776 (GRCm39)	missense	probably damaging	1.00
R4285:Fat4	UTSW	3	38,943,320 (GRCm39)	missense	probably benign	0.00
R4288:Fat4	UTSW	3	38,945,912 (GRCm39)	missense	probably damaging	1.00
R4407:Fat4	UTSW	3	39,012,689 (GRCm39)	missense	probably benign	0.05
R4528:Fat4	UTSW	3	38,945,443 (GRCm39)	missense	probably benign	0.01
R4547:Fat4	UTSW	3	39,005,432 (GRCm39)	missense	probably damaging	1.00
R4681:Fat4	UTSW	3	38,941,491 (GRCm39)	missense	probably damaging	1.00
R4826:Fat4	UTSW	3	39,037,106 (GRCm39)	missense	probably damaging	1.00
R4855:Fat4	UTSW	3	38,942,466 (GRCm39)	missense	probably benign
R4871:Fat4	UTSW	3	38,945,754 (GRCm39)	missense	probably damaging	1.00
R4897:Fat4	UTSW	3	39,034,781 (GRCm39)	missense	probably damaging	1.00
R4928:Fat4	UTSW	3	39,064,614 (GRCm39)	missense	probably damaging	1.00
R4932:Fat4	UTSW	3	39,061,352 (GRCm39)	missense	probably benign	0.00
R4941:Fat4	UTSW	3	39,011,601 (GRCm39)	missense	probably damaging	1.00
R4943:Fat4	UTSW	3	39,034,322 (GRCm39)	missense	probably benign	0.19
R4959:Fat4	UTSW	3	39,037,195 (GRCm39)	missense	probably benign	0.00
R4973:Fat4	UTSW	3	39,037,195 (GRCm39)	missense	probably benign	0.00
R5098:Fat4	UTSW	3	38,942,438 (GRCm39)	missense	probably benign	0.34
R5163:Fat4	UTSW	3	39,034,946 (GRCm39)	missense	probably damaging	1.00
R5213:Fat4	UTSW	3	39,034,340 (GRCm39)	missense	possibly damaging	0.56
R5328:Fat4	UTSW	3	39,011,017 (GRCm39)	missense	probably damaging	1.00
R5337:Fat4	UTSW	3	39,064,527 (GRCm39)	missense	probably benign	0.44
R5337:Fat4	UTSW	3	38,945,776 (GRCm39)	missense	probably damaging	1.00
R5363:Fat4	UTSW	3	38,942,154 (GRCm39)	missense	probably damaging	1.00
R5380:Fat4	UTSW	3	38,943,013 (GRCm39)	missense	probably damaging	1.00
R5384:Fat4	UTSW	3	39,050,095 (GRCm39)	missense	possibly damaging	0.87
R5422:Fat4	UTSW	3	38,941,394 (GRCm39)	missense	possibly damaging	0.92
R5436:Fat4	UTSW	3	38,945,495 (GRCm39)	missense	probably benign	0.00
R5443:Fat4	UTSW	3	39,064,519 (GRCm39)	missense	probably damaging	1.00
R5501:Fat4	UTSW	3	38,941,364 (GRCm39)	missense	probably benign	0.09
R5571:Fat4	UTSW	3	39,064,423 (GRCm39)	missense	probably damaging	1.00
R5625:Fat4	UTSW	3	38,943,083 (GRCm39)	missense	possibly damaging	0.78
R5652:Fat4	UTSW	3	39,057,117 (GRCm39)	missense	probably damaging	0.99
R5725:Fat4	UTSW	3	38,943,774 (GRCm39)	missense	probably damaging	1.00
R5735:Fat4	UTSW	3	39,003,725 (GRCm39)	missense	probably damaging	1.00
R5739:Fat4	UTSW	3	39,037,283 (GRCm39)	missense	probably benign	0.01
R5766:Fat4	UTSW	3	38,943,617 (GRCm39)	missense	probably damaging	1.00
R5780:Fat4	UTSW	3	39,035,104 (GRCm39)	missense	probably damaging	0.96
R5811:Fat4	UTSW	3	38,945,936 (GRCm39)	missense	probably damaging	1.00
R5829:Fat4	UTSW	3	39,061,454 (GRCm39)	missense	probably damaging	1.00
R5879:Fat4	UTSW	3	38,941,485 (GRCm39)	missense	probably benign
R5933:Fat4	UTSW	3	39,005,524 (GRCm39)	critical splice donor site	probably null
R5938:Fat4	UTSW	3	39,005,388 (GRCm39)	missense	probably damaging	1.00
R5940:Fat4	UTSW	3	38,943,798 (GRCm39)	missense	probably benign	0.00
R5945:Fat4	UTSW	3	39,037,355 (GRCm39)	missense	probably benign	0.19
R5963:Fat4	UTSW	3	39,064,696 (GRCm39)	missense	probably damaging	1.00
R6077:Fat4	UTSW	3	39,056,951 (GRCm39)	missense	probably damaging	1.00
R6158:Fat4	UTSW	3	39,037,411 (GRCm39)	missense	possibly damaging	0.95
R6246:Fat4	UTSW	3	38,945,870 (GRCm39)	missense	probably damaging	1.00
R6253:Fat4	UTSW	3	39,005,505 (GRCm39)	missense	probably damaging	0.99
R6259:Fat4	UTSW	3	39,061,395 (GRCm39)	missense	probably benign	0.18
R6295:Fat4	UTSW	3	39,061,229 (GRCm39)	splice site	probably null
R6387:Fat4	UTSW	3	39,037,934 (GRCm39)	missense	probably damaging	1.00
R6390:Fat4	UTSW	3	39,034,529 (GRCm39)	missense	probably damaging	1.00
R6456:Fat4	UTSW	3	39,038,128 (GRCm39)	missense	possibly damaging	0.90
R6493:Fat4	UTSW	3	38,945,036 (GRCm39)	missense	probably damaging	1.00
R6500:Fat4	UTSW	3	39,035,418 (GRCm39)	nonsense	probably null
R6503:Fat4	UTSW	3	39,036,406 (GRCm39)	missense	probably benign	0.00
R6519:Fat4	UTSW	3	39,057,020 (GRCm39)	missense	probably benign
R6566:Fat4	UTSW	3	39,011,275 (GRCm39)	missense	possibly damaging	0.78
R6576:Fat4	UTSW	3	39,033,839 (GRCm39)	missense	probably benign
R6590:Fat4	UTSW	3	39,037,688 (GRCm39)	missense	probably damaging	1.00
R6658:Fat4	UTSW	3	38,997,077 (GRCm39)	missense	probably benign	0.01
R6662:Fat4	UTSW	3	39,010,970 (GRCm39)	missense	possibly damaging	0.95
R6690:Fat4	UTSW	3	39,037,688 (GRCm39)	missense	probably damaging	1.00
R6807:Fat4	UTSW	3	39,036,589 (GRCm39)	missense	probably benign	0.18
R6823:Fat4	UTSW	3	39,038,088 (GRCm39)	missense	probably benign	0.05
R6824:Fat4	UTSW	3	39,011,674 (GRCm39)	missense	probably benign	0.00
R6830:Fat4	UTSW	3	39,035,966 (GRCm39)	missense	probably benign	0.00
R6925:Fat4	UTSW	3	39,050,353 (GRCm39)	critical splice donor site	probably null
R6948:Fat4	UTSW	3	39,063,595 (GRCm39)	missense	probably damaging	1.00
R6970:Fat4	UTSW	3	39,050,120 (GRCm39)	missense	probably damaging	1.00
R6970:Fat4	UTSW	3	39,035,924 (GRCm39)	missense	probably damaging	1.00
R7017:Fat4	UTSW	3	38,945,692 (GRCm39)	missense	probably benign
R7030:Fat4	UTSW	3	39,036,107 (GRCm39)	missense	probably damaging	1.00
R7044:Fat4	UTSW	3	39,064,960 (GRCm39)	missense	probably benign	0.02
R7044:Fat4	UTSW	3	39,064,959 (GRCm39)	missense	probably benign
R7045:Fat4	UTSW	3	38,942,750 (GRCm39)	missense	probably benign	0.01
R7094:Fat4	UTSW	3	38,944,023 (GRCm39)	missense	probably damaging	1.00
R7111:Fat4	UTSW	3	39,064,682 (GRCm39)	missense	probably damaging	1.00
R7130:Fat4	UTSW	3	39,034,936 (GRCm39)	missense	probably damaging	0.99
R7168:Fat4	UTSW	3	39,034,808 (GRCm39)	missense	probably damaging	1.00
R7192:Fat4	UTSW	3	39,034,613 (GRCm39)	missense	probably benign	0.04
R7194:Fat4	UTSW	3	39,038,044 (GRCm39)	missense	probably damaging	1.00
R7194:Fat4	UTSW	3	38,943,033 (GRCm39)	missense	probably damaging	1.00
R7199:Fat4	UTSW	3	39,031,511 (GRCm39)	missense	probably damaging	0.98
R7213:Fat4	UTSW	3	39,053,236 (GRCm39)	missense	possibly damaging	0.63
R7216:Fat4	UTSW	3	38,945,192 (GRCm39)	missense	probably damaging	1.00
R7225:Fat4	UTSW	3	39,034,325 (GRCm39)	missense	possibly damaging	0.50
R7238:Fat4	UTSW	3	38,944,562 (GRCm39)	missense	probably benign	0.31
R7239:Fat4	UTSW	3	39,037,989 (GRCm39)	missense	possibly damaging	0.85
R7283:Fat4	UTSW	3	38,943,842 (GRCm39)	missense	probably damaging	1.00
R7296:Fat4	UTSW	3	38,943,294 (GRCm39)	nonsense	probably null
R7372:Fat4	UTSW	3	38,944,358 (GRCm39)	missense	probably damaging	1.00
R7400:Fat4	UTSW	3	38,942,073 (GRCm39)	missense	probably damaging	1.00
R7419:Fat4	UTSW	3	39,054,385 (GRCm39)	missense	probably damaging	1.00
R7430:Fat4	UTSW	3	39,063,793 (GRCm39)	missense	probably damaging	1.00
R7430:Fat4	UTSW	3	38,941,599 (GRCm39)	missense	probably damaging	0.97
R7431:Fat4	UTSW	3	39,063,306 (GRCm39)	missense	possibly damaging	0.80
R7486:Fat4	UTSW	3	39,011,576 (GRCm39)	nonsense	probably null
R7501:Fat4	UTSW	3	39,012,597 (GRCm39)	nonsense	probably null
R7533:Fat4	UTSW	3	39,061,406 (GRCm39)	missense	probably benign	0.43
R7542:Fat4	UTSW	3	39,035,770 (GRCm39)	missense	possibly damaging	0.64
R7542:Fat4	UTSW	3	39,035,504 (GRCm39)	missense	possibly damaging	0.56
R7548:Fat4	UTSW	3	39,035,263 (GRCm39)	missense	probably benign	0.13
R7567:Fat4	UTSW	3	38,943,485 (GRCm39)	missense	probably damaging	1.00
R7644:Fat4	UTSW	3	39,064,390 (GRCm39)	missense	possibly damaging	0.64
R7660:Fat4	UTSW	3	39,035,309 (GRCm39)	missense	probably benign
R7665:Fat4	UTSW	3	38,943,327 (GRCm39)	missense	probably benign	0.00
R7676:Fat4	UTSW	3	38,945,846 (GRCm39)	missense	probably damaging	0.98
R7832:Fat4	UTSW	3	39,055,353 (GRCm39)	missense	probably benign	0.00
R7848:Fat4	UTSW	3	38,942,000 (GRCm39)	missense	probably benign
R7883:Fat4	UTSW	3	39,035,968 (GRCm39)	missense	probably damaging	1.00
R7892:Fat4	UTSW	3	39,003,588 (GRCm39)	critical splice acceptor site	probably null
R7904:Fat4	UTSW	3	38,941,690 (GRCm39)	missense	probably damaging	1.00
R7952:Fat4	UTSW	3	38,945,870 (GRCm39)	missense	probably damaging	0.98
R8015:Fat4	UTSW	3	39,036,065 (GRCm39)	missense	possibly damaging	0.79
R8040:Fat4	UTSW	3	39,035,815 (GRCm39)	missense	probably damaging	1.00
R8142:Fat4	UTSW	3	38,945,352 (GRCm39)	missense	probably damaging	1.00
R8151:Fat4	UTSW	3	38,946,203 (GRCm39)	missense	probably damaging	0.99
R8163:Fat4	UTSW	3	39,033,881 (GRCm39)	missense	possibly damaging	0.88
R8317:Fat4	UTSW	3	39,012,659 (GRCm39)	missense	possibly damaging	0.80
R8413:Fat4	UTSW	3	39,063,128 (GRCm39)	critical splice acceptor site	probably null
R8447:Fat4	UTSW	3	39,033,824 (GRCm39)	missense	possibly damaging	0.88
R8458:Fat4	UTSW	3	39,035,702 (GRCm39)	missense	probably benign	0.25
R8509:Fat4	UTSW	3	39,036,052 (GRCm39)	missense	probably benign
R8543:Fat4	UTSW	3	39,031,643 (GRCm39)	missense	probably damaging	1.00
R8679:Fat4	UTSW	3	39,064,842 (GRCm39)	missense	probably damaging	1.00
R8726:Fat4	UTSW	3	39,064,647 (GRCm39)	missense	probably damaging	1.00
R8743:Fat4	UTSW	3	38,942,592 (GRCm39)	missense	probably benign	0.16
R8751:Fat4	UTSW	3	38,946,002 (GRCm39)	missense	probably benign	0.01
R8779:Fat4	UTSW	3	39,033,898 (GRCm39)	missense	probably damaging	1.00
R8797:Fat4	UTSW	3	39,053,278 (GRCm39)	missense	probably benign	0.01
R8860:Fat4	UTSW	3	38,946,269 (GRCm39)	missense	probably benign	0.26
R8955:Fat4	UTSW	3	39,037,778 (GRCm39)	missense	probably benign	0.01
R9053:Fat4	UTSW	3	38,941,324 (GRCm39)	nonsense	probably null
R9071:Fat4	UTSW	3	39,037,598 (GRCm39)	missense	probably benign	0.29
R9088:Fat4	UTSW	3	39,061,448 (GRCm39)	missense	probably benign	0.02
R9100:Fat4	UTSW	3	39,064,803 (GRCm39)	missense
R9180:Fat4	UTSW	3	38,942,556 (GRCm39)	missense	possibly damaging	0.78
R9184:Fat4	UTSW	3	39,036,592 (GRCm39)	missense	probably damaging	0.99
R9201:Fat4	UTSW	3	38,945,079 (GRCm39)	missense	probably damaging	1.00
R9206:Fat4	UTSW	3	39,063,390 (GRCm39)	missense	probably damaging	0.99
R9268:Fat4	UTSW	3	38,942,396 (GRCm39)	missense	probably damaging	1.00
R9278:Fat4	UTSW	3	38,945,171 (GRCm39)	missense	probably benign	0.44
R9287:Fat4	UTSW	3	38,945,781 (GRCm39)	missense	probably damaging	0.98
R9355:Fat4	UTSW	3	39,036,047 (GRCm39)	missense	probably damaging	1.00
R9437:Fat4	UTSW	3	38,945,417 (GRCm39)	missense	probably benign	0.00
R9455:Fat4	UTSW	3	38,945,412 (GRCm39)	missense
R9456:Fat4	UTSW	3	38,942,571 (GRCm39)	missense	possibly damaging	0.50
R9476:Fat4	UTSW	3	39,037,886 (GRCm39)	missense	probably benign	0.04
R9510:Fat4	UTSW	3	39,037,886 (GRCm39)	missense	probably benign	0.04
R9511:Fat4	UTSW	3	39,034,802 (GRCm39)	missense	probably damaging	0.98
R9540:Fat4	UTSW	3	39,063,346 (GRCm39)	missense	probably benign
R9568:Fat4	UTSW	3	38,946,156 (GRCm39)	missense	probably damaging	1.00
R9646:Fat4	UTSW	3	39,035,813 (GRCm39)	missense	probably damaging	1.00
R9683:Fat4	UTSW	3	38,943,332 (GRCm39)	missense	possibly damaging	0.52
R9711:Fat4	UTSW	3	39,055,374 (GRCm39)	missense	probably benign	0.00
X0017:Fat4	UTSW	3	39,063,255 (GRCm39)	missense	probably benign	0.00
X0019:Fat4	UTSW	3	39,035,189 (GRCm39)	missense	probably damaging	1.00
X0020:Fat4	UTSW	3	39,054,300 (GRCm39)	missense	probably damaging	1.00
X0024:Fat4	UTSW	3	38,997,051 (GRCm39)	missense	probably benign	0.43
X0064:Fat4	UTSW	3	39,024,901 (GRCm39)	missense	probably damaging	1.00
Z1088:Fat4	UTSW	3	39,012,641 (GRCm39)	missense	probably benign	0.00
Z1088:Fat4	UTSW	3	38,941,199 (GRCm39)	missense	possibly damaging	0.88
Z1176:Fat4	UTSW	3	39,037,964 (GRCm39)	missense	probably damaging	1.00
Z1176:Fat4	UTSW	3	39,037,508 (GRCm39)	missense	probably benign	0.00
Z1177:Fat4	UTSW	3	38,944,496 (GRCm39)	missense	probably damaging	1.00
Z1177:Fat4	UTSW	3	38,942,733 (GRCm39)	missense	probably damaging	1.00
Z1177:Fat4	UTSW	3	39,035,987 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGTTCCCACAGTCAAGGACTTC -3'
(R):5'- CACACACTTGCACTGGGAAG -3'

Sequencing Primer
(F):5'- GGACTTCCTGACTAATCACTACC -3'
(R):5'- TTGCACTGGGAAGGCTGC -3'

Posted On

2014-06-23