Incidental Mutation 'R3015:Rnf115'
ID 257631
Institutional Source Beutler Lab
Gene Symbol Rnf115
Ensembl Gene ENSMUSG00000028098
Gene Name ring finger protein 115
Synonyms Rabring7, Zfp364, 2610028E05Rik
MMRRC Submission 040536-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3015 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 96634869-96698471 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 96661675 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 43 (S43P)
Ref Sequence ENSEMBL: ENSMUSP00000143321 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029740] [ENSMUST00000199051]
AlphaFold Q9D0C1
Predicted Effect probably damaging
Transcript: ENSMUST00000029740
AA Change: S43P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029740
Gene: ENSMUSG00000028098
AA Change: S43P

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
RING 229 269 1.14e-8 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000199051
AA Change: S43P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000143321
Gene: ENSMUSG00000028098
AA Change: S43P

DomainStartEndE-ValueType
low complexity region 2 17 N/A INTRINSIC
Pfam:zf-RING_3 18 49 4.5e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199974
Meta Mutation Damage Score 0.3565 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (38/38)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts9 T C 6: 92,849,913 (GRCm39) H380R probably benign Het
Aff3 A T 1: 38,249,649 (GRCm39) I486N probably benign Het
Bltp1 T A 3: 36,929,611 (GRCm39) F76Y probably damaging Het
Cfap44 A C 16: 44,230,832 (GRCm39) D271A probably benign Het
Dbndd2 T A 2: 164,330,270 (GRCm39) V34D probably damaging Het
Erc2 T A 14: 27,733,732 (GRCm39) probably null Het
Fcgbp T C 7: 27,774,838 (GRCm39) probably benign Het
Frem3 T C 8: 81,417,402 (GRCm39) S2036P probably damaging Het
Golph3l A G 3: 95,499,024 (GRCm39) probably benign Het
Grm7 G T 6: 110,623,309 (GRCm39) V161F probably damaging Het
Ifrd2 G A 9: 107,467,221 (GRCm39) G60S probably null Het
Ints9 T A 14: 65,187,727 (GRCm39) W3R probably benign Het
Jmjd1c A G 10: 66,993,711 (GRCm39) E64G probably damaging Het
Katnip T A 7: 125,465,512 (GRCm39) H1321Q probably damaging Het
Matn3 A C 12: 9,002,217 (GRCm39) Q143P probably damaging Het
Myo18a A T 11: 77,749,846 (GRCm39) probably benign Het
Nop9 T C 14: 55,988,631 (GRCm39) S358P probably benign Het
Pard3b T C 1: 62,384,037 (GRCm39) S801P probably damaging Het
Pax2 T C 19: 44,804,463 (GRCm39) F268L probably damaging Het
Pik3r1 A G 13: 101,823,771 (GRCm39) I538T probably damaging Het
Plekha8 T C 6: 54,599,107 (GRCm39) S214P probably benign Het
Ppme1 T C 7: 99,981,084 (GRCm39) H352R probably damaging Het
Ppp1r26 A C 2: 28,342,314 (GRCm39) D648A probably damaging Het
Prom1 C A 5: 44,191,733 (GRCm39) V337F probably damaging Het
Rapgef4 T C 2: 72,028,717 (GRCm39) I378T probably damaging Het
Rnf216 A G 5: 143,061,480 (GRCm39) probably null Het
Scn7a G T 2: 66,530,240 (GRCm39) Q702K probably benign Het
Shisal2b T A 13: 104,994,899 (GRCm39) I83F possibly damaging Het
Slc2a1 T A 4: 118,989,340 (GRCm39) N13K probably damaging Het
Tnr A G 1: 159,715,829 (GRCm39) I864V probably benign Het
Tspyl3 A T 2: 153,066,650 (GRCm39) M196K probably damaging Het
Ttn A T 2: 76,641,587 (GRCm39) L5176Q possibly damaging Het
Umod T C 7: 119,071,763 (GRCm39) D326G probably damaging Het
Upf2 A G 2: 5,980,890 (GRCm39) D492G unknown Het
Vash1 A G 12: 86,732,194 (GRCm39) T126A probably benign Het
Vsig10l T A 7: 43,116,881 (GRCm39) I574K possibly damaging Het
Other mutations in Rnf115
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03388:Rnf115 APN 3 96,695,984 (GRCm39) missense probably damaging 0.98
R0051:Rnf115 UTSW 3 96,692,338 (GRCm39) missense probably damaging 1.00
R0051:Rnf115 UTSW 3 96,692,338 (GRCm39) missense probably damaging 1.00
R1864:Rnf115 UTSW 3 96,635,153 (GRCm39) unclassified probably benign
R4030:Rnf115 UTSW 3 96,693,299 (GRCm39) missense probably damaging 1.00
R4590:Rnf115 UTSW 3 96,695,889 (GRCm39) missense probably benign 0.00
R5370:Rnf115 UTSW 3 96,665,336 (GRCm39) missense probably benign 0.05
R5820:Rnf115 UTSW 3 96,635,164 (GRCm39) unclassified probably benign
R5978:Rnf115 UTSW 3 96,695,982 (GRCm39) missense probably damaging 1.00
R8767:Rnf115 UTSW 3 96,695,907 (GRCm39) missense probably damaging 1.00
R9351:Rnf115 UTSW 3 96,695,994 (GRCm39) missense probably damaging 1.00
R9649:Rnf115 UTSW 3 96,665,337 (GRCm39) missense probably damaging 0.98
R9650:Rnf115 UTSW 3 96,665,337 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGTACAGTTCAAAACCAGCTTTAA -3'
(R):5'- AGATGAGGTGGATAAAATTATACCATC -3'

Sequencing Primer
(F):5'- GTCCTGGGGATCAAACTCAGATC -3'
(R):5'- CTCTCTCTCTCGTGTGTATGTGTG -3'
Posted On 2015-01-11