Incidental Mutation 'R2107:Lrrk1'
| ID |
232170 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
D130026O16Rik, C230002E15Rik |
| MMRRC Submission |
040111-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R2107 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 65929030 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Tyrosine
at position 1201
(D1201Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000015277
AA Change: D1201Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: D1201Y
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000145954
AA Change: D116Y
PolyPhen 2
Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
AA Change: D116Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Meta Mutation Damage Score |
0.5985 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.2%
|
| Validation Efficiency |
100% (72/72) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 72 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001O22Rik |
A |
T |
2: 30,685,744 (GRCm39) |
L364Q |
probably damaging |
Het |
| A2m |
C |
A |
6: 121,631,571 (GRCm39) |
L623M |
probably benign |
Het |
| Ace2 |
A |
G |
X: 162,923,728 (GRCm39) |
N24S |
probably benign |
Het |
| Acp2 |
G |
A |
2: 91,033,940 (GRCm39) |
|
probably benign |
Het |
| Akap8l |
C |
T |
17: 32,551,457 (GRCm39) |
R511H |
probably damaging |
Het |
| Bcas3 |
G |
A |
11: 85,348,704 (GRCm39) |
V199I |
probably damaging |
Het |
| Cblb |
T |
A |
16: 51,973,079 (GRCm39) |
|
probably null |
Het |
| Ccdc88c |
G |
T |
12: 100,887,808 (GRCm39) |
D1557E |
probably benign |
Het |
| Cdc20 |
T |
C |
4: 118,290,710 (GRCm39) |
Y430C |
probably damaging |
Het |
| Cdk5rap1 |
C |
T |
2: 154,195,166 (GRCm39) |
D350N |
probably benign |
Het |
| Cgrrf1 |
T |
A |
14: 47,090,833 (GRCm39) |
|
probably benign |
Het |
| Chia1 |
T |
A |
3: 106,036,156 (GRCm39) |
Y185* |
probably null |
Het |
| Cmtm8 |
A |
T |
9: 114,625,176 (GRCm39) |
V85D |
possibly damaging |
Het |
| Cplx4 |
A |
G |
18: 66,089,964 (GRCm39) |
S152P |
probably benign |
Het |
| Crmp1 |
G |
T |
5: 37,399,838 (GRCm39) |
R117L |
probably benign |
Het |
| Csad |
G |
C |
15: 102,087,469 (GRCm39) |
L365V |
probably null |
Het |
| Dyrk1a |
C |
T |
16: 94,487,386 (GRCm39) |
T532M |
probably damaging |
Het |
| Fabp3 |
C |
T |
4: 130,206,180 (GRCm39) |
T57I |
probably benign |
Het |
| Fan1 |
T |
G |
7: 64,016,536 (GRCm39) |
R529S |
probably damaging |
Het |
| Fbln5 |
A |
G |
12: 101,737,528 (GRCm39) |
W173R |
probably damaging |
Het |
| Gm9611 |
A |
T |
14: 42,116,611 (GRCm39) |
N42K |
possibly damaging |
Het |
| Gnal |
T |
A |
18: 67,346,649 (GRCm39) |
L257Q |
probably damaging |
Het |
| Hint3 |
A |
T |
10: 30,494,252 (GRCm39) |
F33I |
probably damaging |
Het |
| Ipcef1 |
A |
G |
10: 6,840,501 (GRCm39) |
S403P |
probably benign |
Het |
| Kmt2c |
T |
C |
5: 25,514,822 (GRCm39) |
N3007S |
probably benign |
Het |
| Kpna3 |
T |
C |
14: 61,607,933 (GRCm39) |
D424G |
possibly damaging |
Het |
| Krt90 |
A |
G |
15: 101,471,064 (GRCm39) |
I66T |
probably benign |
Het |
| Lamc2 |
A |
G |
1: 153,030,132 (GRCm39) |
|
probably benign |
Het |
| Lmtk3 |
G |
T |
7: 45,443,393 (GRCm39) |
C692F |
possibly damaging |
Het |
| Lrguk |
T |
C |
6: 34,039,296 (GRCm39) |
M269T |
probably benign |
Het |
| Lrrc19 |
T |
A |
4: 94,527,531 (GRCm39) |
T227S |
probably benign |
Het |
| Matn2 |
T |
A |
15: 34,423,905 (GRCm39) |
Y588N |
probably damaging |
Het |
| Mmp1b |
A |
G |
9: 7,369,310 (GRCm39) |
W346R |
probably damaging |
Het |
| Mpo |
T |
C |
11: 87,686,901 (GRCm39) |
Y177H |
probably damaging |
Het |
| Mprip |
A |
G |
11: 59,660,717 (GRCm39) |
K2166R |
probably damaging |
Het |
| Myo15a |
T |
C |
11: 60,382,636 (GRCm39) |
Y1544H |
probably damaging |
Het |
| Nav1 |
C |
T |
1: 135,376,742 (GRCm39) |
R1694Q |
probably damaging |
Het |
| Nedd9 |
A |
T |
13: 41,492,455 (GRCm39) |
C12* |
probably null |
Het |
| Neu1 |
G |
A |
17: 35,153,374 (GRCm39) |
R299Q |
probably benign |
Het |
| Nisch |
C |
T |
14: 30,894,097 (GRCm39) |
V172I |
probably damaging |
Het |
| Npy2r |
A |
T |
3: 82,448,436 (GRCm39) |
|
probably null |
Het |
| Ogg1 |
C |
A |
6: 113,306,254 (GRCm39) |
N150K |
probably damaging |
Het |
| Or1j4 |
C |
A |
2: 36,740,355 (GRCm39) |
A99E |
possibly damaging |
Het |
| Or1p1 |
T |
C |
11: 74,180,216 (GRCm39) |
V248A |
probably damaging |
Het |
| Or6c219 |
A |
G |
10: 129,781,581 (GRCm39) |
S2P |
probably damaging |
Het |
| Pck1 |
G |
C |
2: 172,995,861 (GRCm39) |
E120Q |
probably benign |
Het |
| Pde11a |
A |
G |
2: 76,168,266 (GRCm39) |
V229A |
probably damaging |
Het |
| Pias2 |
T |
C |
18: 77,185,167 (GRCm39) |
F83L |
probably benign |
Het |
| Plagl1 |
A |
C |
10: 13,004,391 (GRCm39) |
|
probably benign |
Het |
| Plin3 |
A |
T |
17: 56,591,391 (GRCm39) |
S130T |
probably benign |
Het |
| Rcc2 |
A |
G |
4: 140,448,496 (GRCm39) |
Y515C |
probably damaging |
Het |
| Rgs12 |
A |
G |
5: 35,124,079 (GRCm39) |
K621E |
possibly damaging |
Het |
| Rnf6 |
G |
A |
5: 146,148,091 (GRCm39) |
T309I |
probably damaging |
Het |
| Rpusd3 |
G |
T |
6: 113,392,523 (GRCm39) |
T335N |
probably damaging |
Het |
| Scn8a |
A |
T |
15: 100,916,244 (GRCm39) |
I1218F |
probably damaging |
Het |
| Slc23a1 |
T |
A |
18: 35,758,879 (GRCm39) |
Q104L |
possibly damaging |
Het |
| Slc34a3 |
A |
T |
2: 25,120,999 (GRCm39) |
V363D |
probably damaging |
Het |
| Smap1 |
A |
T |
1: 23,887,535 (GRCm39) |
M248K |
possibly damaging |
Het |
| Sp1 |
A |
G |
15: 102,318,113 (GRCm39) |
|
probably null |
Het |
| Tasor |
T |
A |
14: 27,183,744 (GRCm39) |
|
probably null |
Het |
| Tbc1d1 |
T |
G |
5: 64,442,048 (GRCm39) |
N689K |
probably benign |
Het |
| Tff2 |
T |
C |
17: 31,361,256 (GRCm39) |
E99G |
possibly damaging |
Het |
| Tjp3 |
T |
C |
10: 81,116,378 (GRCm39) |
N239D |
possibly damaging |
Het |
| Trim37 |
G |
A |
11: 87,050,651 (GRCm39) |
R230Q |
probably benign |
Het |
| Ubr5 |
A |
G |
15: 37,989,546 (GRCm39) |
M2090T |
probably benign |
Het |
| Unc13a |
T |
C |
8: 72,108,895 (GRCm39) |
|
probably null |
Het |
| Usp43 |
GC |
G |
11: 67,746,566 (GRCm39) |
|
probably null |
Het |
| Utrn |
C |
A |
10: 12,312,108 (GRCm39) |
D616Y |
probably damaging |
Het |
| Vav2 |
T |
C |
2: 27,157,315 (GRCm39) |
E829G |
probably damaging |
Het |
| Vps35l |
T |
C |
7: 118,393,762 (GRCm39) |
|
probably benign |
Het |
| Zfp26 |
A |
T |
9: 20,353,533 (GRCm39) |
D85E |
probably benign |
Het |
| Zfp292 |
A |
T |
4: 34,808,593 (GRCm39) |
F1484I |
possibly damaging |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCATGGTTACAGCGCTAAG -3'
(R):5'- GAGTTCTAGGGTACTGCTCAGAAC -3'
Sequencing Primer
(F):5'- TAAGCCGTGAACTGGTCG -3'
(R):5'- TTCACAGGAGCTGTCCCC -3'
|
| Posted On |
2014-09-18 |
Incidental Mutation