Incidental Mutation 'R2360:Morn1'
| ID |
247103 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Morn1
|
| Ensembl Gene |
ENSMUSG00000029049 |
| Gene Name |
MORN repeat containing 1 |
| Synonyms |
4930417P05Rik, 2900057D20Rik |
| MMRRC Submission |
040342-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2360 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
155171034-155229962 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 155176770 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 98
(S98T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000123207
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030915]
[ENSMUST00000127457]
[ENSMUST00000132367]
[ENSMUST00000155775]
|
| AlphaFold |
A2RTS7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000030915
AA Change: S135T
PolyPhen 2
Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000030915
Gene: ENSMUSG00000029049
AA Change: S135T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
1.4e-3 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
84 |
105 |
1.43e-1 |
SMART |
|
MORN
|
107 |
128 |
8.05e0 |
SMART |
|
MORN
|
130 |
151 |
2.06e-6 |
SMART |
|
MORN
|
153 |
174 |
7.56e-5 |
SMART |
|
MORN
|
176 |
197 |
1.2e0 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000127457
AA Change: S135T
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000116690
Gene: ENSMUSG00000029049
AA Change: S135T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
5.5e-4 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
84 |
105 |
1.43e-1 |
SMART |
|
MORN
|
107 |
128 |
8.05e0 |
SMART |
|
MORN
|
130 |
151 |
2.06e-6 |
SMART |
|
MORN
|
153 |
174 |
7.56e-5 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129180
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000132367
AA Change: S135T
PolyPhen 2
Score 0.947 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000116794
Gene: ENSMUSG00000029049
AA Change: S135T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
6.8e-4 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
84 |
105 |
1.43e-1 |
SMART |
|
MORN
|
107 |
128 |
8.05e0 |
SMART |
|
MORN
|
130 |
151 |
2.06e-6 |
SMART |
|
MORN
|
153 |
174 |
7.56e-5 |
SMART |
|
MORN
|
176 |
197 |
1.2e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155375
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000155775
AA Change: S98T
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000123207
Gene: ENSMUSG00000029049
AA Change: S98T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MORN
|
23 |
35 |
2.7e-4 |
PFAM |
|
MORN
|
37 |
58 |
4.11e-6 |
SMART |
|
MORN
|
60 |
81 |
2.41e-1 |
SMART |
|
MORN
|
93 |
114 |
2.06e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.2559 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.1%
|
| Validation Efficiency |
93% (37/40) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 38 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
A |
T |
7: 29,274,214 (GRCm39) |
|
noncoding transcript |
Het |
| Abca14 |
A |
G |
7: 119,850,431 (GRCm39) |
E761G |
probably benign |
Het |
| Apc |
C |
T |
18: 34,394,179 (GRCm39) |
T35I |
probably damaging |
Het |
| Arhgef2 |
T |
A |
3: 88,541,723 (GRCm39) |
I228N |
probably damaging |
Het |
| Atp6v1g2 |
A |
G |
17: 35,456,638 (GRCm39) |
E74G |
probably damaging |
Het |
| Ccdc70 |
A |
G |
8: 22,463,447 (GRCm39) |
E79G |
probably damaging |
Het |
| Cdc42ep4 |
A |
G |
11: 113,619,528 (GRCm39) |
S288P |
probably damaging |
Het |
| Cip2a |
C |
T |
16: 48,837,828 (GRCm39) |
Q843* |
probably null |
Het |
| Cpn2 |
T |
C |
16: 30,078,321 (GRCm39) |
D460G |
probably benign |
Het |
| Crtam |
A |
G |
9: 40,884,811 (GRCm39) |
*393Q |
probably null |
Het |
| Cwc22 |
A |
G |
2: 77,757,591 (GRCm39) |
I179T |
probably damaging |
Het |
| Cyp3a41b |
T |
C |
5: 145,507,221 (GRCm39) |
M240V |
probably benign |
Het |
| Dnah8 |
A |
T |
17: 30,896,178 (GRCm39) |
D864V |
probably benign |
Het |
| Map3k7 |
T |
C |
4: 31,964,302 (GRCm39) |
S14P |
unknown |
Het |
| Med25 |
A |
G |
7: 44,534,566 (GRCm39) |
S150P |
probably damaging |
Het |
| Mex3b |
T |
C |
7: 82,517,070 (GRCm39) |
V71A |
probably benign |
Het |
| Morc3 |
T |
C |
16: 93,638,275 (GRCm39) |
L19S |
probably damaging |
Het |
| Mthfd1l |
G |
T |
10: 4,006,771 (GRCm39) |
A678S |
probably damaging |
Het |
| Napa |
A |
G |
7: 15,848,083 (GRCm39) |
Y200C |
probably damaging |
Het |
| Nr5a2 |
T |
C |
1: 136,876,565 (GRCm39) |
I33V |
probably benign |
Het |
| Or14j6 |
A |
G |
17: 38,215,345 (GRCm39) |
K303E |
possibly damaging |
Het |
| Pcnx1 |
A |
G |
12: 81,996,960 (GRCm39) |
D952G |
probably damaging |
Het |
| Phf20l1 |
G |
A |
15: 66,466,769 (GRCm39) |
R66Q |
probably damaging |
Het |
| Resf1 |
A |
G |
6: 149,236,145 (GRCm39) |
I1488M |
probably benign |
Het |
| Rfk |
A |
G |
19: 17,375,960 (GRCm39) |
T85A |
probably benign |
Het |
| Sbno2 |
T |
C |
10: 79,893,855 (GRCm39) |
D1179G |
possibly damaging |
Het |
| Serpina3k |
C |
T |
12: 104,307,166 (GRCm39) |
Q133* |
probably null |
Het |
| Setd4 |
T |
C |
16: 93,383,122 (GRCm39) |
|
probably benign |
Het |
| Sh2d4b |
C |
T |
14: 40,582,548 (GRCm39) |
|
probably null |
Het |
| Slc1a6 |
G |
A |
10: 78,648,718 (GRCm39) |
V480I |
possibly damaging |
Het |
| Slc39a3 |
A |
T |
10: 80,867,104 (GRCm39) |
V214E |
possibly damaging |
Het |
| Tll1 |
A |
G |
8: 64,504,435 (GRCm39) |
Y654H |
probably damaging |
Het |
| Traf3ip1 |
T |
A |
1: 91,427,374 (GRCm39) |
C115S |
unknown |
Het |
| Vmn1r209 |
T |
A |
13: 22,989,836 (GRCm39) |
I285F |
probably damaging |
Het |
| Vmn2r87 |
G |
T |
10: 130,315,631 (GRCm39) |
T145K |
probably damaging |
Het |
| Zan |
T |
C |
5: 137,394,388 (GRCm39) |
T4484A |
unknown |
Het |
| Zfp768 |
T |
C |
7: 126,943,810 (GRCm39) |
E106G |
probably benign |
Het |
| Zfp984 |
A |
G |
4: 147,839,234 (GRCm39) |
I539T |
possibly damaging |
Het |
|
| Other mutations in Morn1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00471:Morn1
|
APN |
4 |
155,176,785 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL01143:Morn1
|
APN |
4 |
155,176,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02214:Morn1
|
APN |
4 |
155,176,776 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03112:Morn1
|
APN |
4 |
155,177,601 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Morn1
|
UTSW |
4 |
155,229,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Morn1
|
UTSW |
4 |
155,195,473 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0639:Morn1
|
UTSW |
4 |
155,173,960 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0918:Morn1
|
UTSW |
4 |
155,171,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2041:Morn1
|
UTSW |
4 |
155,175,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5831:Morn1
|
UTSW |
4 |
155,185,733 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6897:Morn1
|
UTSW |
4 |
155,171,112 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8178:Morn1
|
UTSW |
4 |
155,213,160 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8505:Morn1
|
UTSW |
4 |
155,177,792 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGAGCTAATGGGCAGGTC -3'
(R):5'- CTGGGTACTAGGCAGTGCTTTC -3'
Sequencing Primer
(F):5'- GGGGCCCTGGTACTCAATCTTC -3'
(R):5'- GGCAGTGCTTTCTACAAAATCTACC -3'
|
| Posted On |
2014-10-30 |
Incidental Mutation