Incidental Mutation 'R3684:Dok3'
ID 269483
Institutional Source Beutler Lab
Gene Symbol Dok3
Ensembl Gene ENSMUSG00000035711
Gene Name docking protein 3
Synonyms p62Dok-like protein
MMRRC Submission 040682-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R3684 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 55671044-55677109 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 55672306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 154 (S154P)
Ref Sequence ENSEMBL: ENSMUSP00000153308 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047877] [ENSMUST00000223563]
AlphaFold Q9QZK7
Predicted Effect probably damaging
Transcript: ENSMUST00000047877
AA Change: S154P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000046695
Gene: ENSMUSG00000035711
AA Change: S154P

DomainStartEndE-ValueType
PH 7 125 3.54e-5 SMART
IRS 157 256 1.61e-41 SMART
PTBI 158 256 2.59e-24 SMART
low complexity region 273 284 N/A INTRINSIC
low complexity region 304 315 N/A INTRINSIC
low complexity region 358 376 N/A INTRINSIC
low complexity region 410 421 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000223563
AA Change: S154P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000223944
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence of lung adenocarcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamdec1 C T 14: 68,819,447 (GRCm39) V17I probably benign Het
Ahdc1 T C 4: 132,793,013 (GRCm39) L1418P possibly damaging Het
Atr T C 9: 95,802,453 (GRCm39) S1782P probably damaging Het
Btbd9 T A 17: 30,553,281 (GRCm39) N394Y probably damaging Het
Calb2 A G 8: 110,883,620 (GRCm39) Y35H probably benign Het
Cdon A G 9: 35,400,328 (GRCm39) E1014G possibly damaging Het
Cep83 A G 10: 94,622,687 (GRCm39) T588A probably benign Het
Cfap126 T C 1: 170,941,600 (GRCm39) S32P possibly damaging Het
Clcn7 T C 17: 25,369,567 (GRCm39) L301P possibly damaging Het
Corin T C 5: 72,488,198 (GRCm39) D610G probably damaging Het
Ggta1 T A 2: 35,298,000 (GRCm39) T162S probably benign Het
Gldn G A 9: 54,245,624 (GRCm39) E392K possibly damaging Het
Gls A T 1: 52,205,452 (GRCm39) D447E probably damaging Het
Itih5 A T 2: 10,243,435 (GRCm39) N391Y possibly damaging Het
Jchain G A 5: 88,670,398 (GRCm39) P74S probably damaging Het
Lct T C 1: 128,231,963 (GRCm39) M629V probably damaging Het
Lrrn1 T C 6: 107,544,910 (GRCm39) V236A probably benign Het
Mcm3ap T C 10: 76,325,260 (GRCm39) S954P possibly damaging Het
Myh11 T C 16: 14,021,098 (GRCm39) N1725S probably benign Het
Ppcdc C T 9: 57,328,408 (GRCm39) probably null Het
Rhobtb3 A G 13: 76,087,600 (GRCm39) I129T probably damaging Het
Sfxn2 A G 19: 46,579,592 (GRCm39) R252G probably benign Het
Sh2d2a C A 3: 87,759,027 (GRCm39) probably null Het
Sh3gl1 T C 17: 56,325,953 (GRCm39) K159E possibly damaging Het
Slc7a9 A G 7: 35,152,926 (GRCm39) T115A probably benign Het
Spmap1 A T 11: 97,666,525 (GRCm39) Y54N probably damaging Het
Synj2 A T 17: 6,078,718 (GRCm39) D1020V probably damaging Het
Tenm2 C A 11: 35,942,644 (GRCm39) V1342L probably benign Het
Tmem127 T A 2: 127,090,652 (GRCm39) I56N possibly damaging Het
Traj7 A G 14: 54,448,938 (GRCm39) probably benign Het
Unc5d A G 8: 29,184,620 (GRCm39) F627L probably damaging Het
Unc79 T A 12: 103,041,062 (GRCm39) N698K probably benign Het
Usp17la A T 7: 104,510,937 (GRCm39) N514I possibly damaging Het
Uvrag A T 7: 98,637,427 (GRCm39) C341S probably damaging Het
Zfp810 T C 9: 22,189,531 (GRCm39) D459G probably benign Het
Other mutations in Dok3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01837:Dok3 APN 13 55,671,383 (GRCm39) missense probably damaging 1.00
IGL02088:Dok3 APN 13 55,672,183 (GRCm39) missense probably damaging 1.00
IGL02218:Dok3 APN 13 55,671,599 (GRCm39) missense probably damaging 1.00
IGL02656:Dok3 APN 13 55,676,293 (GRCm39) missense probably damaging 0.97
IGL03410:Dok3 APN 13 55,672,044 (GRCm39) nonsense probably null
R0601:Dok3 UTSW 13 55,672,076 (GRCm39) missense probably benign 0.16
R1306:Dok3 UTSW 13 55,675,261 (GRCm39) nonsense probably null
R1749:Dok3 UTSW 13 55,672,168 (GRCm39) frame shift probably null
R4863:Dok3 UTSW 13 55,671,270 (GRCm39) missense probably damaging 1.00
R6195:Dok3 UTSW 13 55,671,389 (GRCm39) missense probably benign 0.00
R7021:Dok3 UTSW 13 55,672,097 (GRCm39) missense probably benign 0.00
R7526:Dok3 UTSW 13 55,675,306 (GRCm39) missense probably benign 0.03
R8379:Dok3 UTSW 13 55,671,833 (GRCm39) missense probably benign
R8983:Dok3 UTSW 13 55,671,535 (GRCm39) missense probably damaging 1.00
R9516:Dok3 UTSW 13 55,672,186 (GRCm39) missense probably benign 0.14
R9585:Dok3 UTSW 13 55,672,057 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TAGGGCCAGCTAAAACAGGC -3'
(R):5'- AGTTTTGTCTGCTGAGCCCATG -3'

Sequencing Primer
(F):5'- GATGTCATCTTGGCCCAGCAC -3'
(R):5'- TCTGCTGAGCCCATGGAAGG -3'
Posted On 2015-02-19