Incidental Mutation 'R2072:Ttn'
ID227195
Institutional Source Beutler Lab
Gene Symbol Ttn
Ensembl Gene ENSMUSG00000051747
Gene Nametitin
Synonyms1100001C23Rik, L56, mdm, shru, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, connectin
MMRRC Submission 040077-MU
Accession Numbers

NCBI RefSeq: NM_011652.3, NM_028004.2; MGI: 98864

Stock #R2072 (G1)
Quality Score225
Status Not validated
Chromosome2
Chromosomal Location76703980-76982547 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to T at 76937776 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Asparagine at position 2947 (T2947N)
Ref Sequence ENSEMBL: ENSMUSP00000097561 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000011934] [ENSMUST00000099980] [ENSMUST00000099981] [ENSMUST00000111846] [ENSMUST00000111882]
Predicted Effect probably benign
Transcript: ENSMUST00000011934
AA Change: T2947N

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000011934
Gene: ENSMUSG00000051747
AA Change: T2947N

DomainStartEndE-ValueType
IGc2 18 87 3.97e-7 SMART
IG 110 194 4.03e-8 SMART
low complexity region 251 270 N/A INTRINSIC
low complexity region 388 407 N/A INTRINSIC
Pfam:Titin_Z 412 454 4.1e-15 PFAM
Pfam:Titin_Z 463 504 2e-14 PFAM
Pfam:Titin_Z 509 548 7.5e-14 PFAM
Pfam:Titin_Z 553 594 2.3e-13 PFAM
Pfam:Titin_Z 599 640 4.1e-10 PFAM
Pfam:Titin_Z 644 686 7.3e-8 PFAM
low complexity region 885 901 N/A INTRINSIC
IGc2 912 979 7.57e-13 SMART
IGc2 1050 1119 9.12e-7 SMART
low complexity region 1169 1177 N/A INTRINSIC
low complexity region 1223 1233 N/A INTRINSIC
IGc2 1259 1327 6.55e-8 SMART
low complexity region 1355 1374 N/A INTRINSIC
IG 1423 1508 8.72e-4 SMART
IG 1522 1610 1.63e-3 SMART
low complexity region 1657 1668 N/A INTRINSIC
IG_like 1669 1755 7.06e0 SMART
IG 1807 1890 7.94e-7 SMART
low complexity region 1988 1999 N/A INTRINSIC
low complexity region 2002 2016 N/A INTRINSIC
IG 2044 2129 6.51e-3 SMART
IG 2140 2223 1.81e-1 SMART
IG 2233 2312 1.34e-4 SMART
IG 2322 2403 2.94e0 SMART
IG 2411 2491 8.99e-6 SMART
IG 2499 2578 1.97e0 SMART
IG 2586 2665 2.18e-4 SMART
IG 2673 2753 5e0 SMART
IG 2761 2840 2.41e-6 SMART
IG 2848 2927 3.3e-4 SMART
IG 2935 3014 6.35e-6 SMART
IG 3024 3103 1.17e-4 SMART
IG 3113 3194 6.97e-3 SMART
IGc2 3211 3278 8.26e-5 SMART
low complexity region 3287 3296 N/A INTRINSIC
IG 3311 3394 1.66e-9 SMART
IG 3469 3553 1.54e-4 SMART
IGc2 3591 3659 8.13e-4 SMART
low complexity region 3876 3887 N/A INTRINSIC
low complexity region 3950 3963 N/A INTRINSIC
low complexity region 4016 4030 N/A INTRINSIC
low complexity region 4148 4160 N/A INTRINSIC
IGc2 4217 4282 1.68e-5 SMART
IGc2 4310 4377 6.02e-7 SMART
low complexity region 4398 4414 N/A INTRINSIC
low complexity region 4419 4461 N/A INTRINSIC
low complexity region 4474 4491 N/A INTRINSIC
low complexity region 4497 4516 N/A INTRINSIC
low complexity region 4518 4532 N/A INTRINSIC
IGc2 4593 4659 3.85e-5 SMART
IG 4681 4763 4.49e-6 SMART
IG 4774 4862 1.1e0 SMART
IG_like 4865 4944 9.78e1 SMART
IG 4954 5032 5.45e-5 SMART
IG 5042 5121 3.08e-4 SMART
IG 5131 5209 1.93e-5 SMART
IG 5219 5298 1.81e-1 SMART
IG 5308 5394 9.49e-5 SMART
IG 5397 5476 2.94e-1 SMART
IG 5486 5574 4.29e-3 SMART
IG_like 5575 5654 7.3e1 SMART
IG 5664 5743 1.85e-7 SMART
IG 5753 5832 5.62e-7 SMART
IG 5842 5921 2.1e-6 SMART
IGc2 5937 6003 1.03e-5 SMART
IG 6020 6099 6.02e-7 SMART
IG 6108 6192 1e-3 SMART
IG 6202 6281 7.36e-2 SMART
IG 6291 6370 1.25e-4 SMART
IG 6380 6459 2.08e-1 SMART
IG 6468 6549 1.56e-5 SMART
FN3 6552 6635 1.85e-14 SMART
FN3 6653 6736 1.75e-15 SMART
FN3 6754 6837 4.44e-17 SMART
IG_like 6869 6936 1.79e0 SMART
FN3 6950 7032 7.73e-17 SMART
FN3 7050 7132 1.22e-14 SMART
IG 7159 7243 2.92e-5 SMART
FN3 7246 7328 4.08e-16 SMART
FN3 7345 7428 3.05e-15 SMART
FN3 7446 7528 1.09e-16 SMART
FN3 7546 7628 2.34e-16 SMART
FN3 7646 7729 3.7e-14 SMART
FN3 7747 7831 2.21e-12 SMART
IG 7855 7939 8.26e-5 SMART
FN3 7942 8024 1.15e-15 SMART
FN3 8042 8125 3.37e-17 SMART
IG 8148 8261 3.74e-3 SMART
FN3 8264 8348 7.62e-16 SMART
FN3 8365 8447 8.75e-16 SMART
FN3 8464 8547 1.95e-13 SMART
IG 8573 8656 3.79e-4 SMART
FN3 8659 8740 6.59e-11 SMART
FN3 8757 8840 3.7e-14 SMART
IGc2 8873 8946 2.21e-5 SMART
FN3 8960 9044 6.73e-17 SMART
FN3 9061 9149 4.95e-15 SMART
FN3 9167 9252 7.11e-16 SMART
IG 9279 9371 1.81e-1 SMART
FN3 9374 9456 3.81e-16 SMART
FN3 9474 9562 3.93e-18 SMART
IG 9585 9676 3.65e-6 SMART
FN3 9679 9762 2.19e-16 SMART
FN3 9779 9866 4.21e-18 SMART
FN3 9880 9966 5.95e-18 SMART
IG 9993 10075 5.28e-3 SMART
FN3 10078 10161 1.51e-10 SMART
FN3 10179 10262 2.34e-16 SMART
IG 10287 10371 2.5e-4 SMART
FN3 10374 10457 1.82e-13 SMART
FN3 10474 10557 6.73e-17 SMART
FN3 10575 10660 8.42e-18 SMART
IG 10687 10769 9.12e-7 SMART
FN3 10772 10854 1.14e-14 SMART
FN3 10872 10953 1.14e-14 SMART
IG 10979 11063 7.3e-6 SMART
FN3 11066 11149 2.19e-16 SMART
FN3 11166 11248 4.38e-16 SMART
FN3 11266 11350 4.88e-14 SMART
IGc2 11383 11450 1.44e-4 SMART
FN3 11464 11545 1.58e-13 SMART
FN3 11563 11646 6.05e-10 SMART
IG 11670 11756 9.12e-7 SMART
FN3 11759 11841 4.76e-17 SMART
FN3 11858 11941 1.14e-14 SMART
FN3 11959 12048 1.66e-16 SMART
IG 12075 12158 9.34e-4 SMART
FN3 12161 12243 6.14e-20 SMART
FN3 12261 12344 4.83e-18 SMART
IG 12367 12451 6.02e-7 SMART
FN3 12454 12537 2.44e-14 SMART
FN3 12554 12637 2.03e-11 SMART
FN3 12652 12737 7.06e-11 SMART
IG 12764 12848 2.44e-7 SMART
FN3 12851 12933 1.38e-13 SMART
FN3 12950 13033 4.69e-16 SMART
FN3 13051 13135 1.93e-17 SMART
IG 13162 13246 3.02e0 SMART
FN3 13249 13331 1.39e-18 SMART
FN3 13346 13426 5.69e-15 SMART
IG 13451 13535 7.08e-4 SMART
FN3 13538 13621 1.22e-14 SMART
FN3 13638 13721 3.5e-15 SMART
FN3 13736 13819 1.92e-12 SMART
IG 13847 13932 1.46e-5 SMART
FN3 13935 14017 1.2e-13 SMART
FN3 14034 14117 3.72e-19 SMART
FN3 14135 14219 1.38e-13 SMART
IG 14245 14327 8.59e-3 SMART
FN3 14330 14412 1.37e-17 SMART
FN3 14427 14508 7.5e-15 SMART
IG 14534 14618 1.81e-1 SMART
FN3 14621 14704 2.15e-15 SMART
FN3 14721 14804 5.31e-15 SMART
FN3 14819 14902 6.95e-10 SMART
IG 14930 15014 7.25e-1 SMART
FN3 15017 15100 8.75e-16 SMART
FN3 15117 15200 5.86e-17 SMART
FN3 15218 15302 4.31e-15 SMART
IG 15329 15411 4.78e-1 SMART
IG_like 15345 15400 1.79e0 SMART
FN3 15414 15496 1.02e-16 SMART
FN3 15511 15592 3.14e-17 SMART
IGc2 15622 15689 4.43e-5 SMART
FN3 15703 15786 3.22e-14 SMART
FN3 15803 15886 1.12e-13 SMART
FN3 15901 15984 1.58e-13 SMART
IG 16012 16096 6.97e-3 SMART
FN3 16099 16182 5.23e-14 SMART
FN3 16199 16282 3.05e-15 SMART
FN3 16300 16384 1.98e-14 SMART
IG 16411 16493 2.5e-4 SMART
FN3 16496 16578 2.69e-16 SMART
FN3 16593 16674 5.86e-17 SMART
IGc2 16704 16771 1.09e-4 SMART
FN3 16785 16868 2.07e-17 SMART
FN3 16885 16968 1.29e-13 SMART
FN3 16983 17066 2.33e-11 SMART
IG 17094 17178 8.72e-4 SMART
FN3 17181 17264 4.62e-15 SMART
FN3 17281 17364 1.47e-17 SMART
FN3 17382 17466 2.61e-14 SMART
IG 17493 17575 3.23e-7 SMART
FN3 17578 17660 1.22e-14 SMART
FN3 17675 17756 1.66e-16 SMART
IGc2 17786 17853 5.16e-6 SMART
FN3 17867 17950 1.88e-15 SMART
FN3 17967 18050 4.8e-13 SMART
FN3 18065 18149 6e-14 SMART
IG 18176 18261 2.08e0 SMART
FN3 18264 18347 2.04e-16 SMART
FN3 18364 18447 6.84e-18 SMART
FN3 18465 18549 1.9e-16 SMART
IG 18576 18658 2.3e-3 SMART
FN3 18661 18743 5.86e-17 SMART
FN3 18758 18839 1.17e-16 SMART
IG 18863 18947 2.08e-1 SMART
FN3 18950 19032 1.38e-13 SMART
FN3 19049 19132 3.64e-13 SMART
FN3 19147 19231 2.72e-12 SMART
IG 19258 19342 3.27e0 SMART
FN3 19345 19428 1.09e-11 SMART
FN3 19445 19528 6.53e-15 SMART
FN3 19546 19628 1.67e-12 SMART
IGc2 19661 19726 8.26e-5 SMART
FN3 19740 19822 2.8e-14 SMART
FN3 19837 19918 4.08e-16 SMART
IG 19945 20029 8.33e-1 SMART
FN3 20032 20115 1.42e-15 SMART
FN3 20132 20215 1.16e-11 SMART
FN3 20230 20313 4.31e-15 SMART
IG 20341 20425 4.16e-1 SMART
FN3 20428 20511 6.34e-13 SMART
FN3 20528 20611 4.24e-14 SMART
FN3 20629 20713 9.52e-17 SMART
IGc2 20746 20813 7.7e-5 SMART
FN3 20828 20910 9.99e-11 SMART
FN3 20925 21006 1.3e-9 SMART
IG 21032 21114 2.64e0 SMART
FN3 21119 21202 4.48e-13 SMART
FN3 21219 21302 1.72e-14 SMART
FN3 21317 21399 1.27e-12 SMART
IGc2 21433 21500 4.07e-4 SMART
FN3 21514 21597 2.46e-10 SMART
FN3 21614 21698 5.1e-17 SMART
FN3 21716 21799 2.93e-17 SMART
IG 21826 21908 2.03e-4 SMART
FN3 21911 21993 1.2e-13 SMART
FN3 22008 22089 2.48e-15 SMART
IG 22116 22200 2.18e-4 SMART
FN3 22203 22286 3.96e-14 SMART
FN3 22303 22386 9.75e-14 SMART
FN3 22401 22487 6.24e-12 SMART
IG 22516 22600 2.94e0 SMART
FN3 22603 22685 1.2e-13 SMART
FN3 22702 22786 1.07e-10 SMART
FN3 22804 22888 8.88e-17 SMART
IG 22915 22997 3.28e-8 SMART
FN3 23000 23082 5.07e-12 SMART
FN3 23097 23180 2.4e-13 SMART
IG 23207 23291 8.26e-5 SMART
FN3 23294 23377 1.44e-16 SMART
FN3 23394 23477 2.76e-13 SMART
FN3 23495 23578 6.63e-16 SMART
IG 23605 23685 5.66e-3 SMART
FN3 23690 23773 9.9e-15 SMART
FN3 23791 23875 9.16e-19 SMART
FN3 23893 23976 3.32e-16 SMART
IGc2 24007 24074 3.51e-8 SMART
IG 24097 24182 2.79e0 SMART
FN3 24185 24269 6.79e-13 SMART
FN3 24287 24370 3.7e-14 SMART
IG 24396 24482 1.85e-7 SMART
IG 24496 24581 1.55e0 SMART
FN3 24584 24665 1.33e-15 SMART
low complexity region 24687 24699 N/A INTRINSIC
S_TKc 24713 24967 9.98e-74 SMART
IG 25036 25121 7.36e-2 SMART
IG 25157 25244 1.78e-9 SMART
IG 25262 25347 1.11e-5 SMART
low complexity region 25533 25549 N/A INTRINSIC
low complexity region 25571 25583 N/A INTRINSIC
low complexity region 25585 25603 N/A INTRINSIC
low complexity region 25688 25698 N/A INTRINSIC
low complexity region 25704 25715 N/A INTRINSIC
low complexity region 25716 25738 N/A INTRINSIC
low complexity region 25767 25799 N/A INTRINSIC
IG 25842 25926 4.6e-3 SMART
IGc2 26035 26102 2.42e-11 SMART
IG 26183 26281 2.64e-3 SMART
IGc2 26326 26393 2.1e-6 SMART
IG 26507 26589 4.53e-2 SMART
IGc2 26608 26675 4.59e-12 SMART
low complexity region 26701 26720 N/A INTRINSIC
low complexity region 26724 26736 N/A INTRINSIC
low complexity region 26743 26771 N/A INTRINSIC
IG 26797 26884 8.51e-7 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000099980
AA Change: T2947N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097560
Gene: ENSMUSG00000051747
AA Change: T2947N

DomainStartEndE-ValueType
IGc2 18 87 3.97e-7 SMART
IG 110 194 4.03e-8 SMART
low complexity region 251 270 N/A INTRINSIC
low complexity region 388 407 N/A INTRINSIC
Pfam:Titin_Z 412 454 7.7e-16 PFAM
Pfam:Titin_Z 463 504 3.8e-15 PFAM
Pfam:Titin_Z 509 548 1.4e-14 PFAM
Pfam:Titin_Z 553 594 4.4e-14 PFAM
Pfam:Titin_Z 599 640 7.8e-11 PFAM
Pfam:Titin_Z 644 686 1.4e-8 PFAM
low complexity region 885 901 N/A INTRINSIC
IGc2 912 979 7.57e-13 SMART
IGc2 1050 1119 9.12e-7 SMART
low complexity region 1169 1177 N/A INTRINSIC
low complexity region 1223 1233 N/A INTRINSIC
IGc2 1259 1327 6.55e-8 SMART
low complexity region 1355 1374 N/A INTRINSIC
IG 1423 1508 8.72e-4 SMART
IG 1522 1610 1.63e-3 SMART
low complexity region 1657 1668 N/A INTRINSIC
IG_like 1669 1755 7.06e0 SMART
IG 1807 1890 7.94e-7 SMART
low complexity region 1988 1999 N/A INTRINSIC
low complexity region 2002 2016 N/A INTRINSIC
IG 2044 2129 6.51e-3 SMART
IG 2140 2223 1.81e-1 SMART
IG 2233 2312 1.34e-4 SMART
IG 2322 2403 2.94e0 SMART
IG 2411 2491 8.99e-6 SMART
IG 2499 2578 1.97e0 SMART
IG 2586 2665 2.18e-4 SMART
IG 2673 2753 5e0 SMART
IG 2761 2840 2.41e-6 SMART
IG 2848 2927 3.3e-4 SMART
IG 2935 3014 6.35e-6 SMART
IG 3024 3103 1.17e-4 SMART
IG 3113 3194 6.97e-3 SMART
IGc2 3211 3278 8.26e-5 SMART
low complexity region 3287 3296 N/A INTRINSIC
IG 3311 3394 1.66e-9 SMART
low complexity region 3409 3420 N/A INTRINSIC
IGc2 3475 3546 9.41e-9 SMART
low complexity region 3672 3685 N/A INTRINSIC
low complexity region 3875 3886 N/A INTRINSIC
IG 3909 3993 6.02e-7 SMART
IGc2 4127 4194 8.78e-9 SMART
low complexity region 4491 4504 N/A INTRINSIC
low complexity region 4673 4683 N/A INTRINSIC
IGc2 5099 5166 1.17e-4 SMART
IGc2 5296 5364 5.7e-8 SMART
IGc2 5430 5497 2.23e-10 SMART
Predicted Effect unknown
Transcript: ENSMUST00000099981
AA Change: T2993N
SMART Domains Protein: ENSMUSP00000097561
Gene: ENSMUSG00000051747
AA Change: T2993N

DomainStartEndE-ValueType
IGc2 18 87 3.97e-7 SMART
IG 110 194 4.03e-8 SMART
low complexity region 251 270 N/A INTRINSIC
Pfam:Titin_Z 382 454 4.6e-13 PFAM
Pfam:Titin_Z 463 504 1.2e-10 PFAM
Pfam:Titin_Z 509 548 2e-11 PFAM
Pfam:Titin_Z 553 594 8.3e-8 PFAM
Pfam:Titin_Z 599 640 5.4e-12 PFAM
Pfam:Titin_Z 645 686 5.4e-10 PFAM
Pfam:Titin_Z 696 730 5.8e-9 PFAM
low complexity region 931 947 N/A INTRINSIC
IGc2 958 1025 7.57e-13 SMART
IGc2 1096 1165 9.12e-7 SMART
low complexity region 1215 1223 N/A INTRINSIC
low complexity region 1269 1279 N/A INTRINSIC
IGc2 1305 1373 6.55e-8 SMART
low complexity region 1401 1420 N/A INTRINSIC
IG 1469 1554 8.72e-4 SMART
IG 1568 1656 1.63e-3 SMART
low complexity region 1703 1714 N/A INTRINSIC
IG_like 1715 1801 7.06e0 SMART
IG 1853 1936 7.94e-7 SMART
low complexity region 2034 2045 N/A INTRINSIC
low complexity region 2048 2062 N/A INTRINSIC
IG 2090 2175 6.51e-3 SMART
IG 2186 2269 1.81e-1 SMART
IG 2279 2358 1.34e-4 SMART
IG 2368 2449 2.94e0 SMART
IG 2457 2537 8.99e-6 SMART
IG 2545 2624 1.97e0 SMART
IG 2632 2711 2.18e-4 SMART
IG 2719 2799 5e0 SMART
IG 2807 2886 2.41e-6 SMART
IG 2894 2973 3.3e-4 SMART
IG 2981 3060 6.35e-6 SMART
IG 3070 3149 1.17e-4 SMART
IG 3159 3240 6.97e-3 SMART
IGc2 3257 3324 8.26e-5 SMART
low complexity region 3333 3342 N/A INTRINSIC
IG 3357 3440 1.66e-9 SMART
IG 3515 3599 1.54e-4 SMART
IGc2 3637 3705 8.13e-4 SMART
low complexity region 3922 3933 N/A INTRINSIC
low complexity region 3996 4009 N/A INTRINSIC
low complexity region 4062 4076 N/A INTRINSIC
low complexity region 4194 4206 N/A INTRINSIC
IGc2 4263 4328 1.68e-5 SMART
IGc2 4356 4423 6.02e-7 SMART
IGc2 4451 4518 1.69e-10 SMART
IGc2 4544 4611 5.79e-9 SMART
IGc2 4638 4705 3.5e-17 SMART
IGc2 4731 4798 2.92e-5 SMART
IGc2 4824 4891 1.7e-6 SMART
IG 4911 4995 2.83e-3 SMART
IGc2 5013 5080 2.35e-9 SMART
IGc2 5106 5173 4.82e-6 SMART
IGc2 5200 5267 7.13e-9 SMART
IG 5287 5371 9.34e-4 SMART
IG 5380 5464 1.32e-3 SMART
IG 5473 5557 5.75e-4 SMART
IGc2 5575 5642 3.03e-12 SMART
IGc2 5668 5735 2.68e-4 SMART
IGc2 5762 5829 1.47e-10 SMART
IGc2 5855 5922 2.28e-7 SMART
IGc2 5948 6015 3.76e-8 SMART
IGc2 6041 6108 1.31e-7 SMART
IGc2 6137 6204 2.44e-7 SMART
IG 6224 6308 2.1e-6 SMART
IGc2 6324 6391 7.13e-9 SMART
IGc2 6417 6484 5.04e-9 SMART
IG 6504 6589 3.46e-7 SMART
IGc2 6604 6671 9.55e-10 SMART
IGc2 6700 6767 4.7e-9 SMART
IGc2 6793 6860 8.26e-5 SMART
IGc2 6886 6953 2.58e-6 SMART
IGc2 6979 7046 1.85e-16 SMART
IGc2 7075 7142 1.33e-8 SMART
IGc2 7171 7238 1.3e-11 SMART
IGc2 7265 7332 1.6e-11 SMART
IGc2 7358 7425 6.21e-9 SMART
IGc2 7451 7519 8.13e-4 SMART
IGc2 7545 7612 1.03e-5 SMART
IGc2 7641 7708 1.28e-10 SMART
IGc2 7734 7801 7.19e-5 SMART
IGc2 7827 7894 2.34e-4 SMART
IGc2 7920 7987 1.54e-13 SMART
IGc2 8016 8083 9.12e-7 SMART
IGc2 8112 8179 1.53e-8 SMART
IGc2 8206 8273 3.01e-7 SMART
IGc2 8299 8366 5.16e-6 SMART
IGc2 8392 8460 1.65e-4 SMART
IGc2 8486 8553 4.63e-8 SMART
IGc2 8582 8649 3.38e-10 SMART
IGc2 8675 8742 1.04e-10 SMART
IGc2 8768 8835 2.54e-5 SMART
IGc2 8861 8928 3.79e-13 SMART
IGc2 8957 9024 1.18e-9 SMART
IGc2 9053 9120 8e-12 SMART
IGc2 9150 9217 5.32e-8 SMART
IGc2 9246 9313 8.57e-12 SMART
low complexity region 9326 9337 N/A INTRINSIC
IGc2 9354 9422 9.26e-8 SMART
low complexity region 9506 9530 N/A INTRINSIC
IG 9550 9631 2.08e-1 SMART
IGc2 9645 9711 1.54e-4 SMART
IG 9728 9812 1.3e-11 SMART
low complexity region 9836 9868 N/A INTRINSIC
low complexity region 9871 9912 N/A INTRINSIC
low complexity region 9938 9955 N/A INTRINSIC
low complexity region 9958 9990 N/A INTRINSIC
low complexity region 10000 10036 N/A INTRINSIC
low complexity region 10049 10077 N/A INTRINSIC
low complexity region 10140 10150 N/A INTRINSIC
Pfam:PPAK 10198 10224 9.4e-8 PFAM
Pfam:PPAK 10255 10281 4e-10 PFAM
low complexity region 10282 10338 N/A INTRINSIC
low complexity region 10370 10416 N/A INTRINSIC
low complexity region 10428 10484 N/A INTRINSIC
Pfam:PPAK 10561 10587 3.5e-10 PFAM
low complexity region 10606 10725 N/A INTRINSIC
low complexity region 10761 10775 N/A INTRINSIC
Pfam:PPAK 10904 10930 1.3e-8 PFAM
Pfam:PPAK 10932 10958 1.4e-8 PFAM
Pfam:PPAK 10960 10986 2.8e-8 PFAM
low complexity region 11147 11280 N/A INTRINSIC
low complexity region 11299 11346 N/A INTRINSIC
low complexity region 11355 11368 N/A INTRINSIC
low complexity region 11369 11378 N/A INTRINSIC
low complexity region 11383 11416 N/A INTRINSIC
low complexity region 11419 11436 N/A INTRINSIC
Pfam:PPAK 11454 11480 7.1e-10 PFAM
low complexity region 11590 11603 N/A INTRINSIC
low complexity region 11647 11658 N/A INTRINSIC
low complexity region 11659 11683 N/A INTRINSIC
low complexity region 11700 11738 N/A INTRINSIC
Pfam:PPAK 11755 11781 9.1e-8 PFAM
Pfam:PPAK 11811 11837 8.9e-8 PFAM
low complexity region 11963 11979 N/A INTRINSIC
low complexity region 12044 12066 N/A INTRINSIC
low complexity region 12090 12109 N/A INTRINSIC
low complexity region 12137 12194 N/A INTRINSIC
Pfam:PPAK 12211 12237 9.1e-8 PFAM
Pfam:PPAK 12267 12293 8.9e-8 PFAM
low complexity region 12459 12570 N/A INTRINSIC
low complexity region 12583 12614 N/A INTRINSIC
low complexity region 12638 12681 N/A INTRINSIC
low complexity region 12691 12717 N/A INTRINSIC
low complexity region 12725 12741 N/A INTRINSIC
low complexity region 12746 12788 N/A INTRINSIC
low complexity region 12801 12818 N/A INTRINSIC
low complexity region 12824 12843 N/A INTRINSIC
low complexity region 12845 12859 N/A INTRINSIC
IGc2 12920 12986 3.85e-5 SMART
IG 13008 13090 4.49e-6 SMART
IG 13101 13189 1.1e0 SMART
IG_like 13192 13271 9.78e1 SMART
IG 13281 13359 5.45e-5 SMART
IG 13369 13448 3.08e-4 SMART
IG 13458 13536 1.93e-5 SMART
IG 13546 13625 1.81e-1 SMART
IG 13635 13721 9.49e-5 SMART
IG 13724 13803 2.94e-1 SMART
IG 13813 13901 4.29e-3 SMART
IG_like 13902 13981 7.3e1 SMART
IG 13991 14070 1.85e-7 SMART
IG 14080 14159 5.62e-7 SMART
IG 14169 14248 2.1e-6 SMART
IGc2 14264 14330 1.03e-5 SMART
IG 14347 14426 6.02e-7 SMART
IG 14435 14519 1e-3 SMART
IG 14529 14608 7.36e-2 SMART
IG 14618 14697 1.25e-4 SMART
IG 14707 14786 2.08e-1 SMART
IG 14795 14876 1.56e-5 SMART
FN3 14879 14962 1.85e-14 SMART
FN3 14980 15063 1.75e-15 SMART
FN3 15081 15164 4.44e-17 SMART
IG_like 15196 15263 1.79e0 SMART
FN3 15277 15359 7.73e-17 SMART
FN3 15377 15459 1.22e-14 SMART
IG 15486 15570 2.92e-5 SMART
FN3 15573 15655 4.08e-16 SMART
FN3 15672 15755 3.05e-15 SMART
FN3 15773 15855 1.09e-16 SMART
FN3 15873 15955 2.34e-16 SMART
FN3 15973 16056 3.7e-14 SMART
FN3 16074 16158 2.21e-12 SMART
IG 16182 16266 8.26e-5 SMART
FN3 16269 16351 1.15e-15 SMART
FN3 16369 16452 3.37e-17 SMART
IG 16475 16588 3.74e-3 SMART
FN3 16591 16675 7.62e-16 SMART
FN3 16692 16774 8.75e-16 SMART
FN3 16791 16874 1.95e-13 SMART
IG 16900 16983 3.79e-4 SMART
FN3 16986 17067 6.59e-11 SMART
FN3 17084 17167 3.7e-14 SMART
IGc2 17200 17273 2.21e-5 SMART
FN3 17287 17371 6.73e-17 SMART
FN3 17388 17476 4.95e-15 SMART
FN3 17494 17579 7.11e-16 SMART
IG 17606 17698 1.81e-1 SMART
FN3 17701 17783 3.81e-16 SMART
FN3 17801 17889 3.93e-18 SMART
IG 17912 18003 3.65e-6 SMART
FN3 18006 18089 2.19e-16 SMART
FN3 18106 18193 4.21e-18 SMART
FN3 18207 18293 5.95e-18 SMART
IG 18320 18402 5.28e-3 SMART
FN3 18405 18488 1.51e-10 SMART
FN3 18506 18589 2.34e-16 SMART
IG 18614 18698 2.5e-4 SMART
FN3 18701 18784 1.82e-13 SMART
FN3 18801 18884 6.73e-17 SMART
FN3 18902 18987 8.42e-18 SMART
IG 19014 19096 9.12e-7 SMART
FN3 19099 19181 1.14e-14 SMART
FN3 19199 19280 1.14e-14 SMART
IG 19306 19390 7.3e-6 SMART
FN3 19393 19476 2.19e-16 SMART
FN3 19493 19575 4.38e-16 SMART
FN3 19593 19677 4.88e-14 SMART
IGc2 19710 19777 1.44e-4 SMART
FN3 19791 19872 1.58e-13 SMART
FN3 19890 19973 6.05e-10 SMART
IG 19997 20083 9.12e-7 SMART
FN3 20086 20168 4.76e-17 SMART
FN3 20185 20268 1.14e-14 SMART
FN3 20286 20375 1.66e-16 SMART
IG 20402 20485 9.34e-4 SMART
FN3 20488 20570 6.14e-20 SMART
FN3 20588 20671 4.83e-18 SMART
IG 20694 20778 6.02e-7 SMART
FN3 20781 20864 2.44e-14 SMART
FN3 20881 20964 2.03e-11 SMART
FN3 20979 21064 7.06e-11 SMART
IG 21091 21175 2.44e-7 SMART
FN3 21178 21260 1.38e-13 SMART
FN3 21277 21360 4.69e-16 SMART
FN3 21378 21462 1.93e-17 SMART
IG 21489 21573 3.02e0 SMART
FN3 21576 21658 1.39e-18 SMART
FN3 21673 21753 5.69e-15 SMART
IG 21778 21862 7.08e-4 SMART
FN3 21865 21948 1.22e-14 SMART
FN3 21965 22048 3.5e-15 SMART
FN3 22063 22146 1.92e-12 SMART
IG 22174 22259 1.46e-5 SMART
FN3 22262 22344 1.2e-13 SMART
FN3 22361 22444 3.72e-19 SMART
FN3 22462 22546 1.38e-13 SMART
IG 22572 22654 8.59e-3 SMART
FN3 22657 22739 1.37e-17 SMART
FN3 22754 22835 7.5e-15 SMART
IG 22861 22945 1.81e-1 SMART
FN3 22948 23031 2.15e-15 SMART
FN3 23048 23131 5.31e-15 SMART
FN3 23146 23229 6.95e-10 SMART
IG 23257 23341 7.25e-1 SMART
FN3 23344 23427 8.75e-16 SMART
FN3 23444 23527 5.86e-17 SMART
FN3 23545 23629 4.31e-15 SMART
IG 23656 23738 4.78e-1 SMART
IG_like 23672 23727 1.79e0 SMART
FN3 23741 23823 1.02e-16 SMART
FN3 23838 23919 3.14e-17 SMART
IGc2 23949 24016 4.43e-5 SMART
FN3 24030 24113 3.22e-14 SMART
FN3 24130 24213 1.12e-13 SMART
FN3 24228 24311 1.58e-13 SMART
IG 24339 24423 6.97e-3 SMART
FN3 24426 24509 5.23e-14 SMART
FN3 24526 24609 3.05e-15 SMART
FN3 24627 24711 1.98e-14 SMART
IG 24738 24820 2.5e-4 SMART
FN3 24823 24905 2.69e-16 SMART
FN3 24920 25001 5.86e-17 SMART
IGc2 25031 25098 1.09e-4 SMART
FN3 25112 25195 2.07e-17 SMART
FN3 25212 25295 1.29e-13 SMART
FN3 25310 25393 2.33e-11 SMART
IG 25421 25505 8.72e-4 SMART
FN3 25508 25591 4.62e-15 SMART
FN3 25608 25691 1.47e-17 SMART
FN3 25709 25793 2.61e-14 SMART
IG 25820 25902 3.23e-7 SMART
FN3 25905 25987 1.22e-14 SMART
FN3 26002 26083 1.66e-16 SMART
IGc2 26113 26180 5.16e-6 SMART
FN3 26194 26277 1.88e-15 SMART
FN3 26294 26377 4.8e-13 SMART
FN3 26392 26476 6e-14 SMART
IG 26503 26588 2.08e0 SMART
FN3 26591 26674 2.04e-16 SMART
FN3 26691 26774 6.84e-18 SMART
FN3 26792 26876 1.9e-16 SMART
IG 26903 26985 2.3e-3 SMART
FN3 26988 27070 5.86e-17 SMART
FN3 27085 27166 1.17e-16 SMART
IG 27190 27274 2.08e-1 SMART
FN3 27277 27359 1.38e-13 SMART
FN3 27376 27459 3.64e-13 SMART
FN3 27474 27558 2.72e-12 SMART
IG 27585 27669 3.27e0 SMART
FN3 27672 27755 1.09e-11 SMART
FN3 27772 27855 6.53e-15 SMART
FN3 27873 27955 1.67e-12 SMART
IGc2 27988 28053 8.26e-5 SMART
FN3 28067 28149 2.8e-14 SMART
FN3 28164 28245 4.08e-16 SMART
IG 28272 28356 8.33e-1 SMART
FN3 28359 28442 1.42e-15 SMART
FN3 28459 28542 1.16e-11 SMART
FN3 28557 28640 4.31e-15 SMART
IG 28668 28752 4.16e-1 SMART
FN3 28755 28838 6.34e-13 SMART
FN3 28855 28938 4.24e-14 SMART
FN3 28956 29040 9.52e-17 SMART
IGc2 29073 29140 7.7e-5 SMART
FN3 29155 29237 9.99e-11 SMART
FN3 29252 29333 1.3e-9 SMART
IG 29359 29441 2.64e0 SMART
FN3 29446 29529 4.48e-13 SMART
FN3 29546 29629 1.72e-14 SMART
FN3 29644 29726 1.27e-12 SMART
IGc2 29760 29827 4.07e-4 SMART
FN3 29841 29924 2.46e-10 SMART
FN3 29941 30025 5.1e-17 SMART
FN3 30043 30126 2.93e-17 SMART
IG 30153 30235 2.03e-4 SMART
FN3 30238 30320 1.2e-13 SMART
FN3 30335 30416 2.48e-15 SMART
IG 30443 30527 2.18e-4 SMART
FN3 30530 30613 3.96e-14 SMART
FN3 30630 30713 9.75e-14 SMART
FN3 30728 30814 6.24e-12 SMART
IG 30843 30927 2.94e0 SMART
FN3 30930 31012 1.2e-13 SMART
FN3 31029 31113 1.07e-10 SMART
FN3 31131 31215 8.88e-17 SMART
IG 31242 31324 3.28e-8 SMART
FN3 31327 31409 5.07e-12 SMART
FN3 31424 31507 2.4e-13 SMART
IG 31534 31618 8.26e-5 SMART
FN3 31621 31704 1.44e-16 SMART
FN3 31721 31804 2.76e-13 SMART
FN3 31822 31905 6.63e-16 SMART
IG 31932 32012 5.66e-3 SMART
FN3 32017 32100 9.9e-15 SMART
FN3 32118 32202 9.16e-19 SMART
FN3 32220 32303 3.32e-16 SMART
IGc2 32334 32401 3.51e-8 SMART
IG 32424 32509 2.79e0 SMART
FN3 32512 32596 6.79e-13 SMART
FN3 32614 32697 3.7e-14 SMART
IG 32723 32809 1.85e-7 SMART
IG 32823 32908 1.55e0 SMART
FN3 32911 32992 1.33e-15 SMART
low complexity region 33014 33026 N/A INTRINSIC
S_TKc 33040 33294 9.98e-74 SMART
IG 33363 33448 7.36e-2 SMART
IG 33484 33571 1.78e-9 SMART
IG 33589 33674 1.11e-5 SMART
low complexity region 33860 33876 N/A INTRINSIC
low complexity region 33898 33910 N/A INTRINSIC
low complexity region 33912 33930 N/A INTRINSIC
low complexity region 34015 34025 N/A INTRINSIC
low complexity region 34031 34042 N/A INTRINSIC
low complexity region 34043 34065 N/A INTRINSIC
low complexity region 34094 34126 N/A INTRINSIC
IG 34169 34253 4.6e-3 SMART
IGc2 34362 34429 2.42e-11 SMART
IG 34510 34608 2.64e-3 SMART
IG_like 34521 34582 3.02e-1 SMART
IGc2 34653 34720 2.1e-6 SMART
IG 34834 34916 4.53e-2 SMART
IGc2 34935 35002 4.59e-12 SMART
low complexity region 35028 35047 N/A INTRINSIC
low complexity region 35051 35063 N/A INTRINSIC
low complexity region 35070 35098 N/A INTRINSIC
IG 35124 35211 8.51e-7 SMART
Predicted Effect unknown
Transcript: ENSMUST00000111846
AA Change: T2993N
SMART Domains Protein: ENSMUSP00000107477
Gene: ENSMUSG00000051747
AA Change: T2993N

DomainStartEndE-ValueType
IGc2 18 87 3.97e-7 SMART
IG 110 194 4.03e-8 SMART
low complexity region 251 270 N/A INTRINSIC
low complexity region 388 407 N/A INTRINSIC
Pfam:Titin_Z 412 454 1.3e-15 PFAM
Pfam:Titin_Z 463 504 6.4e-15 PFAM
Pfam:Titin_Z 509 548 2.4e-14 PFAM
Pfam:Titin_Z 553 594 7.8e-13 PFAM
Pfam:Titin_Z 599 640 8.2e-15 PFAM
Pfam:Titin_Z 645 686 1.3e-10 PFAM
Pfam:Titin_Z 690 732 2.3e-8 PFAM
low complexity region 931 947 N/A INTRINSIC
IGc2 958 1025 7.57e-13 SMART
IGc2 1096 1165 9.12e-7 SMART
low complexity region 1215 1223 N/A INTRINSIC
low complexity region 1269 1279 N/A INTRINSIC
IGc2 1305 1373 6.55e-8 SMART
low complexity region 1401 1420 N/A INTRINSIC
IG 1469 1554 8.72e-4 SMART
IG 1568 1656 1.63e-3 SMART
low complexity region 1703 1714 N/A INTRINSIC
IG_like 1715 1801 7.06e0 SMART
IG 1853 1936 7.94e-7 SMART
low complexity region 2034 2045 N/A INTRINSIC
low complexity region 2048 2062 N/A INTRINSIC
IG 2090 2175 6.51e-3 SMART
IG 2186 2269 1.81e-1 SMART
IG 2279 2358 1.34e-4 SMART
IG 2368 2449 2.94e0 SMART
IG 2457 2537 8.99e-6 SMART
IG 2545 2624 1.97e0 SMART
IG 2632 2711 2.18e-4 SMART
IG 2719 2799 5e0 SMART
IG 2807 2886 2.41e-6 SMART
IG 2894 2973 3.3e-4 SMART
IG 2981 3060 6.35e-6 SMART
IG 3070 3149 1.17e-4 SMART
IG 3159 3240 6.97e-3 SMART
IGc2 3257 3324 8.26e-5 SMART
low complexity region 3333 3342 N/A INTRINSIC
IG 3357 3440 1.66e-9 SMART
IGc2 3474 3541 6.02e-7 SMART
IGc2 3569 3636 1.69e-10 SMART
IGc2 3662 3729 5.79e-9 SMART
IGc2 3756 3823 3.5e-17 SMART
IGc2 3849 3916 2.92e-5 SMART
IGc2 3942 4009 1.7e-6 SMART
IG 4029 4113 2.83e-3 SMART
IGc2 4131 4198 2.35e-9 SMART
IGc2 4224 4291 4.82e-6 SMART
IGc2 4318 4385 7.13e-9 SMART
IG 4405 4489 9.34e-4 SMART
IG 4498 4582 1.32e-3 SMART
IG 4591 4675 5.75e-4 SMART
IGc2 4693 4760 3.03e-12 SMART
IGc2 4786 4853 2.68e-4 SMART
IGc2 4880 4947 1.47e-10 SMART
IGc2 4973 5040 2.28e-7 SMART
IGc2 5066 5133 3.76e-8 SMART
IGc2 5159 5226 1.31e-7 SMART
IGc2 5255 5322 2.44e-7 SMART
IG 5342 5423 2.71e0 SMART
IGc2 5430 5497 7.13e-9 SMART
IGc2 5523 5590 5.04e-9 SMART
IG 5610 5695 3.46e-7 SMART
IGc2 5710 5777 9.55e-10 SMART
IGc2 5806 5873 4.7e-9 SMART
IGc2 5899 5966 8.26e-5 SMART
IGc2 5992 6059 2.58e-6 SMART
IGc2 6085 6152 1.85e-16 SMART
IGc2 6181 6248 1.33e-8 SMART
IGc2 6277 6344 1.3e-11 SMART
IGc2 6371 6438 1.6e-11 SMART
IGc2 6464 6531 6.21e-9 SMART
IGc2 6557 6625 8.13e-4 SMART
IGc2 6651 6718 1.03e-5 SMART
IGc2 6747 6814 1.28e-10 SMART
IGc2 6840 6907 7.19e-5 SMART
IGc2 6933 7000 2.34e-4 SMART
IGc2 7026 7093 1.54e-13 SMART
IGc2 7122 7189 9.12e-7 SMART
IGc2 7218 7285 1.53e-8 SMART
IGc2 7312 7379 3.01e-7 SMART
IGc2 7405 7472 5.16e-6 SMART
IGc2 7498 7566 1.65e-4 SMART
IGc2 7592 7659 4.63e-8 SMART
IGc2 7688 7755 3.38e-10 SMART
IGc2 7781 7848 1.04e-10 SMART
IGc2 7874 7941 2.54e-5 SMART
IGc2 7967 8034 3.79e-13 SMART
IGc2 8063 8130 1.18e-9 SMART
IGc2 8159 8226 8e-12 SMART
IGc2 8256 8323 5.32e-8 SMART
IGc2 8352 8419 8.57e-12 SMART
low complexity region 8432 8443 N/A INTRINSIC
IGc2 8460 8528 9.26e-8 SMART
low complexity region 8612 8636 N/A INTRINSIC
IG 8656 8737 2.08e-1 SMART
IGc2 8751 8817 1.54e-4 SMART
IG 8834 8918 1.3e-11 SMART
low complexity region 8942 8974 N/A INTRINSIC
low complexity region 8977 9021 N/A INTRINSIC
low complexity region 9047 9064 N/A INTRINSIC
low complexity region 9067 9099 N/A INTRINSIC
low complexity region 9109 9145 N/A INTRINSIC
low complexity region 9158 9186 N/A INTRINSIC
low complexity region 9249 9259 N/A INTRINSIC
Pfam:PPAK 9307 9334 2.4e-8 PFAM
Pfam:PPAK 9364 9390 3.6e-10 PFAM
low complexity region 9391 9447 N/A INTRINSIC
low complexity region 9479 9525 N/A INTRINSIC
low complexity region 9537 9593 N/A INTRINSIC
Pfam:PPAK 9614 9641 4e-10 PFAM
Pfam:PPAK 9670 9697 1.5e-9 PFAM
low complexity region 9715 9834 N/A INTRINSIC
Pfam:PPAK 10046 10073 4.6e-8 PFAM
Pfam:PPAK 10074 10101 2.4e-8 PFAM
Pfam:PPAK 10102 10129 1.4e-9 PFAM
low complexity region 10263 10403 N/A INTRINSIC
low complexity region 10422 10469 N/A INTRINSIC
low complexity region 10478 10491 N/A INTRINSIC
low complexity region 10492 10501 N/A INTRINSIC
low complexity region 10506 10539 N/A INTRINSIC
Pfam:PPAK 10599 10626 6.1e-8 PFAM
Pfam:PPAK 10683 10710 1.5e-7 PFAM
low complexity region 10847 10935 N/A INTRINSIC
low complexity region 10945 10971 N/A INTRINSIC
low complexity region 10979 10995 N/A INTRINSIC
low complexity region 11000 11042 N/A INTRINSIC
low complexity region 11055 11072 N/A INTRINSIC
low complexity region 11078 11097 N/A INTRINSIC
low complexity region 11099 11113 N/A INTRINSIC
IGc2 11174 11240 3.85e-5 SMART
IG 11262 11344 4.49e-6 SMART
IG 11355 11443 1.1e0 SMART
IG_like 11446 11525 9.78e1 SMART
IG 11535 11613 5.45e-5 SMART
IG 11623 11702 3.08e-4 SMART
IG 11712 11790 1.93e-5 SMART
IG 11800 11879 1.81e-1 SMART
IG 11889 11975 9.49e-5 SMART
IG 11978 12057 2.94e-1 SMART
IG 12067 12155 4.29e-3 SMART
IG_like 12156 12235 7.3e1 SMART
IG 12245 12324 1.85e-7 SMART
IG 12334 12413 5.62e-7 SMART
IG 12423 12502 2.1e-6 SMART
IGc2 12518 12584 1.03e-5 SMART
IG 12601 12680 6.02e-7 SMART
IG 12689 12773 1e-3 SMART
IG 12783 12862 7.36e-2 SMART
IG 12872 12951 1.25e-4 SMART
IG 12961 13040 2.08e-1 SMART
IG 13049 13130 1.56e-5 SMART
FN3 13133 13216 1.85e-14 SMART
FN3 13234 13317 1.75e-15 SMART
FN3 13335 13418 4.44e-17 SMART
IG_like 13450 13517 1.79e0 SMART
FN3 13531 13613 7.73e-17 SMART
FN3 13631 13713 1.22e-14 SMART
IG 13740 13824 2.92e-5 SMART
FN3 13827 13909 4.08e-16 SMART
FN3 13926 14009 3.05e-15 SMART
FN3 14027 14109 1.09e-16 SMART
FN3 14127 14209 2.34e-16 SMART
FN3 14227 14310 3.7e-14 SMART
FN3 14328 14412 2.21e-12 SMART
IG 14436 14520 8.26e-5 SMART
FN3 14523 14605 1.15e-15 SMART
FN3 14623 14706 3.37e-17 SMART
IG 14729 14842 3.74e-3 SMART
FN3 14845 14929 7.62e-16 SMART
FN3 14946 15028 8.75e-16 SMART
FN3 15045 15128 1.95e-13 SMART
IG 15154 15237 3.79e-4 SMART
FN3 15240 15321 6.59e-11 SMART
FN3 15338 15421 3.7e-14 SMART
IGc2 15454 15527 2.21e-5 SMART
FN3 15541 15625 6.73e-17 SMART
FN3 15642 15730 4.95e-15 SMART
FN3 15748 15833 7.11e-16 SMART
IG 15860 15952 1.81e-1 SMART
FN3 15955 16037 3.81e-16 SMART
FN3 16055 16143 3.93e-18 SMART
IG 16166 16257 3.65e-6 SMART
FN3 16260 16343 2.19e-16 SMART
FN3 16360 16447 4.21e-18 SMART
FN3 16461 16547 5.95e-18 SMART
IG 16574 16656 5.28e-3 SMART
FN3 16659 16742 1.51e-10 SMART