Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02191:Kif15'

283867

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Kif15

Ensembl Gene

ENSMUSG00000036768

Gene Name

kinesin family member 15

Synonyms

N-10 kinesin, 3930402I10Rik, 3110023M17Rik, HKLP2, Knsl7

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02191

Quality Score

Status

Chromosome

Chromosomal Location

122780146-122847798 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 122804744 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 93 (C93S)

Ref Sequence

ENSEMBL: ENSMUSP00000149737 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000213745] [ENSMUST00000214652] [ENSMUST00000216388] [ENSMUST00000217401]

AlphaFold

Q6P9L6

Predicted Effect

probably damaging
Transcript: ENSMUST00000040717
AA Change: C164S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: C164S

Domain	Start	End	E-Value	Type
KISc	24	371	2.86e-179	SMART
Pfam:Kinesin-relat_1	463	551	6.6e-26	PFAM
coiled coil region	579	643	N/A	INTRINSIC
coiled coil region	706	1037	N/A	INTRINSIC
coiled coil region	1065	1133	N/A	INTRINSIC
Pfam:HMMR_C	1265	1387	3.5e-12	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213745
AA Change: C164S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

Predicted Effect

probably benign
Transcript: ENSMUST00000214652

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214880

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215176

Predicted Effect

probably benign
Transcript: ENSMUST00000216388

Predicted Effect

probably damaging
Transcript: ENSMUST00000217401
AA Change: C93S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	T	C	12: 80,220,883 (GRCm39)	I642V	probably benign	Het
Adam5	G	A	8: 25,302,439 (GRCm39)	R185*	probably null	Het
C2	T	C	17: 35,085,539 (GRCm39)	I122V	probably damaging	Het
Camsap1	A	G	2: 25,819,892 (GRCm39)	I1531T	probably damaging	Het
Celsr1	T	C	15: 85,863,205 (GRCm39)	T1276A	possibly damaging	Het
Cnot7	A	T	8: 40,963,068 (GRCm39)	N35K	probably benign	Het
Cyp2a12	A	G	7: 26,736,036 (GRCm39)	I482V	probably benign	Het
Cyp3a57	A	G	5: 145,302,495 (GRCm39)	E97G	probably damaging	Het
Cyp51	C	A	5: 4,150,147 (GRCm39)	R192I	probably benign	Het
Ddx59	T	C	1: 136,344,896 (GRCm39)	L189P	probably damaging	Het
Dnah6	A	G	6: 72,994,780 (GRCm39)	I4127T	probably benign	Het
Dock3	C	T	9: 106,815,340 (GRCm39)	V1217I	probably benign	Het
Ergic2	T	C	6: 148,106,319 (GRCm39)	D57G	probably null	Het
Flvcr2	A	T	12: 85,832,966 (GRCm39)	K329*	probably null	Het
Foxp1	T	C	6: 98,922,561 (GRCm39)	S327G	probably damaging	Het
Gen1	A	C	12: 11,292,297 (GRCm39)	H562Q	probably benign	Het
Gjc2	A	G	11: 59,068,386 (GRCm39)	V32A	probably damaging	Het
Grk4	C	T	5: 34,912,533 (GRCm39)	H574Y	probably benign	Het
Lrtm1	A	C	14: 28,743,906 (GRCm39)	I125L	probably benign	Het
Mrgprb8	A	G	7: 48,038,527 (GRCm39)	Y66C	probably damaging	Het
Pfn1	G	A	11: 70,545,209 (GRCm39)	A33V	probably damaging	Het
Scnn1b	A	C	7: 121,516,736 (GRCm39)	K492Q	probably damaging	Het
Slc22a29	G	A	19: 8,196,045 (GRCm39)		probably benign	Het
Spocd1	A	G	4: 129,847,380 (GRCm39)	D523G	probably damaging	Het
Tmem144	A	T	3: 79,734,159 (GRCm39)	D181E	possibly damaging	Het
Tmem220	G	A	11: 66,921,933 (GRCm39)	C101Y	probably damaging	Het
Tmpo	A	G	10: 90,997,741 (GRCm39)	V682A	probably benign	Het
Wdr93	A	G	7: 79,398,968 (GRCm39)	K34R	probably damaging	Het
Zdhhc16	C	A	19: 41,926,130 (GRCm39)	C8*	probably null	Het
Zfp318	C	T	17: 46,707,736 (GRCm39)	R265*	probably null	Het

Other mutations in Kif15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01459:Kif15	APN	9	122,804,820 (GRCm39)	missense	probably damaging	1.00
IGL01577:Kif15	APN	9	122,825,399 (GRCm39)	missense	probably benign	0.06
IGL01647:Kif15	APN	9	122,792,536 (GRCm39)	intron	probably benign
IGL01921:Kif15	APN	9	122,808,569 (GRCm39)	missense	probably damaging	1.00
IGL02040:Kif15	APN	9	122,846,450 (GRCm39)	missense	probably damaging	0.99
IGL02218:Kif15	APN	9	122,824,892 (GRCm39)	splice site	probably benign
IGL02537:Kif15	APN	9	122,822,914 (GRCm39)	missense	probably benign	0.08
IGL02814:Kif15	APN	9	122,832,705 (GRCm39)	missense	possibly damaging	0.83
PIT4480001:Kif15	UTSW	9	122,840,608 (GRCm39)	missense	probably benign
R0034:Kif15	UTSW	9	122,828,350 (GRCm39)	missense	possibly damaging	0.47
R0458:Kif15	UTSW	9	122,838,424 (GRCm39)	missense	probably benign
R0526:Kif15	UTSW	9	122,826,862 (GRCm39)	missense	probably damaging	0.96
R0533:Kif15	UTSW	9	122,838,498 (GRCm39)	unclassified	probably benign
R0726:Kif15	UTSW	9	122,788,993 (GRCm39)	missense	probably benign	0.21
R1580:Kif15	UTSW	9	122,789,021 (GRCm39)	missense	probably benign	0.22
R1597:Kif15	UTSW	9	122,823,074 (GRCm39)	missense	probably benign	0.22
R2096:Kif15	UTSW	9	122,815,252 (GRCm39)	missense	probably damaging	1.00
R3125:Kif15	UTSW	9	122,817,026 (GRCm39)	missense	probably damaging	0.99
R3176:Kif15	UTSW	9	122,816,905 (GRCm39)	splice site	probably benign
R4088:Kif15	UTSW	9	122,815,254 (GRCm39)	missense	probably benign	0.29
R4308:Kif15	UTSW	9	122,843,047 (GRCm39)	missense	probably benign	0.00
R4597:Kif15	UTSW	9	122,822,914 (GRCm39)	missense	probably benign	0.08
R4705:Kif15	UTSW	9	122,789,058 (GRCm39)	splice site	probably null
R4832:Kif15	UTSW	9	122,831,191 (GRCm39)	splice site	probably null
R5100:Kif15	UTSW	9	122,821,059 (GRCm39)	missense	probably damaging	0.98
R5126:Kif15	UTSW	9	122,804,823 (GRCm39)	missense	probably damaging	1.00
R5180:Kif15	UTSW	9	122,828,275 (GRCm39)	missense	probably damaging	0.99
R5247:Kif15	UTSW	9	122,815,507 (GRCm39)	missense	possibly damaging	0.65
R5376:Kif15	UTSW	9	122,823,036 (GRCm39)	missense	probably benign	0.04
R5392:Kif15	UTSW	9	122,825,360 (GRCm39)	missense	probably damaging	0.99
R5422:Kif15	UTSW	9	122,813,954 (GRCm39)	splice site	probably null
R5562:Kif15	UTSW	9	122,807,081 (GRCm39)	missense	probably damaging	1.00
R5663:Kif15	UTSW	9	122,820,916 (GRCm39)	splice site	probably null
R5767:Kif15	UTSW	9	122,843,039 (GRCm39)	missense	possibly damaging	0.78
R5927:Kif15	UTSW	9	122,846,326 (GRCm39)	missense	probably benign	0.00
R6049:Kif15	UTSW	9	122,840,687 (GRCm39)	missense	probably damaging	0.98
R6435:Kif15	UTSW	9	122,815,556 (GRCm39)	missense	probably damaging	1.00
R7040:Kif15	UTSW	9	122,840,679 (GRCm39)	missense	possibly damaging	0.67
R7158:Kif15	UTSW	9	122,828,379 (GRCm39)	missense	probably benign
R7163:Kif15	UTSW	9	122,846,722 (GRCm39)	missense	probably damaging	1.00
R7197:Kif15	UTSW	9	122,838,991 (GRCm39)	critical splice donor site	probably null
R7318:Kif15	UTSW	9	122,817,014 (GRCm39)	missense	probably damaging	1.00
R7360:Kif15	UTSW	9	122,820,202 (GRCm39)	missense	probably benign
R8039:Kif15	UTSW	9	122,836,490 (GRCm39)	missense	possibly damaging	0.82
R8228:Kif15	UTSW	9	122,821,041 (GRCm39)	missense	possibly damaging	0.82
R8549:Kif15	UTSW	9	122,815,236 (GRCm39)	missense	probably benign
R9001:Kif15	UTSW	9	122,826,855 (GRCm39)	missense	probably benign	0.00
R9031:Kif15	UTSW	9	122,846,492 (GRCm39)	intron	probably benign
R9044:Kif15	UTSW	9	122,840,781 (GRCm39)	missense	probably benign	0.01
R9063:Kif15	UTSW	9	122,833,706 (GRCm39)	missense	probably damaging	1.00
R9306:Kif15	UTSW	9	122,807,056 (GRCm39)	missense	probably damaging	1.00
R9490:Kif15	UTSW	9	122,788,203 (GRCm39)	missense	probably benign	0.10
R9554:Kif15	UTSW	9	122,828,585 (GRCm39)	missense	probably damaging	1.00
R9682:Kif15	UTSW	9	122,815,712 (GRCm39)	missense	probably damaging	0.98
R9752:Kif15	UTSW	9	122,824,890 (GRCm39)	critical splice donor site	probably null
Z1177:Kif15	UTSW	9	122,780,116 (GRCm39)	unclassified	probably benign

Posted On

2015-04-16